DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9044 and Nisch

DIOPT Version :9

Sequence 1:NP_001260114.1 Gene:CG9044 / 33825 FlyBaseID:FBgn0031752 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_073147.2 Gene:Nisch / 64652 MGIID:1928323 Length:1593 Species:Mus musculus


Alignment Length:1603 Identity:311/1603 - (19%)
Similarity:540/1603 - (33%) Gaps:489/1603 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 GAG----------YLQPQSFQVVKPINAKSSVFPDLQLVHDFVQKTTLLKLT----YFPSEHYFE 102
            |||          |...:..|..||..|......||..:.||..:...||::    .|.:.:..|
Mouse   143 GAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIKE 207

  Fly   103 GAI--DIAKFRALRRLEVNKINIGQVVGIQPLRGQLQHLICVKSLTSVDDII------------- 152
            ..:  |::.|::|.::|::..:...:.|:...:..|..:....|.||:.:::             
Mouse   208 QLLPFDLSIFKSLHQVEISHCDAKHIRGLVTSKPTLATMSVRFSATSMKEVLAPEASEFDEWEPE 272

  Fly   153 -TRCGGDNSNGFV--WNELKTADFSYNSLRSVDTALEFAQHLQHLNLRHNKLTSVAAIKWLPHLK 214
             |...|......:  |..|.|.|.|:||:..:|.:::....:::|:|.||.|..|..::.|.:|.
Mouse   273 GTATLGGPVTAIIPTWQALTTLDLSHNSICEIDESVKLIPKIEYLDLSHNGLRVVDNLQHLYNLV 337

  Fly   215 TLDLSYNCLTHLPQFHMEACKRLQLLNISNNYVEELLDVAKLDALYNLDLSDNCLLEHSQLLPLS 279
            .||||||.|:.|...|.: ...::.||::.|::|.|..:.||.:|.|:||.||.:.:..::..:.
Mouse   338 HLDLSYNKLSSLEGVHTK-LGNVKTLNLAGNFLESLSGLHKLYSLVNVDLRDNRIEQLDEVKSIG 401

  Fly   280 ALMSLIVLNLQGNPLACNPKHR-QATAQYLHKNS-------ATVKFVLDFEPLTKA-EKA----- 330
            :|..|..|.|..|||:..|.:| :..:|:..:.|       ||.:..||...:.|| :||     
Mouse   402 SLPCLERLTLLNNPLSIIPDYRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKS 466

  Fly   331 -LTGSQKWRYISGLSHRSPRSTSMSINSS------SAS----INTSDGSQF-------SSFGSQR 377
             |:.::|   .:|...|.|.:..:....|      |||    |.::.|..|       ||..|..
Mouse   467 KLSNTEK---KAGEDFRLPPAPCIRPGGSPPAAPASASLPQPILSNQGIMFVQEEALASSLSSTD 528

  Fly   378 SVSIRGKNYTLEDNQ--SMDTSQSSKRISSCKIRTVDIEESSEINTDAASVSTPNPRSEYEEEPD 440
            |:       ..||::  :...|.|.:.|.:.::.:.|:.   ::......||..:...|.:..|.
Mouse   529 SL-------PPEDHRPIARACSDSLESIPAGQVASDDLR---DVPGAVGGVSPDHAEPEVQVVPG 583

  Fly   441 NSHLETKKKIETLRLTYGNEWLKSGNAELMLGIET--PQPTERERNESRQLFNEYLGELSGFTEA 503
            :..:        :.|.:......:.|.:.:..:.|  .|..||              :|..:.||
Mouse   584 SGQI--------IFLPFTCIGYTATNQDFIQRLSTLIRQAIER--------------QLPAWIEA 626

  Fly   504 KNDSEHHNISSTPTNNVLLASTFDATITPIKSEANDTSGQTLYETCTEGEETNYESFGNNTTELS 568
            .|..|                           ||:...|:      .|.||...|....|.   .
Mouse   627 ANQRE---------------------------EAHGEQGE------EEEEEEEEEDVAENR---Y 655

