DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and AgaP_AGAP009002

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_319750.4	Gene:	AgaP_AGAP009002 / 1279961	VectorBaseID:	AGAP009002	Length:	639	Species:	Anopheles gambiae

Alignment Length:	738	Identity:	161/738 - (21%)
Similarity:	274/738 - (37%)	Gaps:	194/738 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLA 75
            ||||||||:|||.|||:.:|:||.|||:||......|.|..    ..:|.||:.:||:|:.|||.
Mosquito    32 IPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPR----NKQCVVDRVNRNRCQYCRLQ 92

  Fly    76 KCFQSAMNKDAVQHERGPRK--PKLHPQLHHHHHHAAAAAAAAHHAAAAH----------HHHHH 128
            ||.:..|::|||:..|..:|  .|:..::..|.....|...||..::...          ||.::
Mosquito    93 KCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQNDAAPDSSVFDTQTPSSSDQLHHGYN 157

  Fly   129 HHHAHAAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVS--------ASFNYTQHISTHPPAPAAP 185
            .:.:|:....:..            .::.|....|:|:        .|.:|....:|:.|.....
Mosquito   158 GNSSHSYTYSNEV------------GYSSPYGYSTSVTPQQTMGYDISADYVDSTTTYEPRSTMI 210

  Fly   186 PSGFHLTASGAQQGPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGS 250
            .|.|.                     :||   :.:..|.....||..:...|     :|:....|
Mosquito   211 DSDFI---------------------SGH---SEYRSPRDFTCLPVLYDLFV-----DSTTFLPS 246

  Fly   251 GPGSTLPFPSHLLH-HNLIAEAASK--------LPGI-TATAVAAVVSSTSTPYASAAQTSSPSS 305
            .|.|......|..| |..::.||..        |.|: |||||.||.::|
Mosquito   247 PPASQQQQQQHPHHQHQQLSSAAQMVTSNGVGGLAGVPTATAVVAVAATT--------------- 296

  Fly   306 NNHNYSSPSPSNSIQSISSIGSRSGGGEEGLSLGSESPRVNVETETPSPSNSPPLSAGSISPAPT 370
                  .|:|..              |...:.||....:.......|.....|   ...|||:..
Mosquito   297 ------VPTPVT--------------GSGAVFLGRTQKQKCFLLALPLSHYCP---FEFISPSIA 338

  Fly   371 L--TTSSGSPQHRQM---------SRHSLSEATTPPSHASLMICASNNNNNN------NNNNNNG 418
            |  ||::....||.:         .|.:::...|..|..|.::.::..:.|:      ...:.|.
Mosquito   339 LDGTTAARLRSHRVVPGRMVLRTPHRLTITITRTRRSLCSFLLLSAEGDINDVLIKTLAEAHANT 403

  Fly   419 EHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFP 483
            .||                                    ||::      .|:.:.....:.||:.
Mosquito   404 NHK------------------------------------LEIV------HEMFRKPQDVSRLLYY 426

  Fly   484 QQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIP 548
            :.:....|  |....|....::...:.:.|.:..|..||::||.|||:....||.::.:::.
Mosquito   427 KNMTQEEL--WLDCAEKLTAMIQQIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRL--- 486

  Fly   549 LDLTPILESPLIRERVLQDEATQT----EMKTIQEILCRFRQITP---DGSEVGCMKAIALFAPE 606
            :||:  ..|.|..:.:|..||..|    |||.:..|....:.||.   ..:|:...:::.|..||
Mosquito   487 MDLS--TNSVLYGDIMLPQEAFYTSDSFEMKLVACIFETAKSITELKLTETELALYQSLVLLWPE 549

  Fly   607 TAGLCDVQPVEMLQDQA-----QCILSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATIEAL-FF 665
            ..|:.....::.|.:.:     |.|.::|..|:  ...|....||..:|:.|.:....:||| .|
Mosquito   550 RNGVRGNTEIQRLFNMSMSAIRQEIEANHAPLK--GDVTVLDTLLNKIPTFRELSIMHMEALQKF 612

  Fly   666 KETIGNVPIARLLRDMYTMEPAQ 688
            |:.........|.:::::::..|
Mosquito   613 KQDHPQYVFPALYKELFSIDSQQ 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	41/88 (47%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	51/216 (24%)
AgaP_AGAP009002	XP_319750.4	NR_DBD_ROR	27..121	CDD:143526	42/92 (46%)
AgaP_AGAP009002	XP_319750.4	NR_LBD_ROR_like	387..629	CDD:132737	58/292 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910