DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bchs and nbeab

DIOPT Version :10

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:XP_073779907.1 Gene:nbeab / 565885 ZFINID:ZDB-GENE-120329-2 Length:2899 Species:Danio rerio


Alignment Length:3470 Identity:717/3470 - (20%)
Similarity:1161/3470 - (33%) Gaps:1239/3470 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 EPLSEQERD-DKLYEMLPLFC---------------------------KVFSSCPSNDMSEKFWD 113
            :||:....| ||.|    |:|                           |.|..|...|...:.|.
Zfish   258 DPLNNINVDKDKPY----LYCFRTSKGIGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWY 318

  Fly   114 VVAFCQQVSRLMVSEIRKRASNQSTEAASIAIVKFLEVETTEETSS---GWMLLATLNLLANGDV 175
            :|:.....:|...||||...:.|......:|    ..|.|.:....   |....|..|.:..|.:
Zfish   319 MVSIVHIYNRWRNSEIRCYVNGQLVSYGDMA----WHVNTNDSYDKCFLGSSETADANRVFCGQL 379

  Fly   176 SLIQVMTAAAVPSTL---------VKCLYLFFDLPIVEDDEPSADGGAVSEFNAHERRTLLQKVF 231
            ..|.|.:.|..|:.:         .|..:.|..    |.|...||         |.::.|    :
Zfish   380 GAIYVFSEALNPAQIFAIHQLGPGYKSTFKFKS----ESDIHLAD---------HHKQVL----Y 427

  Fly   232 VQLLVKLCSYPYPAEELARMDDLTLLFSAITSPCPIHNIVWRKNAAEILTTISRNGLTDAVVSYI 296
            ...|....|:.|.    |:..|..|...  :||....:|......|.:|..: :..:|.::.|.|
Zfish   428 DGKLANSISFTYN----AKATDAQLCLE--SSPRENPSIFVHSPHALMLQDV-KAIVTHSIHSAI 485

  Fly   297 HSKGCMALCVDNMQRLTFGNPLEI-VEMFV--TVFCFLKDSSQVSQILMDDFRASQGYVFLSDFL 358
            ||.|.:.:......:|.|....|. ||..|  |:..||.:..:.|..:.:.....:|::.:. :|
Zfish   486 HSIGGIQVLFPLFAQLDFHQHNESQVETTVCSTLLAFLMELLKSSVAMQEQMLGGKGFLVIG-YL 549

  Fly   359 LKFDNNRSQSLEIQAAIRNLVLMISSLCMCGFYELRPPASQ------FNTAFKLQNFQLPQATSR 417
            |:    :|..:.:..|:.:..|..:.. :.|.....|...|      ||.|..:   .:|.... 
Zfish   550 LE----KSSRVHVTRAVLDQFLSFAKY-LDGLTHGAPLLKQLCDHILFNAAIWI---HIPAKVQ- 605

  Fly   418 ETCVRNVYAFQVLQNVFLKSTTPALCCTILDAISRVYHSENANYFILESEQTLSSFAERIHMKSP 482
                .::|.:  |.:.|:.:||.......:..:.::.|.....|:.:....| |....: .:..|
Zfish   606 ----LSLYTY--LSSEFIGTTTIYSTIRRVGTVLQIMHILKYYYWAVNPNNT-SGITPK-GLDGP 662

  Fly   483 QIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKHNQSTSCSILCLKTLLNILRHNAVFKDVYREV 547
            :..:|  ::.....|.|.|:  |:||.....:|.::        |:::||.|             
Zfish   663 RPSQK--EISSLRAFMLLFL--KQLILKDRGVKEDE--------LQSILNYL------------- 702

  Fly   548 GILEIFVGCLTRYAAHVQKITKGDESVVVELENESEEELFDTLGKHVLEALTMLLGGGASNNAQL 612
                                          |....:|.|.|     ||:.|..|:....::....
Zfish   703 ------------------------------LTMHEDENLHD-----VLQLLVALMSEHPASMIPA 732

