DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4B and SLC25A27

DIOPT Version :9

Sequence 1:	NP_608977.1	Gene:	Ucp4B / 33833	FlyBaseID:	FBgn0031758	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_004268.3	Gene:	SLC25A27 / 9481	HGNCID:	21065	Length:	323	Species:	Homo sapiens

Alignment Length:	321	Identity:	143/321 - (44%)
Similarity:	211/321 - (65%)	Gaps:	11/321 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EEKERPKLEYLVTNKKTPPVELYLTAFASACSAEIVGYPFDMCKTRMQIQGEIA-SRVG----QK 77
            ||:||    .|...::.|....:|.:..:|..||:..:|.|:.|||:|:|||.| :|:|    :.
Human     5 EEEER----LLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARES 65

  Fly    78 AKYRGLLATAMGIVREEGLLKLYGGISAMLFRHSLFSGIKMLTYDYMREKMIVPDEDGRPQLSFL 142
            |.|||::.||:||:.|||.|||:.|::..::||.::||.:|:||:::||.:....||....|  .
Human    66 APYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPL--W 128

  Fly   143 GSCISGVLAGATASVLTNPTELIKIQMQMEGQRRLRGEPPRIHNVLQALTSIYRTGGVVGLWKGT 207
            .|.|.|::||.....|.|||:|:|:||||||:|:|.|:|.|...|..|...|...||:.|||.|.
Human   129 KSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGW 193

  Fly   208 VPNTWRSALVTIGDVSCYDFCKRFLIAEFDLVDNREVQFVAAMTAGVADAILSLPADVVKSRIMN 272
            |||..|:|||.:||::.||..|.:|:....|.||.....::::.:|:..:||..||||:||||||
Human   194 VPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMN 258

  Fly   273 QPTDEQGRGIHYKGSLDCLSRLVREEGFLAMYKGFIPYWMRVGPASVVFWMTFEQIRRFRG 333
            ||.|:||||:.||.|.|||.:.|:.|||:::||||:|.|:|:.|.|:|||:|:|:||...|
Human   259 QPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSG 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4B	NP_608977.1	PTZ00169	32..306	CDD:240302	122/278 (44%)
		Mito_carr	32..129	CDD:278578	41/101 (41%)
		Mito_carr	138..233	CDD:278578	44/94 (47%)
		Mito_carr	246..331	CDD:278578	46/84 (55%)
SLC25A27	NP_004268.3	Mito_carr	20..118	CDD:365909	40/97 (41%)
		Solcar 1	21..115		39/93 (42%)
		Mito_carr	125..219	CDD:365909	44/95 (46%)
		Solcar 2	125..217		44/93 (47%)
		Solcar 3	226..317		48/90 (53%)
		Mito_carr	227..317	CDD:365909	47/89 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45618
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3722
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.800