DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and nhr-119

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_494368.2	Gene:	nhr-119 / 187340	WormBaseID:	WBGene00003709	Length:	708	Species:	Caenorhabditis elegans

Alignment Length:	697	Identity:	128/697 - (18%)
Similarity:	188/697 - (26%)	Gaps:	320/697 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLAKC 77
            ||||||.::..|||:.:|.||.|||:|::.|...|||:.    .|.|.||:..||.||.||..||
Worm    35 CKVCGDGNAKTHYGVVTCFGCKGFFRRTLKRPSEYTCRH----NGHCVVDRHERNSCRFCRFKKC 95

  Fly    78 FQSAMNKDAVQHER--------------------------------------------------- 91
            .:..|:..||:.:|
Worm    96 IEVGMDPKAVRPDRDATGRHYQGRQRRSKLSAEDEGEVDAEWMRKLPVDMRTTLMQLLNIDLIVG 160

  Fly    92 ---GPRKP-KLHP----------------------QLHHH--------------HHHAAAAAAAA 116
               |..:| |::|                      ::.:.              |....|....|
Worm   161 GGDGHTEPSKIYPLPFATSIRQLLEDPTLLDGKRTEMRYETFREINPDELPCIAHRRLIAMIDWA 225

  Fly   117 HH------------------------------AAAAHH-------------------------HH 126
            .|                              |..:.|                         :|
Worm   226 DHLFDMMDVNNMDDKIAIVKASYGPLMIFSLCANTSRHKMSDIVCLSTFGYISRYAPNGWAEPYH 290

  Fly   127 HHHHHA---------------------------------------------------------HA 134
            ..:..|                                                         |.
Worm   291 FGNQLAERCIDELIDPLKKMNLKEEEITLIKAIIVLNPYLKTLTQDGSEAIMDLRDRIQETLYHV 355

  Fly   135 AAAHHAAVAAAAASG---LHHHHHAMPVSLVT-NVS--ASFNYTQHISTH-------------PP 180
            ....|....|::..|   |......|...||| |:|  .||........|             .|
Worm   356 VRETHPKEVASSRFGNLLLFVPSVMMLGRLVTENLSFVDSFGQMNDALVHDLLQEAPKVEQNRSP 420

  Fly   181 APAAPPSGFHLTASGAQQGPAPPAGHLHHG--GAGHQHATAFHHPGHGHALPAPHGGVVSNPGGN 243
            ...:||     |.||....|:||..: |||  ....|...|.|..|..|:.|..   |.|:...:
Worm   421 TNTSPP-----TTSGMDTSPSPPIMN-HHGVSSQDEQLGGAQHDLGRRHSEPRM---VHSSSSSS 476

  Fly   244 SSAISGS------GPGS------TLPF-------PSHLLHHNLIAEAASKLPGITATAVAAVVSS 289
            ..:::||      |..|      |||:       |:.:....:....||.:|.:.........:.
Worm   477 IESLNGSYQCSSDGGASYQNQIGTLPYNLSCNSLPAQVNDFGVSLNGASSMPNLEMAECDPDYNV 541

  Fly   290 TSTP--YASAAQTSSPSS----------NNHNYSSP------------SPSNSIQSISSIGS--- 327
            |.||  |....|..:.:.          .|:...:|            ||:..:..||::.|
Worm   542 TITPDMYGDMRQAMNVAHGGMEIDESQVGNNGMGTPNLERRDSMQLPQSPTQPMFYISTVESTKH 606

  Fly   328 ----------RSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQ 382
                      |......|.:.|....:..|       ...|..|:||....|    ||||.||..
Worm   607 KFTVTTASYDRFQNAPNGHAYGENGYQNGV-------GGMPQQSSGSFGQMP----SSGSQQHEA 660

  Fly   383 MSRHSLSEATTPPSHAS------------LMICASNNNNNNNNNNNN 417
            :.:.:    :.||.:.|            :|..|.|....::.|..|
Worm   661 LCKTN----SLPPQYMSQQQPQNAQNYDQMMYVAQNQMECDDGNYIN 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	38/139 (27%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748
nhr-119	NP_494368.2	NR_DBD_HNF4A	35..110	CDD:143518	35/78 (45%)
nhr-119	NP_494368.2	Hormone_recep	200..379	CDD:278530	13/178 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910