  Fly   613 FREYGGAKCVHELV--KFKHCRPQALGIVRELILSAGGDD--DMLHILSL---------MHSVSP 664
            |.:..|.:.|::|:  |.:..|.|||.::...:...|...  :::|..||         :||.: 
Zfish   733 FDQRNGIRVVYKLLASKSESIRVQALKVLAYFLKHLGHKRKVEIMHTNSLFTLLGERLMLHSNT- 796

  Fly   665 LQVEFKIQILNMLLGCLKDSHRTRTVFRKVGGFVYVTSVFVSLDGSMALPQPDIPQQDLILLLQI 729
                ..|...|.|...|.:...|:.|.:.          .|..|.::.:..|        ::|::
Zfish   797 ----VSITTYNTLYEILTEQVCTQVVHKP----------HVEPDSTVKIQNP--------MILKV 839

  Fly   730 VFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLG-------CFGGSSALQDY---TGTYEPQQ 784
            |    ||.::....:|..  .|:....|.|.::|..       |....|..||:   .|...|:.
Zfish   840 V----ATLLKNSTPSADL--MEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKN 898

  Fly   785 S--------------LLKYY---HEIFSG-----DILSVSFSEDVPYPL--SYVCIVFR------ 819
            |              :|.|:   || :.|     |.||::.|: |.|..  .|:..::.      
Zfish   899 SEEQKITEMVYNIFRILLYHAIKHE-WGGWRVWVDTLSIAHSK-VTYEAHKEYLAKMYEEYQRQE 961

  Fly   820 ----------LLYSIALDNFEAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPR 874
                      |:.:|:..:.:|.::.|.:.|.:|..|  ::|..|               :.||.
Zfish   962 EENIKKGKKGLVSTISGLSAQASSIKGTLELDADSQT--QTPESE---------------ADEPE 1009

  Fly   875 IVHPGVVLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKLTRR 939
            ....|                        :..||| .|||                         
Zfish  1010 TTDSG------------------------RNILSE-TKSL------------------------- 1024

  Fly   940 ALAEESHP---LHVPMQYILERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPLTRI 1001
               :|.:|   :||.:..:|..:.|:.::.||::.          .|:||....:.||.|.:..:
Zfish  1025 ---DEDNPASGVHVEVHDLLVDIKAEKVEATEVKM----------DDLDLLPVTENGGLVEVDSL 1076

  Fly  1002 KTLVSMTTPRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAG------GTIDANSIG 1060
            ...|.........:..::.|.|...|:....|    .|.:||.:..|.:.      ||:.:    
Zfish  1077 LDNVYSAAVEKLNSSVNNVLVPKASLENKNSG----PLITLADEKDAISSNNTFLFGTLAS---- 1133

  Fly  1061 GIGAGDRIFP--------PQTGLTYSTWFCVEKFSDPKTDPHCVRLLTLVRTIHNPREENLACLS 1117
              |:|:.:.|        |.:|:            :|:              :|.....:|..|:
Zfish  1134 --GSGENLLPEIGPSEPLPLSGV------------EPQ--------------VHTSSSADLGLLA 1170

  Fly  1118 ILLSARDKAIVVSTQETLVTPRKSIGDWEPEGS----DDGIARIWCPDLLHEGQWHNLVVVLNRA 1178
             |:|...|.:..:|    |.........:|..|    .:|.:...||     ||...:.|.|.:.
Zfish  1171 -LMSKSSKELSANT----VALEDDSFKMQPALSGFSISEGESLTKCP-----GQVETVAVDLEQG 1225

  Fly  1179 VLKNSSLFLYLDGVPMHTQKLHYIAQHPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCH 1243
                                        |:|                                  
Zfish  1226 ----------------------------ASG---------------------------------- 1228

  Fly  1244 LIEDVLTQQTVQTIYQLGPHYMGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRK 1308
             ::||.|..|               :....||:.|                           |:|
Zfish  1229 -VKDVSTSDT---------------EKSDDGKEKE---------------------------IKK 1250

