DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9044 and stk11ip

DIOPT Version :9

Sequence 1:	NP_001260114.1	Gene:	CG9044 / 33825	FlyBaseID:	FBgn0031752	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_005166285.1	Gene:	stk11ip / 795019	ZFINID:	ZDB-GENE-040426-1022	Length:	1160	Species:	Danio rerio

Alignment Length:	1421	Identity:	316/1421 - (22%)
Similarity:	520/1421 - (36%)	Gaps:	394/1421 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFT--LIADTEIGTGAGYLQPQSFQVVKPIN 68
            :..||.|||.|||.:|....||||....|:.|...|.  |::.|         ....|..:....
Zfish    12 VHRLATLLRNNGDSVLDGSSTLTLQVGCLQHLTQLFERHLLSRT---------HQHGFLALPSHP 67

  Fly    69 AKSSVFPDLQLVHDFVQKTTLLKLTYFPSEHYFEGAIDIAKFRALRRLEVNKINIGQVVGIQPLR 133
            |.::...::|.:.|.:|||..|||...|... .:..:.|..|::|:.||:.:|....:.|::.:.
Zfish    68 ADTASLLEVQFLFDMLQKTVSLKLVNPPGVK-LQYVVKIFPFKSLKHLELKRIPPHCLEGLRGVY 131

  Fly   134 GQLQHLICVKSLTSVDDIITRCGGDNSNGFVWNELKTADFSYNSLRSVDTALEFAQHLQHLNLRH 198
            .||:...|.|.::|::::::.||||.|:...|.||:|.:|||||:..:|.:|.....|:.|:|.|
Zfish   132 SQLEVFTCSKGVSSLEELLSLCGGDLSSALPWLELQTLNFSYNSISCLDESLSLLNVLKWLDLSH 196

  Fly   199 NKLTSVAA-IKWLPHLKTLDLSYNCLTHLPQFHMEACKRLQLLNISNNYVEELLDVAKLDALYNL 262
            ||:...|. :|.|..|:.|:|:||.|...|...:.|..:|..|.:.||.:|.:..|.:|.:|..|
Zfish   197 NKIEDCAEFLKPLTELEHLNLAYNNLQRAPVLGLSAQAKLTTLILRNNELETINGVEQLSSLQCL 261

  Fly   263 DLSDNCLLEHSQLLPLSALMSLIVLNLQGNPLACNPKHRQATAQYLHKNSATVKFVLDFEPLTKA 327
            ||:.|.|:|||||.|||.|.:|..|.|:||||.....||.:...:|...:|.....||..||:::
Zfish   262 DLAYNLLMEHSQLAPLSLLHNLNTLTLEGNPLYFLKTHRASAVCHLSPRAAFNGLQLDGTPLSQS 326

  Fly   328 EKALTGSQKWRYISGLSHRSPRSTSMSINSSSASINTSDGSQFSSFGSQR--SVSIRGKNYTLED 390
            :..|. .:..:.:..|||          .|..|.....||...||.|...  |:|:.|....
Zfish   327 DLLLI-PKPGQLVGQLSH----------TSLVAMAQDQDGQDVSSGGGDMTDSLSVSGATRV--- 377

  Fly   391 NQSMDTSQSSKRISSCKIRTVDIEESSEINTDAASVSTPNPRSEYEEEPDNSHLETKKKIETLRL 455
                   :..|:.:..|:|...|.|.|:.:.:...||.       .::....|.|..:::::.|.
Zfish   378 -------RKKKQKNKVKVRRASISEPSDTDHEITVVSA-------VQDIVLPHKEDIERMDSFRE 428

  Fly   456 TYGNEWLKSGNAELMLGIETPQPTERERNESRQLFNEYLGE---LSGFTEAKN----------DS 507
            ..|.:||:                          :..:|.:   :..|.||..          .|
Zfish   429 QLGEDWLR--------------------------YQHHLHDTPVIPSFPEADTVVNTNGRCTPPS 467

  Fly   508 EHHNISSTPTNNVLLASTF------------DATITPIKSEANDT---SGQTLYETCTEGEETNY 557
            ......|.||:.|||....            :...:.::.|...|   ||.:...|    |.|..
Zfish   468 PLLKTHSPPTSLVLLPPPLLSSEMKEEEAKEEMESSDVQPETESTLQWSGHSPLNT----ESTIE 528

  Fly   558 ESFGNN--TTELSTEERPP------DRHEELLRLYASSSNAQDEDPV------SDAESDEETYIV 608
            .|.||.  .|:..::.:||      ||..:|.|            |:      .|.|:|
Zfish   529 TSLGNTQAATDAYSDPQPPPEEDEDDRGVDLCR------------PMLVGLLSEDLETD------ 575

  Fly   609 YHEQKPSEVLFLTISSNFIREKDTLTERTKAKWSLKILESCERVRSNTLRINFDTMRKDKQERIY 673
              :::.||.|||.:....:.|.|             :.:.|.:.     |:..|:
Zfish   576 --QKRVSEPLFLRVRQGHLLEVD-------------MHQGCVKT-----RVELDS---------- 610

  Fly   674 CVENTLCQELEKKLRDILSQRDLTEMNISIYRCVNCLTQFTIEQKSKRYKAKELRCPDCRSVYVA 738
                         |||:::    ||...::.: || .||.::|... ||.::|.|    :..|:.
Zfish   611 -------------LRDVVT----TEALCTVEK-VN-ETQPSVELHF-RYISRERR----KRCYIM 651

