DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bchs and Lrba

DIOPT Version :9

Sequence 1:	NP_608968.2	Gene:	bchs / 33819	FlyBaseID:	FBgn0043362	Length:	3489	Species:	Drosophila melanogaster
Sequence 2:	XP_006502410.1	Gene:	Lrba / 80877	MGIID:	1933162	Length:	2871	Species:	Mus musculus

Alignment Length:	3120	Identity:	653/3120 - (20%)
Similarity:	1046/3120 - (33%)	Gaps:	1147/3120 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 VLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKLTRRA---LA 942
            ::||::||...:.      ..|.:|: |.....|.:|.||.|:..:.||.||:|....:.   :|
Mouse    92 IMCMVELLEKCDV------TCQAEVW-SMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDSMIA 149

  Fly   943 EESHPLHVPMQYILERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGG-----PVPLTRIK 1002
            :    |.|.|   |..||:..|...||:.|..                ||.|     |....::.
Mouse   150 D----LLVDM---LGVLASYNLTVRELKLFFS----------------KLQGDKGQWPPHAGKLL 191

  Fly  1003 TLVSMTTPRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDR 1067
            :::.         |......|....:...:....:.||.:|.
Mouse   192 SVLK---------HMPQKYGPDAFFNFPGKSAAAIALPPIAR----------------------- 224

  Fly  1068 IFPPQTGLTYSTWFCVEKFSDPKTDP-----HCVRLLTLVRTIHNPREENL--------ACLSIL 1119
             :|.|.|.|:.||..::..::...|.     :|.|           ..:.|        .||
Mouse   225 -WPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFR-----------TSKGLGYSAHFVGGCL--- 274

  Fly  1120 LSARDKAIVVSTQETLVTPRKSIG---------DWEPEGSDDGIARIWCPDLLHEGQWH--NLVV 1173
                           ::|..||.|         |::|:                  :|:  .:|.
Mouse   275 ---------------IITSIKSKGKGFQHCVKFDFKPQ------------------KWYMVTIVH 306

  Fly  1174 VLNRAVLKNSSLFLYLDGVPMHTQKLHYIAQHPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWK 1238
            :.||  .|||.|..|::|......::.:...         ||.|....::|:..........|.:
Mouse   307 IYNR--WKNSELRCYVNGELASYGEITWFVN---------TSDTFDKCFLGSSETADANRVFCGQ 360

  Fly  1239 QGVCHLIEDVLTQQTVQTIYQLGPHYMGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTL 1303
            ....:|..|.|....:..|||||..|.|:.:.     ::||...|....::|| .:.|..|.:..
Mouse   361 MTAVYLFSDALNAAQIFAIYQLGLGYKGTFKF-----KAESDLFLAEHHKLLL-YDGKLSSAIAF 419

  Fly  1304 VKIRKVYSRADNKSIAKQLNMNSHENATPIKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPV 1368
            .        .:.::...||.:.|.....|...:|:....:             ...|:....|.:
Mouse   420 T--------YNPRATDAQLCLESSPKDNPSIFVHSPHALM-------------LQDVKAVLTHSI 463

  Fly  1369 SAMIDTVGGCNVLLGIIAMAQDVESLYAGVKALTC---------VVRSNRAAQAEMDRKRCYQTL 1424
            .:.:.::||..||..:.|.....:.|...|....|         :::::.|.|.:|...:.:..:
Mouse   464 QSAMHSIGGVQVLFPLFAQLDYKQYLSDEVDLTICTTLLAFIMELLKNSIAMQEQMLACKGFLVI 528

  Fly  1425 GMFFKK--KKHL---------------------------LNSHIL-------------------H 1441
            |...:|  |.|:                           |..|||                   :
Mouse   529 GYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQLCDHILLNPAVWIHTPAKVQLMLYTY 593

  Fly  1442 LTFGLVGTVNSGQDMSAIPNVTAFQDLLCDLEIWHN----------------APNGL-------- 1482
            |:...:||||....:..:..|         |.|.|.                .|.||
Mouse   594 LSTEFIGTVNIYNTIRRVGTV---------LLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQK 649

  Fly  1483 ----LRS-LLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHIITQIQDHSTREILFSLLETLLGG 1542
                ||: ||..:.:||::.|..|::     :||.:  |.:::|..:|.:..::| .||..|:..
Mouse   650 EILSLRAFLLMFIKQLVMKDSGVKED-----ELQAI--LNYLLTMHEDDNLMDVL-QLLVALMAE 706

