DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4C and UCP3

DIOPT Version :9

Sequence 1:	NP_608976.1	Gene:	Ucp4C / 33832	FlyBaseID:	FBgn0031757	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_003347.1	Gene:	UCP3 / 7352	HGNCID:	12519	Length:	312	Species:	Homo sapiens

Alignment Length:	299	Identity:	106/299 - (35%)
Similarity:	163/299 - (54%)	Gaps:	30/299 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 FIGAN----LAESCVFPLDVAKTRMQVDGE-QAKKTGKAMPTFR---ATLTNMIRVEGFKSLYAG 100
            |:||.    .|:...||||.||.|:|:.|| ||.:|.: :..:|   .|:..|:|.||..|.|.|
Human    17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTAR-LVQYRGVLGTILTMVRTEGPCSPYNG 80

  Fly   101 FSAMVTRNFIFNSLRVVLYDVFRRPFLYQNERNEEVLKIYMALGCSFTAGCIAQALANPFDIVKV 165
            ..|.:.|...|.|:|:.|||..::.:..:...|..:....:| ||  |.|.:|...|.|.|:|||
Human    81 LVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILA-GC--TTGAMAVTCAQPTDVVKV 142

  Fly   166 RMQTE---GRRRQLGYDVRVNSMVQAFVDIYRRGGLPSMWKGVGPSCMRACLMTTGDVGSYDISK 227
            |.|..   |..|.   |.:.:..:.|:..|.|..|:..:|||..|:.||..::...:|.:|||.|
Human   143 RFQASIHLGPSRS---DRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILK 204

  Fly   228 RTFKRLLD---LEEGLPLRFVSSMCAGLTASVLSTPADVIKSRMMNQPVDESGKNLYYKNSLDCV 289
               ::|||   |.:..|..|||:..||..|:|:::|.||:|:|.||.|..:      |.:.|||:
Human   205 ---EKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQ------YFSPLDCM 260

  Fly   290 RKLVREEGVLTLYKGLMPTWFRLGPFSVLFWLSVEQLRQ 328
            .|:|.:||....|||..|::.|||.::|:.:::.|||::
Human   261 IKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4C	NP_608976.1	Mito_carr	49..124	CDD:278578	31/78 (40%)
		Mito_carr	137..232	CDD:278578	32/97 (33%)
		Mito_carr	237..329	CDD:278578	35/92 (38%)
UCP3	NP_003347.1	Mito_carr	10..110	CDD:278578	34/93 (37%)
		Solcar 1	11..105		34/88 (39%)
		PTZ00169	14..302	CDD:240302	106/299 (35%)
		Mito_carr	112..210	CDD:278578	35/106 (33%)
		Solcar 2	114..206		32/100 (32%)
		Mito_carr	214..303	CDD:278578	35/92 (38%)
		Solcar 3	215..300		35/91 (38%)
		Purine nucleotide binding. /evidence=ECO:0000250	279..301		7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810