DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bchs and Nbeal2

DIOPT Version :9

Sequence 1:	NP_608968.2	Gene:	bchs / 33819	FlyBaseID:	FBgn0043362	Length:	3489	Species:	Drosophila melanogaster
Sequence 2:	XP_003750638.1	Gene:	Nbeal2 / 316014	RGDID:	1306501	Length:	2752	Species:	Rattus norvegicus

Alignment Length:	3321	Identity:	737/3321 - (22%)
Similarity:	1157/3321 - (34%)	Gaps:	1097/3321 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 ILESEQTLSSFAER----------------IHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLS 511
            :.|...:|||...|                :|:.:.|:.:   |.||           :.|:.|.
  Rat    33 VFEKTISLSSLEPRRPEEAGAEVPLLPLDALHVLAEQLDQ---DNLE-----------QALLLLK 83

  Fly   512 LLLKHNQSTSCSILCLKTLLNILRHNAVFKDVYREVGILEIFV----GCLTRYAAHVQKITKGDE 572
            |.:         ||| :.|.|:            |.|..::.|    ..||...|.::......|
  Rat    84 LFI---------ILC-RNLENV------------EAGWGQVLVPRVLALLTGLMAELKGSPPSQE 126

  Fly   573 SVVVELENESEEELFDTLGKHVLEALTMLLGGGASNNAQLFREYGGAKCVHELVKFKHCRPQAL- 636
            ....:|||.:            |.||  ||..|..:..|.:|.....:.:....|.|:..|.|.
  Rat   127 DRSTQLENVA------------LHAL--LLCEGLFDPYQTWRRQHSGEAISSKEKSKYKFPPAAL 177

  Fly   637 -----GIVRELILSAGGDDDMLH-----ILSLMHSVSPL--------QVEFKIQILNMLLGCLK- 682
                 ...:|.:      .|..|     :|.|:|....:        |:......:..|||.|:
  Rat   178 PCEFGAFFQESL------QDAEHLPPTLLLRLIHLFGAVLAGGKENGQMAVSSGSVQGLLGVLRG 236

  Fly   683 -------DSHRTRTVFRKVGGFVYVTSVFVSLDGSMALPQPDIPQQDLILLLQIVFQTLATAMRF 740
                   |.|:.:...|.:.|.|:|      |..|.|.|:    ..:|..||:..|..|......
  Rat   237 WGRGPAQDPHKMQLALRALVGAVHV------LHASRAPPR----GPELRTLLEGYFHILNADWPA 291

  Fly   741 EPANAKFFHQEISSSSLCDTLRLLGCFGGSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSE 805
            .|:::                                    |:::|:          .|.||..:
  Rat   292 SPSSS------------------------------------PEEALV----------ALRVSMLD 310

  Fly   806 DVPYPLSYVCIVFRLLYSIALDN--FEAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLN--- 865
            .:|..|:  |....:|.:..|.|  ||     .:|.|..:....|::    .|||...|.|.
  Rat   311 AIPMMLA--CEDRPVLQATFLSNNCFE-----HLIRLIQNSKLYLQA----RAPPEGDSDLATRL 364

  Fly   866 LTQPSPEPRI--------VH-PGVVLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQ 921
            ||:|..:..:        || ..|:.|::...|:.:                |:.|..:..:..|
  Rat   365 LTEPDVQKVLDQDTDAIAVHVVRVLTCIMSGSPSAK----------------EVFKERIGYQHLQ 413

  Fly   922 QIMCDHG-----LAEKLLKLTRRALAEESHPLHVP------------MQYILERLAAQALQPTEL 969
            :::..||     |.::||.:.    .|..|.:|.|            .|::      .||...||
  Rat   414 EVLQSHGPPTHRLLQELLNMA----VEGDHSMHPPPPIRNEQPVLVLTQWL------PALPTAEL 468

  Fly   970 RQFLRLGEPLSCADIDLQQPYKLGGPVPLTR------------IKTLVSMTTPRD---------F 1013
            |.||            .|:.:.|....|.:|            ::||.:.|....         .
  Rat   469 RLFL------------AQRLWWLCDSCPASRATCVQAGLVSYLLETLNTGTALGARCQEQLFALL 521

