DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bchs and LRBA

DIOPT Version :9

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:XP_005263429.1 Gene:LRBA / 987 HGNCID:1742 Length:2868 Species:Homo sapiens


Alignment Length:3395 Identity:701/3395 - (20%)
Similarity:1186/3395 - (34%) Gaps:1108/3395 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 KVFSSCPSNDMSEKFWDVVAFCQQVSRLMVSEIRKRASNQSTEAASIA-IVKFLEV-ETTEETSS 159
            |.|..|...|...:.|.:|......:|...||:|...:.   |.||.. |..|:.. :|.::...
Human   284 KGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNG---ELASYGEITWFVNTSDTFDKCFL 345

  Fly   160 GWMLLATLNLLANGDVSLIQVMTAAAVPSTLVKCLYLFF------------DLPIVEDDEPSADG 212
            |....|..|.:..|.::.:.:.:.|...:.:.....|..            ||.:.|..:.....
Human   346 GSSETADANRVFCGQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYD 410

  Fly   213 GAVSE---FNAHERRTLLQKVFVQLLVKLCSYPYPAEELARMDDLTLLFSAITSPCPIHNIVWRK 274
            |.:|.   |..:.|.|..|         ||....|       .|...:|  :.||   |.::.:.
Human   411 GKLSSAIAFTYNPRATDAQ---------LCLESSP-------KDNPSIF--VHSP---HALMLQD 454

  Fly   275 NAAEILTTISRNGLTDAVVSYIHSKGCMALCVDNMQRLTFGNPL-EIVEMFV--TVFCFLKDSSQ 336
            ..|.         ||.::.|.:||.|.:.:......:|.:...| :.:::.:  |:..|:.:..:
Human   455 VKAV---------LTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLK 510

  Fly   337 VSQILMDDFRASQGYVFLSDFLLKFDNNRSQSLEIQAAIRNLVL--------------MISSLCM 387
            .|..:.:...|.:|::     ::.:...:|....:..|:..|.|              ::..|| 
Human   511 NSIAMQEQMLACKGFL-----VIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQLC- 569

  Fly   388 CGFYELRPPASQFNTAFKLQNFQLPQATSRETCVRNVYAFQVLQNVFLKSTTPALCCTILDAISR 452
              .:.|..||...:|..|:|.......::......|:|      |...:..|..|   |:..:..
Human   570 --DHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIY------NTIRRVGTVLL---IMHTLKY 623

  Fly   453 VYHSENANYFILESEQTLSSFAERIHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKHN 517
            .|.:.|        .|..|....: .:..|:..:|  ::|....|.|.|:  |:|:.....:|.:
Human   624 YYWAVN--------PQDRSGITPK-GLDGPRPNQK--EMLSLRAFLLMFI--KQLVMKDSGVKED 675

  Fly   518 QSTSCSILCLKTLLNILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKITKGDESVVVELENES 582
            :        |:.:||.|                                           |....
Human   676 E--------LQAILNYL-------------------------------------------LTMHE 689

  Fly   583 EEELFDTLGKHVLEALTMLLGGGASNNAQLFREYGGAKCVHELV--KFKHCRPQALGIV------ 639
            ::.|.|     ||:.|..|:....::....|.:..|.:.:::|:  |.:..|.|||..:      
Human   690 DDNLMD-----VLQLLVALMSEHPNSMIPAFDQRNGLRVIYKLLASKSEGIRVQALKAMGYFLKH 749

  Fly   640 ------RELILSAGGDDDMLHILSLMHSVSPLQVE-FKIQILNMLLGCLKDSHRTRTVFRKVGGF 697
                  .|::|..|       :.||:.....||.. ..:...|:|...|.:...|:.:.::    
Human   750 LAPKRKAEVMLGHG-------LFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQ---- 803

  Fly   698 VYVTSVFVSLDGSMALPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLR 762
                  ....|.|:.:..|.|            .:.:||.:|..|...:  ..|:..:.|.|.::
Human   804 ------HPDPDSSVKIQNPQI------------LKVIATLLRNSPQCPE--SMEVRRAFLSDMIK 848

  Fly   763 LLGCFGGSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSF----SEDVPYPLSYVCIVFRLL-- 821
            |            :..:.|.::|||:.  .::...:||:.:    :.|.......|..:||:|  
Human   849 L------------FNNSRENRRSLLQC--SVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLY 899

  Fly   822 ---------YSIALD---------NFE--APNLSGI-----------ITLFSDPPTTLRSPS--- 852
                     :.:.:|         .||  ..||:.|           |.|.|.  |::::.|   
Human   900 HAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSS--TSVQAASGIR 962

