Protein Alignment bchs and lrba

DIOPT Version :10

• Sequence 1: NP_608968.2
• Gene: bchs / 33819
• FlyBaseID: FBgn0043362
• Length: 3489
• Species: Drosophila melanogaster
• Sequence 2: XP_002933545.3
• Gene: lrba / 734030
• XenbaseID: XB-GENE-951020
• Length: 2809
• Species: Xenopus tropicalis
• Alignment Length: 3361
• Identity: 698/3361 - (20%)
• Similarity: 1153/3361 - (34%)
• Gaps: 1148/3361 - (34%)

  Fly    97 KVFSSCPSNDMSEKFWDVVAFCQQVSRLMVSEIRKRASNQSTEAASIAIVKFL--EVETTEETSS 159
            |.|..|...|...:.|.:|:.....:|...||:|...:.   |.||...:.:|  ..:|.::...
 Frog   279 KGFQHCVKYDFKPQKWYMVSLVHIYNRWKNSELRCYVNG---ELASYGEITWLVNTSDTFDKCFL 340

  Fly   160 GWMLLATLNLLANGDVSLIQVMTAAAVPSTL---------VKCLYLF---FDLPIVEDDEPSADG 212
            |....|..|.:..|.::.:.:.:.|...:.:         .|..:.|   .||.:.|..:.....
 Frog   341 GSSETADSNRVFCGQMAAVYLFSEALNAAQIFAVYQLGPGYKGTFKFKAESDLFLAEHHKLLLYD 405

  Fly   213 GAVSE---FNAHERRTLLQKVFVQLLVKLCSYPYPAEELARMDDLTLLFSAITSPCPIHNIVWRK 274
            |.:|.   |..:.|.|..|         ||....|       .|...:|  :.||   |.::.:.
 Frog   406 GKLSSSIAFTYNPRATDAQ---------LCLESSP-------KDNPSIF--VHSP---HALMLQD 449

  Fly   275 NAAEILTTISRNGLTDAVVSYIHSKGCMALCVDNMQRLTF---GNPLEIVEMFVTVFCFLKDSSQ 336
            ..|.         ||.::.|.:||.|.:.:......:|.|   |:......:..|:|.|:.:..:
 Frog   450 VKAV---------LTHSIQSAMHSIGGVQVLFPVFAQLDFRQYGSDHVDASVCSTLFAFILELLK 505

  Fly   337 VSQILMDDFRASQGYVFLSDFLLKFDNNR--SQSLEIQAA-------IRNLVLMISSLCMCGFYE 392
            .|..:.:...:|:|::.:...|.|...:.  ...||:..|       :.|.|.::..||   .:.
 Frog   506 NSLAMQEQMLSSKGFLVIGYSLEKSSKSHVTRTVLELSLAFAKYLSSLHNGVPLLKQLC---DHI 567

  Fly   393 LRPPASQFNTAFKLQNFQLPQATSRETCVRNVYAFQVLQNVFLKSTTPALCCTILDAISR----- 452
            |..||...:|...:|              ..:|.|  :...|:.|.      :|.:|:.|
 Frog   568 LLNPAIWIHTPATVQ--------------LALYTF--MSTEFISSV------SIYNAVRRTGTVL 610

  Fly   453 -VYHSENANYFILESEQTLSSFAERIHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKH 516
             |.|:....|:.:..:.......:.:....|.                   | ||::||..:|
 Frog   611 LVMHTLKYYYWTVNPQDRSGITPKGLDGPRPN-------------------P-KEILSLRAML-- 653

  Fly   517 NQSTSCSILCLKTLLNILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKITKGDESVVVELENE 581
                   ::.:|.|            |.::.|:.|..:..:..|...:.:
 Frog   654 -------LIFIKQL------------VMKDHGVKEDELQAILNYLLTIHE--------------- 684

  Fly   582 SEEELFDTLGKHVLEALTMLLGGGASNNAQLFREYGGAKCVHELV--KFKHCRPQALGIV----- 639
             ::.|.|     ||:.|..|:.....:....|.:..|.:.|::|:  |.:..|.|||.::
 Frog   685 -DDNLMD-----VLQLLVALMSEHPGSMIPAFDQRNGLRIVYKLLASKTEGIRVQALKVLGYFLK 743

