DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and NR2F2

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_066285.1	Gene:	NR2F2 / 7026	HGNCID:	7976	Length:	414	Species:	Homo sapiens

Alignment Length:	677	Identity:	149/677 - (22%)
Similarity:	207/677 - (30%)	Gaps:	360/677 - (53%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLA 75
            |.|.||||:|||||||.::|:||..|||||:.||..|||:|..:    ||:|:.|||||:.|||.
Human    77 IECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN----CPIDQHHRNQCQYCRLK 137

  Fly    76 KCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAHHA 140
            ||.:..|.::||
Human   138 KCLKVGMRREAV----------------------------------------------------- 149

  Fly   141 AVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPAPPAG 205
                                                                    |:|..||.
Human   150 --------------------------------------------------------QRGRMPPT- 157

  Fly   206 HLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLIAE 270
                            .|.||
Human   158 ----------------QPTHG-------------------------------------------- 162

  Fly   271 AASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGEEG 335
                                     ..|.|:....|.|:|.|
Human   163 -------------------------QFALTNGDPLNCHSYLS----------------------- 179

  Fly   336 LSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHASL 400
                                                                        .:.||
Human   180 ------------------------------------------------------------GYISL 184

  Fly   401 MICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPD 465
            ::.|.                                |.|.|..||.|             :.|
Human   185 LLRAE--------------------------------PYPTSRFGSQC-------------MQP- 203

  Fly   466 KCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLL 530
                                   :.::..|.:.|..||:||.||.|.:.:..|..|...||..||
Human   204 -----------------------NNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALL 245

  Fly   531 QESWKELFLLNLAQWTIPLDLTPIL------ESPLIRERVLQDEATQTEMKTIQEILCRFRQITP 589
            :.:|.|||:||.||.::||.:.|:|      .||:..:||:   |....::..||.:.:.:.:..
Human   246 RLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVV---AFMDHIRIFQEQVEKLKALHV 307

  Fly   590 DGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSLRT 654
            |.:|..|:|||.||..:..||.||..||.||:::||.|.::||.:||.|.||||:|||.||||||
Human   308 DSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRT 372

  Fly   655 IRAATIEALFFKETIGNVPIARLLRDM 681
            :.::.||.|||...:|..||..|:|||
Human   373 VSSSVIEQLFFVRLVGKTPIETLIRDM 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	43/86 (50%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	76/209 (36%)
NR2F2	NP_066285.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72
		NR_DBD_COUP_TF	79..151	CDD:143516	42/184 (23%)
		Interaction with ZFPM2. /evidence=ECO:0000250	117..414		123/637 (19%)
		NR_LBD_COUP-TF	177..411	CDD:132746	95/378 (25%)
		Important for dimerization	337..414		35/63 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910