  Fly  1309 VYSRADNKSIAKQLNMNSHENATPIKILHNSAG-HLAGAGRSLGGVVVGYLGV-------RVFSP 1365
            :.:.|..:|                  ||..:| ||   .|.| .|.:|:..:       |.|||
Zfish  1251 IQTTATTQS------------------LHGRSGSHL---DRDL-RVDLGFRAMPMTEEQRRQFSP 1293

  Fly  1366 HPVSAMIDTVGGCNVLLGIIAMAQDVESLYAGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKK 1430
            .|.:.|...                                      .|......:|.|      
Zfish  1294 GPRTTMFRI--------------------------------------PEFKWSPMHQRL------ 1314

  Fly  1431 KKHLLNSHILHLTFGLVGTVNSGQDMSAIPNVTAFQDLLCDLEIWHNAPNGLLRSLLEHLLELVV 1495
                    :..|.|.|..                      |:.||.:           |..:.::
Zfish  1315 --------LTDLLFALES----------------------DVHIWRS-----------HSTKSIM 1338

  Fly  1496 ESSDKKQNVKIMRDLQLLVKLLHIITQIQDHSTREILFSLLETLLGGQPRHTDLLLFGQYVAAKL 1560
            :..:..:|:..:.:      .:|:|:|:.|:    |:.:                          
Zfish  1339 DFVNSNENIIFVHN------TIHLISQMVDN----IIIA-------------------------- 1367

  Fly  1561 PHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTL 1625
                .||:  ..||.:..:|:.:.:|                                  :..|.
Zfish  1368 ----CGGI--LPLLSAATSPSSEMEG----------------------------------LEVTQ 1392

  Fly  1626 GMDWLLLFMQPHVHFTTVIIAVRILVVICANESFL-VRFRDATHNGGY----LRFTEMVSQRKML 1685
            ||.     .:..|.|.|.::|:..::|..::.:|. :.......:||.    ||....|:.|..|
Zfish  1393 GMS-----SETAVIFLTRLMAIVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCL 1452

  Fly  1686 GLGAQQLNQ---------RPTNGTGTVIVATPQNTIQHLPTQIA--------------GEVRAAA 1727
            ....:|.::         :...|..:|..|: :.||::.|:.::              ..:|||.
Zfish  1453 ECRQRQRDRSLKSSLSCSKSQEGLQSVSTAS-KTTIENFPSNVSPIKDPDRLLQDVDINRLRAAV 1516

  Fly  1728 LNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHTKFDLDRVWSFLWGAPVSANTQL 1792
                 |:.::       |..:..||..|::..  :.||.....:..|:         |.....:.
Zfish  1517 -----FRDVD-------DSKQAQFLALAVVYF--ISVLMVSKYRDILE---------PQRETGRF 1558

  Fly  1793 PKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQNLTDFAPVMMTGDVVTSLV 1857
              :|....|       :|..::    :|....||..           |||            |..
Zfish  1559 --INQSGRG-------IRQEIN----SPTSTDHPSL-----------LTD------------SRK 1587

  Fly  1858 AVLFPLASRPADSEPNSGASTPTDDTGSSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVD 1922
            ..|..|.||...|.|:|.:....|...|        .::||                        
Zfish  1588 EALGVLESRQESSLPHSDSGLGDDQVSS--------VMNGA------------------------ 1620

  Fly  1923 SLGLNMQGKPTPVIDL--VLDAAPESAEL---PLQVQY-QTQIIIA-------------LMDHLL 1968
            .|.|.| |.|..:..|  .|.:...|.|.   |..|:: :|...|:             ::..|:
Zfish  1621 DLDLAM-GGPNGMSGLFCTLSSVARSQESLIEPSSVEHLKTASSISSINQANKGINVKEILKSLV 1684

  Fly  1969 AADVLVGEQA--ALPL--VPLLQSQMQYIAPNVFYLTARIVDKLWQGCLARNPHDIFDFVIKLIV 2029
            ||.|...|..  |||.  ...::.:.|.:.|..|:                      .|...::|
Zfish  1685 AAPVETTESGTEALPYPEQQAMKREAQAMMPMQFH----------------------SFDRSVVV 1727