  Fly   853 KELAPPVHPSQLNLTQPSPE-PRIVHPGVVLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVR 916
            :::...|...|.: |:.||. |.....|.....::...::|      .|..:::..:......::
Human   963 RDINVSVGSQQPD-TKDSPVCPHFTTNGNENSSIEKTSSLE------SASNIELQTTNTSYEEMK 1020

  Fly   917 SERNQQIMCDHG-LAEKLLKLTRRALAEESHPLHVPMQYILERLAAQALQPTELRQFLRLGEPLS 980
            :|:..|.:.|.| |.|.|...||.|     ..|.|... |:|.:|..:      ..|:..|:.  
Human  1021 AEQENQELPDEGTLEETLTNETRNA-----DDLEVSSD-IIEAVAISS------NSFITTGKD-- 1071

  Fly   981 CADIDLQQPYKLGGPVPLTRIKTLVSMTTPRDFRAHGSSTLPPFVE------------LDMSAEG 1033
                            .:|..:...|:::|.:   ..:|.:|.|::            :::..||
Human  1072 ----------------SMTVSEVTASISSPSE---EDASEMPEFLDKSIVEEEEDDDYVELKVEG 1117

  Fly  1034 FGC--LYLP------SLAPQATATAGGTIDANSIGGIGAGDR-IFPPQTGLTYSTWFCVEKFSDP 1089
            ...  ..||      ||:| |.:.||..:|.     .|..|: ||.....:|       ||.:|.
Human  1118 SPTEEANLPTELQDNSLSP-AASEAGEKLDM-----FGNDDKLIFQEGKPVT-------EKQTDT 1169

  Fly  1090 KTD---PHCVRLLTLVRTIHNPREENLACLSI------LLSARDKAIVVSTQETLVTPRKSIGDW 1145
            :|.   ...::.:|...:.....|..::.:::      :|....||..::.:..|:  ....|..
Human  1170 ETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLI--NDCHGSV 1232

  Fly  1146 EPEGSDDGIARIWCPDLLHEGQWHNLVVVLNRAVLKNSSLFLYLDGVPMHTQKLHYIAQHPAAGN 1210
            ....|:..||::   |:      .|:.....|..||.|.   .::....|...|....||...|.
Human  1233 SEASSEQKIAKL---DV------SNVATDTERLELKASP---NVEAPQPHRHVLEISRQHEQPGQ 1285

  Fly  1211 ASLTSPTQIFGYIGTPPIWRRYSR--------LCWKQGVCHLIEDVLTQQTVQTIYQLGPHYMGS 1267
            .  .:|..:.|.       ||.||        ..|.|....|:.|:|.  :::|..|:.      
Human  1286 G--IAPDAVNGQ-------RRDSRSTVFRIPEFNWSQMHQRLLTDLLF--SIETDIQMW------ 1333

  Fly  1268 LQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNSHENATP 1332
                                        ::.|..|::..                 :||.:|   
Human  1334 ----------------------------RSHSTKTVMDF-----------------VNSSDN--- 1350

  Fly  1333 IKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDT-VGGCNVLLGIIAMAQDVESLYA 1396
            :..:||:.                         |.:|.::|. |..|..:|.:::.|        
Human  1351 VIFVHNTI-------------------------HLISQVMDNMVMACGGILPLLSAA-------- 1382

  Fly  1397 GVKALTCVVRSNRAAQAEMDRKRCYQTLGM-----FFKKKKHLLNSHILHLTFGLVGTVNSGQDM 1456
                        .:|..|::.....|.|.:     |.::...|::..|...:.|.. .:.:.:.|
Human  1383 ------------TSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFT-EIEAEKSM 1434

  Fly  1457 SAIPNVTAFQDLLCDLEIWHNAPNGLLRSLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHIIT 1521
            |:                     .|:||..|..:..:.|.:..:.|.              |  :
Human  1435 SS---------------------GGILRQCLRLVCAVAVRNCLECQQ--------------H--S 1462

  Fly  1522 QIQDHSTREILFSLLETLLGGQPRHTDLLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAEDQDG 1586
            |::....:.:           :|.|: |:..|:..|.......:||:          :|..|.| 
Human  1463 QLKTRGDKAL-----------KPMHS-LIPLGKSAAKSPVDIVTGGI----------SPVRDLD- 1504

  Fly  1587 GVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTLGMDWLLLFMQPHVHFTTVIIAVRILV 1651
                         .||..:   ..|.:..|:..||..:....:|.|.:   |:|.:|::      
Human  1505 -------------RLLQDM---DINRLRAVVFRDIEDSKQAQFLALAV---VYFISVLM------ 1544

  Fly  1652 VICANESFLVRFRD------ATHNGGYLRFTEMVSQRKMLGLGAQQLNQRPTNGTGTVIVATPQN 1710
                    :.::||      ..|:..   .||..|:.:.:.|.........|..|.:|..:...:
Human  1545 --------VSKYRDILEPQNERHSQS---CTETGSENENVSLSEITPAAFSTLTTASVEESESTS 1598

