DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dsf and NR0B2

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_068804.1	Gene:	NR0B2 / 8431	HGNCID:	7961	Length:	257	Species:	Homo sapiens

Alignment Length:	264	Identity:	71/264 - (26%)
Similarity:	108/264 - (40%)	Gaps:	51/264 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 CNTASSSSGFLELLLSP---------DKC----QELIQYQVQHNTLLFPQQLLDSRLLSWEMLQE 499
            |..|:|....|..|||.         .:|    ...:|....|.|.   ::.||
Human    11 CQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTC---REALD----------- 61

  Fly   500 TTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDL--TPILESPLIRE 562
                :|...|.:::.|..|..|...||..|||..|..||||.|||..:..::  .|:   |.|.:
Human    62 ----VLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPV---PSILK 119

  Fly   563 RVLQDEAT------------QTEMKTIQEILC---RFRQITPDGSEVGCMKAIALFAPETAGLCD 612
            ::|.:|.:            |..:..:|.:.|   .|..:.....|..|:|...||.|:..||..
Human   120 KILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDVPGLQA 184

  Fly   613 VQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARL 677
            ...:..||.:|..:|.:.:....|....|..|:||...:|::|..:.:..|||:..||:|.||.|
Human   185 ASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGL 249

  Fly   678 LRDM 681
            |.||
Human   250 LGDM 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	56/224 (25%)
NR0B2	NP_068804.1	NR_LBD_SHP	32..254	CDD:132763	64/243 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910