  Fly   640 ------RELILSAGGDDDMLHILSLMH----SVSPLQVEFKIQILNMLLGCLKDSHRTRTVFRKV 694
                  :..::.|.|...:|....::|    :::...|.|:|.|..:   |.:..|:..
 Frog   744 HLSAKRKSEVMQAHGLFSLLAERLMLHTNLITMTTYNVLFEILIEQI---CTQVIHKQH------ 799

  Fly   695 GGFVYVTSVFVSLDGSMALPQPDIP---QQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSS 756
                               |.||..   |..|||      :.:||.:|..|.:.:..  |:....
 Frog   800 -------------------PDPDSTVKIQNPLIL------KVIATLLRNCPQHPEVI--EVKRVF 837

  Fly   757 LCDTLRLLGCFGGSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPYPLSYVCIVFRLL 821
            |.|.::|            :..:.|.::|||:                          |.|:: .
 Frog   838 LSDMIKL------------FNNSRENRRSLLQ--------------------------CSVWQ-E 863

  Fly   822 YSIALDNFEAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPRIVHPGVVLCMLQ 886
            :.::|..|...|                                    :.|.:|......:..:.
 Frog   864 WMLSLCYFNPKN------------------------------------TEEQKITEMVYAIFRIL 892

  Fly   887 LLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKLTRRALAEESHPLHVP 951
            |..||:|:..                       ..::..|      .:.:|...:..|.|
 Frog   893 LYHAVKYEWG-----------------------GWRVWVD------TISITHSKVTFEMH----- 923

  Fly   952 MQYILERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGG---PVPLTRIKTLVSMTTPRDF 1013
                              |:        |.|.:..:...:.||   |.|.:.|:|:..::...:.
 Frog   924 ------------------RE--------SLARVFNEYQDRDGGEICPSPSSPIRTVSGISAELES 962

  Fly  1014 RAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFPPQTGLTYS 1078
            |    :..||   |:::.......::.::..::||....|         ...:.|..|:|
 Frog   963 R----TQTPP---LEITEAASTSTFIENVVTESTADFEVT---------QFSEHISSPKT----- 1006

  Fly  1079 TWFCVEKFSDPKTDPHCVRLLTLVRTIHNPREENLACLSILLSARDKAIVVSTQETLVTPRKSIG 1143
                 |:....::|.:..  :||...:.:..|......|| ......|:|...:|..::...:..
 Frog  1007 -----EQMEPDESDDYVE--VTLDTNMSDAEETETKEQSI-EGTVPSALVEECEEATLSLDTNSC 1063

  Fly  1144 DWEPEG-SDDGIARIWCPDLLHEGQWHNLVVVLN---RAVLKNSSLFLYLDGVPMHTQKLHYIAQ 1204
            |:.|.| |:|           :||....|...:|   .||:.:||     |..|.:|.
 Frog  1064 DFVPIGCSED-----------NEGISEMLESKMNVGSSAVVLDSS-----DSAPDNTV------- 1105

  Fly  1205 HPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCHLIEDVLTQQTVQTIYQLGPHYMGSLQ 1269
             |.|...|..|                       ..:..::.|.                .||.:
 Frog  1106 -PTASENSAVS-----------------------DELSAMVNDA----------------AGSNE 1130

  Fly  1270 A-PQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNSHENAT-- 1331
            | .:||:......|:.|:|:                       ::|.||       ||.||.|
 Frog  1131 AVSELGENKGDGPPVDPQDQ-----------------------KSDGKS-------NSSENTTAE 1165

  Fly  1332 PIKILHNSAG----HLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDTVGGCNV------LLGIIA 1386
            .|..|...|.    .:.||   :||:.         ||.......:.:....|      .|.:.:
 Frog  1166 AIPTLKEVAETQNLDIEGA---VGGIT---------SPKESEIKTNALAASQVSERKIAKLDVSS 1218

  Fly  1387 MAQDVESL-YAGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKKKKHLLNSHILHLTFGLVG-T 1449
            :|.|.|:| |            .|:...|.|     ||.|...:|         :....|..| .
 Frog  1219 IASDTENLDY------------RRSVSHEAD-----QTTGAMPEK---------IRQPAGADGQR 1257