  Fly  1711 TIQHLPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHTKFDLD 1775
            :.:...:.|..|                               ||..:|..|:|  |.||     
Human  1599 SARRRDSGIGEE-------------------------------TATGLGSHVEV--TPHT----- 1625

  Fly  1776 RVWSFLWGAPVSANTQLPKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQNL 1840
                    ||       |.::..|:.:..:|:.:         :..::..|||.......|....
Human  1626 --------AP-------PGVSAGPDAISEVLSTL---------SLEVNKSPETKNDRGNDLDTKA 1666

  Fly  1841 TDFAPV---MMTGDVVTSLVAVLFPLASRPADSEPNSGASTPTDDTGSSFALPPPETLHGAPQPK 1902
            |....|   :...|::.|||.:                   |.|......||.||..| ||....
Human  1667 TPSVSVSKNVNVKDILRSLVNI-------------------PADGVTVDPALLPPACL-GALGDL 1711

  Fly  1903 LTAHPVCNCIIDFLRVIVVDSLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQI------II 1961
            ....||  ....|.|.::|                    ||.:||..|  ..:.|.|      ::
Human  1712 SVEQPV--QFRSFDRSVIV--------------------AAKKSAVSP--STFNTSIPTNAVSVV 1752

  Fly  1962 ALMDHLLAADVLVGE-------QAALPLVPLLQSQMQYIAPNVFYLTARIVDKLWQGCLARNPHD 2019
            :.:|...|:| :.||       .|.||.||.:.|                        ::::|  
Human  1753 SSVDSAQASD-MGGESPGSRSSNAKLPSVPTVDS------------------------VSQDP-- 1790

  Fly  2020 IFDFVIKLIVQAKRRSSSLSL-EHLHHSLNRSILFL----------LSRPTDDSRADQMSVLEAL 2073
                           .|::|: |.|.|:|.::...|          |||                
Human  1791 ---------------VSNMSITERLEHALEKAAPLLREIFVDFAPFLSR---------------- 1824

  Fly  2074 HKIIQHRLLIFGAGNHELEFIGCLTYCLLQLTADMKIILEPATSRNTTWHVNPQTETAEPKDEDL 2138
                    .:.|:...||...|....|:...::.:::::...:..   |.               
Human  1825 --------TLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQE---WQ--------------- 1863

  Fly  2139 NQLQGRNLIVGAAFRVWEELYVCKKPAIEEVFKVSLTSPPPNSKAPDLQTTREQVMELASKLWFN 2203
            |.:| :|  .|.||             ||.|.:..|.|          ||.::.::.:|::..|.
Human  1864 NSIQ-KN--AGLAF-------------IELVNEGRLLS----------QTMKDHLVRVANEAEFI 1902

  Fly  2204 YVEAERKATYRAPWELHTQIQSKIQKVTGGLSRLTSRTKTKKEELVRTRSTLTREAAYESTGIHV 2268
            ......:..:|     |.:.:|           |.::....|.|..:....|.|.|.|.......
Human  1903 LSRQRAEDIHR-----HAEFES-----------LCAQYSADKREDEKMCDHLIRAAKYRDHVTAT 1951

  Fly  2269 QLIKDLLDLRAKQYQQMLQHTQRYVYQDWVQSEMELTRERGLWGPTG-SCSLDKWILDTTEGPHR 2332
            |||:.::::                          ||.:.|.||.:. |..|:.|.||..|...|
Human  1952 QLIQKIINI--------------------------LTDKHGAWGNSAVSRPLEFWRLDYWEDDLR 1990

  Fly  2333 MRKKTMRNDVFYLHYPYRPELELADNRQ----LKYKVASSLDSKTYALHGPQQPRILAEAGEHHA 2393
            .|::.:||.:...|    ||..|....:    .|.:..|....:.....|.|..|..|...::..
Human  1991 RRRRFVRNPLGSTH----PEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSE 2051

  Fly  2394 MQ-----QQSSLEAVQSHRLETSS---STSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEE 2450
            .:     ...:|.:|....||..:   |.|||..:|.|.:|..|:.     ||..:....:.:||
Human  2052 NEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTL-----SVTSSELYFEVDEE 2111

  Fly  2451 DTSMTSDNETFLRLLEEQEKISFMFRCARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDID 2515
            |.:....:...|               |..:||.                               
Human  2112 DPNFKKIDPKIL---------------AYTEGLH------------------------------- 2130

  Fly  2516 TLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNY 2580
                                            .|:.:.|||.:..||||||..|||:|..:....
Human  2131 --------------------------------GKWLFTEIRSIFSRRYLLQNTALEIFMANRVAV 2163

