Protein Alignment dsf and Nr2e1

DIOPT Version :9

• Sequence 1: NP_001260109.1
• Gene: dsf / 33823
• FlyBaseID: FBgn0015381
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_689415.1
• Gene: Nr2e1 / 21907
• MGIID: 1100526
• Length: 385
• Species: Mus musculus
• Alignment Length: 693
• Identity: 187/693 - (26%)
• Similarity: 244/693 - (35%)
• Gaps: 339/693 - (48%)

  Fly     7 RLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRA 71
            |:||||||||||||||||||:|:||||||||||||.|||.|.||:..  :|.|||||||||||||
Mouse    10 RILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGN--QGGCPVDKTHRNQCRA 72

  Fly    72 CRLAKCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAA 136
            |||.||.:..|||||||||||||...:..|
Mouse    73 CRLKKCLEVNMNKDAVQHERGPRTSTIRKQ----------------------------------- 102

  Fly   137 AHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPA 201
                                        |:..|.
Mouse   103 ----------------------------VALYFR------------------------------- 108

  Fly   202 PPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHN 266
               ||....||      |.|.|  ..|||||
Mouse   109 ---GHKEDNGA------AAHFP--STALPAP---------------------------------- 128

  Fly   267 LIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGG 331
                                      .:.:|.....|
Mouse   129 --------------------------AFFTAVTQLEP---------------------------- 139

  Fly   332 GEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPS 396
              .||.|.:.|                                                 .||
Mouse   140 --HGLELAAVS-------------------------------------------------ATP-- 151

  Fly   397 HASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELL 461
                                   .:|:..:...|||..|
Mouse   152 -----------------------ERQTLVSLAQPTPKYP-------------------------- 167

  Fly   462 LSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQ 526
                           |.....|..|.:   ::.|.:.|:.||||||:::|.|.:..|.|||..||
Mouse   168 ---------------HEVNGTPMYLYE---VATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQ 214

  Fly   527 HLLLQESWKELFLLNLAQWTIPLDLTPIL----------ESPLIRERVLQDEATQTEMKTIQEIL 581
            .:||:::|:|||:|.:|||.||:|...:|          :|..:.:.:       :|::.:||::
Mouse   215 LMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNTDNTDSQKLNKII-------SEIQALQEVV 272

  Fly   582 CRFRQITPDGSEVGCMKAIALF-------APETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQA 639
            .||||:..|.:|..|:|.|..|       ..|.....:...:..|||:||..|:.::..|||.|.
Mouse   273 ARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQP 337

  Fly   640 TRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARLLRDMY 682
            .|||:||||||:||:|..:|||.:|||:|||||||.|||.|||
Mouse   338 CRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMY 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	70/90 (78%)
		NR_LBD_Tlx_PNR_like	467..671	CDD:132748	78/220 (35%)
Nr2e1	NP_689415.1	NR_DBD_TLX	8..99	CDD:143537	70/90 (78%)
		NR_LBD_Tlx_PNR_like	154..369	CDD:132748	83/265 (31%)
		Required for transcriptional repression	341..385		29/40 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC6Q
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37750
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2434
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.900