DRSC/TRiP Functional Genomics Resources

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Protein Alignment bchs and NBEAL1

DIOPT Version :9

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:XP_006712761.1 Gene:NBEAL1 / 65065 HGNCID:20681 Length:2736 Species:Homo sapiens


Alignment Length:3137 Identity:691/3137 - (22%)
Similarity:1124/3137 - (35%) Gaps:960/3137 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 LCCTILDAISRVYHSENANYFILESEQTLSSFAERIHMKSPQIQEKFYD---LLEFIVFQLNFVP 503
            :.|..|..:..:......||.|     |:::...: .:||.:.:::..|   :.||::..|.|  
Human    99 ILCRNLSNVEEIGTCSYINYVI-----TMTTLYIQ-QLKSKKKEKEMADQTCIEEFVIHALAF-- 155

  Fly   504 CKELISLSLLLKHNQSTSCSILCLKTLLNILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKIT 568
            |:.|.......:|..|.       :.|..:.:....:|.....|..:..|..|.           
Human   156 CESLYDPYRNWRHRISG-------RILSTVEKSRQKYKPASLTVEFVPFFYQCF----------- 202

  Fly   569 KGDESVVVELENESEEELFDTLGKHVLEALTMLLGGGASNNAQ---------LFR---------- 614
                        :..|.|.::|...:|.....::.||..|..|         |.|          
Human   203 ------------QESEHLKESLKCCLLHLFGAIVAGGQRNALQAISPATMEVLMRVLADCDSWED 255

  Fly   615 ----EYG-----GAKCVHELVKFKHCRPQALGIVRELILSAGGD----------DDMLHILSLMH 660
                |.|     ..||:.|:|              .::||:..|          ::...:|:..|
Human   256 GDPEEVGRKAELTLKCLTEVV--------------HILLSSNSDQRQVETSTILENYFKLLNSDH 306

  Fly   661 SVSPLQ----------VEFKIQILNMLLGCLKDSHR--TRTVFRKVGGFVYV------TSVFVSL 707
            |..|.|          :..:|::||.:...|..:.|  .:.:|.....|.::      ..:|::.
Human   307 SALPNQRRSRQWENRFIALQIKMLNTITAMLDCTDRPVLQAIFLNSNCFEHLIRLLQNCKLFLNA 371

  Fly   708 DGSMA--------------LPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLC 758
            :..:|              :.:..:.|..|..|.....|.|...|...||..:.|.:.|..:.:.
Human   372 NNKVADKNEKDLANKLLTEMNEDQVFQGQLDCLAISTIQALTAVMNKSPAAKEVFKERIGYTHML 436

  Fly   759 DTLRLLGCFGGSSALQDYTGTYEPQQSLLKYYHEIFS----GDILSVSFSEDVPYPLSYVCIVFR 819
            :.|:.||               :|...|||   |:.:    ||..||                  
Human   437 EVLKSLG---------------QPPLELLK---ELMNMAVEGDHTSV------------------ 465

  Fly   820 LLYSIALDNFEAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPRIVHPGVVLCM 884
                            ||:.:.:..|                                   :|.:
Human   466 ----------------GILGISNVQP-----------------------------------LLLL 479

  Fly   885 LQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMC-DHGLAEKLLKLTRRALAEESHPL 948
            :|.||       .||:..||:::|:.:|.:....|..:..| :..:..:::         |:..|
Human   480 IQWLP-------ELQSHDLQIFISDWLKRICCINRQSRTTCVNANMGIRII---------ETLDL 528

  Fly   949 HVPM-QYILERLAA-------QALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPLTRIKTLV 1005
            |..: |...|.|.|       |::...|:|:.|||   |...:.:...||    ..|:||    .
Human   529 HSSLHQTCAENLIAIHGSLGSQSVSSEEIRRLLRL---LRVDESESVHPY----VTPVTR----A 582

  Fly  1006 SMTTPRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFP 1070
            .:|..|.            :.|:.:.:.|..                   ::|:.||........
Human   583 ILTMARK------------LSLESALQYFNL-------------------SHSMAGISVPPIQKW 616

  Fly  1071 PQTGLTYSTWFCVEKFSDPKTDPHCVRLLTLVRTIHNPREENLACL---------SILLSARDKA 1126
            |.:..::|.|||:::..           |||.......:.:.|...         :.:..:....
Human   617 PGSAFSFSAWFCLDQDQ-----------LTLGIANKGGKRKQLYSFFTGSGMGFEAFITHSGMLV 670

