DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9044 and Stk11ip

DIOPT Version :9

Sequence 1:	NP_001260114.1	Gene:	CG9044 / 33825	FlyBaseID:	FBgn0031752	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_038939297.1	Gene:	Stk11ip / 301535	RGDID:	1305046	Length:	1138	Species:	Rattus norvegicus

Alignment Length:	1485	Identity:	316/1485 - (21%)
Similarity:	493/1485 - (33%)	Gaps:	549/1485 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTLIADTEIGTGAGYLQP----QSFQVVKP 66
            :.:||.|||::||.:||...||:|..:.|:.||..|.|           ||.|    |:..|..|
  Rat    10 VWKLAGLLRESGDAVLSGCSTLSLLTATLQQLNRVFEL-----------YLGPWGPGQTGFVALP 63

  Fly    67 IN-AKSSVFPDLQLVHDFVQKTTLLKLTYFPSEHYFEGAIDIAKFRALRRLEVNKINIGQVVGIQ 130
            .: |.|.|...||.:.|.:|||..|||.:.|... ..|.|.|..|::||:||:..:.|..:.|::
  Rat    64 SHPADSPVILQLQFLFDVLQKTLSLKLVHTPGVG-LPGPIKIFPFKSLRQLELRGVPIHSLCGLR 127

  Fly   131 PLRGQLQHLICVKSLTSVD--------------DIITRCGGDNSNGFVWNELKTADFSYNSLRSV 181
            .:..||:.|:|.:|:.:::              ::::.||||..:...|..|.:||||||:|.::
  Rat   128 GIYSQLETLVCNRSIQALEGQRLELSSELRGLQELLSACGGDLCSALPWLALLSADFSYNALSNL 192

  Fly   182 DTALEFAQHLQHLNLRHNK----------------LTSVAAIKWLP---------HLKTLDLSYN 221
            |::|.....|:.|||.||.                |..:..:..||         .|..||:|||
  Rat   193 DSSLRLLSALRFLNLSHNHIQDCKGFLMHTTRLGILDDLGQVSQLPASFTCKDLSELYHLDISYN 257

  Fly   222 CLTHLPQFHMEAC-------KRLQLLNISNNY--------------------VEELLDVAKLDAL 259
            .|..:|:......       :..:|.::..|.                    :|:|.::..||..
  Rat   258 HLRLVPRMGPSGAALGTLILRANELRSLQGNTTPHPLTHNMPPQGLLSSAVGLEQLKNLRHLDVA 322

  Fly   260 YNLDLSDNCLLEHSQLLPLSALMSLIVLNLQGNPLACNPKHRQATAQYL--HKNSATVKFVLDFE 322
            |||      |..|::|.||..|..|..|.|:||||..:|.||..|||||  ....|...|:||.:
  Rat   323 YNL------LEGHTELAPLWLLAELRKLYLEGNPLWFHPAHRATTAQYLSPRARDAAHGFLLDGK 381

  Fly   323 PLTKAEKALTGSQKWRYISGLSHRSPRSTSMSINSSSASINTSDGSQFSSFGSQRSVSIRGKNYT 387
            .|:..:...|        |..|...|.:..:|....|.: .||.|.:.|.              :
  Rat   382 VLSLKDLQQT--------SESSRLGPMTQPLSWPVGSTT-ETSGGPELSD--------------S 423

  Fly   388 LEDNQSMDTSQSSKRISSCKIRTVDIEESSEINTDAASVSTPNPRSEYEEEPDNSHLETKKKIET 452
            |.....:..:...|..|..::|...|.|.|:.:.:..::. |:|...:.::    |.|. :.:.:
  Rat   424 LSSGGIVAQAPLRKVKSRVRVRRASISEPSDTDPELRTLD-PSPAGWFVQQ----HREL-ELLAS 482

  Fly   453 LRLTYGNEWLKSGNAELMLGIETPQPTERERNESRQLFNEYLGELSGFTEAKNDSEHHNISSTPT 517
            .|..:|.:||                             :|...|            ..:.|.|
  Rat   483 FRERFGCDWL-----------------------------QYRSHL------------ETMGSPP- 505

  Fly   518 NNVLLASTFDATITPIKSEANDT---SGQTLYETCTE----GEETNYESFGNNTTELSTEERPPD 575
                        :..||:.|..|   ..|:| ||...    ||:|. || ....:|...||..|
  Rat   506 ------------LATIKTPALGTPPLDAQSL-ETARSPPAIGEDTK-ES-PEKVSEEGREELEP- 554

  Fly   576 RHEELLRLYASSSNAQDEDPVSDAESDEETYIVYHEQKPSEV---------------------LF 619
             |||     ......::|....|...:||     .|||..|.                     .|
  Rat   555 -HEE-----EREEQEREEGSREDLGEEEE-----QEQKAVEAELCRPMLVCPLQGTEGVQGRECF 608

  Fly   620 LTISSNFIREKDTLTERTKAKWSLKILESCERVRSNT-------------------LRINFDTMR 665
            |.::|..:.|......:|..:..|:.|.|.| ::|.|                   |.:.|..:.
  Rat   609 LRVTSAHLFEVGLQAAQTLERLELQSLVSAE-LQSETESQREPGSEGSGPPSGAPVLVLRFSYIC 672

  Fly   666 KDKQERIYCVENTLCQELEKKLRDILSQRDLTEMNISIYRCVNCLTQFTIEQKSKRYKAKE---- 726
            .|:|.|.|.|   |..|..:.::::|:                .||.||..:..:..:||:
  Rat   673 PDRQLRCYAV---LEPEAHEAIQELLA----------------VLTPFTSVKDQQPGEAKDPQGP 718

