DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and RXRB

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001257330.1	Gene:	RXRB / 6257	HGNCID:	10478	Length:	537	Species:	Homo sapiens

Alignment Length:	684	Identity:	128/684 - (18%)
Similarity:	190/684 - (27%)	Gaps:	360/684 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AGDRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQ 68
            ||.||    |.:|||||||||||:|||:||.|||||:|.::..|:|:...|    |.|||..||:
Human   200 AGKRL----CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKD----CTVDKRQRNR 256

  Fly    69 CRACRLAKCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAH 133
            |:.||..||..:.|.::|||.||...|.|
Human   257 CQYCRYQKCLATGMKREAVQEERQRGKDK------------------------------------ 285

  Fly   134 AAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQ 198

Human   286 ----------------------------------------------------------------- 285

  Fly   199 GPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLL 263
                                                             .|.|.|
Human   286 -------------------------------------------------DGDGEG---------- 291

  Fly   264 HHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSR 328
                                           |..|....|           ....:::..::..:
Human   292 -------------------------------AGGAPEEMP-----------VDRILEAELAVEQK 314

  Fly   329 SGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATT 393
            |..|.||                                 |..|..|||
Human   315 SDQGVEG---------------------------------PGGTGGSGS---------------- 330

  Fly   394 PPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFL 458
                                                    :|..|     |.:.|..|.
Human   331 ----------------------------------------SPNDP-----VTNICQAAD------ 344

  Fly   459 ELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSK 523
                                                        :.||..|.|.|.:..|.:|..
Human   345 --------------------------------------------KQLFTLVEWAKRIPHFSSLPL 365

  Fly   524 NDQHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEA------TQTEMKTIQEILC 582
            :||.:||:..|.||.:.:.:..:|.:....:|.:.|...|.....|      .::..:.:.|::.
Human   366 DDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVS 430

  Fly   583 RFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLL 647
            :.|.:..|.:|:||::||.||.|:..||.:...||:|:::....|..:.:.:||.|..||.:|||
Human   431 KMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 495

  Fly   648 LLPSLRTIRAATIEALFFKETIGNVPIARLLRDM 681
            .||:||:|....:|.|||.:.||:.||...|.:|
Human   496 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEM 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	47/92 (51%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	54/209 (26%)
RXRB	NP_001257330.1	Modulating. /evidence=ECO:0000250	1..204		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..181
		NR_DBD_RXR	204..279	CDD:143514	42/82 (51%)
		Hinge	271..295		11/214 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..299		10/213 (5%)
		NR_LBD_RXR_like	298..515	CDD:132741	68/371 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..336		11/116 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910