DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gpdh1 and Gpdh3

DIOPT Version :9

Sequence 1:	NP_001260112.1	Gene:	Gpdh1 / 33824	FlyBaseID:	FBgn0001128	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_732726.2	Gene:	Gpdh3 / 42624	FlyBaseID:	FBgn0263048	Length:	1304	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	169/354 - (47%)
Similarity:	245/354 - (69%)	Gaps:	1/354 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADKVNVCIVGSGNWGSAIAKIVGANAAALPEFEERVTMFVYEELIDGKKLTEIINETHENVKYL 65
            ||.|:.:||:|:..||||||.:|..|... .:|:.||.::||:|:|....|:||||..|||||||
  Fly     1 MAGKLKICIIGAEGWGSAIAAVVSNNVLE-GDFDSRVHLYVYDEMIRDTALSEIINTRHENVKYL 64

  Fly    66 KGHKLPPNVVAVPDLVEAAKNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGG 130
            .|.|||.|::||.||:|||:|||||:|..|.:|:.::|..|.|.:|.:|.|:|:.||.....|.|
  Fly    65 PGIKLPNNLIAVNDLLEAAQNADILVFSTPLEFVQSYCNILSGNVKESAFAVSMTKGLLSENGEG 129

  Fly   131 IDLISHIITRHLKIPCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDD 195
            |:|:||.|:..|.|||..:|.|:.|.|:|:|..||.||||:|..:.|:|....|.|:.||:.|:|
  Fly   130 IELVSHAISESLGIPCYSMMSAHSAMEMAQGKLCEVTIGCSDNSHSKLLISAMQTNNCRVISVND 194

  Fly   196 ADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVFYPGSKLSTFFESCGVA 260
            .|.||:||.|.::||.||||:|||:||:|.:.|.|.||:.|::||:..|:|.||:|||:|||||.
  Fly   195 VDGVELCGTLTDVVALGAGFIDGLRLGENARLAAIHLGVKEIMRFIKTFFPSSKMSTFYESCGVT 259

  Fly   261 DLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKFPLFTA 325
            :.:.:.:..:|...:::.||||:||||:|..:.:|:||.||..|..||..|:|..::.:||||||
  Fly   260 NAVASSFVDKNVTFAKSLVTSGQTIEEIEANLHSGRKLLGPMVASNVNAFLENGLMQHEFPLFTA 324

  Fly   326 IHKICTNQLKPNDLIDCIRNHPEHMDTSI 354
            ||.||.::..|..:|:.:||||:...:||
  Fly   325 IHLICQSEAPPELMIEALRNHPDLSSSSI 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpdh1	NP_001260112.1	glycerol3P_DH	6..343	CDD:274551	160/336 (48%)
Gpdh3	NP_732726.2	glycerol3P_DH	6..342	CDD:274551	160/336 (48%)
		NADB_Rossmann	6..174	CDD:304358	83/168 (49%)
		NAD_Gly3P_dh_C	195..336	CDD:284817	67/140 (48%)
		BCOR	<961..1109	CDD:292436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473020
Domainoid	1	1.000	63	1.000	Domainoid score	I567
eggNOG	1	0.900	-	-		E1_COG0240
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346303at33208
OrthoFinder	1	1.000	-	-		FOG0000846
OrthoInspector	1	1.000	-	-		otm51337
orthoMCL	1	0.900	-	-		OOG6_100385
Panther	1	1.100	-	-	P	PTHR11728
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750