Protein Alignment dsf and NR1I2

DIOPT Version :9

• Sequence 1: NP_001260109.1
• Gene: dsf / 33823
• FlyBaseID: FBgn0015381
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_071285.1
• Gene: NR1I2 / 8856
• HGNCID: 7968
• Length: 473
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 127/680 - (18%)
• Similarity: 195/680 - (28%)
• Gaps: 301/680 - (44%)

  Fly    13 CKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLAKC 77
            |:||||:::|.|:.:.:|:||.|||:|::.||....|...   ||.|.:.:..|.||:||||.||
Human    80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR---KGACEITRKTRRQCQACRLRKC 141

  Fly    78 FQSAMNK------DAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAA 136
            .:|.|.|      :||:..|...|.|                                      .
Human   142 LESGMKKEMIMSDEAVEERRALIKRK--------------------------------------K 168

  Fly   137 AHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPA 201
            :...........||......|...|:.....:|:.|
Human   169 SERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTT----------------------------- 204

  Fly   202 PPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHN 266
                        ..|...|..|           ||:|         ||.....:|..||.
Human   205 ------------FSHFKNFRLP-----------GVLS---------SGCELPESLQAPSR----- 232

  Fly   267 LIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGG 331
               |.|:|...:.....:..||         .|......:..||..|:.|              |
Human   233 ---EEAAKWSQVRKDLCSLKVS---------LQLRGEDGSVWNYKPPADS--------------G 271

  Fly   332 GEEGLSLGSESPRVNVETETPSPSN-SPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPP 395
            |:|..||            .|..:: |..:..|.||.|..::.....|...|:   ||.:.
Human   272 GKEIFSL------------LPHMADMSTYMFKGIISFAKVISYFRDLPIEDQI---SLLKG---- 317

  Fly   396 SHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLEL 460
              |:..:|....|...|......|..:.||                      | ...::.||.:|
Human   318 --AAFELCQLRFNTVFNAETGTWECGRLSY----------------------C-LEDTAGGFQQL 357

  Fly   461 LLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKND 525
            ||.|                                                  ::.|..:.|.
Human   358 LLEP--------------------------------------------------MLKFHYMLKK- 371

  Fly   526 QHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEMKTIQEILCRFRQITPD 590
              |.|.|                            .|.||
Human   372 --LQLHE----------------------------EEYVL------------------------- 381

  Fly   591 GSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATR--FGRLLLLLPSLR 653
                  |:||:||:|:..|:...:.|:.||:|....|..::....|:.|.|  |.:::.:|..||
Human   382 ------MQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELR 440

  Fly   654 TIRAATIEALFFKETIGNVPIAR-LLRDMY 682
            :|.|...:.|...:.|.  |.|. |:::::
Human   441 SINAQHTQRLLRIQDIH--PFATPLMQELF 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	36/90 (40%)
		NR_LBD_Tlx_PNR_like	467..671	CDD:132748	31/205 (15%)
NR1I2	NP_071285.1	NR_DBD_PXR	79..166	CDD:143536	35/88 (40%)
		NR_LBD_PXR_like	182..467	CDD:132732	89/534 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910