  Fly  1014 RAHGSSTLPPFVEL--------DMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIG------- 1063
            :|.|..:|.| :||        .:.:|..|      ...|....||..|.|  :.|:.
  Rat   522 QALGRVSLRP-LELRRLLRPPPGLDSESCG------TESQKAQHAGAIIRA--LSGMARHRGPAR 577

  Fly  1064 -----------AGDRIFP----PQTGLTYSTWFCVEK-----FSDPKTDPHCVRLLTLVRTIHNP 1108
                       ||..:.|    |..|.|:..|.|::.     .|.|.......:|.:...:..:.
  Rat   578 ALRYFDLTPSMAGIMVPPVQRWPGPGFTFHAWLCLQSTEAAPTSAPSRPLQRKQLYSFFTSSGSG 642

  Fly  1109 REENLACLSILLSARDKAIVVSTQE---TLVTPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWHN 1170
            .|      :...:|....:.|.|::   ||..|..|..|                     ..||:
  Rat   643 FE------AFFTAAGTLVVAVCTRKEYMTLSLPEVSFAD---------------------SAWHS 680

  Fly  1171 LVV--VLNRAVLKNSSLFLYLDGVPMHTQKLHYIA-QHP-------AAGNASLTSPTQI------ 1219
            :.:  |..|.....:.:.::.||..:.|..|.:.: ..|       :||:.:.|:.|.:
  Rat   681 VAIVHVPGRRPFSQNLVNVFKDGHLVKTAPLRFPSLSEPFSSCCIGSAGHRTTTTTTGLPVSSVS 745

  Fly  1220 ---------------------FGY---IGTPP---------------IWRRYSRLCWKQGVCHLI 1245
                                 .|:   :|.||               .|...:.|..:.|...:.
  Rat   746 TALSHTHPSLTRSQSVPASTGLGWGPGLGAPPQEGSISSTLAGTQDTRWGSPTSLEGELGTVAIF 810

  Fly  1246 EDVLTQQTVQTIYQLGPHYMGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVY 1310
            .:.|....::.:..|||:               ..||..||.. |..|.||.:..         |
  Rat   811 HEALQASALRILCILGPN---------------EPAPFKPEGE-LHELGAKLLLH---------Y 850

  Fly  1311 S-RADNKSIAKQLNMNSHENATPIKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDT 1374
            | :|...:|...|                |.||      .|.|.:.|:   || ....|..:::.
  Rat   851 SPQACKNNICLDL----------------SPGH------GLDGRLTGH---RV-ETWDVKDVVNC 889

  Fly  1375 VGGCNVLLGII----AMAQDVES------------LYAGVKALTCVVRSNRAAQAEMDRKRCYQT 1423
            |||...||.::    ...|:.|:            |.:|......::...::::..|:|    ..
  Rat   890 VGGMGALLPLLERVAVQPQEAEAGPCETHDLVGPELTSGHNTQGLLLPLGKSSEERMER----NA 950

  Fly  1424 LGMFFKKKKHLLNSHILHLTFGLV---GTVNSGQDMSAIP------NVTAFQDLLCDLEIWHNAP 1479
            :..|....::.|..|.::.. .||   |....|..:..:|      ||.....||.: ::..::.
  Rat   951 VAAFLLMLRNFLQGHTVNQE-SLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLME-QVAADSS 1013

  Fly  1480 NGLLRSLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHIITQIQDHSTREILFSLLETLLGGQP 1544
            ..||..|.:|||          .|..:.......|:|.||  |......||
  Rat  1014 GPLLYLLYQHLL----------FNFHLWTLSDFAVRLGHI--QYMSSIIRE-------------- 1052

  Fly  1545 RHTDLL--LFG-QYVAAKLPHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLL 1606
             |...|  .:| |::...|...:|         |..:.|....|        ||....||| ||:
  Rat  1053 -HRQKLRKKYGVQFILDALRTHYS---------PQRERPLAADD--------LRTVQTSLL-GLV 1098

  Fly  1607 --FTPRNTVNYVICDDISKTLG--------------MDWLLLFMQ------PHVHFTTVIIAVRI 1649
              |..||    :..||:...|.              :|.||..:|      |...|......:.:
  Rat  1099 REFLVRN----LSVDDMQVVLSFLAAANEDCQVVGTLDLLLALLQGSPAQEPLAIFLLEPGNLEV 1159

