DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dsf and NR1I3

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_005245750.1	Gene:	NR1I3 / 9970	HGNCID:	7969	Length:	429	Species:	Homo sapiens

Alignment Length:	416	Identity:	87/416 - (20%)
Similarity:	137/416 - (32%)	Gaps:	142/416 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 SPAPTLTTS----SGSPQHRQMSRHSLSEATTPPS------HAS--------LMICASNNNNNNN 412
            ||:|..|..    :|...|..:...|...|.||.|      |..        |.:...|:|:...
Human    10 SPSPCATNQHFCHAGKTSHPGLCPESRVCALTPQSLRATGGHIKQTSLVFQILRVIIPNSNHWQL 74

  Fly   413 NNNNNGEHKQSSYTSGSPTPTT-PTPP--PPRS------GVGSTCNTASSSSGFLELLLSPDKCQ 468
            ..:...:.::.|...|.|.... |...  |.||      .:|.||..|.|             |
Human    75 LRSEENQQQRGSLGRGIPYQILWPAGDMLPKRSRRTVSKSIGPTCPFAGS-------------C- 125

  Fly   469 ELIQYQVQHNTLLFPQQLLDS-----RLLSWEML------------QETTARL------------ 504
            |:.:.|.:|......|:.||:     .:||.|.|            |:|..:|
Human   126 EVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLL 190

  Fly   505 ----------------------LFM----------------------------AVRWVKCLMPFQ 519
                                  ||:                            .:::.|.|..|:
Human   191 GAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFR 255

  Fly   520 TLSKNDQHLLLQESWKEL--FLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEMKTIQ---- 578
            :|...||..||:.:..|:  .:||.   |..|.....|..||  ...::|.|..:.....|
Human   256 SLPIEDQISLLKGAAVEICHIVLNT---TFCLQTQNFLCGPL--RYTIEDGARVSPTVGFQVEFL 315

  Fly   579 EILCRF----RQITPDGSEVGCMKAIALFAP-----ETAGLCDVQPVEMLQDQAQCILSDHVR-- 632
            |:|..|    |::.....|...:.|:|||:|     :..|:.....::.||::....|..:::
Human   316 ELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQ 380

  Fly   633 LRYPRQATRFGRLLLLLPSLRTIRAA 658
            .|.||....:.:||.||..||:|..|
Human   381 QRRPRDRFLYAKLLGLLAELRSINEA 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	60/288 (21%)
NR1I3	XP_005245750.1	NR_DBD_like	<108..154	CDD:295381	12/59 (20%)
NR1I3	XP_005245750.1	NR_LBD_PXR_like	178..427	CDD:132732	47/234 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910