  Fly  2581 LLSFP-----RKVRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRW 2640
            :.:||     :||.|.:.:..:..:..|....:.|:|..::             |...:::||||
Human  2164 MFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQ-------------LFKASNMTQRW 2215

  Fly  2641 VRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEER 2705
            ...|||||:|||.|||:||||||||.|||||||::.:|:|||||||.|..|||.|:|:||...:|
Human  2216 QHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKR 2280

  Fly  2706 LEQFQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSI 2770
            ...|.:|::.|:|  .:.|.:|||||||:|..|.::|:|:|||:..||.||||.||.|||.|.||
Human  2281 AAFFAERYESWED--DQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSI 2343

  Fly  2771 KEAWLSASKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQNGETLNHVILPPWAKHDPREFIRL 2835
            ..||.: |:.:.:|:|||||||:||||...||||::||...:|..::.|.|||||| ...||:.:
Human  2344 SRAWRN-SQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAK-TSEEFVHI 2406

  Fly  2836 HRSALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFI 2900
            :|.|||.::||..||.|||||||.|||||.||.|:|||::|.|||.|::.:|.||:.:.|....|
Human  2407 NRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQI 2471

  Fly  2901 NNFGQIPKQLFKKAHPAKKMGGSRHSALIDPTSLIQGNSTVLQTDR--------LFF-------H 2950
            .:|||.|.||..:.||.:   ||.....:    |:|  |.::.||:        |.|       |
Human  2472 RSFGQTPSQLLIEPHPPR---GSAMQVYL----LLQ--SPLMFTDKAQQDVIMVLKFPSNSPVTH 2527

  Fly  2951 NLDNLKPSLQPIKELKGPVGQILQPDK------TVFAVEQNKVMMPPSYTKYIAWGFADHSLRIG 3009
            ...|.:|.|.....:.....::...:|      ...||:.....:|......||.....|..:| 
Human  2528 VAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQI- 2591

  Fly  3010 LYDTDRASFVSEASAQNSGEILTCACPNAKMIVTAGTSSVVTIWKFDANRKSLAVKHSLHGHTDA 3074
               ||    :.:.|.|...:.......|..::|.........::..|..|....|    .||.|.
Human  2592 ---TD----LLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVV----FGHWDV 2645

  Fly  3075 VTCLAASAAY----NVIVSGSRDGTAIVWDMTRFTFVRQLRGHAGVVAAVSINE----------L 3125
            |||||.|.:|    ..|:|||||.|.::|...            |..:.:..|.          |
Human  2646 VTCLARSESYIGGNCYILSGSRDATLLLWYWN------------GKCSGIGDNPGSETAAPRAIL 2698

  Fly  3126 TGD--IATCSATWLH--------------VWSINGDALAMVNTCVGSADRMQQIL--------CV 3166
            ||.  ..||:|....              :.|:|||   ::.|..|..:.::..|        ||
Human  2699 TGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGD---LLRTLEGPENCLKPKLIQASREGHCV 2760

  Fly  3167 AFSQIREWDQQNVIITGSTDGVVRMWSLEHTQVPIDRKLKRGTEVSSQDKPDTVSLEGK---DNK 3228
            .|.      :..:..|.|.:|                ||:...|.....:...:|.:|:   ...
Human  2761 IFY------ENGLFCTFSVNG----------------KLQATMETDDNIRAIQLSRDGQYLLTGG 2803

  Fly  3229 DDKMSLMKQIKSLSQ 3243
            |..:.:::|:..|.|
Human  2804 DRGVVVVRQVSDLKQ 2818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 22/135 (16%)
Beach 2638..2918 CDD:280327 154/279 (55%)
WD40 <2991..3252 CDD:225201 61/294 (21%)
WD40 2995..>3194 CDD:295369 52/236 (22%)
WD40 repeat 3031..3070 CDD:293791 5/38 (13%)
WD40 repeat 3075..3111 CDD:293791 15/39 (38%)
FYVE_WDFY3 3418..3482 CDD:277259
LRBAXP_005263429.1 LamG 229..376 CDD:304605 21/94 (22%)
DUF4704 446..717 CDD:292415 60/368 (16%)
DUF1088 1880..2058 CDD:284000 44/233 (19%)
PH_BEACH 2084..2181 CDD:291510 32/179 (18%)
Beach 2213..2489 CDD:280327 154/279 (55%)
WD40 <2595..2862 CDD:225201 55/265 (21%)
WD40 repeat 2605..2641 CDD:293791 5/39 (13%)
WD40 <2610..2850 CDD:295369 53/250 (21%)
WD40 repeat 2647..2700 CDD:293791 17/64 (27%)
WD40 repeat 2705..2740 CDD:293791 8/37 (22%)
WD40 repeat 2745..2774 CDD:293791 6/34 (18%)
WD40 repeat 2787..2821 CDD:293791 6/32 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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