DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gpdh1 and gpd2

DIOPT Version :9

Sequence 1:	NP_001260112.1	Gene:	Gpdh1 / 33824	FlyBaseID:	FBgn0001128	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_594542.1	Gene:	gpd2 / 2541502	PomBaseID:	SPAC23D3.04c	Length:	373	Species:	Schizosaccharomyces pombe

Alignment Length:	350	Identity:	175/350 - (50%)
Similarity:	238/350 - (68%)	Gaps:	12/350 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VNVCIVGSGNWGSAIAKIVGANAAALPE-FEERVTMFVYEELI--DGKK--LTEIINETHENVKY 64
            ::|.|:||||||:|||||.|.||.|.|: |..:|.|::|||.|  :||:  |||:.|.|||||||
pombe    25 ISVGIIGSGNWGTAIAKICGENAKAHPDIFHPQVHMWMYEEKIQHEGKECNLTEVFNTTHENVKY 89

  Fly    65 LKGHKLPPNVVAVPDLVEAAKNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGG 129
            |||.|.|.||.|.||:.:....:|||::|:||||:...|.||.|.:|.:|:|||.|||....: .
pombe    90 LKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAVAISCIKGVSVTK-D 153

  Fly   130 GIDLISHIITRHLKIPCAVLMGANLANEVAEGNFCETTIG-----CTDKKY-GKVLRDLFQANHF 188
            .:.|.|.||..:..:.|.||.|||:|:|||:..|||||||     ..:.:| .|.::.||...:|
pombe   154 RVRLFSDIIEENTGMYCGVLSGANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYF 218

  Fly   189 RVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVFYPGSKLSTF 253
            ||.:|:|...|.:.||||||||..||.:|||:||||||:||:|:||:||.:|..:|:....|:..
pombe   219 RVNIVEDVPGVALGGALKNIVAVAAGIIDGLELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTMS 283

  Fly   254 FESCGVADLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLED 318
            .||||:|||||||.||||.:.:.|||.:||.:..:|:|:|:||||||..||:||...|.|:....
pombe   284 EESCGIADLITTCLGGRNHKCAVAFVKTGKPMHVVEQELLDGQKLQGAATAKEVYEFLDNQNKVS 348

  Fly   319 KFPLFTAIHKICTNQLKPNDLIDCI 343
            :||||||:::|....|.||.|::.|
pombe   349 EFPLFTAVYRIVYEGLPPNKLLEAI 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpdh1	NP_001260112.1	glycerol3P_DH	6..343	CDD:274551	174/347 (50%)
gpd2	NP_594542.1	glycerol3P_DH	26..373	CDD:274551	174/347 (50%)
		NAD_Gly3P_dh_N	26..194	CDD:279543	88/168 (52%)
		NAD_Gly3P_dh_C	226..367	CDD:284817	73/140 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	178	1.000	Domainoid score	I824
eggNOG	1	0.900	-	-		E1_COG0240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5593
Inparanoid	1	1.050	326	1.000	Inparanoid score	I535
OMA	1	1.010	-	-		QHG56883
OrthoFinder	1	1.000	-	-		FOG0000846
OrthoInspector	1	1.000	-	-		mtm9285
orthoMCL	1	0.900	-	-		OOG6_100385
Panther	1	1.100	-	-	O	PTHR11728
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R508
SonicParanoid	1	1.000	-	-		X660
TreeFam	1	0.960	-	-
	14	13.860