Protein Alignment bchs and nbeaa

DIOPT Version :9

• Sequence 1: NP_608968.2
• Gene: bchs / 33819
• FlyBaseID: FBgn0043362
• Length: 3489
• Species: Drosophila melanogaster
• Sequence 2: NP_001013518.2
• Gene: nbeaa / 541373
• ZFINID: ZDB-GENE-050320-68
• Length: 2998
• Species: Danio rerio
• Alignment Length: 3488
• Identity: 714/3488 - (20%)
• Similarity: 1165/3488 - (33%)
• Gaps: 1180/3488 - (33%)

  Fly    77 EPLSEQERD-DKLYEMLPLFC---------------------------KVFSSCPSNDMSEKFWD 113
            :||:....| ||.|    |:|                           |.|..|...|...:.|.
Zfish   262 DPLNNINVDKDKPY----LYCFRTSKGIGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWY 322

  Fly   114 VVAFCQQVSRLMVSEIRKRASNQSTEAASIAIVKFLEVETTEETSS---GWMLLATLNLLANGDV 175
            :::.....:|...||||...:.|......:|    ..|.|.:....   |....|..|.:..|.:
Zfish   323 MISIVHIYNRWRNSEIRCYVNGQLVSYGDMA----WHVNTNDSYDKCFLGSSETADANRVFCGQL 383

  Fly   176 SLIQVMTAAAVPSTL---------VKCLYLFFDLPIVEDDEPSADGGAVSEFNAHERRTLLQKVF 231
            ..:.|.:.|..|:.:         .|..:.|                 .||.:.|......|.::
Zfish   384 GAVYVFSEALNPAQIFAIHQLGPGYKSTFKF-----------------KSESDIHLAEHHKQVLY 431

  Fly   232 VQLLVKLCSYPYPAEELARMDDLTLLFSAITSPCPIHNIVWRKNAA-------EILTTISRNGLT 289
            ...|....|:.|.    |:..|..|...  :||        |:||:       .::....:..:|
Zfish   432 DGKLASSISFTYN----AKATDAQLCLE--SSP--------RENASIFVHSPHALMLQDVKAIVT 482

  Fly   290 DAVVSYIHSKGCMALCVDNMQRLTFGNPLEI-VEMFV--TVFCFLKDSSQVSQILMDDFRASQGY 351
            .::.|.|||.|.:.:......:|.:..|.:. ||..|  |:..||.:..:.|..:.:.....:|:
Zfish   483 HSIHSAIHSIGGIQVLFPLFSQLDYRQPNDSPVETTVCATLLAFLVELLKSSVAMQEQMLGGKGF 547

  Fly   352 VFLSDFLLKFDNNRSQSLEIQAAIRNLVL--------------MISSLCMCGFYELRPPASQFNT 402
            :.:. :||:    :|..:.|..|:....|              ::..||   .:.|...|...:|
Zfish   548 LVIG-YLLE----KSSRVHITRAVLEQFLSFAKYLDGLTHGAPLLKQLC---DHVLFNAAIWIHT 604

  Fly   403 AFKLQNFQLPQATSRETCVRNVYAFQVLQNVFLKSTTPALCCTILDAISRVYHSENANYFILESE 467
            ..|:|              .::|.:  |...|:.:.|.......:..:.::.|:  ..|:...|.
Zfish   605 PAKVQ--------------LSLYTY--LSAEFIGTATIYSTIRRVGTVLQLMHT--LKYYYWASN 651

  Fly   468 QTLSSFAERIHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKHNQSTSCSILCLKTLLN 532
            ...||......:..|:..:|  :::....|.|.|:  |:||.....:|.::        |:::||
Zfish   652 PLESSGITPKGLDGPRPSQK--EIISLRAFMLLFL--KQLILKDRGVKEDE--------LQSILN 704

  Fly   533 ILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKITKGDESVVVELENESEEELFDTLGKHVLEA 597
            .|                                           |....:|.:.|     ||:.
Zfish   705 YL-------------------------------------------LTMHEDENIHD-----VLQL 721