  Fly  1127 IVVSTQE---TLVTPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWHNLVVV--LNRAVLKNSSLF 1186
            :.|.|:.   |::.|..|                :|..|     |||:.||  ..:.....|.::
Human   671 VAVCTKREYATVMLPDHS----------------FCDSL-----WHNITVVHMPGKRPFGQSFVY 714

  Fly  1187 LYLDGVPMHTQKLHYIAQHP--------AAGNASLT-SPTQI---------------FGYIGTPP 1227
            :|.:|....:..|.:.|.:.        :||..:.| .|:||               ||.|.:..
Human   715 IYDNGQQKVSAPLRFPAMNEPFTSCCIGSAGQRTTTPPPSQIPDPPFSSPITPHRTSFGGILSSA 779

  Fly  1228 IWR---RYSRLCWK--------------------QGVCHLIEDVLTQQTVQTIYQLGPHYMGSLQ 1269
            .|.   ..|:|..|                    .|...:..:.|....|:.:|..||:.:...:
Human   780 SWGGTIEKSKLITKLISAGTQDSEWGCPTSLEGQLGSVIIFYEPLQPPQVKALYLAGPNCLSPWK 844

  Fly  1270 APQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNSHENATPIK 1334
            .     |...:|.|  ...:||...|||.                ..||...|:.|         
Human   845 C-----QESDMADL--PGNILLYYTAKAC----------------KNSICLDLSTN--------- 877

  Fly  1335 ILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDTVGGCNVLLGIIAM------------ 1387
            .||         ||..|..||.:         .:..:|:.:||.|||..::..            
Human   878 CLH---------GRLTGNKVVNW---------DIKDIINCIGGLNVLFPLLEQISHFSEGQIPEE 924

  Fly  1388 --AQDVESLYAGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKKKKHLLNSH------ILH--- 1441
              ...|......|:....|..|.:|:::.::|    ..:..|....||.:..|      ::|   
Human   925 KNESTVPESVTPVEGDWLVWTSTKASESRLER----NLVATFILIVKHFIQRHPINQGNLIHSHG 985

  Fly  1442 -LTFG---------------------LVGTVNSGQDMSAIPNVTAFQDLLCDLEIWHNAPNGLLR 1484
             .|.|                     |:..|:..::|..:..:  :|.||.|..||:   .|...
Human   986 VATLGALLQKVPSTLMDVNVLMAVQLLIEQVSLEKNMQLLQQM--YQYLLFDFRIWN---RGDFP 1045

  Fly  1485 SLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHII---------TQIQDHST-REILFSLLETL 1539
            ..:.|:..|.....|.::..:....:|.|:..|.|.         ..:.|..| |..|:.|::..
Human  1046 FRIGHIQYLSTIIKDSRRVFRKKYGVQFLLDTLRIYYGNGCKYNELSLDDIRTIRTSLYGLIKYF 1110

  Fly  1540 L--GGQPRHTDLLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLL 1602
            |  ||.  |.::.....|:||........|:...:......:|...|       ::|        
Human  1111 LCKGGS--HEEIQSIMGYIAATNEEEQLFGILDVLFSLLRTSPTRGQ-------LFL-------- 1158

  Fly  1603 HGLLFTPRNTVNYVICDDISKTLGMDWLLLFMQPHVHFTTVIIAVRILVVICAN----ESFLVRF 1663
              |||.|.|.       ||     :..|||..:.......:|..:...::.|.|    ....:|.
Human  1159 --LLFEPGNA-------DI-----LYALLLNQKYSDRLREIIFKIMEQMLKCTNVYERSKQHIRL 1209

  Fly  1664 RDATHNG-GYLRFTEMVSQRKMLGLGAQQLNQRPTNGTGTVIVATPQNTIQHLPTQIAGEVRAAA 1727
            |:..::| |.|....:|:...:..|..|.:|..|......::.....:...|:..::|  :....
Human  1210 REVGYSGLGLLLNEALVNTSLIKNLTHQIINTDPVINFKDLLSVVYISHRAHINVRVA--ICRKV 1272

  Fly  1728 LNIPGF---------QLLEW---LMNHHLDVP-----ELYFLITALIMGQPVKVLATEHT----- 1770
            |.|..|         |.:.|   |:...|...     .|:....|::|....|.::||.|     
Human  1273 LQILQFQPDAAHQISQQVGWQDTLVRLFLKAKFENGNTLHKHSRAVLMKDNDKNMSTEDTKKNSD 1337

  Fly  1771 -KFDLDRVWSFL--------WGA----PVSANTQLPKLNICPEGVCVLLAMVRGIVHGGECA--- 1819
             |.|.:::.||.        |..    .:.:||.|     .||...|           ||.:   
Human  1338 EKTDEEKITSFASANVSSDQWSLEDRHSLDSNTPL-----FPEDSSV-----------GELSFKS 1386

