DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and NR5A1

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_004950.2	Gene:	NR5A1 / 2516	HGNCID:	7983	Length:	461	Species:	Homo sapiens

Alignment Length:	705	Identity:	151/705 - (21%)
Similarity:	204/705 - (28%)	Gaps:	284/705 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCR 70
            |..||..|.||||:.||.|||:.:|:.|.|||||::..|:.|||..:..    |.:|||.|.:|.
Human     6 DEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQS----CKIDKTQRKRCP 66

  Fly    71 ACRLAKCFQSAMNKDAVQHE--RGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAH 133
            .||..||....|..:||:.:  ||.|. |..|.                             :..
Human    67 FCRFQKCLTVGMRLEAVRADRMRGGRN-KFGPM-----------------------------YKR 101

  Fly   134 AAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAP----PSGFHLTAS 194
            ..|......|...|:|.         .|.|.        ..:...||.|.||    |...|
Human   102 DRALKQQKKAQIRANGF---------KLETG--------PPMGVPPPPPPAPDYVLPPSLH---- 145

  Fly   195 GAQQGP-------APPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGP 252
                ||       .||||.|...||          |....|:|..||
Human   146 ----GPEPKGLAAGPPAGPLGDFGA----------PALPMAVPGAHG------------------ 178

  Fly   253 GSTLPFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSN 317
                |...:|.         ...||      .|:.|....||||..|...|      |..|.|.
Human   179 ----PLAGYLY---------PAFPG------RAIKSEYPEPYASPPQPGLP------YGYPEPF- 217

  Fly   318 SIQSISSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQ 382
                       |||           |.|                     |...|......|...|
Human   218 -----------SGG-----------PNV---------------------PELILQLLQLEPDEDQ 239

  Fly   383 MSRHSLSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGST 447
            :             .|.::.|..                       .||.:.|..|   :..|..
Human   240 V-------------RARILGCLQ-----------------------EPTKSRPDQP---AAFGLL 265

  Fly   448 CNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWV 512
            |..|..:  |:.:                                                |.|.
Human   266 CRMADQT--FISI------------------------------------------------VDWA 280

  Fly   513 KCLMPFQTLSKNDQHLLLQESWKELF----------------LLNLAQWTIPLDLTPILESPLIR 561
            :..|.|:.|...||..|||..|.||.                :|.:....:.|.........|:.
Human   281 RRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLH 345

  Fly   562 ERVLQDEATQTEMKTIQEILCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCI 626
            ..||:          .||::.:...:..|..|..|:|.|.||:.:...|.:...|:..|::|...
Human   346 SLVLR----------AQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAA 400

  Fly   627 LSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARLLRDM 681
            |.|:....||....:|.:|||.|..:|.:.....|.|:.|.....:|...||.:|
Human   401 LLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEM 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	40/93 (43%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	44/219 (20%)
NR5A1	NP_004950.2	NR_DBD_Lrh-1_like	13..105	CDD:143541	39/125 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..157		11/53 (21%)
		MISS	<140..>221	CDD:318115	34/164 (21%)
		NR_LBD_SF-1	223..459	CDD:132755	63/353 (18%)
		Important for dimerization	230..461		60/325 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910