DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and NR1D1

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_068370.1	Gene:	NR1D1 / 9572	HGNCID:	7962	Length:	614	Species:	Homo sapiens

Alignment Length:	680	Identity:	142/680 - (20%)
Similarity:	227/680 - (33%)	Gaps:	234/680 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIY-TCKATGDLKG-RCPVDKTHRNQCRACRLA 75
            ||||||.:||.|||:::|:||.|||:|||.:|..| .|     ||. .|.:.:.:||:|:.||..
Human   132 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRC-----LKNENCSIVRINRNRCQQCRFK 191

  Fly    76 KCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAHHA 140
            ||....|::|||:..|.|::.|                                        ...
Human   192 KCLSVGMSRDAVRFGRIPKREK----------------------------------------QRM 216

  Fly   141 AVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGP---AP 202
            .....:|..|.::..:....|.|:.      |||.:..|..|:.||:.......|..|.|   .|
Human   217 LAEMQSAMNLANNQLSSQCPLETSP------TQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTP 275

  Fly   203 PAGH---------LHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGG-NSSAISGSGPGSTLP 257
            |...         :......|:....:.|...|           |:||. |::..|||.|
Human   276 PRSPSPEPTVEDVISQVARAHREIFTYAHDKLG-----------SSPGNFNANHASGSPP----- 324

  Fly   258 FPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSI 322
                                            .:||:....|...|:.|::|..:....|...:
Human   325 --------------------------------ATTPHRWENQGCPPAPNDNNTLAAQRHNEALN- 356

  Fly   323 SSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHS 387
               |.|.                       :||:.||
Human   357 ---GLRQ-----------------------APSSYPP---------------------------- 367

  Fly   388 LSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTAS 452
                |.||..|         :::.:.:|:||.....::...:|....|...|.:   |::.|.
Human   368 ----TWPPGPA---------HHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQ---GNSKNV-- 414

  Fly   453 SSSGFLELLLSPDKCQELIQYQVQHNTLLFP--------QQLLDSRLLSWEMLQETTARLLFMAV 509
                   ||..|..              ::|        |::       ||....:....:...|
Human   415 -------LLACPMN--------------MYPHGRSGRTVQEI-------WEDFSMSFTPAVREVV 451

  Fly   510 RWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEM 574
            .:.|.:..|:.||::||..||:....|:.::..|......|.|.:.   |.|......|.....|
Human   452 EFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMF---LSRTTYSLQELGAMGM 513

  Fly   575 KTIQEILCRFRQ------ITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRL 633
            ..:...:..|.:      :|.:  |:|...|:.|.:.:.:|:.:...||.||:.....|...|..
Human   514 GDLLSAMFDFSEKLNSLALTEE--ELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLK 576

  Fly   634 RYPRQATRFGRLLLLLPSLRTIRAATIEAL 663
            ..|.:.:||.:|||.||.|||:.....|.|
Human   577 NRPLETSRFTKLLLKLPDLRTLNNMHSEKL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	39/86 (45%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	47/211 (22%)
NR1D1	NP_068370.1	Modulating	1..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q3UV55	1..70
		Crucial for activation of GJA1. /evidence=ECO:0000250	49..284		56/202 (28%)
		NR_DBD_REV_ERB	127..215	CDD:143540	40/127 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..285		14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..345		12/70 (17%)
		NR_LBD	418..611	CDD:325017	48/215 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910