DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9044 and Nisch

DIOPT Version :9

Sequence 1:	NP_001260114.1	Gene:	CG9044 / 33825	FlyBaseID:	FBgn0031752	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_001057307.5	Gene:	Nisch / 306255	RGDID:	1306950	Length:	1646	Species:	Rattus norvegicus

Alignment Length:	1657	Identity:	318/1657 - (19%)
Similarity:	549/1657 - (33%)	Gaps:	544/1657 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GAG----------YLQPQSFQVVKPINAKSSVFPDLQLVHDFVQKTTLLKLT----YFPSEHYFE 102
            |||          |...:..|..||..|......||..:.||..:...||::    .|.:.:..|
  Rat   143 GAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIRE 207

  Fly   103 GAI--DIAKFRALRRLEVNKINIGQVVGIQPLRGQLQHLICVKSLTSVDDII------------- 152
            ..:  |::.|::|.::|::..:...|.|:...:..|..:....|..|:.:::
  Rat   208 QLLPFDLSIFKSLHQVEMSHCDAKHVRGLVTSKPTLATMSVRFSAASMKEVLVPEASEFDEWEPE 272

  Fly   153 -TRCGGDNSNGF-VWNELKTADFSYNSLRSVDTALEFAQHLQHLNLRHNKLTSVAAIKWLPHLKT 215
             |..||..:... .|..|.|.|.|:||:..:|.:::....:::|:|.||.:..|..::.|.:|..
  Rat   273 GTTLGGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEYLDLSHNGVLVVDNLQHLYNLVH 337

  Fly   216 LDLSYNCLTHLPQFHMEACKRLQLLNISNNYVEELLDVAKLDALYNLDLSDNCLLEHSQLLPLSA 280
            ||||||.|:.|...|.: ...::.||::.|::|.|..:.||.:|.||||.||.:.:..::..:..
  Rat   338 LDLSYNKLSSLEGVHTK-LGNVKTLNLAGNFLERLSGLHKLYSLVNLDLRDNRIEQLDEVKSIGN 401

  Fly   281 LMSLIVLNLQGNPLACNPKHR-QATAQYLHKNS-------ATVKFVLDFEPLTKA-EKA------ 330
            |..|..:.|..|||:..|.:| :..:|:..:.|       ||.:..||...:.|| :||
  Rat   402 LPCLEHVALLNNPLSIIPDYRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKSK 466

  Fly   331 LTGSQKWRYISGLSHRSPRSTSMSINSS-------SAS----INTSDGSQF-------SSFGSQR 377
            |:.::|   ..|...|.|.:..:..:||       |||    |.::.|..|       ||..|..
  Rat   467 LSSTEK---KVGEDFRLPTAPCIRPSSSPPTAVPTSASLPQPILSNQGIMFVQEEALASSLSSTD 528

  Fly   378 SVSIRGKNYTLEDNQSMDTSQSSKRISSCKIRTVDIEESSEINTDAASVSTPNPRSEYEEEPDNS 442
            |:.        .|::.: ....|..:.|.....|..|:..::......||..:...|.:..|.:.
  Rat   529 SLP--------PDDRPI-AQACSNSMGSLPTGQVAAEDLRDLPGAVGGVSPDHAEPEVQVVPGSG 584

  Fly   443 HLETKKKIETLRLTYGNEWLKSGNAELMLGIET--PQPTERERNESRQLFNEYLGELSGFTEAKN 505
            .:        :.|.:......:.|.:.:..:.|  .|..||              :|..:.||.|
  Rat   585 QI--------IFLPFTCIGYTATNQDFIQRLSTLIRQAIER--------------QLPAWIEAAN 627

  Fly   506 DSEHHNISSTPTNNVLLASTFDATITPIKSEANDTSGQTLYETCTEGEETNYESFGNNTTELSTE 570
            ..|                           ||:...|:       |.||...|....:.   ..|
  Rat   628 QRE---------------------------EAHGEQGE-------EEEEEEEEDVAESR---YFE 655

  Fly   571 ERPPDRHEELLRLYASSSNAQDEDPVSDAESDEETYIVYHEQKPSEVLFLTISSNFIREKDTLTE 635
            ..|||..||     ..|...::::...|.|::||.              |.:......::|.|.|
  Rat   656 MGPPDAEEE-----EGSGQGEEDEEDEDEEAEEER--------------LALEWALGADEDFLLE 701

  Fly   636 R---TKAKW--------SLKILESC-----------------ERVRS----NTLRINFDTMRKDK 668
            .   .|..|        |::...:|                 .|..|    ::||..|.....|.
  Rat   702 HIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDL 766

  Fly   669 QE------------RIYCVENTL--------CQELEKKLRDILSQRDLTEM-NISIYRCVNCLTQ 712
            .|            ::...||||        ..|....||...:.:.:..: :..:|.....|.:
  Rat   767 TEFGFLMPELCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQE 831

  Fly   713 FTIEQKSKRYK---AKELRCPDCRSVYV--AEVTELSSSLSKPSGEVA-AEPKLSPAMIVEES-- 769
            | :.|....||   ..:.|...|..||:  ::...:.::....||.:. |...|..|  |..|
  Rat   832 F-LRQLLTFYKVAGGSQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSA--VRRSCC 893

  Fly   770 -PVEELAAA-------INKEESNSIVA-----------NCR-----------LTTAKITPKLRSL 804
             |.|.:.:|       :..:..|.|.|           |||           |:|..:.| .||.
  Rat   894 APSEAVKSAAIPYWLLLTSQHLNVIKADFNPMPSRGTHNCRNRNSFKLSRVPLSTVLLDP-TRSC 957

