DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9044 and stk11ip

DIOPT Version :9

Sequence 1:	NP_001260114.1	Gene:	CG9044 / 33825	FlyBaseID:	FBgn0031752	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_989177.1	Gene:	stk11ip / 394784	XenbaseID:	XB-GENE-947946	Length:	1129	Species:	Xenopus tropicalis

Alignment Length:	1408	Identity:	311/1408 - (22%)
Similarity:	523/1408 - (37%)	Gaps:	386/1408 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQKITE-LANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTLIADTEIGTGAGYLQPQSFQVVKP 66
            |:.:.: ||.:|.::|||:|.....|.|....|:.:...|..:.....|||        ||.: |
Frog     6 PESLVQALAQILHEHGDKVLDGSRILALLTPCLQVVTRLFEQLFPRGPGTG--------FQAL-P 61

  Fly    67 INAKSSVFPDL--QLVHDFVQKTTLLKLTYFPSEHYFEGAIDIAKFRALRRLEVNKINIGQVVGI 129
            .:...|| |.|  |.:.|.:|||..|||.: |:|...:..::|..|::||.||:..:....:.|:
Frog    62 AHPADSV-PILRAQFMLDMLQKTPSLKLVH-PAECPRQFDVNIFPFKSLRSLELRCLPPHCLRGL 124

  Fly   130 QPLRGQLQHLICVKSLTSVDDIITRCGGDNSNGFVWNELKTADFSYNSLRSVDTALEFAQHLQHL 194
            :.:..||:.|.|.:.::|::::|..||||.|:...|..|.|.|||||:|:::|.:||....|:.|
Frog   125 RSVYSQLEVLTCYRCVSSLEEVIALCGGDLSSALPWLVLHTLDFSYNTLKNLDGSLELLNSLKIL 189

  Fly   195 NLRHNKLTSVAA-IKWLPHLKTLDLSYNCLTHLPQFHMEACKRLQLLNISNNYVEELLDVAKLDA 258
            :|.||::|...: :|.|..|:.|:|.||.||.:|:..:....:|..|.:.:|.:.....:..|..
Frog   190 DLSHNQITECGSYLKVLSELQYLNLGYNHLTAVPELSVGNTAKLHSLILKHNQLSGTSGLENLPN 254

  Fly   259 LYNLDLSDNCLLEHSQLLPLSALMSLIVLNLQGNPLACNPKHRQATAQYL-HKNSATVKFVLDFE 322
            |.:||||.|.|||||||..|:.|.:|..|.|:||||.....:|..|||:| ||.|..|  :||.:
Frog   255 LQHLDLSYNLLLEHSQLSGLARLHNLKQLFLEGNPLYFQKDYRALTAQHLSHKASDNV--LLDGK 317

  Fly   323 PLTKAE--KALTGSQKWRYISGLSHRSPRSTSMSINSSSASINTSDGSQFSSFGSQRSVSIRGKN 385
            .|:.:|  .|....:|.|.       .|        ||||:.::..|....|:.:
Frog   318 LLSSSEIMNAQAFGEKVRL-------QP--------SSSATESSCTGDLTDSYSA---------- 357

  Fly   386 YTLEDNQSMDTSQSSKRI----SSCKIRTVDIEESSEINTDAASVSTPNPRSEYEEEPDNSHLET 446
                      ..:|:.|:    |..|:||..|.|.|:              ||||.......|:.
Frog   358 ----------AEKSAPRLPRKKSRVKVRTASISERSD--------------SEYERRGQPIVLQH 398

  Fly   447 KKKIE---TLRLTYGNEWLKSGNAELMLGIETPQPTERERNESRQLFNEYL-GELSGFTEAKNDS 507
            :::||   :.|..||.:||:                          :..:| |||        |.
Frog   399 QREIERTDSFREQYGEDWLQ--------------------------YRPHLEGEL--------DP 429

  Fly   508 EHHNISSTPTNNVLLASTFDATITPIKS-------EANDTSGQT-----LYETCTEGEETNYESF 560
            |:.|...:|......:.|..:::...||       ..:..||..     |.|...||.|.:....
Frog   430 EYVNRPHSPPPRASPSPTAPSSVPKQKSPVPAPEPSPSPKSGHVAPDDQLMEKAEEGLEEHLWGL 494

  Fly   561 GNNTTELSTEERPPDRHEELLR-------LYASSSNAQDEDPVSDAESDEETYIVYHEQKPSEVL 618
                    .|.:.|:..|.|:.       :.....|.|..:|       :..::
Frog   495 --------QEAKKPNEEEGLIGGALCSPVVVCPVLNGQPRNP-------DWPWV----------- 533

  Fly   619 FLTISSNFIREKDTLTERTKAKWSLKILE---------SC--ERVRSNTLRINFDTMRKDKQERI 672
            ||.|:.:|:.|.|....|...|..|:.|.         .|  |......|.::||::.::||...
Frog   534 FLRITLHFLLEMDPERGRILLKRELRSLRGIQTSLAPWKCNGEEQELPLLTLSFDSVCEEKQTVN 598

  Fly   673 YCVENTLCQELEKKLRDILSQRDLTEMNISIYRCVNCLTQFTIEQKSKRYKAKELRCPDCRSVYV 737
            |.|.:...:.....|.|:|  |.:.|.|:.             |:...:.:...::|..|::.:.
Frog   599 YIVLDNSPESSVTTLLDLL--RPMLERNLR-------------EKAESQDELTRMQCLKCKAEFR 648

  Fly   738 AEVTELSSSLSKPSGEVAAEPKLSPAMIVEESPVEELAAAINKEESNSIVANCRLTTAKITPKLR 802
            .||         ..|::.:...|...        :|..|.:::..:
Frog   649 NEV---------DGGDIYSPESLQQG--------KEPTAGLHRNHT------------------- 677