  Fly   569 TEERPPDRHEELLRLYASSSNAQDEDPVSDAESDEETYIVYHEQKPSEVLFLTISSNFIREKDTL 633
            .|..|||..||     ..|...::::...|.|::||.              |.:......::|.|
Mouse   656 FEMGPPDAEEE-----EGSGQGEEDEEDEDEEAEEER--------------LALEWALGADEDFL 701

  Fly   634 TER---TKAKW--------SLKILESC-----------------ERVRS----NTLRINFDTMRK 666
            .|.   .|..|        |::...:|                 .|..|    ::||..|.....
Mouse   702 LEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHG 766

  Fly   667 DKQE------------RIYCVENTL--------CQELEKKLRDILSQRDLTEM-NISIYRCVNCL 710
            |..|            ::...||||        ..|....||...:.:.:..: :..:|.....|
Mouse   767 DLTEFGFLMPELCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTTL 831

  Fly   711 TQFTIEQKSKRYK---AKELRCPDCRSVYVAEVTELSSSLSKPSGEVAAEPKLSPAMIVEE---- 768
            .:| :.|....||   ..:.|...|..||:  |......:..|:|:.:...:.:...:...    
Mouse   832 QEF-LRQLLTFYKVAGGSQERSQGCFPVYL--VYSDKRMVQTPAGDYSGNIEWASCTLCSAVRRS 893

  Fly   769 --SPVEELAAA-------INKEESNSIVA-----------NCR-----------LTTAKITPKLR 802
              :|.|.:.:|       :..:..|.|.|           |||           |:|..:.| .|
Mouse   894 CCAPSEAVKSAAIPYWLLLTSQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDP-TR 957

  Fly   803 SLTQATKSSANS-----LNGSSSCSKI---TNSQSSF--DSNQSVVGSSNTDRDMEFRANESD-- 855
            |.||...:.|:.     |.|....:.|   .:.:..|  ..||             .||:..|  
Mouse   958 SCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQ-------------LRASLQDLK 1009

  Fly   856 -VDIISNPSQSSIEVLDPNYVQSASRKTSEERRISQLP-----------------HLETIHDEVA 902
             |.|..|||.....       |.|..:.|.|:|:.:.|                 ..|.:..::|
Mouse  1010 TVVISKNPSAKPRN-------QPAKSRASAEQRLQETPADAPAPAAVPPTASAPAPAEALAPDLA 1067

  Fly   903 KSKSFIEREFGQLLAEQAQPTTPSTAAPLAPAKSAVPSHVPLTESSSSGSVTDSICTTYEQQATD 967
            ..::  ..|...|.:.:|.....:.||..|||.:..|:......::.:.:..::........|.:
Mouse  1068 PVQA--PGEDRGLTSAEAPAAAEAPAAAEAPAAAEAPAAAEAPAAAEAPAAAEAPAPAEAPAAAE 1130

  Fly   968 APQNLQNSLLTESSNSQVSGSDAESNS---------------------------RLKSAEDASLL 1005
            ||...:.....|:..:..:.:.||:.:                           .|..||..:..
Mouse  1131 APAAAEAPAAAEAPAAAEAPASAEAPAPNQAPAPARGPAPARGPAPAGGPAPAEALAQAEVPAQY 1195

  Fly  1006 PFASVFQSTNLLMSSSKKLIESEATVFGTQPYKFNYSDFNDIDHRLKL-------YFYQRKFKED 1063
            |...:.|||     |.:..|.|...|..:            :.|..:|       .|:....:.:
Mouse  1196 PSERLIQST-----SEENQIPSHLPVCPS------------LQHIARLRGRAIIDLFHNSIAEVE 1243

  Fly  1064 GEHFKWLAKGRIYNEQTQSLG-EGLVVMSNCKCY------LMEAFAEPHDDVAKW---------- 1111
            .|..:.|....:...||..|. ...|::|:...|      |...|:||..|.  |          
Mouse  1244 NEELRHLLWSSVVFYQTPGLEVTACVLLSSKAVYFILHDGLRRYFSEPLQDF--WHQKNTDYNNS 1306