  Fly  1450 VNSGQDMSAIPNV---TAFQDLLCDL--------EIWHNAPNGLLRSLLEHLLELVVESSDKKQN 1503
            .:|...|..||..   |..|.||.||        ::|.:           |..:.:::..:...|
 Frog  1258 RDSRSTMFRIPEFRWSTMHQRLLTDLLFSIETDIQMWRS-----------HSTKTIMDFVNSNDN 1311

  Fly  1504 VKIMRDLQLLVKLLHIITQIQDHSTREILFSLLETLLGGQPRHTDLLLFGQYVAAKLPHAHSGGL 1568
            |..:.:      .:|:|:||.|:         :....||             :...|..|.|...
 Frog  1312 VIFVHN------TIHLISQITDN---------MIMACGG-------------ILPLLSAATSATH 1348

  Fly  1569 ERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTLGMDWLLLF 1633
            |...:.|:       |...:..:|....|.:||:..|:|              :.:||    ...
 Frog  1349 ELEHIEPT-------QGLSLETSISFLQRAISLVDVLIF--------------ASSLG----FAD 1388

  Fly  1634 MQPHVHFTTVIIAVRILVVICANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQQLNQRPTN 1698
            ::...:.:...|..:.|.::||     |..|:.         .|.....|:...|....||:..:
 Frog  1389 IEAEKNMSPGGILRQCLRLVCA-----VAVRNC---------LECQQHLKLKTTGEPIKNQKGVH 1439

  Fly  1699 ---GTGTVIVATPQNTI--------QH---LPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPEL 1749
               |||.....:|.:.|        .|   |.......:||..     |:.:|       |..:.
 Frog  1440 SLVGTGKPAAKSPIDIITGGMSPVRDHDRLLQDMDINRLRAVV-----FRDVE-------DSKQA 1492

  Fly  1750 YFLITALIMGQPVKVLA---------------------TEHTKFD---LDRVWSFLWGAPVSANT 1790
            .||..|::....|.:::                     .||...|   ||.|.|.   |||:|:.
 Frog  1493 QFLALAVVYFISVLMVSKYRDILEPQNERKQSTRTPKDAEHESGDMGSLDAVQSV---APVTADM 1554

  Fly  1791 QLPKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQNLTDFAPVMMTGDVVTS 1855
            : ..|:|..:.         ||......||...|....:.....|...:.|...||....|.::.
 Frog  1555 E-NALSIRRDS---------GIGEESAIAPTRTSDESAVAPTKSSDAVSDTGPEPVSSGPDAISE 1609

  Fly  1856 LVAVLFPLASRPADSEPNSGA-----------------STPTDDTGSSFALPPPETLHGAPQPKL 1903
               ||..|:|....|...||:                 |.|:|:..:..||.||..| ||.....
 Frog  1610 ---VLHTLSSEVIQSSQESGSEASAKNVNVKDILRSLVSIPSDEPLTDPALLPPAFL-GALGDLA 1670

  Fly  1904 TAHPVCNCIIDFLRVIVVDSLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQIIIALMDHLL 1968
            ..:||  ....|.|.:|:      .|.|..|.|...:..||.:..           :::..|...
 Frog  1671 AENPV--QFRSFDRSVVI------AQKKSVPPIPATVSTAPHAVS-----------VVSATDSSQ 1716

  Fly  1969 AADV---LVGEQAALPLVPLLQSQMQYIAPNVFYLTARIVDKLWQGCLARNPHDIFDFVIKLIVQ 2030
            |||.   ..|..::...:|.:|:                        :|..|.|
 Frog  1717 AADADRESSGSGSSNSKLPSVQT------------------------VASVPED----------- 1746

  Fly  2031 AKRRSSSLSL-EHLHHSLNRSILFL----------LSRPTDDSRADQMSVLEALHKIIQHRLLIF 2084
               .:|.:|: |.|.|:|.::...|          |||                        .:.
 Frog  1747 ---SASHMSITERLEHALEKAAPLLREIFVDFAPFLSR------------------------TLL 1784