  Fly   739 EVTELSSSLSKPSGEVAAEPKLSPAMIVEESPVEELAAAINKEESNSIVANCRLTTAKITPKLRS 803
            ...:...||     :|.||..|   .:|||:..:     ::.|...:|...|....|:
Zfish   652 LDDKPQESL-----QVLAEVLL---RVVEENKQQ-----VDDERPETIWLQCLKCQAE------- 696

  Fly   804 LTQATKSSANSLN-----GSSSCSKITNSQSSFDSNQSVVGSSNTDRDMEFRANE------SDVD 857
            ..|....|.|.||     |::.|:.|. |:.:.|....:...|.......|..|.      .|.|
Zfish   697 FCQPANESDNCLNHLDEQGNNKCTVIC-SECNSDHVVQLAAQSTPSTSTPFEQNGERYFTFDDRD 760

  Fly   858 IISNPSQSSIEVL-----DPNYVQSASRKTSEERRISQLPHLETIHDEVAKSKSFIEREF-GQLL 916
            ...:...|.::.|     .|.::...|..::|.      .:..|.|       ||:...| .|..
Zfish   761 NADHLQHSEVQSLVLSHGSPLHLTQQSEVSTEG------AYFHTAH-------SFLSNCFPNQNE 812

  Fly   917 AEQAQPTTPSTAAPLAPAKSAVPSHVPLTESSSSG---SVTD-SICTTYEQQA------TDAPQN 971
            |||.  |:|.....:...::         :|.|.|   ::.| |.|.:||:||      |..|..
Zfish   813 AEQR--TSPLINFSITDGEA---------QSDSEGMKENLADKSCCNSYEKQALLSPKYTGGPNT 866

  Fly   972 LQNSLLTESSNSQVSGSDAESNSRLKSAEDASLLPFASVFQSTNLLMSSSKKLIESEATVFGTQP 1036
            .|..||:|:
Zfish   867 AQFDLLSEA-------------------------------------------------------- 875

  Fly  1037 YKFNYSDFNDIDHRLKLYFYQRKFKEDGEHFKWLAKGRIYNEQTQSLGEGLVVMSNCKCYLMEAF 1101
                      :||||:|:.....|..: |..:...|..|...........|:|:|:...|::|..
Zfish   876 ----------VDHRLQLFLDVEVFGGE-EELRCFLKMSIVKFGDAVEFHSLMVVSDQYIYILEIT 929

  Fly  1102 AEPHDDVAKWLRQVVSVAVNRLVAIDLLPWKLGLSFTLKDWG----GFVLLLHDMLRTESLLNYL 1162
            ::.....:.|||:..|   ::|..:..|...||......::|    .:.||:.:..|.:...:.|
Zfish   930 SQSEGQPSDWLRKRES---HQLCELSYLEVGLGSQTIHLEFGEGEAAYTLLVRNSARCKWFFSKL 991

  Fly  1163 QQI-----PLPEQ-------CKLNHQPSVTLSHQWETIASEPVKMCSLIPSCQWICDQEK----- 1210
            .::     |..:.       .:||.|     .|.|..:..:.:.           ||:|.
Zfish   992 TEVARELAPKSDSKLKGISTTRLNPQ-----HHLWRLVCEDSLP-----------CDEESHPPFR 1040

  Fly  1211 ---------SSFEPSLLLITETHLYISGNGKFSWLSDKVQEKPIQP---------ELSLNQPLSN 1257
                     .|.:...:|.|:..|::        |.:..|....||         .:...||:|.
Zfish  1041 YLLAFLQQDESLDSVSVLATKEMLFL--------LDEDHQWSKSQPGDQISSGTVTIQETQPISC 1097

  Fly  1258 LVDVERITDQ--KYAINFIDETQNRCEIWKLQFETHANAACCLNVIGKGWEQLFGV 1311
            :..:...:..  |..|...||.....:.|.|..|........:..|...||.:|||
Zfish  1098 VSSIHLFSSNPCKVDIKLYDELAKEEKTWSLNAEDEELVQDLVGWITNQWETMFGV 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9044	NP_001260114.1	LIP1	6..96	CDD:292526	28/91 (31%)
		LRR_RI	<102..302	CDD:238064	75/200 (38%)
		leucine-rich repeat	168..190	CDD:275380	9/21 (43%)
		LRR_4	189..229	CDD:289563	16/40 (40%)
		LRR_8	190..245	CDD:290566	19/55 (35%)
		leucine-rich repeat	191..212	CDD:275380	9/21 (43%)
		leucine-rich repeat	213..236	CDD:275380	8/22 (36%)
		leucine-rich repeat	237..258	CDD:275380	7/20 (35%)
		leucine-rich repeat	259..283	CDD:275380	15/23 (65%)
stk11ip	XP_005166285.1	LIP1	6..95	CDD:292526	28/91 (31%)
		LRR_RI	<110..273	CDD:238064	58/162 (36%)
		LRR_8	165..222	CDD:290566	24/56 (43%)
		leucine-rich repeat	166..188	CDD:275380	9/21 (43%)
		leucine-rich repeat	189..211	CDD:275380	9/21 (43%)
		LRR_8	210..268	CDD:290566	20/57 (35%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..257	CDD:275380	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581734
Domainoid	1	1.000	102	1.000	Domainoid score	I6830
eggNOG	1	0.900	-	-		E1_KOG1859
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3616
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1041637at2759
OrthoFinder	1	1.000	-	-		FOG0005584
OrthoInspector	1	1.000	-	-		oto39122
orthoMCL	1	0.900	-	-		OOG6_107568
Panther	1	1.100	-	-	LDO	PTHR15454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760