  Fly   598 LTMLLGGGASNNAQLFREYGGAKCVHELV--KFKHCRPQALGIVRELILSAGGDD--DMLHILSL 658
            |..|:....::....|.:..|.:.:::|:  |.:..|.|||.::...:...|...  :::|..||
Zfish   722 LVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIRVQALKVLGYFLKHLGHKRKVEIMHTHSL 786

  Fly   659 ---------MHSVSPLQVEFKIQILNMLLGCLKDSHRTRTVFRKVGGFVYVTSVFVSLDGSMALP 714
                     ||:.:     ..|...|.|...|.:...|:.|.:                     |
Zfish   787 FTLLGERLMMHTST-----VTITTYNTLYEILTEQVCTQVVHK---------------------P 825

  Fly   715 QPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLG-------CFGGSSA 772
            .|: |...:.:...::.:.:||.::....:|:.  .|:....|.|.::|..       |....|.
Zfish   826 HPE-PDSTVKIQNPMILKVVATLLKSSSPSAEL--MEVRRLFLSDMIKLFSNSRENRRCLLQCSV 887

  Fly   773 LQD------YTGTYEPQQSLLK----------YYHEI---FSG-----DILSVSFSEDVPYPL-- 811
            .||      |.....|::..:.          .||.|   :.|     |.||::.|: |.|..
Zfish   888 WQDWMFSLGYINPKNPEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSK-VTYEAHK 951

  Fly   812 SYVCIVFRLLYSIALDNFEAPNLSGIITL--FSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPR 874
            .|:..::........:|.:......:.|:  .|..||::..              ||     |.|
Zfish   952 EYLAKMYEEYQRQEEENIKKGKKGSVSTISGLSAQPTSVNG--------------NL-----EIR 997

  Fly   875 IVHPGVVLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKLTRR 939
            .:.                |.:..|..:.:|...|...|.:       ::.:..:.|...:.:..
Zfish   998 EID----------------DTSQTQTPESEVDYGENADSRI-------LLAEAKVPESEAESSAA 1039

  Fly   940 ALAEESHPLHVPMQYILERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPLTRIKTL 1004
            .:..|.|.|.|.::       |:.::.||::          ..|:|| .|..|||
Zfish  1040 GVRVEVHDLLVDIK-------AEKVEATEVK----------LDDLDL-SPEVLGG---------- 1076

  Fly  1005 VSMTTPRDFRAHGSSTLPPFVELDMSAEGFGCLYL----PSLAP--QATATAGGTIDANSIGG-I 1062
                       .|.....|.||:|...:...|..:    .||.|  :.:...|.|.|..::|. |
Zfish  1077 -----------GGGMENGPLVEVDSLLDSAYCAAVHKLNGSLVPKEEESVVVGLTEDDGNMGPLI 1130

  Fly  1063 GAGDR----------IFPPQTGLTYSTWFCVEKFSDPKTD-------PHC------VRLLT---- 1100
            ...|.          :||........:....|....|..|       ||.      :.||.
Zfish  1131 TLADEKDSVPSNNGFLFPKVDEKLLPSLASTEPLVLPSPDQPPCSTTPHTSSASDDLSLLAHMTS 1195

  Fly  1101 ----LVRTIHNPREE------NLACLSILLSARDKAIVVSTQETL------VTPRKSIGD----- 1144
                ||:|.....::      :||.:|.|..|..:| ...|.|.|      ....||.||
Zfish  1196 CGSDLVQTPSGLEDDGFKLQSSLADISTLAEAEAQA-AARTAECLEQESGDARAGKSSGDAASTT 1259

  Fly  1145 WEPEGSDDG-------IARIWCPDLLH---EGQWHNLVVVLNRAVLKNSSLFLYLDGVPMHTQKL 1199
            .:.|.||||       |........||   .||..           ::..:.|...|:||..::.
Zfish  1260 SDTERSDDGKDKEMKKIQTTATTQALHGRMSGQME-----------RDLRVDLGFRGMPMTEEQR 1313

  Fly  1200 HYIAQHPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCHLIEDVLTQQTVQTIYQLGPHY 1264
            ...:..|.         |.:|          |.....|......|:.|:|
Zfish  1314 RQFSPGPR---------TTMF----------RIPEFKWSPMHQRLLTDLL--------------- 1344

