Protein Alignment dsf and RORA

DIOPT Version :9

• Sequence 1: NP_001260109.1
• Gene: dsf / 33823
• FlyBaseID: FBgn0015381
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_599022.1
• Gene: RORA / 6095
• HGNCID: 10258
• Length: 556
• Species: Homo sapiens
• Alignment Length: 708
• Identity: 134/708 - (18%)
• Similarity: 220/708 - (31%)
• Gaps: 284/708 - (40%)

  Fly    11 IPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLA 75
            ||||:|||:|||.|||:.:|:||.|||:||...|..|:|..    :..|.:|:|.||:|:.|||.
Human   104 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPR----QKNCLIDRTSRNRCQHCRLQ 164

  Fly    76 KCFQSAMNKDAVQHERGPRKPK--LHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAH 138
            ||....|::|||:..|..:|.:  |:.::..|.
Human   165 KCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHR-------------------------------- 197

  Fly   139 HAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAP--PSGFHLTASGAQQGPA 201
                                          ....|......|..|.|  |: ::::|:|..:
Human   198 ------------------------------MQQQQRDHQQQPGEAEPLTPT-YNISANGLTE--- 228

  Fly   202 PPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHN 266
                                                                         ||.:
Human   229 -------------------------------------------------------------LHDD 232

  Fly   267 LIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGG 331
            |                                     ||..:..:|..|.:..::||.
Human   233 L-------------------------------------SNYIDGHTPEGSKADSAVSSF------ 254

  Fly   332 GEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPS 396
                        .::::   |||..| .|....|.|.|...                   .||.|
Human   255 ------------YLDIQ---PSPDQS-GLDINGIKPEPICD-------------------YTPAS 284

  Fly   397 HASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELL 461
                                 |.....|:|:|..:||.                   |...||.|
Human   285 ---------------------GFFPYCSFTNGETSPTV-------------------SMAELEHL 309

  Fly   462 LSP------DKCQELIQYQVQHNTLLFPQQLLDS-----RLLSWEMLQETTARLLFMAVRWVKCL 515
            ...      :.||.|.:...|.....|.|:.:::     |.:.|::........:...|.:.|.:
Human   310 AQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRI 374

  Fly   516 MPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEMKTIQEI 580
            ..|..|.:|||.:||:....|:..:.:.:.....:.|...:.......|.:....:..:..:.|.
Human   375 DGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEF 439

  Fly   581 ---LCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRF 642
               ||.. .:|.|  |:....|..|.:.:.:.|.:...:|.||.:.|..| .||..:..|:.
Human   440 GKSLCSM-HLTED--EIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL-QHVLQKNHRED--- 497

  Fly   643 GRLLLLLPSLRTIRAA----TIEALFFK---ETIGNVPIARLLRDMYT--MEPA-QVD 690
            |.|..|:..:.|:||.    |.:.:.||   ..|..:....|.::::|  .||| |:|
Human   498 GILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQID 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	41/88 (47%)
		NR_LBD_Tlx_PNR_like	467..671	CDD:132748	47/218 (22%)
RORA	NP_599022.1	NR_DBD_ROR	99..193	CDD:143526	42/92 (46%)
		NR_LBD_ROR_like	305..544	CDD:132737	51/245 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910