DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and nhr-48

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001362159.1	Gene:	nhr-48 / 181661	WormBaseID:	WBGene00003638	Length:	833	Species:	Caenorhabditis elegans

Alignment Length:	771	Identity:	145/771 - (18%)
Similarity:	267/771 - (34%)	Gaps:	195/771 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLAKC 77
            |:||||::...::.:.:|:.|..||:|:.::.:...|    ....:|.::...|..|:.|||.||
Worm   110 CRVCGDKAFSYNFNVITCESCKAFFRRNANKEKEIRC----PFNEQCEINMVSRRFCQRCRLTKC 170

  Fly    78 FQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAHHAAV 142
            |...|.|:.:..|....:.|...:.:.......|...|...|.......:.:..| .|.:|..:|
Worm   171 FAVGMKKEWIMSEEARLEKKQRVEENRERRLQDAMNRALEEACMEDESENSYDEA-PAPSHQMSV 234

  Fly   143 AAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGA----QQGPAPP 203
            ....|:....|            .:|.....|:..|         |::......    |.||: .
Worm   235 RQYLANDDAPH------------KSSDEVQPHLGHH---------GYNQKEDKMMNFYQDGPS-D 277

  Fly   204 AGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVS------NPGGNSSAISGSGPGSTL------ 256
            .|:.:|              ...::||:......|      |.|..:.|.:|:.|.:|:
Worm   278 QGYSNH--------------DFDYSLPSNSCASSSQLDTSVNCGATTIADNGASPSNTVTIPAAV 328

  Fly   257 -----PFPSHLLHH----------NLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSN 306
                 |.|:::|..          .:|:.|.:|..|:.|   ..||:......|.|| ..:.:..
Worm   329 DVERKPIPTNVLFSASMSAIQDVAAIISNAETKNLGMCA---PDVVNENLMNVAQAA-VQAQAIV 389

  Fly   307 NHNYSSPSPSNSIQSISSIGSRSGGGEEGLSLGSESPRVN----------VETETPSPSNSP--- 358
            ||.....:...:.|.:|             ::....|.||          :....|:|.|.|
Worm   390 NHTQQLAAAVVAQQVVS-------------NMAPVMPTVNPLDPLLAPAFIAPPMPTPINVPITT 441

  Fly   359 PLSAGSIS---PAPTLTTSSGS--------PQHRQMS-------RHSLSEATTPPSHASLMICAS 405
            |: ||::|   |.|.:.....|        |:...:|       ..:.:|..|.|....:.:...
Worm   442 PI-AGALSTPLPPPIVPPGHSSINPVIPIIPKEMPVSVSLLNQLEQTPAEMVTVPKDMLMKLIQK 505

  Fly   406 NNNNN--------------------NNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSG-VGSTCN 449
            |:.:.                    ..:..|.|....|:.|....|....|.....:| :...||
Worm   506 NSRSTCTCSCMCGRYPPGSCIVDEVTKDLLNGGSSNSSNATDRDETRLETTEDMQMNGLLPGDCN 570

  Fly   450 TA-------SSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSW-EMLQETTARLLF 506
            ::       ||:..|::.:......:|....:.:.:::.......|...::. :.:||.|.
Worm   571 SSIQWLNQQSSAQAFVDPITHSMTAEEAQTQRERRDSIFGSFSAADQGTVTQPKSVQEETI---- 631

  Fly   507 MAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQW-TIPLDLTPILESPLIRERVLQDEAT 570
                |...:...::...:|:.:   |..:||..:: .|| ::.||..|||:        |..:..
Worm   632 ----WEHTVAENESRELSDEEI---EKMEELTEIS-NQWISMRLDSMPILD--------LFSKKN 680

  Fly   571 QTEMKTIQEILCRFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVR--- 632
            ..::....::|..|| ..|...:...:|. .||     ..|.|:.::..:..:...|||..|
Worm   681 VEKIVNGLKLLSSFR-FLPQVDKRSVVKR-GLF-----NYCVVKWMQHKESMSIDGLSDAARRDF 738

  Fly   633 --------LRYPRQATRFGRLLL--LLPSLRTIRAAT---IEALFFKETIG-NVPI 674
                    ..|..|...|..|.:  |..|:.....:|   :|.|.||:.:. |:||
Worm   739 MNIIRREEFNYRVQPGAFNTLAISVLFHSISDNLISTDVYMEHLVFKKLLDKNLPI 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	23/84 (27%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	42/222 (19%)
nhr-48	NP_001362159.1	NR_DBD_CAR	108..200	CDD:143524	24/93 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910