DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and Nr6a1

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_034394.1	Gene:	Nr6a1 / 14536	MGIID:	1352459	Length:	495	Species:	Mus musculus

Alignment Length:	691	Identity:	147/691 - (21%)
Similarity:	199/691 - (28%)	Gaps:	300/691 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCR 70
            ||.....|.:||||::|.||||.||:||.|||||||...|:|.|....:    |.:.:..||:|:
Mouse    68 DRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKN----CVMSRKQRNRCQ 128

  Fly    71 ACRLAKCFQSAMNKDAVQHE--RGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAH 133
            .|||.||.|..||:.|::.:  .|.|...:.|
Mouse   129 YCRLLKCLQMGMNRKAIREDGMPGGRNKSIGP--------------------------------- 160

  Fly   134 AAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQ 198
                                           |..|....:.|                 .||  |
Mouse   161 -------------------------------VQISEEEIERI-----------------MSG--Q 175

  Fly   199 GPAPPAGH-LHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHL 262
            .....|.| .:||.:.|                       |:||..:|..:...|||||.
Mouse   176 EFEEEANHWSNHGDSDH-----------------------SSPGNRASESNQPSPGSTLS----- 212

  Fly   263 LHHNLIAEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGS 327
                  :..:.:|.|..|.                         ...|...|.....|.|..:.|
Mouse   213 ------SSRSVELNGFMAF-------------------------RDQYMGMSVPPHYQYIPHLFS 246

  Fly   328 RSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEAT 392
            .||          .||.:            || .|.|:.|      .|.|..|:.||...|....
Mouse   247 YSG----------HSPLL------------PP-QARSLDP------QSYSLIHQLMSAEDLEPLG 282

  Fly   393 TPPSHASLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGF 457
            ||
Mouse   283 TP--------------------------------------------------------------- 284

  Fly   458 LELLLSPDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLS 522
               :|..|      .|.|....|             :.:|......|||..:.|:|.|..|..||
Mouse   285 ---MLIED------GYAVTQAEL-------------FALLCRLADELLFRQIAWIKKLPFFCELS 327

  Fly   523 KNDQHLLLQESWKELFLLN------------LAQWTIPLDLTPILESPLIRE-RVLQDEATQTEM 574
            ..|...||..:|:||.||:            ||..|...       ||...| ....||.    |
Mouse   328 IKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKY-------SPSDEELHRFSDEG----M 381

  Fly   575 KTIQEILC---RFRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYP 636
            :.|:.::.   :|.|:.....|..|||||.....:..||.....:|.|..:...|..|....:|.
Mouse   382 EVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYT 446

  Fly   637 RQATRFGRLLLLLPSLRTIRAATIEALFFKETIGNVPIARL 677
            .|..||..|::.||.:|.|....:          |||:.:|
Mouse   447 HQPNRFPDLMMCLPEIRYIAGKMV----------NVPLEQL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	41/93 (44%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	54/219 (25%)
Nr6a1	NP_034394.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		NR_DBD_GCNF_like	67..156	CDD:143543	41/91 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..165		4/83 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..214		14/70 (20%)
		Sufficient for interaction with UIMC1	187..268		30/168 (18%)
		NR_LBD_DHR4_like	271..482	CDD:132751	65/313 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910