Protein Alignment dsf and Nr2f6

DIOPT Version :10

• Sequence 1: NP_477140.1
• Gene: dsf / 33823
• FlyBaseID: FBgn0015381
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_034280.2
• Gene: Nr2f6 / 13864
• MGIID: 1352453
• Length: 390
• Species: Mus musculus
• Alignment Length: 679
• Identity: 156/679 - (22%)
• Similarity: 208/679 - (30%)
• Gaps: 361/679 - (53%)

  Fly     9 LDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACR 73
            |.:.|.||||:|||||||:::|:||..||||||.||..|||::..|    |.:|:.|||||:.||
Mouse    53 LQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRD----CQIDQHHRNQCQYCR 113

  Fly    74 LAKCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAH 138
            |.|||:..|.|:|||..|.|
Mouse   114 LKKCFRVGMRKEAVQRGRIP--------------------------------------------- 133

  Fly   139 HAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPAPP 203
                            ||:|                    .||..:||.     |:|.:....||
Mouse   134 ----------------HALP--------------------GPAACSPPG-----ATGVEPFTGPP 157

  Fly   204 AGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLI 268
            .                                                       |.|:...|.
Mouse   158 V-------------------------------------------------------SELIAQLLR 167

  Fly   269 AEAASKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGE 333
            ||                      ||.:|                             .|.|||
Mouse   168 AE----------------------PYPAA-----------------------------GRFGGG- 180

  Fly   334 EGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHA 398
                                         |::
Mouse   181 -----------------------------GAV--------------------------------- 183

  Fly   399 SLMICASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLS 463
                                                       .|:.:.|
Mouse   184 -------------------------------------------LGIDNVC--------------- 190

  Fly   464 PDKCQELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHL 528
                                               |..|||||..|.|.:....|..|...||..
Mouse   191 -----------------------------------ELAARLLFSTVEWARHAPFFPELPAADQVA 220

  Fly   529 LLQESWKELFLLNLAQWTIPLDLTPIL------ESPLIRERVLQDEATQTEMKTIQEILCRFRQI 587
            ||:.||.|||:||.||..:||...|:|      .:|:..||.:   |...:::..||.:.:..::
Mouse   221 LLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAV---AFMDQVRAFQEQVDKLGRL 282

  Fly   588 TPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSL 652
            ..|.:|.||:||||||.|:..||.|...||.||::||..|:::||.:||.|..|||||||.||:|
Mouse   283 QVDAAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPAL 347

  Fly   653 RTIRAATIEALFFKETIGNVPIARLLRDM 681
            |.:.|:.|..|||...:|..||..|:|||
Mouse   348 RAVPASLISQLFFMRLVGKTPIETLIRDM 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_477140.1	NR_DBD_TLX	5..98	CDD:143537	48/88 (55%)
		NR_LBD_Tlx_PNR_like	467..671	CDD:132748	75/209 (36%)
Nr2f6	NP_034280.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		NR_DBD_COUP_TF	57..129	CDD:143516	44/75 (59%)
		NR_LBD_COUP-TF	157..387	CDD:132746	98/485 (20%)
		Important for dimerization. /evidence=ECO:0000250	314..390		33/63 (52%)