  Fly  1650 LVVICANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQQLNQRPTNGTGTVIVATPQNTIQH 1714
            |:.:      |||.:.          |.::|.|....|...|.|:|           .|:...|.
  Rat  1160 LLTL------LVRPKS----------TPLLSDRVCKILRRLQQNER-----------LPERNRQR 1197

  Fly  1715 LPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHTKF-DLDRVW 1778
            |           .|:..|.|.|...:...:..|:|...:..|.:|...:|::.:.... ||..|.
  Rat  1198 L-----------RLHDCGLQGLVASLPEGIASPQLCQGLYKLFVGTVPQVVSPDCLNLSDLLAVV 1251

  Fly  1779 SFLWGAPVSANTQLPKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQNLTDF 1843
            .....|.:|.     :|:||           |.:.|      .::..|: :::||
  Rat  1252 QLSLQADLSV-----RLDIC-----------RQLFH------LIYGQPD-VVRLL---------- 1283

  Fly  1844 APVMMTG--DVVTSLVAVLFPLASRPADSEPNSGASTPTDDTGSSFALPPPETLHGA-------- 1898
              ....|  ||:|.    |:.|.:...||.|  ....|...|.|..||.||.|...|
  Rat  1284 --ARQAGWQDVLTR----LYVLEATATDSGP--PRFVPELPTSSELALSPPPTELPAESSDVFLP 1340

  Fly  1899 -----PQPKLTAHPVCNCIIDF---LRVIVVDS----LGLNMQGKPTPVIDLVLDAAPESAELPL 1951
                 |.|....|.:....:.|   |....|||    .|.:..|..||       |:......||
  Rat  1341 SESPCPDPDAFYHALSPFSMPFDLGLERASVDSGNTAGGSSSNGTITP-------ASQPGTPSPL 1398

  Fly  1952 ---------QVQYQTQIIIALMDHLLAADVLVGEQAALPLVP--LLQSQMQYIAPNVFYLTARIV 2005
                     |.::.:.:...|.|..|....:.|:..:....|  ..:.::..:..||.:...
  Rat  1399 DGPRPFPTTQGRHSSSLSNVLEDGSLLEPTISGDDTSNTSNPQQTPEEELCNLLTNVLFSVT--- 1460

  Fly  2006 DKLWQG------CLARNPHDIFDFVIKLIVQAKRRSSSLSLEHLHHSLNRSIL--FLLSRPTDDS 2062
               |:|      ...|....:|..:.:|       .:|..|......:.||:|  .|.|..||..
  Rat  1461 ---WRGVEGSDEAAWRERGQVFSVLTQL-------GASAMLVRSPDCIKRSLLEMMLESALTDIK 1515

  Fly  2063 RADQMSVLEA------LHKIIQHRLLIFGAGNHE-------------LEFIGCLTYCLLQLTADM 2108
            .|....:...      |.:::|..|...|.||.|             |:.:|...: |....||:
  Rat  1516 EAPPGGLANLSQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCNLLDRLGAWPH-LANSIADL 1579

  Fly  2109 K-------------IILE-PATSRNTTWHVNPQTETAEPKDED-----LNQLQ---GRNLIVGAA 2151
            :             |:|| |.........::...:||.|...:     |::|:   .|.|...::
  Rat  1580 REMAQIGLRLVLGYILLEDPQLHAQAYVKLHTLLQTAVPTRREEACYVLSKLEAALSRALTASSS 1644

  Fly  2152 FRVWEELYVCKKPAIEE--------------------VFKVSLTSPPPNSKAP----DLQTTREQ 2192
                |..:.|...|..|                    ..:..|.|.||.:.:|    |.|..
  Rat  1645 ----ETEHSCAAMAASERCSWLVPLVRTLLDRAYGPLGLQWGLPSLPPTNGSPTFFEDFQAF--- 1702

  Fly  2193 VMELASKLWFNYVEAERKATYRAPWELHTQIQSKIQKVTGGLSRLTSRTKTKKEELVRTRSTLTR 2257
               .|:..|.::::.:.:.| .:.:|:.|..:|. ..::|..:.......:..:.|.|.|  :..
  Rat  1703 ---CATPEWRHFIDKQVQPT-MSKFEMDTYAKSH-DLMSGFWNACYDTLMSSGQRLQRDR--IQS 1760

