Protein Alignment bchs and CG43367

DIOPT Version :10

• Sequence 1: NP_608968.2
• Gene: bchs / 33819
• FlyBaseID: FBgn0043362
• Length: 3489
• Species: Drosophila melanogaster
• Sequence 2: NP_001189048.2
• Gene: CG43367 / 38505
• FlyBaseID: FBgn0263110
• Length: 2754
• Species: Drosophila melanogaster
• Alignment Length: 3281
• Identity: 733/3281 - (22%)
• Similarity: 1186/3281 - (36%)
• Gaps: 1054/3281 - (32%)

  Fly   231 FVQLLVKLCSYPYPAEELARMDDLTLLFSAITSPC-PIHNIV------WRKNAAEILTTISRNGL 288
            |:.:...:|......||.| ::::.:|...:...| ...||:      ::.|...||:.:.:..:
  Fly    75 FIIVARDVCETEGKLEEQA-IEEVAILVDCLVIVCRHFDNILSIIKYEYKPNLIAILSRVFKQQM 138

  Fly   289 ----TDAVVSYIHSKGCMALCVDNMQRLTFGNPLEIV-EMFVTVFCFLK-DSSQVSQILMDDFRA 347
                :...:|::.|              :|...||:: :.::|...|:: .|:..|::   .::.
  Fly   139 ELPQSVPAISHLFS--------------SFSAFLEVMYDPYLTWRSFVRGQSADYSRL---SYKP 186

  Fly   348 SQGYVFLSDFLLKFDNNRSQSLEIQAAIRNLVLMISSLCMCGFYELRPPASQFNTAFKLQNFQLP 412
            ...:|.:..|:  :|..:.:.|...|.|...:|.|....:||...........|:...|.|
  Fly   187 HSVHVEIVPFI--YDCFQEEKLIRYAEIGESLLNILGAVICGSQLQLKVQKSLNSTSTLTN---- 245

  Fly   413 QATSRETCVRNVYAFQ-----------VLQNVFLKSTTPALC-CTILDAISRVYHSENANYFILE 465
                     ||..|..           :|....|::...|:| .|:...:|.:...|:||.....
  Fly   246 ---------RNTNALTTSSLAPCSGDGLLDCDNLRNGMKAICPATVSITMSILRQWESANNLRRV 301

  Fly   466 SEQTLSSFAERIHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKHNQSTSCSILCLKTL 530
            :.|..:.....:...||  :|:..||:..:  ||.....:||    |..||..|...:.
  Fly   302 ALQCYALMVIVLQKSSP--EERQIDLVTLV--QLYCDALQEL----LATKHFDSGDANF------ 352

  Fly   531 LNILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKITKGDESVVVELENESEEELFDTLGK--- 592
                   .:..|..::|.   |.:..|:...|.|:....||..|...:.:.:..||...|.|
  Fly   353 -------DITSDADQDVA---IDMAALSSTVAAVKFFVTGDAGVSEAVSDSNLLELLTNLPKLIK 407

  Fly   593 --HV---------LEALTMLLGGGASNNAQL------------FREYGGAKCVHELVKFKHCRPQ 634
              |:         :|||.:|......:.:||            .:|||....
  Fly   408 PWHISHSSSLCSTMEALAILARHSPQSASQLRQGERIERLFTSLQEYGSPTV------------- 459

  Fly   635 ALGIVRELILSAG--GDDDMLH-------ILSLMHSVSPLQVEFKIQILNMLL-GCLKDSHRTRT 689
                  ||:.:..  |.|:..|       :|.|::.|..||...::.:.:::| || .|::||:|
  Fly   460 ------ELLDTCFMLGYDESEHFLLLPEVMLRLLNWVPTLQEREQLHVTSLVLKGC-TDNYRTKT 517