  Fly  2030 QAKRRSSSLSLEHLHHSLNRSILFLLSRPTDDSRADQMSVLEALHKIIQHRLLIFGAGNHELEFI 2094
            |||:..|.|::..:..|.:.|.|...|.|.                       ||.|.:...:.:
Zfish  1728 QAKKPPSGLTVNTVGTSGSSSALTSGSTPN-----------------------IFAAASITPKSM 1769

  Fly  2095 GCLTYCLLQLTADMKIILEPATSRNTTWHVNPQTETAEPKDEDLNQLQGRNLIVGAAF-RVWEEL 2158
            ...|......::.....:..|||:|.     |..:|..|..||..:    |:.:.... |..|::
Zfish  1770 INTTGATDTSSSSSASFVNGATSKNL-----PAVQTVAPMPEDTME----NMSITTKLERALEKV 1825

  Fly  2159 YVCKKPAIEEVFKVSLTSPPPNSKAPDLQTTR-----------------------EQVMELASKL 2200
                .|.:.|:|.         ..||.|..|.                       |.||.|.|:.
Zfish  1826 ----APLLREIFV---------DFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQE 1877

  Fly  2201 WFNYVEAERKATYRAPWELHTQIQSKIQKVTGGLSRLTSRTKTKKEELVRTRS----TLTREAAY 2261
            |.|.::......:             |:.:..|  ||...  ..|:.:||..:    .|.|:.| 
Zfish  1878 WQNSIQKNAGLAF-------------IELINEG--RLLCH--AMKDHIVRVANEAEFILNRQRA- 1924

  Fly  2262 ESTGIHVQLIKDLLDLRA--KQYQQMLQH-TQRYVYQDWVQSEM-------ELTRERGLWGPT-- 2314
            |....|.:.........|  |:.:.|..| .....::|.|.:..       .||.:.|.||..  
Zfish  1925 EDVHKHAEFESSCAQYAADRKEEETMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAAAQ 1989

  Fly  2315 -GSCSL---------DKWILDTTEGPHRMRKKTMRNDVFYLHY--------PYRPELELADNRQL 2361
             .||..         |.|.||..|...|.|::.:||.....|.        .|.||.:.|...:.
Zfish  1990 RSSCLFPFSSQQQQHDFWRLDYWEDDLRRRRRFIRNPFGSTHLDITCKSLEDYGPEEDEALRGRK 2054

  Fly  2362 KYKVASSLDSKTYALHGPQQPRILAEAGEHHAM-----QQQSSLEAVQSHRLETSSS---TSTPP 2418
            .::..:|:...|       :..::.| |:..|:     ::..:|.|....|:..|..   .|||.
Zfish  2055 GFRGQASVSQNT-------ETELMLE-GDDDAVSLLQEKEVDNLAASLYPRVNVSRGPVVLSTPA 2111

  Fly  2419 PMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMFRCARVQGL 2483
            .::.|..|..|:.......:.....|||.                          .||....:.|
Zfish  2112 QLIAPVTVARGTLSITTTEIYFEVDEDDP--------------------------AFRRIDAKVL 2150

  Fly  2484 DTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCS 2548
            ...|||                                                    |     .
Zfish  2151 VYSEGL----------------------------------------------------H-----G 2158

  Fly  2549 KFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFP-RKVRNKVNQRFLALATALNDNAQQSVA 2612
            |:.:.|||.|..||:|||..|||:|..:..:.:.:|| :....||......:....:....|:  
Zfish  2159 KWMFSEIRAVFTRRFLLQNTALEIFMANRTSVMFNFPDQPTVKKVVYSLPCVGVGTSYGLPQA-- 2221

  Fly  2613 GQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILAD 2677
               |..|:.....:|.    .:::||||.|.|||||:|||.|||:|||:||||.|||||||:|.:
Zfish  2222 ---RRISLASPRQLFK----SSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTN 2279