  Fly  1265 MGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNSHEN 1329
                              ...|..|.:..:....|.:..|                    ||:||
Zfish  1345 ------------------FALESDVHMWRSHSTKSVMDFV--------------------NSNEN 1371

  Fly  1330 ATPIKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDTVGGCNVLLGIIAMAQDVESL 1394
               |..:||:.                         |.:|.|:|.:        |||....:..|
Zfish  1372 ---IIFVHNTI-------------------------HLISQMVDNI--------IIACGGILPLL 1400

  Fly  1395 YAGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKKKKHLLNSHILHLTFGLVGTVNSGQDMSAI 1459
            .|.....:..|.:|....:.     |.|.     ..|...:||        |.|:..:|.: :.:
Zfish  1401 SAATSPSSSKVSANPTQGSS-----CLQK-----GAKSSEVNS--------LPGSSGTGVE-TEL 1446

  Fly  1460 PNVTAFQDLLCDLEIWHNAPNGLLRSLLEHLLELV-------------VESSDKKQNVKIMRDLQ 1511
            .||.|.|.:..:..:          :.|..|:.:|             :|:.....:..:||...
Zfish  1447 ENVEATQGMSSETAV----------TFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCL 1501

  Fly  1512 LLVKLLHI---------------ITQIQDHSTREIL---FSLLETLLGGQPRHTDLLLFGQYVAA 1558
            .||..:.:               .|.:....|:|.|   .|..:|::...||:.
Zfish  1502 RLVCCVAVRNCLECRQRQRDRGSKTSLPISKTQENLQTAASASKTVIQNVPRNL----------- 1555

  Fly  1559 KLPHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISK 1623
                                :|.:|.| .:.|::.:                |.:..|:..|:..
Zfish  1556 --------------------SPIKDPD-RLLQDVDI----------------NRLRAVVFRDVDD 1583

  Fly  1624 TLGMDWLLLFMQPHVHFTTVIIAVRILVVICANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLG 1688
            :....:|.|.:   |:|.:|::              :.::||.......:..:..:|.|.:
Zfish  1584 SKQAQFLALAV---VYFISVLM--------------VSKYRDILEPQREIGRSSSLSGRSI---- 1627

  Fly  1689 AQQLNQRPTNGTGTVIVA----------TP------QNTIQHLPTQIAGEVRAAALNIPGFQLLE 1737
            .|::|. ||:.....:.:          ||      :.::.|..:.|..|....|||  |..|
Zfish  1628 RQEINS-PTSTENPSLFSDGVRGERQAMTPLEDLPLEASLPHTDSGIGEEQVTGALN--GSDL-- 1687

  Fly  1738 WLMNHHLDVPELYFLITALIMGQPVKVLATEHTKFDLDRVWSFLWGAPVSANTQLPKLNICPEGV 1802
             ..:||          :.|:.|.                      |.| .|.::|         :
Zfish  1688 -GTDHH----------SGLVGGS----------------------GGP-DAMSEL---------L 1709

  Fly  1803 CVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQNLTDFAPVMMTGDVVTSLVAVLFPLASRP 1867
            |.|.:.||             ...|::::            :|:.         |.||.|.||..
Zfish  1710 CTLSSEVR-------------KSSESLLE------------SPLG---------VEVLKPAASIS 1740

  Fly  1868 ADSEPNSG----------ASTPTDDTGSSFALPPPETLHGAPQPKLTAHPVCNCIIDFL---RVI 1919
            :.|:.|.|          .:.|.:   .:.|.|.|:..|  |.|.|.........:.|.   |.:
Zfish  1741 SISQANKGINVKEILKSLVAAPVE---GAEAGPEPQPYH--PDPALKREAAAMLPMQFHSFDRSV 1800

  Fly  1920 VV-------DSLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQ 1977
            ||       .||.:|..|.||.      .|.|.|...|......|....::::...|.|......
Zfish  1801 VVPVKKPPPGSLAVNTVGTPTS------GAVPSSGSTPNIFAAATATPKSMINTTGATDSASSSS 1859

  Fly  1978 AA------------LPLVPLLQSQMQYIAP----NVFYLTARI-VDKLWQGCLAR---NPHDIFD 2022
            ::            ||.|       |.:||    .|..::|.. ||:    |..|   .|.::..
Zfish  1860 SSSSSFVNGATSKNLPAV-------QTVAPMPEDTVENMSAFCEVDQ----CPLRTRLTPPELKS 1913

