DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsf and AgaP_AGAP009575

DIOPT Version :9

Sequence 1:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_318587.4	Gene:	AgaP_AGAP009575 / 1278936	VectorBaseID:	AGAP009575	Length:	761	Species:	Anopheles gambiae

Alignment Length:	817	Identity:	332/817 - (40%)
Similarity:	408/817 - (49%)	Gaps:	220/817 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GDRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQC 69
            |||||||||||||||||||||||||||||||||||||||||:|||||.|:|||||||||||||||
Mosquito     1 GDRLLDIPCKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRVYTCKAAGELKGRCPVDKTHRNQC 65

  Fly    70 RACRLAKCFQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHA 134
            |||||:||||||||||.....|                                       ||..
Mosquito    66 RACRLSKCFQSAMNKDGKYTAR---------------------------------------HACQ 91

  Fly   135 AAAHHAAVAAAAASGLHH--------HHHAM-PVSLVTNVSASF---------NYTQHISTH--- 178
            .......|..:...|:..        |..|| .:.::..:.:.|         :|...|:..
Mosquito    92 EVLPSVKVLLSVRPGMKRGSFFLSPFHFAAMGRLLVIERIESKFIAIKRYVEMDYAHFIANASNT 156

  Fly   179 --PPAPA---APP-------------SGFH-----LTASGAQQGPAPPAGHLHHGGAGHQHATAF 220
              .|:|.   :||             .||.     |:.....|..|.| ||..|.......:..:
Mosquito   157 RLSPSPCKMLSPPILSLFLLRDLQKLGGFFFLVHLLSLLPLDQLSAFP-GHFTHCHVLSHVSKCY 220

  Fly   221 --HHP------GHG----------HALPAP--------HGGVVSN------PGGNSSAISGSGPG 253
              |||      |.|          |::|.|        .|...||      |....:....|..|
Mosquito   221 NTHHPVTRRCTGLGLAKVFWEVAKHSIPKPLFTFPVPNRGSCSSNRPTRAWPAETETPAPASERG 285

  Fly   254 STLPFPS----------HLLHHNLIAEAA----SKLPGITATAVAAVVSSTSTPYASAAQTSSPS 304
            ...|.||          ...:..|.|.||    .:.....|.:.||::.:..:||.|........
Mosquito   286 PPGPSPSGRPVREQCIVRTRNVPLPARAAPFRNGRFERAAAPSPAALLCTARSPYRSLVTAVKLE 350

  Fly   305 SNNHNYSSPSPSNSIQSISSIGSRSGGGEEGLSLGSE--SP-RVNVETETPSPSNSPPLSAG--- 363
            .|...:|..:|:.|       ...:|||...:..|:.  || ::.......|.......:||
Mosquito   351 QNKFEFSLGTPNGS-------NGGNGGGAGQMPGGTNLLSPIKIEHSKMMTSVGGFEFSAAGHVQ 408

  Fly   364 ----SISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHASLMICASNNNNNNNNNNNNGEHKQSS 424
                |:.|.|...|.|.|    .:|..|.||:.|.| |:::                     ..|
Mosquito   409 HMYKSLEPMPPSPTDSKS----SISVDSPSESLTSP-HSTV---------------------DGS 447

  Fly   425 YTSGSPTPTTPTP---PPPRSGVGSTCNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQL 486
            .:..||||...|.   |.|           .|.:|.|::|:|.|||||.||||:.::::.||...
Mosquito   448 SSVLSPTPINATSLSLPSP-----------LSQNGVLDILMSTDKCQEFIQYQMHNSSIAFPGFT 501

  Fly   487 LDS---------------------------------RLLSWEMLQETTARLLFMAVRWVKCLMPF 518
            ..|                                 ||.:||:|||||||||||:||||:||:||
Mosquito   502 PVSSASITPHPPPPPPPLVPHPIALTALPPEGPTIIRLPTWEILQETTARLLFMSVRWVRCLIPF 566

  Fly   519 QTLSKNDQHLLLQESWKELFLLNLAQWTIPLDLTPILESPLIRERVLQDEATQTEMKTIQEILCR 583
            |||||||||||||||||||||||.|||::|.||:.:|:||.:|:|:..|.|||.||||:||||||
Mosquito   567 QTLSKNDQHLLLQESWKELFLLNFAQWSVPWDLSGLLDSPQVRDRLPPDAATQLEMKTMQEILCR 631

  Fly   584 FRQITPDGSEVGCMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLL 648
            ||||:||.||:|||||:.||:|||:.||||||||||||||||:||:|||:|||||.|||||||||
Mosquito   632 FRQISPDLSELGCMKAVILFSPETSELCDVQPVEMLQDQAQCVLSEHVRVRYPRQPTRFGRLLLL 696

  Fly   649 LPSLRTIRAATIEALFFKETIGNVPIARLLRDMYTME 685
            ||.|||||:.|||.||||||||.|||:|||.|||.||
Mosquito   697 LPLLRTIRSTTIETLFFKETIGTVPISRLLIDMYQME 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	78/92 (85%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	151/236 (64%)
AgaP_AGAP009575	XP_318587.4	NR_DBD_like	1..81	CDD:295381	75/79 (95%)
AgaP_AGAP009575	XP_318587.4	NR_LBD	530..718	CDD:299703	140/187 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	282	1.000	Domainoid score	I4086
eggNOG	1	0.900	-	-		E33208_3BC6Q
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I2920
OMA	1	1.010	-	-		QHG27537
OrthoDB	1	1.010	-	-		D34630at7147
OrthoFinder	1	1.000	-	-		FOG0016853
OrthoInspector	1	1.000	-	-		oto109346
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15434
TreeFam	1	0.960	-	-
	12	11.940