DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13992 and MUC1

DIOPT Version :9

Sequence 1:	NP_001188703.1	Gene:	CG13992 / 33831	FlyBaseID:	FBgn0031756	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	NP_001358649.1	Gene:	MUC1 / 4582	HGNCID:	7508	Length:	1230	Species:	Homo sapiens

Alignment Length:	731	Identity:	173/731 - (23%)
Similarity:	230/731 - (31%)	Gaps:	197/731 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LAIGLTVLPGATA---------SGHEAS-PASRDLLNRSKRTMTTICVEIRPSSPQDEPYYMCR- 70
            |.:.||||...||         |||.:| |......:.::|:..       |||.:.....|..
Human    11 LLLLLTVLTATTAPKPATVVTGSGHASSTPGGEKETSATQRSSV-------PSSTEKNAVSMTSS 68

  Fly    71 -------GANFGGDSSQQSCVEVRSQGGQGEPFYMCQGAKS---TEPAI--------------EN 111
                   |:.......|...:...::...|......|...|   |.||:              :|
Human    69 VLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTSAPDN 133

  Fly   112 QPS----------MEHMPPFNPQPAEHHDYGHNF----PVFPAFEGGSYPQQPVTEDPTRILQVQ 162
            :|:          :...|...|.|.......|..    ...||....:.|...||..|    ..:
Human   134 KPAPGSTAPPAHGVTSAPDTRPAPGSTAPQAHGVTSAPDTRPAPGSTAPPAHGVTSAP----DTR 194

  Fly   163 PA---------GPTSYQEKPHQQPNPQQHQPHAQYGFYGGPMAAPPTAPAAESAGMQEFHHPIVG 218
            ||         |.||   .|..:|.|....|.|.     |..:||.|.||..|...|.  |.:..
Human   195 PAPGSTAPPAHGVTS---APDTRPAPGSTAPAAH-----GVTSAPDTRPAPGSTAPQA--HGVTS 249

  Fly   219 SP---PA----APP--GVPAG----PSPASTAASYDPAAFARSSSRPNENPVAGN---GRHRFTI 267
            :|   ||    |||  ||.:.    |:|.|||    |.|...:|: |:..|..|:   ..|..|.
Human   250 APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTA----PPAHGVTSA-PDTRPAPGSTAPPAHGVTS 309

  Fly   268 DEEVLAVPDVGFRREELQQQYRRPVSQPRPEDQLMWVPLSQ--TQDPENDPVMKAFYSSLGDERH 330
            ..|....|  |............|.|:|.|...   .|.:.  |..||:.|..    .|.....|
Human   310 APESRPAP--GSTAPAAHGVTSAPESRPAPGST---APAAHGVTSAPESRPAP----GSTAPPAH 365

  Fly   331 PTQEAPVSNQDEPMLGQMSP-----GYSPYNNQYPEAPAPP---------TLPPP----PPTY-- 375
            ....||   ...|..|..:|     ..:|.....|.:.|||         |.|.|    ||.:
Human   366 GVTSAP---DTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGV 427

  Fly   376 -SQADVTPSANTYCNGCPPTAPPIQCPVDNGVSYSTTCPSFQPVIISMPCYAQRAPTPYFGLPRA 439
             |..|..|:..:       ||||.     :||   |:.|.      |.|.....|| |..|:..|
Human   428 TSAPDTRPAPGS-------TAPPA-----HGV---TSAPE------SRPAPGSTAP-PAHGVTSA 470

  Fly   440 PPAL-APAGSFGGGFGLGAQLGS---PFGMSPQMGGQGYDMEHQVG----GPFGMGMQLGMGMNP 496
            |.:. ||..:.....|:.:...|   |...:|...|.....|.:..    .|...|:.......|
Human   471 PESRPAPGSTAPAAHGVTSAPESRPAPGSTAPAAHGVTSAPESRPAPGSTAPRAHGVTSAPDTRP 535

  Fly   497 FGPFGALNPFNPFNRVLGA----PAP--AAPTQNGNFFQRVFKFNQDAASTSTTEAAPTTEVQSE 555
             .| |:..|  |.:.|..|    |||  .||..:|            ..|...|..||.:.....
Human   536 -AP-GSTAP--PAHGVTSAPDTRPAPGSTAPPAHG------------VTSAPDTRPAPGSTAPPA 584

  Fly   556 RSGKLNFSSSTPAPPSSEQPDTIVGDDHDSDEAEDS----AEDFDKEDDT----AMTTPLPASEP 612
            . |..:...:.|||.|:..|...|....|:..|..|    |.......||    ..|.| ||...
Human   585 H-GVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAP-PAHGV 647

  Fly   613 DDSADTSGVPAIVSKA 628
            ..:.||...|...:.|
Human   648 TSAPDTRPAPGSTAPA 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13992	NP_001188703.1	PLN03142	573..>642	CDD:215601	16/64 (25%)
MUC1	NP_001358649.1	PRK07003	<92..437	CDD:235906	90/375 (24%)
		PHA03247	<276..826	CDD:223021	108/445 (24%)
		PRK12323	<758..982	CDD:237057
		SEA	1009..1127	CDD:214554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CNHI
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900