DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ICAM1 and side-VIII

DIOPT Version :9

Sequence 1:	NP_000192.2	Gene:	ICAM1 / 3383	HGNCID:	5344	Length:	532	Species:	Homo sapiens
Sequence 2:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	652	Identity:	130/652 - (19%)
Similarity:	212/652 - (32%)	Gaps:	227/652 - (34%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAPSSPRPA-LPALLVLLGALFPGPGNAQTSVSPSK--------------VILPRGGSVL----- 45
            |:.:|.|.. ||..|::|.|| .||..|.:.|..|.              ::|..|..||
  Fly     1 MSRTSSRSLFLPLCLLVLSAL-NGPAAAASRVRVSSSTTMTRNIEEENALLLLLAGPPVLSESIM 64

Human    46 -----VTCSTSC----DQPKL-----LGIETPL-------------------PKKELL---LPGN 74
                 :.|:.:.    |:..|     :|::||:                   ..:|.|   :.|.
  Fly    65 GTVGRLPCNVTPPIYEDRVALVIWYKVGLKTPIYSVDTRDSNFAQGTHWSDETYRERLSFHVEGR 129

Human    75 NRKVYELSNVQEDS-QPMC---YSNCPDGQSTAKTFLTVYWTPERV-------------ELAPLP 122
            ...:...|..::|: :..|   :...|...|  |..|||...||.|             .|.|..
  Fly   130 AGTLTIKSTTEDDTGEYRCRVDFQKSPTRNS--KVNLTVIIPPESVIILDSKGVTIEDHTLGPYN 192

Human   123 SWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEP---AEVTTTV----LVRRDHH 180
            .    |..:.:.|...||.|:..:|  .|.|....| ..:||:|   ..|..|:    |.||:.|
  Fly   193 E----GSGINITCVAIGGRPQPRVT--WLHGNTVYK-NASVGQPLSERRVGNTLSLARLERRNLH 250

Human   181 GANFSCRTE---------------LDLRP-----QGLELFENTSAPYQLQTFVLPATPPQLVSPR 225
             ...:||.|               ::|||     ||.....:....|||...|:.|.|
  Fly   251 -MQLTCRAENNNLTTPIISSVVLDMNLRPLIVKLQGENRALSAGNSYQLSCVVIGARP------- 307

Human   226 VLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTC 290
                   ...:....|..|:.... .:|..|..|..:|          .:.:.|.:|.| :.|:|
  Fly   308 -------APTITWWKGSTPMKNTH-EIATPDGNLTTSV----------LTFTPTIDDRG-KFLSC 353

Human   291 AV---ILGNQSQETLQTVTIYSFPAPNVIL----TKPEVSEGTEVTVKC--EAHP---------R 337
            ..   ::.....|....:.||..|..::.|    ....:.||.:|..:|  :::|         .
  Fly   354 RAEQSMIPESGMEDGWKLDIYHIPVVSLELGTNSLNSTLREGIDVFFECNIKSNPWIYEVSWRHN 418

Human   338 AKVTLNGVPAQPLGPRAQ-LLLKATPEDNGRSFSC-SATLEVAGQLIHKNQTRELRVLYGPRLDE 400
            .|:..|. ||:.:....| |:|:.........::| .:..|..|:    :...:|.:.:.|....
  Fly   419 GKILTNN-PAEGIAVSNQSLVLQNASRARSGIYTCVGSNREGDGE----SNPVQLDIRFAPVCRP 478

Human   401 RDCPGNWTWPENSQQT--PMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQ 463
            |.   ..::.....:|  ..|:...||                         .|.||:.:..:||
  Fly   479 RQ---RLSYSSGRHETVKVACEIDANP-------------------------AEATYVWKFNATQ 515

Human   464 GEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQ 528
            ||     ||::  |..::.:                    :|.|.|..|        |||..|..
  Fly   516 GE-----TVDI--PASQVAV--------------------DRGRSIAHY--------TPMTENDY 545

Human   529 AT 530
            .|
  Fly   546 GT 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICAM1	NP_000192.2	ICAM_N	24..110	CDD:252248	25/144 (17%)
		Ig2_ICAM-1_like	113..207	CDD:143232	31/133 (23%)
		Cell attachment site, atypical. /evidence=ECO:0000255	152..154		0/1 (0%)
		Ig	311..387	CDD:325142	17/92 (18%)
		IG_like	404..474	CDD:214653	13/71 (18%)
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845	19/112 (17%)
		IG_like	60..166	CDD:214653	16/107 (15%)
		Ig	182..266	CDD:299845	23/91 (25%)
		Ig	296..373	CDD:299845	18/102 (18%)
		IG_like	389..464	CDD:214653	15/79 (19%)
		IGc2	394..459	CDD:197706	13/65 (20%)
		Ig_3	490..554	CDD:290638	23/118 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910