DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and Rxra

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_035435.1	Gene:	Rxra / 20181	MGIID:	98214	Length:	467	Species:	Mus musculus

Alignment Length:	676	Identity:	122/676 - (18%)
Similarity:	186/676 - (27%)	Gaps:	363/676 - (53%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLAKC 77
            |.:|||||||||||:|||:||.|||||::.::..|||:...|    |.:||..||:|:.||..||
Mouse   140 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD----CLIDKRQRNRCQYCRYQKC 200

  Fly    78 FQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAHHAAV 142
            ....|.::|||.||
Mouse   201 LAMGMKREAVQEER--------------------------------------------------- 214

  Fly   143 AAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPAPPAGHL 207
                                                                  |:|
Mouse   215 ------------------------------------------------------QRG-------- 217

  Fly   208 HHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLIAEAA 272

Mouse   218 ----------------------------------------------------------------- 217

  Fly   273 SKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGEEGLS 337
                                           ...|.|
Mouse   218 -------------------------------KDRNEN---------------------------- 223

  Fly   338 LGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHASLMI 402
                      |.|:.|.:|                        ..|....:.|       |.|.:
Mouse   224 ----------EVESTSSAN------------------------EDMPVEKILE-------AELAV 247

  Fly   403 CASNNNNNNNNNNNNGEHKQSSYTSGSP--TPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPD 465
                            |.|..:|...:.  .|::|..|     |.:.|..|.
Mouse   248 ----------------EPKTETYVEANMGLNPSSPNDP-----VTNICQAAD------------- 278

  Fly   466 KCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLL 530
                                                 :.||..|.|.|.:..|..|..:||.:||
Mouse   279 -------------------------------------KQLFTLVEWAKRIPHFSELPLDDQVILL 306

  Fly   531 QESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEM-----KTIQEILCRFRQITPD 590
            :..|.||.:.:.:..:|.:....:|.:.|   .|.::.|....:     :.:.|::.:.|.:..|
Mouse   307 RAGWNELLIASFSHRSIAVKDGILLATGL---HVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMD 368

  Fly   591 GSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSLRTI 655
            .:|:||::||.||.|::.||.:...||.|:::....|..:.:.:||.|..||.:|||.||:||:|
Mouse   369 KTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSI 433

  Fly   656 RAATIEALFFKETIGNVPIARLLRDM 681
            ....:|.|||.:.||:.||...|.:|
Mouse   434 GLKCLEHLFFFKLIGDTPIDTFLMEM 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	42/84 (50%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	54/208 (26%)
Rxra	NP_035435.1	Modulating domain. /evidence=ECO:0000250	1..139
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..112
		Nuc_recep-AF1	18..131	CDD:288658
		NR_DBD_RXR	138..214	CDD:143514	40/77 (52%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P19793	165..170		2/4 (50%)
		Hinge	206..229		11/269 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		11/292 (4%)
		NR_LBD_RXR_like	234..445	CDD:132741	66/291 (23%)
		Required for nuclear export. /evidence=ECO:0000250\|UniProtKB:P19793	353..373		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910