Protein Alignment dsf and NR2F6

DIOPT Version :9

• Sequence 1: NP_001260109.1
• Gene: dsf / 33823
• FlyBaseID: FBgn0015381
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_005225.2
• Gene: NR2F6 / 2063
• HGNCID: 7977
• Length: 404
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 158/679 - (23%)
• Similarity: 212/679 - (31%)
• Gaps: 347/679 - (51%)

  Fly     9 LDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACR 73
            |.:.|.||||:|||||||:::|:||..||||||.||..|||::..|    |.:|:.|||||:.||
Human    52 LQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRD----CQIDQHHRNQCQYCR 112

  Fly    74 LAKCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAH 138
            |.|||:..|.|:|||..|.|
Human   113 LKKCFRVGMRKEAVQRGRIP--------------------------------------------- 132

  Fly   139 HAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPAPP 203
                                                                             
Human   133 ----------------------------------------------------------------- 132

  Fly   204 AGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLI 268
                                   |:||           |..:|.|||.|||.|.         .:
Human   133 -----------------------HSLP-----------GAVAASSGSPPGSALA---------AV 154

  Fly   269 AEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGE 333
            |......||...:.:.|.: ..:.||.:||                        ...|  :|||.
Human   155 ASGGDLFPGQPVSELIAQL-LRAEPYPAAA------------------------GRFG--AGGGA 192

  Fly   334 EGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHA 398
            .|..||.::
Human   193 AGAVLGIDN-------------------------------------------------------- 201

  Fly   399 SLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLS 463
               :|
Human   202 ---VC------------------------------------------------------------ 203

  Fly   464 PDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHL 528
                                               |..|||||..|.|.:....|..|...||..
Human   204 -----------------------------------ELAARLLFSTVEWARHAPFFPELPVADQVA 233

  Fly   529 LLQESWKELFLLNLAQWTIPLDLTPIL------ESPLIRERVLQDEATQTEMKTIQEILCRFRQI 587
            ||:.||.|||:||.||..:||...|:|      .:|:..||.:   |...:::..||.:.:..::
Human   234 LLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAV---AFMDQVRAFQEQVDKLGRL 295

  Fly   588 TPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSL 652
            ..|.:|.||:||||||.|:..||.|...||.||::||..|:::||.:||.|..|||||||.||:|
Human   296 QVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPAL 360

  Fly   653 RTIRAATIEALFFKETIGNVPIARLLRDM 681
            |.:.|:.|..|||...:|..||..|:|||
Human   361 RAVPASLISQLFFMRLVGKTPIETLIRDM 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	48/88 (55%)
		NR_LBD_Tlx_PNR_like	467..671	CDD:132748	75/209 (36%)
NR2F6	NP_005225.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		NR_DBD_COUP_TF	56..128	CDD:143516	44/75 (59%)
		NR_LBD_COUP-TF	165..400	CDD:132746	95/409 (23%)
		Important for dimerization. /evidence=ECO:0000250	327..404		33/63 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910