DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and Nr5a2

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_068510.1	Gene:	Nr5a2 / 60349	RGDID:	68353	Length:	560	Species:	Rattus norvegicus

Alignment Length:	706	Identity:	150/706 - (21%)
Similarity:	221/706 - (31%)	Gaps:	281/706 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCR 70
            |..|:..|.||||:.||.|||:.:|:.|.|||||::...:.|||....:    |.:|||.|.:|.
  Rat   100 DEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQN----CQIDKTQRKRCP 160

  Fly    71 ACRLAKCFQSAMNKDAVQHE--RGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAH 133
            .||..||....|..:||:.:  ||.|. |..|.                             :..
  Rat   161 YCRFKKCIDVGMKLEAVRADRMRGGRN-KFGPM-----------------------------YKR 195

  Fly   134 AAAAHHAAVAAAAASGLHHHH-----HAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTA 193
            ..|......|...|:||....     .|||..|.:.:       |:|  |..:...|.|...|..
  Rat   196 DRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAI-------QNI--HSASKGLPLSHVALPP 251

  Fly   194 SGAQQGP---------APPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISG 249
            :...:.|         .||.|.||    |:|        .:||
  Rat   252 TDYDRSPFVTSPISMTMPPHGSLH----GYQ--------PYGH---------------------- 282

  Fly   250 SGPGSTLPFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPS 314
                    ||:.                       |:.|....||:|:.::....|....|
  Rat   283 --------FPNR-----------------------AIKSEYPDPYSSSPESMMGYSYMDGY---- 312

  Fly   315 PSNSIQSISSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQ 379
                                               :|.||::.|.|....:.
  Rat   313 -----------------------------------QTSSPASIPHLILELLK------------- 329

  Fly   380 HRQMSRHSLSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGV 444
                     .|...|...|.:|.......||.|.     :.|.|::
  Rat   330 ---------CEPDEPQVQAKIMAYLQQEQNNRNR-----QEKLSAF------------------- 361

  Fly   445 GSTCNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAV 509
            |..|..|..:                                                  ||..|
  Rat   362 GLLCKMADQT--------------------------------------------------LFSIV 376

  Fly   510 RWVKCLMPFQTLSKNDQHLLLQESWKELFLLNL--------AQWTIPL------DLTPILESPLI 560
            .|.:..:.|:.|..:||..|||..|.||.:|:.        .:.||.|      |.:.|:.:
  Rat   377 EWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSSIISN--- 438

  Fly   561 RERVLQDEATQTEMKTIQEILCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQC 625
                 .:.|....:...||::.|.|.:..|..|..|:|.:.||:.:...|.:.|.||.:|:|...
  Rat   439 -----TEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENFQLVEGVQEQVNA 498

  Fly   626 ILSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARLLRDM 681
            .|.|:....||:|..:||:|||.||.:|.|.....:.|::|...|:||...||.:|
  Rat   499 ALLDYTLCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEM 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	38/93 (41%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	53/217 (24%)
Nr5a2	NP_068510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..54
		NR_DBD_Lrh-1_like	107..199	CDD:143541	38/125 (30%)
		FTZ-F1 box. /evidence=ECO:0000250	176..205		8/58 (14%)
		NR_LBD_Lrh-1	320..560	CDD:132754	73/339 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910