DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4C and Slc25a11

DIOPT Version :9

Sequence 1:	NP_608976.1	Gene:	Ucp4C / 33832	FlyBaseID:	FBgn0031757	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_071793.2	Gene:	Slc25a11 / 64201	RGDID:	708476	Length:	314	Species:	Rattus norvegicus

Alignment Length:	331	Identity:	102/331 - (30%)
Similarity:	168/331 - (50%)	Gaps:	55/331 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IEEEPRFPPTNVADPLTARNLFQLYVNTFIGANLA--ESCVF--PLDVAKTRMQVDGEQAKKTGK 76
            ::.:||..|.:|               .|:...||  .:.||  |||:.|.|||:.||.| ||.:
  Rat    12 MDGKPRTSPKSV---------------KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGA-KTRE 60

  Fly    77 AMPTFRATLTNMIRVEGFKSLYAGFSAMVTRNFIFNSLRVVLYDVFRRPFLYQNERNEE------ 135
            ...:|.| ||::::.||.:.:|.|.||.:.|...:.:.|:.:|.|     |::.....:
  Rat    61 YKTSFHA-LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTV-----LFERLTGADGTPPGF 119

  Fly   136 VLKIYMALGCSFTAGCIAQALANPFDIVKVRMQTEGR-----RRQLGYDVRVNSMVQAFVDIYRR 195
            :||..:.:    |||.....:..|.::..:||..:||     ||  ||    .::..|.:.|.|.
  Rat   120 LLKALIGM----TAGATGAFVGTPAEVALIRMTADGRLPADQRR--GY----KNVFNALIRIARE 174

  Fly   196 GGLPSMWKGVGPSCMRACLMTTGDVGSYDISKRTFKRLLD---LEEGLPLRFVSSMCAGLTASVL 257
            .|:|::|:|..|:..||.::....:.||..||:.   |||   ..:.:...|.:||.:||..:..
  Rat   175 EGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQF---LLDSGYFSDNILCHFCASMISGLVTTAA 236

  Fly   258 STPADVIKSRMMNQPVDESGKNLYYKNSLDCVRKLVREEGVLTLYKGLMPTWFRLGPFSVLFWLS 322
            |.|.|::|:|:.|..:.: ||. .|||.||.:.|:||.||..:|:||..|.:.||||.:||.::.
  Rat   237 SMPVDIVKTRIQNMRMID-GKP-EYKNGLDVLLKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIF 299

  Fly   323 VEQLRQ 328
            :||:.:
  Rat   300 LEQMNK 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4C	NP_608976.1	Mito_carr	49..124	CDD:278578	30/78 (38%)
		Mito_carr	137..232	CDD:278578	28/99 (28%)
		Mito_carr	237..329	CDD:278578	35/92 (38%)
Slc25a11	NP_071793.2	Solcar 1	23..108		33/106 (31%)
		Mito_carr	24..102	CDD:395101	29/79 (37%)
		Mito_carr	116..213	CDD:395101	31/109 (28%)
		Solcar 2	117..208		28/100 (28%)
		Mito_carr	215..313	CDD:395101	35/93 (38%)
		Solcar 3	217..306		35/91 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810