  Fly   690 VFRKVGGFVYVTSVFVSLDGSMALPQPDIPQQDLILL-------------LQIVFQTLATAMRFE 741
            |   ..|...:.:|...|..:.:|.:..:  |:||.|             |:.:|..|....:|
  Fly   518 V---ACGSHIIKAVCGCLLTAESLAENCV--QNLIKLIEELSKLSIVPAELKCIFSLLRQGTKF- 576

  Fly   742 PANAKFFHQEISSSSLCDTLRLLGCFGGSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSED 806
             ...|...|.:...:| .:||      ||::..::....:|...:|       ..||.:.:.|..
  Fly   577 -PQFKQLQQTLVVIAL-QSLR------GSNSCAEFFSIEQPTDGIL-------VPDIRNWTISGS 626

  Fly   807 VPYPLSYVCIVF----------RLLYSI------ALDNFEAPNLSGIIT-------LFSDPPT-T 847
            ..: :.::.:.|          |:|.::      ..:.|..||.:.::.       |.|...| |
  Fly   627 YGF-IFHILVRFNQLKEQSNSRRMLLTLQTASGSGFEVFVQPNGNVVVAALTRREYLTSSTATKT 690

  Fly   848 LRSP-----SKELAPPVHP---SQLNL-------TQPSPEPRIVHPGVVLCMLQLLPAVEYDMAP 897
            |...     :..:.||..|   ||:|:       ...:.:.:.|:....:|.:..:      :||
  Fly   691 LMDGQWHYLTVAITPPKRPFSYSQINIYVDFVQKLSATLKVQAVNEPFTVCSIGAV------VAP 749

  Fly   898 LQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKLTRRAL-AEESHPLHVPMQYILERLAA 961
            .|.       .|:.|:......:.|.....|....|..|..|.| |..|:...:||:      ..
  Fly   750 PQP-------GEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVSNYFTLPMR------TQ 801

  Fly   962 QALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPV-------PLTRIKTLVSMTTPRDFRAHGSS 1019
            .|..| .::.|     |:...|....:...|.|.:       |.|.:||:.      |..|:.||
  Fly   802 TAFDP-NVKNF-----PIGMQDTVFGEQTCLNGHLGGVLLADPTTSLKTIF------DAGANFSS 854

  Fly  1020 TLPPFVELDMSAEGFGCLYLPSLAPQATA----TAG---GTIDA------------NSIGGIGAG 1065
            ......:|......|...|.|......|.    ..|   |.|:|            ||||||.|
  Fly   855 IFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINAQHCKIVKIQETINSIGGISA- 918

  Fly  1066 DRIFPPQTGLTYSTWFCVEKFSDPKTDPHCVRLLTLVRT----IHNPREENLACLSILLSARDKA 1126
                                     ..|...||:||.:|    |.:..||:|:|          |
  Fly   919 -------------------------ILPMLHRLITLDQTTDISIGSVSEESLSC----------A 948

  Fly  1127 IVVSTQETLVTPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWHNLVVVLNRAVLKNSSLFLYLDG 1191
            ...|.:|        ..|||...|:.            ..:|..|...|        :.||.|
  Fly   949 PTPSAEE--------FTDWEMLSSNS------------YTEWKMLQHPL--------ASFLCL-- 983

  Fly  1192 VPMHTQKLHYIAQHPAAGNASLTSPTQIFGYIGT-----PPIWRRYSRLCWKQGVCHLIEDVLTQ 1251
                   |.|:..........|.| ::....:||     ||.....:.|.    ..||:.:.|..
  Fly   984 -------LRYLTHEHETNQEQLLS-SECLAIVGTMLQRCPPSLFDVNALM----ATHLLMESLQG 1036

  Fly  1252 QTVQTIYQLGPHYMGSLQAP---------------QLGKQSESLAPLVPEDRVLLGLNAKAVSKL 1301
            ...:.    |...:.:|.|.               .|| .::.|:.::..||..  ...:...:.
  Fly  1037 HKAEA----GGQLLDALYAHIVFDFAIWSRLQFQITLG-HAQYLSAMIKNDRKF--FRKRYGVQF 1094