  Fly  1820 ----PWLHSHPETIIQLLFSLYQNLTDFAPVMMTG-DVVTSLVAVLFPLASRPADSEPNSGASTP 1879
                .:.||:|..:     ||..:..|...:..:| .|..||.:...|:.|..:.|..:...|:.
Human  1387 ENQEEFWHSNPSHL-----SLDLSGIDSCEMSDSGSQVPDSLPSTPSPVESTKSFSVHSDRESSI 1446

  Fly  1880 TDDTGSS--FALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVDSLGLNMQGKPTPVIDLVLDA 1942
            |:|.|.|  |:|...:.               .|..:.|:::             |.:::.|:..
Human  1447 TNDMGFSDDFSLLESQE---------------RCEEELLQLL-------------THILNYVMCK 1483

  Fly  1943 APESAELPLQVQYQTQIIIALMDHLLAADVL-VGEQAALPLVPLLQSQMQY-IAPNVFYLTARIV 2005
            ..|.::....:: :.|:..||....:::::| ..::..|   .|||..::: |:.|....|..:.
Human  1484 GLEKSDDDTWIE-RGQVFSALSKPGISSELLRPSDEIKL---TLLQKMLEWAISENREAKTNPVT 1544

  Fly  2006 DKLWQGCLARNPHDIFDFVIKLIVQAKRRSSSLSLEHLHHSLNRSILFLLSRPTDDSRADQMSVL 2070
                    |.|.     |.:.||:|...:|..|        :|.::.      |:....|.|.:.
Human  1545 --------AENA-----FRLVLIIQDFLQSEGL--------VNSNMW------TEKLLEDMMLLF 1582

  Fly  2071 EALH----------KI--IQHRLLI--FGAGNHELEFIGCLTYCLLQLTADMKIILEPATSRNTT 2121
            :.|.          |:  ||.:||:  .|.||        |..|.: .:|.:..:|         
Human  1583 DCLSVCYSESPVWVKLSQIQIQLLLGFIGRGN--------LQVCAM-ASAKLNTLL--------- 1629

  Fly  2122 WHVNPQTETAEPKDEDLNQLQGRNLIVGAAFRVWEELYVCKKP----AIEEVFKVSLTSPPPNSK 2182
                 ||:..|.:||....|.....::..:.:...|:|....|    .:.:::::...    |..
Human  1630 -----QTKVIENQDEACYILGKLEHVLSQSIKEQTEIYSFLIPLVRTLVSKIYELLFM----NLH 1685

  Fly  2183 APDLQTTR------EQVMELA-SKLWFNYVEAERKATYRAPWELHTQIQSKIQKVTGGLSRLTSR 2240
            .|.|..|.      |...|.. |..|..|:| :....|...:|.||        ...|...:...
Human  1686 LPSLPFTNGSSSFFEDFQEYCNSNEWQVYIE-KYIVPYMKQYEAHT--------FYDGHENMALY 1741

  Fly  2241 TKTKKEELVRTRSTLTREAAYESTGIHVQLIKDLLDLRAKQ----YQQMLQH---TQRYVYQDWV 2298
            .|...|.|:.......||.. ||.....:|..:..:.:|:|    |..||:.   .|....:.|.
Human  1742 WKDCYEALMVNMHKRDREGG-ESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWK 1805

  Fly  2299 QSEMELTRERGLWGPTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLHYPYRPELELADNRQLKY 2363
            ..::.||.|||.|.......: .|.|...|...|||.|.:.|..|..|                 
Human  1806 AIQLYLTCERGPWAKRKQNPI-HWKLANVENYSRMRLKLVPNYNFKTH----------------- 1852

  Fly  2364 KVASSLDSKTYALHG-PQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLVG 2427
            :.||:|.......|. |....:|              ||.|:..::.         .||..||  
Human  1853 EEASALRDNLGIQHSQPSSDTLL--------------LEVVKQVKVS---------DMVEDKL-- 1892

  Fly  2428 HGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMFRCARVQGLDTFEGLLLF 2492
                ..|:|.:......|::||:|               ::||:..|..|..:..:|...|.|..
Human  1893 ----DLPEEDITARVNVDEKEEQD---------------QKEKLVLMEDCELITIIDVIPGRLEI 1938

  Fly  2493 GKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIRE 2557
            ..:|.|..||                      .|....|....            .|:.:.:|||
Human  1939 TTQHIYFYDG----------------------SIEKEDGVGFD------------FKWPHSQIRE 1969