  Fly  1543 QPRHTDLLLF----GQYVAAKLPHAHSGGLERAVLLPSM---------KNPAEDQDGG-----VA 1589
            .| ::.:..|    |..|..||..:.|.|: |...|.::         |..||...|.     :|
Mouse   707 HP-NSMIPAFDQRNGLRVIYKLLASKSEGI-RVQALKALGYFLKHLAPKRKAEVMLGHGLFSLLA 769

  Fly  1590 QNIYLRNRCLSL-LHGLLF-----------------TPRNTV----------------NYVIC-- 1618
            :.:.|:...::: ::.:||                 .|.:||                |...|
Mouse   770 ERLMLQTNLITMTMYNVLFEILIEQICTQVIHKQHPDPDSTVKIQNPQILKVIATLLRNSPQCPE 834

  Fly  1619 ---------DDISK---------------TLGMDWL--LLFMQP----HVHFTTVIIAV-RILV- 1651
                     .|:.|               ::..:|:  |.:..|    ....|.::.|: |||:
Mouse   835 SMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLY 899

  Fly  1652 ------------------VICANESFLVR-------FRDATHNG----------------GYLR- 1674
                              :..:..:|.:.       ||:....|                |..|
Mouse   900 HAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREEQRKGDEETGPCSSSLVPEGTGATRG 964

  Fly  1675 --------------------FT--------------------------EMVSQRKMLGLGAQQL- 1692
                                ||                          :|.|..|.:....|:|
Mouse   965 VDVSVGSQHEDRKDSPISPHFTRNSDENSSIGRASSIDSASNTELQTHDMSSDEKKVERENQELL 1029

  Fly  1693 -----NQRPTNG---------------------------TGTV-----IVATPQN---------- 1710
                 .:..|||                           |.|:     .:::|..
Mouse  1030 DQATVEETATNGAKDDLETSSDAAEPVTINSNSLEPGKDTVTISEVSASISSPSEEDAAEMPELL 1094

  Fly  1711 ----------------TIQHLPTQIAG---EVRAAALNIPGFQLLEW--LMNHHLDV-------- 1746
                            .::..||:.||   |::...|::...:..|.  :..|..:|
Mouse  1095 EKSGVEEEEDDDYVELKVEGSPTEEAGLPTELQGEGLSVAASEGREEPDMCGHGCEVQVEAPITK 1159

  Fly  1747 ----PELY--------------FLITALIMGQP-VKVLATEHTKFDLDRVWSFLWG--------- 1783
                ||..              .|.|:..:..| ..|.:..|...|.....:.|.|
Mouse  1160 IHNDPETTDSEDSRFPTVATAGSLATSSEVPVPQATVQSDSHEMLDGGMKATNLAGETESVSDCA 1224

  Fly  1784 -----APVSANTQLPKLNIC---------------------PEGVCVLLAMVRGIVHGGE----- 1817
                 ||.::..::.||::.                     |:.            ||.|
Mouse  1225 DNVSEAPATSEQKITKLDVSSVASDTERFELKASTSTEAPQPQR------------HGLEISRQQ 1277

  Fly  1818 ------CAP---------------------WLHSHPETIIQLLFSL-----------YQNLTDFA 1844
                  .||                     |...|...:..||||:           .:.:.||.
Mouse  1278 EQTAQGTAPDAVDQQRRDSRSTMFRIPEFKWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFV 1342

  Fly  1845 -----------PVMMTGDVVTSLVAV---LFPLASRPADS-------EPNSGASTPTDDT----- 1883
                       .:.:...|:.::|..   :.||.|....:       ||..|.|.....|
Mouse  1343 NSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRL 1407

  Fly  1884 ---------GSSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVDSL------GLNMQG--- 1930
                     .||......|    |.:...:...:..|:.....|.|.:.|      .|..:|
Mouse  1408 ISLVDVLIFASSLGFTEIE----AEKNMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKARGDTA 1468

  Fly  1931 KPTPVIDLVLDAAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVPLLQS-QMQYIA 1994
            |.:..|..::.....:|:.|:.:.......:..:|.|| .|:.:....|:....:..| |.|::|
Mouse  1469 KSSKTIHSLIPMGKSAAKSPVDIVTGGISPVRDLDRLL-QDMDINRLRAVVFRDIEDSKQAQFLA 1532

  Fly  1995 -PNVFYLTARIVDKLWQGCLARNPHDIFDFVIKLIVQAKRRSSSLSLEHLHHSLNRSILFLLSRP 2058
             ..|::::..:|.|.         .||.:      .|.:|.|.||. |....:.|.|:....:.|
Mouse  1533 LAVVYFISVLMVSKY---------RDILE------PQDERHSQSLK-ETSSDNGNASLPDAENTP 1581