  Fly  1302 TLVKIRKVYSRADNKSIAKQLNMNSHENATPIKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPH 1366
            .|..:|:.||..|  ||       |.::|..|:             .:|.|::..||...| :..
  Fly  1095 VLDVVRQYYSTPD--SI-------SDDDAKTIR-------------ATLFGIIKFYLQKDV-NIK 1136

  Fly  1367 PVSAMIDTVGGCNVLLGIIAMAQDVESLYAGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKKK 1431
            .|::||..         :.::.||| .|...::.:|..||.          |.|         |.
  Fly  1137 EVNSMITF---------LASVRQDV-VLVEFLEMMTFYVRG----------KNC---------KD 1172

  Fly  1432 KHLLNSHILHLTFGLVGTVNSGQDMSAIPNVTAFQDLLCDLEIWHNAPNGLLRSLLEHLLELVVE 1496
            :.:|   :||            :..||        :||.:..:..:..|.:..:.:..:..|:..
  Fly  1173 QMVL---LLH------------EPQSA--------NLLYNFFVDKSYSNEIQEAAIRFISGLLAT 1214

  Fly  1497 SSDKKQNVKIMR------DLQLLVKLLHIITQIQDHSTREILFSLLETLLGGQPRHTDLLLFGQY 1555
            |...::..:::|      :..:.......||.:...||  |||.|::.:||.||.:..|:....:
  Fly  1215 SRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSST--ILFHLVDEMLGLQPDYAGLIFLVYH 1277

  Fly  1556 VAA-KLPHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICD 1619
            |:: .||          |.|...|.                     ||.......::||
  Fly  1278 VSSCDLP----------VKLEIAKR---------------------LLQTTFVKQQSTV------ 1305

  Fly  1620 DISKTLGMDW-----LLLFMQPHVHFTTV--------IIAVRILVVICANESFLVRFRDATHNGG 1671
            .::|..|  |     .||..:|   .|:.        ...:.:.|::..|.:||.:       ..
  Fly  1306 AMAKQTG--WQESIARLLIRKP---ITSSPPDEEKRRSFGINLDVLLEDNSNFLAQ-------AD 1358

  Fly  1672 YLRFTEMVSQRKMLGLG-AQQLNQRPTNGTGTVIVATPQNTIQHLPTQIAGEVRAAALNIPGFQL 1735
            .:.|:|     :.:||. .||..|...:.:|.::     |.||...|:
  Fly  1359 LITFSE-----QEIGLAQLQQQQQEELSDSGLIL-----NEIQASVTE----------------- 1396

  Fly  1736 LEWLMNHHLDVPELYFLITALIMGQPVKVLATEHTKFDLDRVWSFLWGAPV-SANTQLPKLNICP 1799
                              .|.::...:|.||..            :.||.| :||:
  Fly  1397 ------------------AATVIESEIKELAES------------VSGAVVENANS--------- 1422

  Fly  1800 EGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQNLTDFAPVMMTGDVVTSLVAVLFPLA 1864
                 |.:::|...|.                 |...:::||
  Fly  1423 -----LFSVIRQTTHD-----------------LQDTFESLT----------------------- 1442

  Fly  1865 SRPADSEPNSGASTPTDDTGSSFALPPPETL---------HGAPQPKLTAHPVCNCIIDFLRVIV 1920
                     .|:||.|.|...:.::...|:|         ||.|:..
  Fly  1443 ---------QGSSTDTADGSQTPSIQREESLSSDTSSQSPHGPPKKS------------------ 1480

  Fly  1921 VDSLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVPL 1985
             |||      :.|...|.|.|...::.|
  Fly  1481 -DSL------ESTSAFDFVADGDVDTEE------------------------------------- 1501

  Fly  1986 LQSQMQYIAPN-VFYLTARIV----DKLWQ------GC---LARNPHDIFDF------VIKLIVQ 2030
               |:.|:..| :|.:..|.:    .:.||      ||   ||.|...|...      ::::.||
  Fly  1502 ---QLVYLVSNTLFNIFWRGIPNDHPQCWQERGQVLGCINLLALNNELITSHLSLRLRILEMAVQ 1563