  Fly  2023 FVIKLIVQAKRRSSSLSLEHLHHSLNRSILFLLSRPTDDSRADQMSVLEALHKIIQHRLLIFGAG 2087
            |......|...|.:...|         ||...|.|              ||.|:
Zfish  1914 FSSLTGFQTAPRDAGQFL---------SITTKLER--------------ALEKV----------- 1944

  Fly  2088 NHELEFIGCLTYCLLQLTADMKIILEPATSRNTTWHVNPQTETAEPKDEDLNQLQGRNLIV-GAA 2151
                          ..|..::.:...|..||.                  |....|:.|:: |..
Zfish  1945 --------------APLLREIFVDFAPFLSRT------------------LLGSHGQELLIEGTG 1977

  Fly  2152 FRVWEELYVCKKPAIEEVFKVSLTSPPPNSKAPDLQTTREQVMELASKLWFNYVEAERKATYRAP 2216
            .       ||.|.:...|                     |.||.|.|:.|.|.::......:
Zfish  1978 L-------VCMKSSTSVV---------------------ELVMLLCSQEWQNSIQKNAGLAF--- 2011

  Fly  2217 WELHTQIQSKIQKVTGGLSRLTSRTKTKKEELVRTRS----TLTREAAYESTGIHVQLIKDLLDL 2277
                      |:.:..|  ||...  ..|:.:||..:    .|.|:.| |....|.:...:....
Zfish  2012 ----------IELINEG--RLLCH--AMKDHIVRVANEAEFILNRQRA-EDVHKHAEFESNCAQY 2061

  Fly  2278 RA--KQYQQMLQH-TQRYVYQDWVQSEM-------ELTRERGLWGPTGSCSL-DKWILDTTEGPH 2331
            .|  ::.::|..| .....::|.|.:..       .||.:.|.||......| |.|.||..|...
Zfish  2062 AADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGTMSQSQLHDFWRLDYWEDDL 2126

  Fly  2332 RMRKKTMRNDVFYLH--------YPYRPELELADNRQLKYKVASSLDSKTYALHGPQQPRILAEA 2388
            |.|::.:||.....|        ..|.||    :...:|.|  .|..|.:.....|:...:|  .
Zfish  2127 RRRRRFVRNAFGSTHTDVTLKSLEEYGPE----EEEGMKSK--KSFRSHSVVSQNPETELML--E 2183

  Fly  2389 GEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTS 2453
            |:..|:   |.|:..:...|......|||..:|.|.:|..|:.......:.....|||
Zfish  2184 GDDDAV---SLLQEKEIDNLAGPVVLSTPAQLVAPVIVARGTLSITTTEIYFEVDEDD------- 2238

  Fly  2454 MTSDNETFLRLLEEQEKISFMFRCARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLP 2518
                 .||       :||.     |:|.|..  |||
Zfish  2239 -----PTF-------KKID-----AKVLGYT--EGL----------------------------- 2255

  Fly  2519 PGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLS 2583
                                   |     .|:.:.|||.|..||||||...||||..:..:.:.:
Zfish  2256 -----------------------H-----GKWMFSEIRAVFSRRYLLQNTGLEVFMANRTSVMFN 2292

  Fly  2584 FP-----RKVRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRG 2643
            ||     :||...:.:..:..:..|....:.|:|..::             |...:::||||.|.
Zfish  2293 FPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQ-------------LFKSSNMTQRWQRR 2344

  Fly  2644 EISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQ 2708
            |||||:|||.|||:|||:||||.|||||||:|.:|:||:||||.|..|||.|:|:||...:|...
Zfish  2345 EISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEDLDLTLPGNFRDLSKPIGALNPKRAVF 2409

  Fly  2709 FQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEA 2773
            :.:|::.|:|  ....|:||.:.||:|.....:|||:|||:..||......||..||.|..|..:
Zfish  2410 YAERYETWED--DGAAPHHYSSLYSTAASTLYWLVRIEPFTTFFLNCNENKFDHPDRTFSGIARS 2472