  Fly  2085 GAGNHELEFIGCLTYCLLQLTADMKIILEPATSRNTTWHVNPQTETAEPKDEDLNQLQGRNLIVG 2149
            |:...||...|....|:...::.:::::...:..   |.               |.:| :|  .|
 Frog  1785 GSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQE---WQ---------------NSIQ-KN--AG 1828

  Fly  2150 AAFRVWEELYVCKKPAIEEVFKVSLTSPPPNSKAPDLQTTREQVMELASKLWFNYVEAERKATYR 2214
            .||             ||.|.:..|.|          ||.::.::.:|:       |||...:.:
 Frog  1829 LAF-------------IELVNEGRLLS----------QTMKDHLVRVAN-------EAEFILSRQ 1863

  Fly  2215 APWELHTQIQSKIQKVTGGLSRLTSRTKTKKEELVRTRSTLTREAAYESTGIHVQLIKDLLDLRA 2279
            ...|:|...:.:        |:....|..|:|| .:....|.|.|.|.......||::.::::
 Frog  1864 RAEEIHRHAEFE--------SQCAQYTADKREE-EKMCDHLIRAAKYRDNVTATQLVQKIINI-- 1917

  Fly  2280 KQYQQMLQHTQRYVYQDWVQSEMELTRERGLWGPTGSCSLDK----WILDTTEGPHRMRKKTMRN 2340
                                    ||.:.|.|   ||.|:.:    |.||..|...|.|::.:||
 Frog  1918 ------------------------LTDKHGAW---GSSSISRPCEFWRLDYWEDDLRRRRRFVRN 1955

  Fly  2341 DVFYLHYPYRPELELADNRQLKYKVASSLDSKTYALHGPQQPRI---------------LAEA-- 2388
            .:...|    ||..|          .|:::      |.|.:..:               ::|.
 Frog  1956 PLGSTH----PEATL----------RSAIE------HDPDEDALVKGKQSIKGQVVGGQISEGDS 2000

  Fly  2389 ---GEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEE 2450
               ||...:   ||||......|....:.|||..:|.|.:|..|:.     ||..:....:.||:
 Frog  2001 LLDGEDDTL---SSLEEKDLESLTGPVNLSTPAQLVAPSVVLKGTL-----SVTSSELYFEVEED 2057

  Fly  2451 DTSMTSDNETFLRLLEEQEKISFMFRCARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDID 2515
            |......:...|               |..:||.
 Frog  2058 DPGFKKMDAKIL---------------AYTEGLH------------------------------- 2076

  Fly  2516 TLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNY 2580
                                            .|:.:.|||.|..||||||..|:|:|..:..:.
 Frog  2077 --------------------------------GKWLFTEIRAVFSRRYLLQNTAVEIFMANRVSV 2109

  Fly  2581 LLSFP-RKVRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGE 2644
            :.:|| :....||......:....|....|:     |..|:.....||..    :::||||...|
 Frog  2110 MFNFPDQSTVKKVIHCLPRVGIGTNFGLPQT-----RRISLATPKQIFKA----SNMTQRWQHRE 2165

  Fly  2645 ISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQF 2709
            ||||:|||.|||:|||::|||.|||||||::.:|:||:||||.|..|||.|:|:||...:|.:.|
 Frog  2166 ISNFEYLMFLNTIAGRTFNDLNQYPVFPWVITNYESEQLDLTLPSNFRDLSKPIGALNPKRADFF 2230

  Fly  2710 QKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAW 2774
            .:|:|.|:|  .:.|.:|||||||:|..|.|:|:|:|||:..||.||||.||.|||.|.||..||
 Frog  2231 DERYKSWED--DQVPKFHYGTHYSTASFVLSWLLRIEPFTTFFLNLQGGKFDHADRAFSSIARAW 2293

  Fly  2775 LSASKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQNGETLNHVILPPWAKHDPREFIRLHRSA 2839
            .: |:.:.:|:|||||||:||||...|.||:.||...:|..::.|.|||||| .|.||:|::|.|
 Frog  2294 RN-SQRDTSDIKELIPEFYYLPEMFVNANNYSLGVMDDGTVVSDVDLPPWAK-SPEEFVRINRLA 2356