  Fly  2031 A------KRRSSSL-SLEHLHHSLNRSI--LFLLSRPTDDSRADQMSVLEALHKIIQHRLLIFGA 2086
            |      :..|.:| :.|:..|.| |.:  |.:|....|:|:.....:|:.:..::. .|:||..
  Fly  1564 ASLFDLSEHGSQTLVNQENASHIL-RMVYELVVLGSNEDESKKCSTKLLDGVLALLD-ALMIFQQ 1626

  Fly  2087 GNHELEFIGCLTYCLLQLTADMKI-------ILEPATSRNTTWHVNPQTETAEPKDEDLNQLQGR 2144
            |:.: ::...:..||..|   :|.       |:..||::   .|...|:.:.|...|....|...
  Fly  1627 GSSD-DWSDMIRLCLGLL---LKCSHHPNPGIVAMATAK---LHAILQSRSTEDPAELSYLLYSI 1684

  Fly  2145 NLIVGAAFRVWE-ELYVCKKPAIEEVFKVSLTSPPPNSKAPDLQTT-------REQVMELASKLW 2201
            |..:..|..|.. |.|....|.::.:.:....:...:|..|||.:|       .:..|...||.|
  Fly  1685 NRALDNAIEVGNPEEYSFLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKW 1749

  Fly  2202 FNYVEAERKATYRA--------PWELHTQIQSKIQKVTGGLSRLTSRTKTKKEELVRTRSTLTRE 2258
            .|::|...|..|..        .||...:..::..:.....|:..:..:.:...|.:.:..:..:
  Fly  1750 RNFIERMVKPLYDRYQRDIELHLWEPINRFWAECYEACKAASKQRATNQAENRRLFQQKIYMPWK 1814

  Fly  2259 AAYESTGIHVQLIKDLLDLRAKQYQQMLQH--TQRYVYQDWVQSEMELTRERGLWGPTGSCSLDK 2321
                     |:.::::..|:|    ..|||  ...::.:.|..::..|...||.| .||....:.
  Fly  1815 ---------VRQVEEMQRLQA----AALQHKTIDSHIRKRWKTAKRFLYGPRGPW-YTGEVDEEF 1865

  Fly  2322 WILDTTEGPHRMRKKTMRNDVFYLHYPYRPE--LELADNRQLKYKVASSLDSKTYALHGPQQPRI 2384
            |.|...|...|||.|....     .||.:.|  ..|.||      ..|:.|:|
  Fly  1866 WKLSQHENVARMRLKLEPQ-----LYPNKHENAANLRDN------ATSAYDTK------------ 1907

  Fly  2385 LAEAGEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEE 2449
                                    |.|...||....|:...:.                 |||..
  Fly  1908 ------------------------EISEFDSTIKNAVVRDFLA-----------------DDESS 1931

  Fly  2450 EDTSMTSDNETFLRLLEEQEKISFMFRCARVQGLDT-------FEGLLLFGKEHCYIVDGFTLLK 2507
            :              |||:.:          |.:||       .|.|::  .:.|.::...|.:|
  Fly  1932 Q--------------LEEELR----------QLIDTQAQQDVALEKLVM--SQDCELITLMTKVK 1970

  Fly  2508 NR-EIRD-----IDTLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLLQ 2566
            .| |:..     :|..||                |.....:..|    |:..:|||||.|:|.|:
  Fly  1971 GRIEVNQSVFTFVDLSPP----------------TEDGSKYDFR----FSTNKIREVHLRKYNLR 2015

  Fly  2567 PIALEVFSEDGRNYLLSFPRKVRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLI 2631
            ..|||:|..|..:|.|:|..|.||||..:.:.|.      ....:.|..|:.         :.|:
  Fly  2016 RSALEIFLVDQTSYFLNFTTKTRNKVFTKIVGLP------LPNILYGSGRSP---------AELL 2065