  Fly  2059 TDDSRADQMSVLEALHKIIQHRLLIFGAGNHELEFIG---------------------CLTYCLL 2102
            .:.|.....||.|:|......|....|.|......:|                     ....|.|
Mouse  1582 AEFSSLTLSSVEESLEGTSCTRRRDSGLGEETASGLGSGLSVASPAAPLGVSAGPDAISEVLCTL 1646

  Fly  2103 QLTA--------------DMKIILEPATSRNTTWH------VNPQTE--TAEP---KDEDLNQLQ 2142
            .|..              |.|:......|:|....      ||...:  |.:|   ....|..|.
Mouse  1647 SLEVNKSQETRIDGGNELDRKVTPSVPVSKNVNVKDILRSLVNMPADGVTVDPALLPPACLGALG 1711

  Fly  2143 GRNLIVGAAFRVWEE--LYVCKKPAI-----------EEVFKVSLTSP--------------PPN 2180
            ..::.....||.::.  :...||.::           ..|..||...|              .||
Mouse  1712 DLSVDPPMQFRSFDRSVIIATKKSSVLPSALTTSAPSSAVSVVSSVDPTHASDTGGESPGSRSPN 1776

  Fly  2181 SKAPD--------------------LQTTREQVMELASKLWFNYVEAERKATYRAPWELHTQI-- 2223
            :|.|.                    |:...|:...|..:::.::          ||:...|.:
Mouse  1777 AKLPSVAAVGSVPQDPAAHMSITERLEHALEKAAPLLREIFVDF----------APFLSRTLLGS 1831

  Fly  2224 ---------------------------------QSKIQKVTGGLS--------RLTSRTKTKKEE 2247
                                             |:.||| ..||:        ||.|  :|.|:.
Mouse  1832 HGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQK-NAGLAFIELVNEGRLLS--QTMKDH 1893

  Fly  2248 LVRTRS------------TLTREAAYESTGIHVQLIKDLLDLRAKQYQQMLQHTQRYV-YQDWVQ 2299
            |||..:            .:.|.|.:||  :..|...|     .::.::|..|..|.. |:|.|.
Mouse  1894 LVRVANEAEFILSRQRAEDIHRHAEFES--LCAQYSAD-----KREEEKMCDHLIRAAKYRDHVT 1951

  Fly  2300 SEM-------ELTRERGLWGPTG-SCSLDKWILDTTEGPHRMRKKTMRNDVFYLHYPYRPELELA 2356
            :..       .||.:.|.||.:. |...:.|.||..|...|.|::.:||.:...|    ||..|.
Mouse  1952 ATQLIQKIINLLTDKHGAWGSSAVSRPREFWRLDYWEDDLRRRRRFVRNPLGSTH----PEATLK 2012

  Fly  2357 D--------NRQLKYKVASSLDSKTYALHGPQQPRILA---EAGEHHAMQQ--QSSLEAVQSHRL 2408
            .        |..|  .:|::.|....| .|.|..:..|   :..|:.|:.:  ..:|.:|....|
Mouse  2013 TAVEHGQCLNHSL--PIAAAADEDILA-KGKQSIKSQALGNQNSENEALLEGDDDTLSSVDEKDL 2074

  Fly  2409 ETSS---STSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEK 2470
            |..:   |.|||..:|.|.:|..|:.     ||..:....:.:|||.:....:...|
Mouse  2075 ENLAGPVSLSTPAQLVAPSVVVKGTL-----SVTSSELYFEVDEEDPNFKKIDPKIL-------- 2126

  Fly  2471 ISFMFRCARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSST 2535
                   |..:||.
Mouse  2127 -------AYTEGLH--------------------------------------------------- 2133

  Fly  2536 TSRAVSHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFP-----RKVRNKVNQR 2595
                        .|:.:.|||.:..||||||..|||:|..:....:.:||     :||.|.:.:.
Mouse  2134 ------------GKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRV 2186

  Fly  2596 FLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAGR 2660
            .:..:..|....:.|:|..::             |...:::||||...|||||:|||.|||:|||
Mouse  2187 GVGTSFGLPQTRRISLATPRQ-------------LFKASNMTQRWQHREISNFEYLMFLNTIAGR 2238

  Fly  2661 SYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPP 2725
            |||||.|||||||::.:|:|||||||.|..|||.|:|:||...:|...|.:||:.|:|  .:.|.
Mouse  2239 SYNDLNQYPVFPWVITNYESEELDLTLPSNFRDLSKPIGALNPKRAAFFAERFESWED--DQVPK 2301