  Fly  2840 LECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFG 2904
            ||.::||..||.|||||||.|||||.||.|:|:|::|.|||.|::.:|.||:.:......|.:||
 Frog  2357 LESEFVSCQLHQWIDLIFGYKQQGPEAVRALNMFYYLTYEGAVNLSSITDPVLREGVEAQIRSFG 2421

  Fly  2905 QIPKQLFKKAHPAKKMG----------GSRHSALI-------DPTSLIQGN---------STVLQ 2943
            |.|.||..:.||.:...          .::|..::       .|.:.:..|         :..:.
 Frog  2422 QTPSQLLIEPHPPRSSAMQVTPLMFTDQAQHDVIMVLKFPSNSPITHVAANTQPGLATPAAITVT 2486

  Fly  2944 TDRLF----FHNLD-----------NLKPSLQPI---------KELKGPVGQILQPDKTVFAVEQ 2984
            .:|||    :|.|.           .|...:.|:         :::...:.|.:|.....|.:..
 Frog  2487 ANRLFAVNKWHGLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQISDLLDQSIQVHSQCFVITA 2551

  Fly  2985 NKVMMPPSYTKYIAWGFADHSLRIGLYDTDRASFVSEASAQNSGEILTCACPNAKMI-----VTA 3044
            :...:       :..||.|.|.|:  |.||...........  .:::||...:...|     |.:
 Frog  2552 DNRFI-------LVCGFWDKSFRV--YSTDTGKLTQVVFGH--WDVVTCLARSESYIGGDCYVLS 2605

  Fly  3045 GT-SSVVTIWKFDANRKSLAVKHS---------LHGHTDAVTCLAASAAYNVIVSGSRDGTAIVW 3099
            |: .:.:.:|.::.....:....|         |.||..|:||....|...:::|||:||..::.
 Frog  2606 GSRDATLLLWYWNGKSNGIGDHPSTEFATPRAILTGHDCAITCATVCAELGLVISGSKDGPCLIH 2670

  Fly  3100 DMTRFTFVRQL----------------RGHAGVVAAVSINELTGDIATCSATWLHVWSINGDALA 3148
            .|.. ..:|.|                .||..|.....|        .|      |:||||...|
 Frog  2671 SMNG-DLLRTLEAAENCLRPKLIQVSREGHCVVYYEKGI--------FC------VFSINGKLQA 2720

  Fly  3149 MVNTCVGSADRMQQILCVAFSQIREWDQQNVIITGSTDGVVRMWSL 3194
            .:..    .|..:.||.....|        .::||..:|||.:|.:
 Frog  2721 SMEI----EDNTRAILLSRDGQ--------YLLTGGDNGVVMVWQV 2754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	21/131 (16%)
		Beach	2638..2918	CDD:460459	152/279 (54%)
		WD40	2995..>3194	CDD:475233	51/229 (22%)
		WD40 repeat	3031..3070	CDD:293791	8/53 (15%)
		WD40 repeat	3075..3111	CDD:293791	11/51 (22%)
		FYVE_WDFY3	3418..3482	CDD:277259
lrba	XP_002933545.3	Neurobeachin	<60..192	CDD:466574
		Laminin_G_3	224..371	CDD:463865	20/94 (21%)
		DUF4704	436..916	CDD:464870	114/720 (16%)
		MDN1	965..>1225	CDD:444083	69/389 (18%)
		DUF1088	1837..2004	CDD:461925	44/241 (18%)
		PH_BEACH	2030..2127	CDD:434260	31/179 (17%)
		Beach	2159..2435	CDD:460459	152/279 (54%)
		NBCH_WD40	2530..2794	CDD:466575	54/263 (21%)
		WD40 repeat	2544..2582	CDD:293791	9/46 (20%)
		WD40 repeat	2588..2641	CDD:293791	8/52 (15%)
		WD40 repeat	2646..2681	CDD:293791	10/35 (29%)
		WD40 repeat	2686..2715	CDD:293791	7/42 (17%)
		WD40 repeat	2722..2762	CDD:293791	10/45 (22%)