DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bchs and nsmaf

DIOPT Version :9

Sequence 1:	NP_608968.2	Gene:	bchs / 33819	FlyBaseID:	FBgn0043362	Length:	3489	Species:	Drosophila melanogaster
Sequence 2:	XP_003199050.1	Gene:	nsmaf / 550506	ZFINID:	ZDB-GENE-050417-342	Length:	911	Species:	Danio rerio

Alignment Length:	784	Identity:	241/784 - (30%)
Similarity:	358/784 - (45%)	Gaps:	172/784 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  2504 TLLKNREIRDIDTLPPGAYE-----PIIPNSGGTSSTTSRAVSHKLR----QCSKFAYEEIREVH 2559
            |.......:::..||....|     |::.|:|....|........|.    ...:.....:|.::
Zfish   172 TRFDKNSFQNVTELPHMECEAEMVSPLVTNAGHVCITDCNLYFQPLNSYPDSVVQIGLHSVRRIY 236

  Fly  2560 KRRYLLQPIALEVFSED----GRNYLLSFPRKVRNKVNQRFLALATALNDNAQQSVAGQKRTASV 2620
            |||:.|:|:.||||..:    ...||..:..|.|:::   :..:||.|.::.            .
Zfish   237 KRRHGLRPLGLEVFCTENDLCSDIYLKFYKTKDRDEL---YYYIATFLENHV------------A 286

  Fly  2621 EQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDL 2685
            |.||         .|...:|.||.|||:|||:|||.||.||.|||.|||||||:::||.|.:|||
Zfish   287 EHTA---------ESYMLQWQRGHISNYQYLLHLNNLADRSVNDLSQYPVFPWVISDYSSTQLDL 342

  Fly  2686 TNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQ 2750
            .||.:|||.|:|:||..:||||:..:|:::..:|.     :.||:||||...|..||||:.|  :
Zfish   343 LNPASFRDLSKPIGALNKERLERLLERYRDMPEPR-----FMYGSHYSSPGYVLFYLVRVAP--E 400

  Fly  2751 PFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYL-PEFLSNFNNFDLGTKQNGE 2814
            ..|.||.|.||.|||||:||.|.|.:..: ...|.|||||||:.. ..||.|....|||.:|.|.
Zfish   401 HMLCLQNGRFDHADRMFNSIGETWKNCLE-GGTDFKELIPEFYGSDSSFLRNLLGLDLGRRQGGG 464

  Fly  2815 TLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYE 2879
            .:.:|.|||||. ||.:|::....|||..|||:|||.|||||||.||:|..||.:.||||.|.||
Zfish   465 RVENVELPPWAS-DPDDFLQKMCLALESQYVSEHLHEWIDLIFGYKQRGSEAVASHNVFHPLTYE 528

  Fly  2880 GNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKMGGSRHSALIDPTSLIQGNSTVLQT 2944
            |.||..:|:||.:|.|.:..|..|||.|:|||...||.:          |.|.
Zfish   529 GGVDCDSIEDPDQKIAMLTQILEFGQTPRQLFVTPHPQR----------ITPR------------ 571

  Fly  2945 DRLFFHNLDNLKPS-----LQPIKELKGPVGQILQPDKTVFAVEQNKVMMPPSYTKY------IA 2998
                |:|| :..||     |.|:.........:.:..:.:.....||:::...:..:      :|
Zfish   572 ----FYNL-STTPSLSSSELSPVSPCMESFEDLTEESRKMAWSNMNKLVLQSCHKIHKEAVTGVA 631

  Fly  2999 WGFADHSLRIGLYDTDRASFVSEASAQNS---GEILTCAC---PNAKMIVTAGTSSVVTIWKFDA 3057
            ...:..|:.....|:....|..|...|.|   ..:...:|   |:.|::|.:...:.|..:....
Zfish   632 VTLSGDSIFTTSQDSTLKMFSKENGLQRSVSFSNMALSSCLMLPDDKIVVCSSWDNNVYFYSIAY 696

  Fly  3058 NRKSLAVKHSLHGHTDAVT----------------------CLAA-------------------- 3080
            .|:    :.:|.||.|||:                      |:||
Zfish   697 GRR----QDTLMGHDDAVSDICWRDDKLYTASWDSTVKVWECVAADISSNKRTQFDPLAEFEHEA 757

  Fly  3081 -------SAAYNVIVSGSRDGTAIVWDMTRFTFVRQLRGHAGVVAAVSINELTGDIATCSATWLH 3138
                   |.|..::.:|:::||..|||:.....|.||..|:|.:..|:.          |....|
Zfish   758 GVNTLDLSPAGTLLATGTKEGTLTVWDLASPLPVNQLTCHSGKIHQVAF----------SPDSRH 812

  Fly  3139 VWSINGDALAMVNTCVGS--------ADRMQQILCVAFSQIREWDQQNVIITGSTDGVVRMWSLE 3195
            :.|:..|:..|| |.|.:        |::.|:..|        || .|.:::|...|.:.:|:|.
Zfish   813 ILSVGEDSCLMV-TDVQTGMLIATIPAEQEQRCFC--------WD-GNTVLSGGISGDLSVWNLL 867

  Fly  3196 HTQV 3199
            :::|
Zfish   868 NSKV 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	23/108 (21%)
		Beach	2638..2918	CDD:280327	145/280 (52%)
		WD40	<2991..3252	CDD:225201	55/278 (20%)
		WD40	2995..>3194	CDD:295369	53/267 (20%)
		WD40 repeat	3031..3070	CDD:293791	7/41 (17%)
		WD40 repeat	3075..3111	CDD:293791	14/84 (17%)
		FYVE_WDFY3	3418..3482	CDD:277259
nsmaf	XP_003199050.1	PH-like	184..277	CDD:302622	22/95 (23%)
		Beach	296..567	CDD:280327	145/279 (52%)
		WD40	<610..910	CDD:225201	57/286 (20%)
		WD40	620..908	CDD:238121	55/276 (20%)
		WD40 repeat	627..663	CDD:293791	7/35 (20%)
		WD40 repeat	669..705	CDD:293791	7/39 (18%)
		WD40 repeat	710..754	CDD:293791	4/43 (9%)
		WD40 repeat	760..795	CDD:293791	10/34 (29%)
		WD40 repeat	801..837	CDD:293791	9/46 (20%)
		WD40 repeat	883..907	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820