  Fly   803 SLTQATKSSANSLNGSSSCSKITNSQSSFDSNQSVVGSSNTDRDMEFRANESDVDIISNPSQSSI 867
                          |.:||                                        ||..|:
Frog   678 --------------GDASC----------------------------------------PSCGSL 688

  Fly   868 EVLDPNYVQSASRKTSEERRISQLPHLETIHDEVAKSKSFIEREFGQLLAEQAQPTTPS--TAAP 930
            .:                                             :||    |..|:  |:.|
Frog   689 HI---------------------------------------------ILA----PLNPTGETSTP 704

  Fly   931 LAPAKSAVPSHVPLTESSSSGSVTDSICTTYEQQATDAPQNLQNSLLTESSNSQVSGSDAESNSR 995
            |.|. ||.|   |..:....|....|...:.::.:::...: .|:..:|:.::.....|.|...:
Frog   705 LRPL-SAEP---PQGDDGGGGLAAKSFYLSEDEDSSETDSS-PNTAPSEAESTIFYSFDTEGQDQ 764

  Fly   996 LKSAEDASLLPFASVFQSTNLLMSSSKKLIESEATVFGTQPYKFNYSDFNDIDHRLKLYFYQRKF 1060
             :||:|.........::.|.|..|.:   :..:.  :...|...:..||..:|||||||......
Frog   765 -QSAQDTGRSSLTGSYKYTALNQSGA---LSQDG--WQISPGPASTLDFRLVDHRLKLYLDMEVL 823

  Fly  1061 KEDGEHFKWLAKGRIYNEQTQSLGEGLVVMSNCKCYLMEAFAEPHDDVAKWLRQVVSVAVNRL-- 1123
            ..|.|.|:...|..:......|....:|.:||.|.|.:|...|..|:.:.||:.:.|.::..|
Frog   824 NGDMEEFRCCMKVPVIRFGKVSEFWAVVAVSNQKIYFLEITGEIRDNPSDWLQPIESQSLTSLAR 888

  Fly  1124 VAIDLLPWKLGLSFTLKDWGGFVLLL----HDMLRTESLLNYLQQIP---LPEQCKLNHQPSVTL 1181
            :.:.|....|.|.|. ...|.:.||.    |..:..:.:|:.|.::|   |....:.:.:| :|.
Frog   889 LHVGLQEHSLHLGFG-GSGGAYTLLTRNQQHCRVFHKHMLDVLAELPARYLGNIQQSSEEP-ITP 951

  Fly  1182 SHQ-WETI--------ASEPVKMC----------SLIPSCQWICDQEKSSF-------------- 1213
            .|: |..:        ::.|.:..          .:.|:....|....|..
Frog   952 QHRLWPFLQDKVGAPESNAPPRFLYVPLFFLREDIVSPNADSPCANANSQLPLLNTASPAALIQG 1016

  Fly  1214 ----EPSLLLITETHLYISGNGKFSWLSDKVQ-EKPIQPELSLNQPLSNLVDVE--RITDQKYAI 1271
                .|..||:|.||:|:. .....||.|.:. |.|...::...||:||:..|.  :.......|
Frog  1017 AAAAAPLSLLVTRTHMYLL-EEDHQWLPDTLDTELPDSVQMKEKQPISNISSVHLFQSATLHLRI 1080

  Fly  1272 NFIDETQNRCEIWKLQFETHANAACCLNVIGKGWEQLFGVPFS 1314
            :..:|||.....|.|..|........:..:.:.||..:.:.|:
Frog  1081 HLYNETQQNESAWLLWTEDPDRTREIVEWLREPWEAEYHIHFN 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9044	NP_001260114.1	LIP1	6..96	CDD:292526	29/92 (32%)
		LRR_RI	<102..302	CDD:238064	72/200 (36%)
		leucine-rich repeat	168..190	CDD:275380	11/21 (52%)
		LRR_4	189..229	CDD:289563	16/40 (40%)
		LRR_8	190..245	CDD:290566	18/55 (33%)
		leucine-rich repeat	191..212	CDD:275380	8/21 (38%)
		leucine-rich repeat	213..236	CDD:275380	8/22 (36%)
		leucine-rich repeat	237..258	CDD:275380	4/20 (20%)
		leucine-rich repeat	259..283	CDD:275380	15/23 (65%)
stk11ip	NP_989177.1	LIP1	7..91	CDD:292526	29/94 (31%)
		LRR_RI	22..289	CDD:238064	96/277 (35%)
		LRR 1	107..128		5/20 (25%)
		LRR 2	130..150		6/19 (32%)
		leucine-rich repeat	131..156	CDD:275380	9/24 (38%)
		LRR 3	162..183		11/20 (55%)
		LRR_8	163..219	CDD:290566	24/55 (44%)
		leucine-rich repeat	163..185	CDD:275380	11/21 (52%)
		LRR 4	185..206		7/20 (35%)
		leucine-rich repeat	186..208	CDD:275380	8/21 (38%)
		LRR 5	208..229		8/20 (40%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_8	232..290	CDD:290566	24/57 (42%)
		LRR 6	232..253		3/20 (15%)
		leucine-rich repeat	233..254	CDD:275380	4/20 (20%)
		LRR 7	254..275		13/20 (65%)
		LRR 8	279..300		8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..392		21/105 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..475		9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..678		4/64 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..724		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..749		1/19 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5889
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1041637at2759
OrthoFinder	1	1.000	-	-		FOG0005584
OrthoInspector	1	1.000	-	-		otm47938
Panther	1	1.100	-	-	LDO	PTHR15454
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3315
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100