  Fly   805 TQATKSSANS-----LNGSSSCSKI---TNSQSSF--DSNQSVVGSSNTDRDMEFRANESD---V 856
            ||...:.|:.     |.|....:.|   .:.:..|  ..||             .||:..|   |
  Rat   958 TQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQ-------------LRASLKDLKTV 1009

  Fly   857 DIISNPS-----QSSIEVLDPNYVQSASRKTSEERRISQLPHLETIHDEVAKSKSFIEREFGQLL 916
            .|..|||     |..:....|     |..:.|.|:|:.:.|
  Rat  1010 VIAKNPSARPRTQGPLAGGQP-----AKSRVSAEQRLQETP------------------------ 1045

  Fly   917 AEQAQPTTPSTAAPL---------------APAKSAVPSHVPLTESSSSGSVTDSICTTYEQQAT 966
            ||...|..|..|.|.               |||.:|..:..|...:|::|:...:......:.||
  Rat  1046 AEAPAPVPPPAAVPPTASAPAATEAAAPAGAPAAAASAAEAPAVAASAAGAPAAAETPAAAESAT 1110

  Fly   967 DAPQNLQNSLLTESSNSQVSGSDAESNSRLK---SAEDASLLPFA--SVFQSTNLLMSSSKKLIE 1026
            :||...:::..|.::....:.:.|.:.|..:   :||.|:..|.|  |..::.....|:::....
  Rat  1111 EAPAAAESAAETPATAESAAEAPAAAESAAEAPAAAESAAEAPAAAESAAEAPAAAESAAEAPAA 1175

  Fly  1027 SEAT---------------------------------------VFGTQ----------------- 1035
            :||:                                       :.|.|
  Rat  1176 AEASAPAGAPAPAGAPAPAGAPAGAQAPAPAGAPAGAPAGAQALAGAQAPAPAGAPAGAQAPVEA 1240

  Fly  1036 ----PYKF-------NYSDFNDIDHRLKL-----------------YFYQRKFKEDGEHFKWLAK 1072
                |.::       :.|:.|.|...|.:                 .|:....:.:.|..:.|..
  Rat  1241 QAEVPAQYPSERLIQSTSEENQIPSHLPVCPSLQHIARLRGRAIIDLFHSSIAEVENEELRHLLW 1305

  Fly  1073 GRIYNEQTQSLGEGLVVMSNCKCY-------LMEAFAEPHDDVAKW-------------LRQVVS 1117
            ..:...||..|.....|:.:.|..       |...|:||..|.  |             :.|...
  Rat  1306 SSVVFYQTPGLEVTACVLLSTKAVYFILHDGLRRYFSEPLQDF--WHQKNTDYNNSPFHISQCFV 1368

  Fly  1118 VAVNRLVAIDL------------LPWKLGLSFTLKDWGGFVLLLHDMLRTESLLNYLQQIPLP-- 1168
            :.::.|.::::            .|.::....|...:.....|.|.||    :|:.|::.|.|
  Rat  1369 LKLSDLQSVNVGLFDQYFRLTGSSPTQVVTCLTRDSYLTHCFLQHLML----VLSSLERTPSPEP 1429

  Fly  1169 -----------------EQCKLNHQPSVTLSHQWE--------TIA---SEPVKMCSL-----IP 1200
                             |..:|.|...|..::..|        .:|   ::|.|..:|     |.
  Rat  1430 IDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSEEEVGDLTYVVAQKMADPAKNPALSILLYIQ 1494

  Fly  1201 SCQWICDQ---EKSSFEPSLLLITETHLYISGNGKFSWLSDKVQEKPIQPELSLNQPLSN---LV 1259
            :.|.|..|   .:....|..||:|...:::        |.:.....|: ||.:...|..:   |.
  Rat  1495 AFQVITPQLGRGRGPLRPKTLLLTSAEIFL--------LDEDYIHYPL-PEFAKEPPQRDRYRLD 1550

  Fly  1260 DVERITD------------QKYAINFIDET-------------------------QNRCEIWKLQ 1287
            |..|:.|            |...:.| |:|                         |.|...|::.
  Rat  1551 DGRRVRDLDRVLMGYNPYPQALTLVF-DDTQGHDLMGSVTLDHFGEMPGGPGRAGQGREVQWQVF 1614

  Fly  1288 FETHANAACCLNVIGKGWEQLFG--VPFSLSG 1317
            ..:..:....::::.:.||.|.|  :|..|:|
  Rat  1615 VPSAESREKLISLLARQWEALCGRELPVELTG 1646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9044	NP_001260114.1	LIP1	6..96	CDD:292526	14/57 (25%)
		LRR_RI	<102..302	CDD:238064	59/217 (27%)
		leucine-rich repeat	168..190	CDD:275380	7/21 (33%)
		LRR_4	189..229	CDD:289563	15/39 (38%)
		LRR_8	190..245	CDD:290566	18/54 (33%)
		leucine-rich repeat	191..212	CDD:275380	6/20 (30%)
		leucine-rich repeat	213..236	CDD:275380	10/22 (45%)
		leucine-rich repeat	237..258	CDD:275380	7/20 (35%)
		leucine-rich repeat	259..283	CDD:275380	8/23 (35%)
Nisch	XP_001057307.5	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1859
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810