DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and eif4a3.1

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001107349.1	Gene:	eif4a3.1 / 100135173	XenbaseID:	XB-GENE-5773453	Length:	415	Species:	Xenopus tropicalis

Alignment Length:	377	Identity:	262/377 - (69%)
Similarity:	320/377 - (84%)	Gaps:	0/377 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQ 91
            :|...||.|.|||:||||||.||||||||||||||...::|||||||:||||||||||.:::||.
Frog    39 DVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFCVSVLQC 103

  Fly    92 IDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARILESGCHVVVGTP 156
            :|..:||.||||||||||||.|||:|::|||:||.|..|||||||||.||.|.|:.|.|||.|||
Frog   104 LDIQVRETQALILAPTRELAGQIQKVLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTP 168

  Fly   157 GRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVS 221
            |||:|||.|:.|||:.||:.|||||||||::|||:||.||::.|||..||.|:|||:|.::||::
Frog   169 GRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVCLISATLPHEILEMT 233

  Fly   222 RCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLT 286
            ..||.||:.||||::||||||||||:|.|::|.||..|||||||||:|||:||||||:||||.||
Frog   234 NKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLT 298

  Fly   287 QEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRE 351
            ::|...|||||:|||||.|::||.|||:||||:|||||:||:.|||:||.||||:||||||:|||
Frog   299 EKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRE 363

  Fly   352 NYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIADLI 403
            .|||||||.||:|||||||||:.:||.|||:||||:|.|.|:|||.|:||||
Frog   364 LYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	260/375 (69%)
		DEADc	32..232	CDD:238167	134/199 (67%)
		Helicase_C	254..358	CDD:278689	76/103 (74%)
eif4a3.1	NP_001107349.1	PTZ00424	39..415	CDD:185609	260/375 (69%)
		Q motif	42..70		21/27 (78%)
		DEADc	44..244	CDD:238167	134/199 (67%)
		DEAD box. /evidence=ECO:0000305	191..194		2/2 (100%)
		HELICc	255..384	CDD:238034	95/128 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D321438at33208
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X250
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930