DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and NR5A2

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_995582.1	Gene:	NR5A2 / 2494	HGNCID:	7984	Length:	541	Species:	Homo sapiens

Alignment Length:	692	Identity:	161/692 - (23%)
Similarity:	232/692 - (33%)	Gaps:	251/692 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCR 70
            |..|:..|.||||:.||.|||:.:|:.|.|||||::..|:.|||....:    |.:|||.|.:|.
Human    79 DEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQN----CQIDKTQRKRCP 139

  Fly    71 ACRLAKCFQSAMNKDAVQHE--RGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAH 133
            .||..||....|..:||:.:  ||.|. |..|.                             :..
Human   140 YCRFQKCLSVGMKLEAVRADRMRGGRN-KFGPM-----------------------------YKR 174

  Fly   134 AAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQ 198
            ..|......|...|:||             .:.|.....|          |.||  .||.|.|.|
Human   175 DRALKQQKKALIRANGL-------------KLEAMSQVIQ----------AMPS--DLTISSAIQ 214

  Fly   199 GPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLL 263
                   ::|....|               ||..|                    :.||
Human   215 -------NIHSASKG---------------LPLNH--------------------AALP------ 231

  Fly   264 HHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSR 328
                                       .|.|..:...:||.|     .:..|..|:|...:.|
Human   232 ---------------------------PTDYDRSPFVTSPIS-----MTMPPHGSLQGYQTYG-- 262

  Fly   329 SGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATT 393
                        ..|...:::|.|.|..|.|
Human   263 ------------HFPSRAIKSEYPDPYTSSP---------------------------------- 281

  Fly   394 PPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFL 458
                .|:|                |.....||.:.||                    ||.....|
Human   282 ----ESIM----------------GYSYMDSYQTSSP--------------------ASIPHLIL 306

  Fly   459 ELLLSPDKCQELIQYQVQHNTLLFPQQLLDSR-----LLSWEMLQETTARLLFMAVRWVKCLMPF 518
            |||    || |..:.|||...:.:.||...:|     |.::.::.:...:.||..|.|.:..:.|
Human   307 ELL----KC-EPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFF 366

  Fly   519 QTLSKNDQHLLLQESWKELFLLNL--------AQWTIPLDLTPILESPLIRERVLQDEATQTE-M 574
            :.|..:||..|||..|.||.:|:.        .:.:|.|.....::..:|..   |..||... |
Human   367 RELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIAS---QAGATLNNLM 428

  Fly   575 KTIQEILCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQA 639
            ...||::.:.|.:..|..|..|:|.:.||:.:...|.:.|.||.:|:|....|.|:....||:|.
Human   429 SHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQT 493

  Fly   640 TRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARLLRDM 681
            .:||:|||.||.:|.|.....|.|::|...|:||...||.:|
Human   494 EKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEM 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	39/93 (42%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	63/217 (29%)
NR5A2	NP_995582.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		NR_DBD_Lrh-1_like	86..178	CDD:143541	39/125 (31%)
		FTZ-F1 box	155..184		8/58 (14%)
		NR_LBD_Lrh-1	301..541	CDD:132754	74/243 (30%)
		Phosphatidylglycerol phosphate binding. /evidence=ECO:0000269\|PubMed:15897460	421..424		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910