  Fly  2558 VHKRRYLLQPIALEVFSEDGRNYLLSFPRKVRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQ 2622
            :|.|||.|:..|||:|..|..||.|:|.::||||:..|.|:|      ::..|..|.:....:.:
Human  1970 IHLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSL------HSPNSYYGSRSPQELFK 2028

  Fly  2623 TAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTN 2687
            .:|:          ||:||..|||||.||:.:||:|||:||||.|||||||||.||.||||||.|
Human  2029 ASGL----------TQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNN 2083

  Fly  2688 PKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPF 2752
            |..|||.|:|:|...|:..:..:::::.::||.|....:|||||||::..|..||:|:|||:...
Human  2084 PAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVEPFTTLH 2148

  Fly  2753 LKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQ-NGETL 2816
            ::||.|.||.|||.||||...| .|...|..|||||||||||.||||.|.|.|:||..| :.|.:
Human  2149 IQLQSGRFDCADRQFHSIPATW-QALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISKELV 2212

  Fly  2817 NHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGN 2881
            |.||||.||| ...:||..||.|||.:|||.|||.|||||||.||:|||||:|:|||::..|||.
Human  2213 NDVILPKWAK-SAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGA 2276

  Fly  2882 VDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKMGGSRHSALIDPTS------------- 2933
            ||:..:.|..::.|..|.||||||.|.||.|:.||.:.   |...|:..||.             
Human  2277 VDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRL---SAEEAVQKPTKIDTSTLNLFQHLP 2338

  Fly  2934 -----------------------------LIQGNSTVLQTDRL-----------FFHNLDN---- 2954
                                         :.||:..:|.|..:           :..|:.|    
Human  2339 ELKSFFIEGISDGIPLLKATIPKNQYRSFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTF 2403

  Fly  2955 ------LKPSLQPIKELKGPVGQILQPDKTVFAVEQNKVMMPPSYTKYIAWGFADHSLRIGLYDT 3013
                  ..|..|  :.:.|.....|:....:|.|..:..::       .:.|:.|:|:::  ...
Human  2404 IKDQTVTNPKTQ--RSINGSFAPGLEITSKLFVVSHDAKLL-------FSAGYWDNSIQV--MSL 2457

  Fly  3014 DRASFVSEASAQNSGEILTCACPN--AKMIVTAGTSSVVTIWKFDAN---RKSLAVK--HSLHGH 3071
            .:...:|......  :|:||...:  ...:::....:...||:....   ...||.|  ..|:||
Human  2458 TKGKIISHIIRHM--DIVTCLATDYCGIHLISGSRDTTCMIWQITQQGGVPVGLASKPFQILYGH 2520

  Fly  3072 TDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQLRGHAGVVAAVSINELT----GDIATC 3132
            |:.|..:..|...::.||||||||.|:..:.:..::|.||........::|..|.    |.|...
Human  2521 TNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVY 2585

  Fly  3133 SAT----------WLHVWSINGDALAMVNTCVGSADRMQQI--LCVAFSQIREWDQQNVIITGST 3185
            |:|          .||::||||..|       ||....:|:  :|:....         |:|||.
Human  2586 SSTEEKTTLKDKNALHLFSINGKYL-------GSQILKEQVSDICIIGEH---------IVTGSI 2634

  Fly  3186 DGVVRMWSLEHTQVPID 3202
            .|.:.:..|....:.|:
Human  2635 QGFLSIRDLHSLNLSIN 2651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 37/130 (28%)
Beach 2638..2918 CDD:280327 158/280 (56%)
WD40 <2991..3252 CDD:225201 54/235 (23%)
WD40 2995..>3194 CDD:295369 52/221 (24%)
WD40 repeat 3031..3070 CDD:293791 8/45 (18%)
WD40 repeat 3075..3111 CDD:293791 12/35 (34%)
FYVE_WDFY3 3418..3482 CDD:277259
NBEAL1XP_006712761.1 DUF4704 888..1148 CDD:292415 51/279 (18%)
DUF4800 1609..1862 CDD:292675 65/307 (21%)
PH_BEACH 1915..2012 CDD:275391 38/136 (28%)
Beach 2034..2313 CDD:280327 158/280 (56%)
WD40 <2390..2699 CDD:225201 62/291 (21%)
WD40 repeat 2435..2468 CDD:293791 5/41 (12%)
WD40 2438..2682 CDD:295369 54/241 (22%)
WD40 repeat 2474..2519 CDD:293791 8/44 (18%)
WD40 repeat 2524..2560 CDD:293791 12/35 (34%)
WD40 repeat 2572..2606 CDD:293791 8/33 (24%)
WD40 repeat 2619..2654 CDD:293791 8/42 (19%)
WD40 repeat 2659..2699 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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