  Fly  2678 YDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYL 2742
            ::|||||||.|..|||.|:|:||...:|...:..|::.||:   ||||.||.||||:|.....:|
Zfish  2280 FESEELDLTVPSNFRDLSKPIGALNPKRAVFYADRYESWDE---ETPPCHYTTHYSTANSTLHWL 2341

  Fly  2743 VRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYLPEFLSNFNNFDL 2807
            ||:|||:..||...|..||..:|.|.||..:|....: :.||||||||||:||||...|.|.:.|
Zfish  2342 VRIEPFTTFFLNANGNKFDHPNRTFSSIARSWRHCQR-DTADVKELIPEFYYLPEMFVNSNGYCL 2405

  Fly  2808 GTKQNGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNV 2872
            |.:.:|..:..|.||.||| .|.:|:|::|.|||.::||..||.|||||||.||:||.|..|:||
Zfish  2406 GDRDDGVPVCDVELPAWAK-KPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAARALNV 2469

  Fly  2873 FHHLFYEGNVDIYNI-DDPLKKNATIGFINNFGQIPKQLFKKAHPAKKMGGSRHSALIDPTSLIQ 2936
            ||||.|||:|::.:: .||..:.||...|.:.||.|.||..:.||.:  ..:.|...:..:.|:.
Zfish  2470 FHHLTYEGSVNLDSLASDPPLREATEAQIQSVGQSPSQLLIEPHPPR--SSAMHLCFLPQSPLMF 2532

  Fly  2937 GNSTVLQTDRLFFHNLDNLK-PSLQPIKELKGPVGQILQPDKT-----------VFAVEQ--NKV 2987
            .:.  :|.|.:..     || ||..|:..    |.....|..|           :|||.:  |.|
Zfish  2533 KDQ--MQQDVIMV-----LKFPSNSPVTH----VAANTLPHLTLPAVVTVTCSRLFAVNRWHNTV 2586

  Fly  2988 MM--PPSYTKYIAWGFADHSLRIGLYDTDRASFVSEASAQNSGEI---------LTCACPNAKMI 3041
            .:  .|.|:...|     |.|.|     :..|.::..|..|..:|         :...|    .:
Zfish  2587 GLRGAPGYSLEQA-----HHLPI-----EMDSLIANNSGTNKRQITDLVDQSIQINTQC----FV 2637

  Fly  3042 VTAGTSSVVTIWKFDANRKSLAVKHS--------LHGHTDAVTCLAASAAY----NVIVSGSRDG 3094
            |||....::....:|   ||..|..|        :.||.|.|||||.|.:|    ..|||||||.
Zfish  2638 VTADNRYILVCGFWD---KSFRVYSSDTGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDA 2699

  Fly  3095 TAIVW-------------DMTRFTFVRQ-LRGHAGVVAAVS------------------INELTG 3127
            |.::|             :.:.:...|. |.||...|..||                  ::.:||
Zfish  2700 TLLLWYWSGRHHIIGDNPNNSDYPAPRAVLTGHDFEVVCVSVCAELGIIISGAKEGPCLVHTITG 2764

  Fly  3128 DI--------------ATCSATWLHV-----------WSINGDALAMVNTCVGSADRMQQILCVA 3167
            |:              ..|.::..|.           :||||..||.:.  :..:.|     .:.
Zfish  2765 DLLRALEGPDSCVLPRLICVSSEGHCIIYFDRGQFCSFSINGKLLAQME--INDSTR-----AIV 2822

  Fly  3168 FSQIREWDQQNVIITGSTDGVVRMW 3192
            .|.    |.|| ::||..:|||.:|
Zfish  2823 LSS----DGQN-LVTGGDNGVVEVW 2842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 25/131 (19%)
Beach 2638..2918 CDD:460459 147/280 (53%)
WD40 2995..>3194 CDD:475233 65/276 (24%)
WD40 repeat 3031..3070 CDD:293791 9/46 (20%)
WD40 repeat 3075..3111 CDD:293791 17/53 (32%)
FYVE_WDFY3 3418..3482 CDD:277259
nbeabXP_073779907.1 None
Blue background indicates that the domain is not in the aligned region.

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