  Fly  2632 GETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSR 2696
            ..:.:||||:..|||||:|||:|||:||||||||.||||||||||||.|:.||||:||:|||.|:
  Fly  2066 RASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSK 2130

  Fly  2697 PMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFD 2761
            |:|....:...:.:.::..::||.|..|.:|||||||::..|..||:|:|||:...:.||.|.||
  Fly  2131 PIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFD 2195

  Fly  2762 LADRMFHSIKEAWLSASKL---NMADVKELIPEFFYLPEFLSNFNNFDLGTKQ-NGETLNHVILP 2822
            :|||.||||.:.|    ||   |..|||||||||||.||||.|.|.||||..| ..|.::.||||
  Fly  2196 VADRQFHSIPQTW----KLLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILP 2256

  Fly  2823 PWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNI 2887
            .||. .|.|||.:||.|||.:|||||||.|||||||.||:||.|.:|:|||::..|||.||:..|
  Fly  2257 AWAT-TPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKI 2320

  Fly  2888 DDPLKKNATIGFINNFGQIPKQLFKKAHPAKKMGGSRHSALI----------------------- 2929
            .:|:::.|..|.||||||:|.||.::.||.:.........|:
  Fly  2321 TNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVVQYYCEL 2385

  Fly  2930 ---------------DPTSLIQ---------GNSTVL--------QTDRLFFHNLDNLKPSLQPI 2962
                           .|.|.:|         ..||:|        ..|:.|...:|....:|:..
  Fly  2386 STPKDPIVYLSPPRSPPRSFLQLSPDVLVSISKSTILGCNSWLSFDKDQGFLLEIDATTANLKNR 2450

  Fly  2963 KELKGPVGQILQPDKTVFAVEQNKVMMPPSYTKYIAWGFADHSLRIGLYDTDRASFVSEASAQNS 3027
            |.:.||.....||...:|||..:..::       .|.|..|:|||:  |:.::...|  ||....
  Fly  2451 KRIFGPFHSSQQPHSQLFAVSTDGKLL-------YAGGIWDNSLRV--YNLNKGKAV--ASVTRH 2504

  Fly  3028 GEILTC-ACPN-AKMIVTAGTSSVVTIWKFDANRK-----------------------SLAVKHS 3067
            .:|:|| |..| ...:||........:|....|::                       .|..::|
  Fly  2505 LDIITCIALDNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAITQLNTQNS 2569

  Fly  3068 --------LHGHTDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQLRGHAGVVAAVSINE 3124
                    |:||.||::.:|.....:::||||.|||..|:.:....|||.|:......:.|.|:.
  Fly  2570 YSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQISF 2634

  Fly  3125 LT----GDIATC----SATWLHVWSINGDAL 3147
            :|    |.||..    ::..:||:||||.:|
  Fly  2635 VTLSYHGHIAFSALDDTSHSVHVYSINGCSL 2665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	37/143 (26%)
		Beach	2638..2918	CDD:460459	162/283 (57%)
		WD40	2995..>3194	CDD:475233	52/194 (27%)
		WD40 repeat	3031..3070	CDD:293791	11/71 (15%)
		WD40 repeat	3075..3111	CDD:293791	12/35 (34%)
		FYVE_WDFY3	3418..3482	CDD:277259
CG43367	NP_001189048.2	Laminin_G_3	644..752	CDD:463865	20/113 (18%)
		DUF4704	906..>1162	CDD:464870	73/373 (20%)
		DUF4800	1646..1899	CDD:464996	55/274 (20%)
		PH_BEACH	1952..2046	CDD:275391	34/115 (30%)
		Beach	2072..2351	CDD:460459	162/283 (57%)
		NBCH_WD40	2395..2742	CDD:466575	70/282 (25%)
		WD40 repeat	2465..2503	CDD:293791	13/48 (27%)
		WD40 repeat	2509..2580	CDD:293791	11/70 (16%)
		WD40 repeat	2585..2621	CDD:293791	12/35 (34%)