DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and daf-12

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001024547.1	Gene:	daf-12 / 181263	WormBaseID:	WBGene00000908	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	466	Identity:	95/466 - (20%)
Similarity:	156/466 - (33%)	Gaps:	172/466 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GTAGDRLLDI---------PCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKG 57
            |:..|.|||.         .|:||||.::|.::.:.:|:.|..||:|:..|.:.:.|..:.|
Worm    98 GSPDDGLLDSSEESRRRQKTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSED--- 159

  Fly    58 RCPVDKTHRNQCRACRLAKCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAA 122
             |.::...|..|:.|||.|||...|.|:.:.:|...|:.|
Worm   160 -CEINSVSRRFCQKCRLRKCFTVGMKKEWILNEEQLRRRK------------------------- 198

  Fly   123 HHHHHHHHHAHAAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPS 187
                                                .|.:.|.......:|
Worm   199 ------------------------------------NSRLNNTGTCNKRSQ-------------- 213

  Fly   188 GFHLTASGAQQGPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGP 252
                  .|.||.|.         |...|...:.||||.....|.|...:..||..|
Worm   214 ------PGNQQSPQ---------GPNQQPHLSPHHPGVAIYPPQPQRPLTINPMDN--------- 254

  Fly   253 GSTLPFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSN 317
                    .::|| :.|...:.:|.:           .|.|.|.....:||..::   :|.||.|
Worm   255 --------QMMHH-MQANRPNAMPQL-----------ISPPGAQPYPLTSPVGSS---ASDSPPN 296

  Fly   318 SIQSISSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQ 382
            ...::...|.:|..|.:...:...:|       .||.:|.|.:.:|.:    .|:|.    :::|
Worm   297 RSLTMMHNGEKSPDGYDPNIMAHRAP-------PPSFNNRPKMDSGQV----VLSTE----EYKQ 346

  Fly   383 -MSRHSLSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSSYT-SGSPTPTTPTPP--PPRSG 443
             :||  :..|..|    .||            |.....:|:::|. :|.|.|...|||  .|.|.
Worm   347 LLSR--IPGAQVP----GLM------------NEEEPINKRAAYNCNGHPMPAETTPPYSAPMSD 393

  Fly   444 VGSTCNTASSS 454
            :..:.:.::||
Worm   394 MSLSRHNSTSS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	31/101 (31%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748
daf-12	NP_001024547.1	NR_DBD_CAR	116..209	CDD:143524	30/157 (19%)
daf-12	NP_001024547.1	NR_LBD_F1	548..733	CDD:132727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910