  Fly  2774 WLSASKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQNGETLNHVILPPWAKHDPREFIRLHRS 2838
            |.|..: :.:||:||||||:||||...|.:.:|||.:::...:..|.||.||| .|.:|:|::|.
Zfish  2473 WRSCQR-DTSDVRELIPEFYYLPEMFVNSSGYDLGVREDRTAVCDVELPVWAK-KPEDFVRINRM 2535

  Fly  2839 ALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNF 2903
            |||.::||..||.|||||||.||:||.||.|:||||:|.|||::::..|.||..:.:....|.:|
Zfish  2536 ALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLSYEGSINLDTITDPQLRESMEAQIQSF 2600

  Fly  2904 GQIPKQLFKKAHPAKKMGGSRHSALIDPTSLI---------------QGNSTV------------ 2941
            ||.|.||..:.||.:  ..:.|...:..:.|:               ..||.|
Zfish  2601 GQAPSQLLIEPHPPR--SSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLS 2663

  Fly  2942 ------LQTDRLF----FHNLDNLKP----SLQ-----PI--------------KELKGPVGQIL 2973
                  :...|||    :||...|:.    ||:     ||              :::...|.|.:
Zfish  2664 IPAAVTVTCSRLFAVNRWHNTVGLRGAPGYSLEQAHHLPIEMDSLIANNSGISKRQITDLVDQSI 2728

  Fly  2974 QPDKTVFAVEQNKVMMPPSYTKYI-AWGFADHSLRIGLYDTDRASFVSEASAQNSGEILTCACPN 3037
            |.:...|.|..:        .:|| |.||.|.|.|:  |.|:...........  .:::||...:
Zfish  2729 QINTHCFVVTAD--------NRYILACGFWDKSFRV--YSTETGKLTQIVFGH--WDVVTCLARS 2781

  Fly  3038 AK------MIVTAGTSSVVTIWKFDA----------NRKSLAVKHSLHGHTDAVTCLAASAAYNV 3086
            ..      .||:....:.:.:|.:..          |....|.:..|.||...|.|::..|...:
Zfish  2782 ESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNNSDYPAPRAVLTGHDHEVVCVSVCAELGL 2846

  Fly  3087 IVSGSRDGTAIVWDMTRFTFVRQLRGHAGVV--AAVSINELTGDIATCSATWLHVWSINGDALAM 3149
            ::||:::|..:|..:|. ..:|.|.|....:  ..:|::.....|..........:||||..||.
Zfish  2847 VISGAKEGPCLVHTITG-DLLRALEGPENCLRPRLISVSSEGHCIIYYERGQFCNFSINGKLLAQ 2910

  Fly  3150 VNTCVGSADRMQQILCVAFSQIREWDQQNVIITGSTDGVVRMW 3192
            :..    .|..:.||..:       |.|| ::||..:|||.:|
Zfish  2911 MEI----NDSTRAILLSS-------DGQN-LVTGGDNGVVEVW 2941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	28/135 (21%)
		Beach	2638..2918	CDD:280327	138/279 (49%)
		WD40	<2991..3252	CDD:225201	51/221 (23%)
		WD40	2995..>3194	CDD:295369	51/217 (24%)
		WD40 repeat	3031..3070	CDD:293791	8/54 (15%)
		WD40 repeat	3075..3111	CDD:293791	9/35 (26%)
		FYVE_WDFY3	3418..3482	CDD:277259
nbeaa	NP_001013518.2	LamG	251..398	CDD:304605	29/143 (20%)
		DUF4704	468..739	CDD:292415	59/356 (17%)
		DUF1088	2017..2184	CDD:284000	41/179 (23%)
		PH_BEACH	2210..2307	CDD:291510	37/179 (21%)
		Beach	2339..2615	CDD:280327	138/279 (49%)
		WD40	<2687..2986	CDD:225201	61/280 (22%)
		WD40	2729..2986	CDD:295369	54/238 (23%)
		WD40 repeat	2776..2830	CDD:293791	8/53 (15%)
		WD40 repeat	2835..2870	CDD:293791	9/35 (26%)
		WD40 repeat	2875..2904	CDD:293791	3/28 (11%)
		WD40 repeat	2913..2951	CDD:293791	12/41 (29%)
		WD40 repeat	2959..2985	CDD:293791

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910