  Fly   727 ----LRCPDCRSVYVAEVTELSSSLSKPSGEVAAEPKL--------SPAMIVEESPVEELAAAIN 779
                |||               |...||.     ||:|        .|.....||||
  Rat   719 RFQCLRC---------------SCEFKPQ-----EPRLGLESDDGWKPLFQNTESPV-------- 755

  Fly   780 KEESNSIVANCRLTTAKITPKLRSLTQATKSSANSLNGSSSCSKITNSQSSFDSNQSVVGS-SNT 843
                  :..||                          ||.....:           :|.|. .|.
  Rat   756 ------VCPNC--------------------------GSDHVVLL-----------AVSGEVPNR 777

  Fly   844 DRDMEFRANESDVDIISNPSQSSIEVLDPNYVQSASRKTSEERRISQLPHLETIHDEVAKSKSFI 908
            :|:.|.::::|..|:..:
  Rat   778 ERNQEEQSSDSACDLADH----------------------------------------------- 795

  Fly   909 EREFGQLLAEQAQPTTPSTAAPLAPAKSAVPSHVPLTESSSSGSVTDSICTTYEQQATDAPQNLQ 973
                              :..|      :||..:|...|.|.|      |:::         ||.
  Rat   796 ------------------SGCP------SVPDGIPPQASISHG------CSSW---------NLS 821

  Fly   974 NSLLTESSNSQVSGSDAESNSRLKSAEDASLLPFASVFQSTNLLMSSSKKLIESEATVFGTQPYK 1038
            .:|
  Rat   822 PTL-------------------------------------------------------------- 824

  Fly  1039 FNYSDFNDIDHRLKLYFYQRKFKEDGEHFKWLAKGRIY--NEQTQSLGEGLVVMSNCKCYLMEAF 1101
             .::.|..:||||:|:.....|.:..|.|:...|..:.  ....:||  .|||:|:...||::..
  Rat   825 -GHTGFRSVDHRLRLFLDVEVFSDSEEEFQCCTKVPVVLAGHTRESL--CLVVVSDRMLYLLKVT 886

  Fly  1102 AEPHDDVAKWLRQVVSVAVNRLVAIDL--------LPWKLGLSFTLKDWGGFVLLLHDMLR---- 1154
            .......|.||...:::.:..|..::|        |.|..|.       |..|||..|..:
  Rat   887 GPICGPPASWLEPTLAIPLQDLSGMELGLAGQSLRLEWAAGT-------GHCVLLPRDARQCRAF 944

  Fly  1155 TESLLNYLQQIPLPEQ-CKLNHQPSVTLSHQ-W-----ETIASEPVKMCSLIPSCQWICDQEKSS 1212
            .|.|...||.:|..:: |....:.:||..|: |     :|.|..|..........:...:...||
  Rat   945 LEELTGVLQSLPRTQRNCISATEETVTPQHRLWPLLGKDTSAETPQFFYLRAFLAEGKAESAGSS 1009

  Fly  1213 FEPSLLLITETHLYI---------------SGNGKFSWLSDKVQEKPIQPELSL----NQPLSNL 1258
            ..|..||:|.:.||:               .|:|:.|     .|..|..|..||    .||||:|
  Rat  1010 TCPVSLLLTLSTLYLLDEDPVRSHAESPLPVGSGEAS-----EQPAPQGPGPSLQVREQQPLSSL 1069

  Fly  1259 VDVE--RITDQKYAINFIDETQNRCEIWKLQFETHANAACCLNVIGKGWEQLFGV 1311
            ..|:  |.:.....:.|.||.......|.|:..........|..|.:.||:||.:
  Rat  1070 SSVQLYRTSPLDLRLIFYDEVSRLESFWALRVVCGEQLTDLLAWIREPWEELFSI 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9044	NP_001260114.1	LIP1	6..96	CDD:292526	35/94 (37%)
		LRR_RI	<102..302	CDD:238064	71/265 (27%)
		leucine-rich repeat	168..190	CDD:275380	10/21 (48%)
		LRR_4	189..229	CDD:289563	17/64 (27%)
		LRR_8	190..245	CDD:290566	18/86 (21%)
		leucine-rich repeat	191..212	CDD:275380	9/45 (20%)
		leucine-rich repeat	213..236	CDD:275380	8/29 (28%)
		leucine-rich repeat	237..258	CDD:275380	5/40 (13%)
		leucine-rich repeat	259..283	CDD:275380	9/23 (39%)
Stk11ip	XP_038939297.1	LIP1	8..92	CDD:406355	35/92 (38%)
		LRR	<101..>361	CDD:227223	71/265 (27%)
		leucine-rich repeat	179..201	CDD:275380	10/21 (48%)
		leucine-rich repeat	202..224	CDD:275380	6/21 (29%)
		leucine-rich repeat	225..248	CDD:275380	3/22 (14%)
		leucine-rich repeat	249..271	CDD:275380	8/21 (38%)
		leucine-rich repeat	272..315	CDD:275380	4/42 (10%)
		leucine-rich repeat	316..340	CDD:275380	11/29 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341715
Domainoid	1	1.000	101	1.000	Domainoid score	I6785
eggNOG	1	0.900	-	-		E1_KOG1859
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3568
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1041637at2759
OrthoFinder	1	1.000	-	-		FOG0005584
OrthoInspector	1	1.000	-	-		oto96210
orthoMCL	1	0.900	-	-		OOG6_107568
Panther	1	1.100	-	-	LDO	PTHR15454
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760