  Fly  1112 -----------LRQVVSVAVN------RLVAIDLLPWKLGLSFTLKDWGGFVLLLHDMLRTESLL 1159
                       |..:.||.|.      ||....  |.::....|...:.....|.|.||    :|
Mouse  1307 PFHVSQCFVLKLSDLQSVNVGLFDQYFRLTGSS--PTQVVTCLTRDSYLTHCFLQHLML----VL 1365

  Fly  1160 NYLQQIPLP-------------------EQCKLNHQPSVTLSHQWE--------TIA---SEPVK 1194
            :.|::.|.|                   |..:|.|...|..::..|        .:|   ::|.|
Mouse  1366 SSLERTPSPEPVDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSEEEVGDLTYIVAQKMADPAK 1430

  Fly  1195 MCSL-----IPSCQWI---CDQEKSSFEPSLLLITETHLYISGNGKFSWLSDKVQEKPIQPELSL 1251
            ..:|     |.:.|.:   ..:.:....|..||:|...:::        |.:.....|: ||.:.
Mouse  1431 NPALSILLYIQAFQVVTPHLGRGRGPLRPKTLLLTSAEIFL--------LDEDYIHYPL-PEFAK 1486

  Fly  1252 NQPLSN---LVDVERITD------------QKYAINFIDET------------------------ 1277
            ..|..:   |.|..|:.|            |...:.| |:|                        
Mouse  1487 EPPQRDRYRLDDGRRVRDLDRVLMGYYPYPQALTLVF-DDTQGHDLMGSVTLDHFGEMPGGPGRV 1550

  Fly  1278 -QNRCEIWKLQFETHANAACCLNVIGKGWEQLFG--VPFSLSG 1317
             |.|...|::...:..:....::::.:.||.|.|  :|..|:|
Mouse  1551 GQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG 1593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9044NP_001260114.1 LIP1 6..96 CDD:292526 14/57 (25%)
LRR_RI <102..302 CDD:238064 59/218 (27%)
leucine-rich repeat 168..190 CDD:275380 7/21 (33%)
LRR_4 189..229 CDD:289563 16/39 (41%)
LRR_8 190..245 CDD:290566 19/54 (35%)
leucine-rich repeat 191..212 CDD:275380 7/20 (35%)
leucine-rich repeat 213..236 CDD:275380 10/22 (45%)
leucine-rich repeat 237..258 CDD:275380 7/20 (35%)
leucine-rich repeat 259..283 CDD:275380 7/23 (30%)
NischNP_073147.2 Necessary for binding to phosphoinositide-3-P, not sufficient for targeting to endosomes. /evidence=ECO:0000250 1..134
PX_IRAS 15..130 CDD:132785
Necessary for homooligomerization and targeting to endosomes. /evidence=ECO:0000250 121..695 141/642 (22%)
Interaction with PAK1. /evidence=ECO:0000269|PubMed:15229651 246..869 151/716 (21%)
LRR_RI <271..>417 CDD:238064 46/146 (32%)
LRR_8 291..346 CDD:290566 21/54 (39%)
leucine-rich repeat 291..313 CDD:275380 7/21 (33%)
LRR_4 312..352 CDD:289563 16/39 (41%)
leucine-rich repeat 314..335 CDD:275380 7/20 (35%)
LRR_8 335..391 CDD:290566 23/56 (41%)
leucine-rich repeat 336..358 CDD:275380 10/22 (45%)
leucine-rich repeat 359..380 CDD:275380 7/20 (35%)
leucine-rich repeat 381..405 CDD:275380 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 466..499 6/35 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..687 19/98 (19%)
Interaction with LIMK 661..869 42/229 (18%)
Interaction with ITGA5 709..807 16/97 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1016..1185 26/177 (15%)
10 X 6 AA tandem repeat of A-E-A-P-A-A 1081..1146 11/64 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1859
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3315
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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