  Fly  2726 YHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIP 2790
            :|||||||:|..|.::|:|:|||:..||.||||.||.|||.|.|:..||.: |:.:.:|:|||||
Mouse  2302 FHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSVSRAWRN-SQRDTSDIKELIP 2365

  Fly  2791 EFFYLPEFLSNFNNFDLGTKQNGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDL 2855
            ||:||||...||||::||...:|..::.|.|||||| ...||:|::|.|||.::||..||.||||
Mouse  2366 EFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAK-TSEEFVRINRLALESEFVSCQLHQWIDL 2429

  Fly  2856 IFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKM 2920
            |||.|||||.||.|:|||::|.|||.|::.:|.||:.:.|....|.:|||.|.||..:.||.:
Mouse  2430 IFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPR-- 2492

  Fly  2921 GGSRHSALIDPTSLIQGNSTVLQTDRLFFHNLDNLK-PSLQPIKELKGPVGQILQPD-------- 2976
             ||...|.:    |:|  |.::.||:.....:..|| ||..|:..    |....||.
Mouse  2493 -GSAMQAYL----LLQ--SPLMFTDQAQQDVIMVLKFPSNSPVTH----VAANTQPGLAMPAVIT 2546

  Fly  2977 ---KTVF-------------AVEQNKVMMPPSYTKYIAWGFADHSLRIGLYDTDRASFVSEASAQ 3025
               ..:|             ||:.....:|......||.|...|..::    ||    :.:.|.|
Mouse  2547 VTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIACGTGTHRRQV----TD----LLDQSIQ 2603

  Fly  3026 NSGEILTCACPNAKMIVTAGTSSVVTIWKFDANRKSLAVKHSLHGHTDAVTCLAASAAY----NV 3086
            ...:.......|..::|.........::..|..:....|    .||.|.|||||.|.:|    ..
Mouse  2604 VHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGKLIQVV----FGHWDVVTCLARSESYIGGNCY 2664

  Fly  3087 IVSGSRDGTAIVWDMTRFTFVRQLRGHAGVVAAVSINE----------LTG---DIATCSATWLH 3138
            |:|||||.|.::|...            |..:.:..|.          |||   :| ||:|....
Mouse  2665 ILSGSRDATLLLWYWN------------GKSSGIGDNPGGETATPRAILTGHDYEI-TCAAVCAE 2716

  Fly  3139 --------------VWSINGDALAMVNTCVGSADRMQQIL--------CVAFSQIREWDQQNVII 3181
                          :.|:|||   ::.|..|..:.::..|        ||.|.      :.....
Mouse  2717 LGLVLSGSQEGPCLIHSMNGD---LLRTLEGPENCLKPKLIQASREGHCVIFY------ENGCFC 2772

  Fly  3182 TGSTDGVVRMWSLEHTQVPIDRKLKRGTEVSSQDKPDTVSLEGK---DNKDDKMSLMKQIKSLSQ 3243
            |.|.:|                ||:...|.....:...:|.:|:   ...|:.:.:::|:..|.|
Mouse  2773 TFSVNG----------------KLQATVETDDHIRAIQLSRDGQYLLTGGDNGVVIVRQVSDLKQ 2821

Fly 3244 3243
Mouse 2822 2821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	22/135 (16%)
		Beach	2638..2918	CDD:280327	155/279 (56%)
		WD40	<2991..3252	CDD:225201	61/295 (21%)
		WD40	2995..>3194	CDD:295369	52/237 (22%)
		WD40 repeat	3031..3070	CDD:293791	4/38 (11%)
		WD40 repeat	3075..3111	CDD:293791	15/39 (38%)
		FYVE_WDFY3	3418..3482	CDD:277259
Lrba	XP_006502410.1	LamG	229..376	CDD:389952	34/204 (17%)
		DUF4704	446..717	CDD:374111	52/301 (17%)
		DUF1088	1882..2061	CDD:368928	48/194 (25%)
		PH_BEACH	2087..2184	CDD:373333	32/179 (18%)
		Beach	2216..2492	CDD:366934	155/279 (56%)
		WD40 repeat	2608..2644	CDD:293791	4/39 (10%)
		WD40	<2613..2813	CDD:392136	50/241 (21%)
		WD40 repeat	2650..2703	CDD:293791	17/64 (27%)
		WD40 repeat	2708..2743	CDD:293791	9/38 (24%)
		WD40 repeat	2748..2777	CDD:293791	6/34 (18%)
		WD40 repeat	2784..2824	CDD:293791	7/38 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920