  Fly  2258 EAAYESTGIHVQLIKDLLDLRAK----QY-----QQMLQHTQRYVYQDWVQSEMELTRERGLWG- 2312
            ..|::      :|:.:....||:    :|     ||..||:...::  |.....:|:...|.|.
  Rat  1761 RRAFQ------ELVLEPAQRRARLEGLRYASVLKQQAAQHSTALLH--WGALWRQLSSPCGAWAL 1817

  Fly  2313 ---PTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLHYPYRPELE---LADNRQLKYKVASSLDS 2371
               ||     ..|.|.:.|...|||.|.:.|     |: :.|.||   |.||..
  Rat  1818 RVPPT-----PHWKLSSAETYSRMRLKLVPN-----HH-FDPHLEASALRDNLG----------- 1860

  Fly  2372 KTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLVGHGSTPCPQE 2436
                 ..|..|            .:::||...    :...:..|.||..:|
  Rat  1861 -----EAPMTP------------TEEASLPLA----VTKEAKISAPPEELL-------------- 1890

  Fly  2437 SVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMFRCARVQGLDTFEGLLLFGKEHCYIVD 2501
                   ||...||:.::.........|.|::||:.....|..|..:....|||....:|.|..|
  Rat  1891 -------EDQLGEEELAVLETLMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQHVYFYD 1948

  Fly  2502 GFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLLQ 2566
            |.|                  |.:         .|...:.|..|:    ...::||||.||:.|:
  Rat  1949 GST------------------ERV---------ETEEGIGHDFRR----PLAQLREVHLRRFNLR 1982

  Fly  2567 PIALEVFSEDGRNYLLSFPRK-------------------------VRNKVNQRFLALATALNDN 2606
            ..|||:|..|..||.|:||.|                         |||:|....|.|
  Rat  1983 RSALELFFIDQSNYFLNFPHKVAGASASPPCQAPRPQLYPIPPHTQVRNQVYSLLLRL------- 2040

  Fly  2607 AQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVF 2671
             :....|...:.|.::       ::..:.:||:||:.|||||:|||.|||:|||:||||.|||||
  Rat  2041 -RPPTQGYLSSRSPQE-------MLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVF 2097

  Fly  2672 PWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAM 2736
            ||:|.||.|..|||.||..|||.|:|:|....:..:..:::::.::||.|....:|||||||:|.
  Rat  2098 PWVLQDYVSPVLDLNNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAA 2162

  Fly  2737 IVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYLPEFLSN 2801
            .|..||:|:|||:...::||.|.||.:||.|||:..|| .|...:.||||||||||||.|:||.|
  Rat  2163 GVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAW-QARLESPADVKELIPEFFYFPDFLEN 2226

  Fly  2802 FNNFDLGTKQ-NGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPA 2865
            .|.||||..| ..|.:..|:|||||. .|.:||:.||.|||.:|||.|||.|||||||.||:|||
  Rat  2227 QNGFDLGCLQLTNEKVGDVVLPPWAS-SPEDFIQKHRRALESEYVSTHLHEWIDLIFGYKQRGPA 2290

  Fly  2866 AVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKMGGSRHSALID 2930
            |.:|:|||::..|||.||:.::.|..::.|..|.|:||||.|.||.|:.||.:
  Rat  2291 AEEALNVFYYCTYEGAVDLDHVADERERKALEGIISNFGQTPCQLLKEPHPPR------------ 2343

  Fly  2931 PTSLIQGNSTVLQTDRL------FFHNLDNLKP--------------SLQPIKELKGPVGQI--- 2972
                :......::..||      .|.|||.||.              :|.|.::....:.|.
  Rat  2344 ----LSAEEAAIRLARLDTHSPSIFQNLDQLKAFFAEVVSEGVPLLLALVPHRQTHSFITQSASD 2404

  Fly  2973 ----------------LQPDKTV---FAVEQNKVMMPPSYTKYIA--W----------------- 2999
                            |..|:.:   |:..::..|..|...|.::  |
  Rat  2405 MLVTVSASGLLGTHSWLPYDRNINNYFSFSKDPTMGNPKVQKLLSGPWAPGSGVRGQALAVAPDG 2469

  Fly  3000 ------GFADHSLRIGLYDTDRASFVSEASAQNSGEILTC----ACPNAKMIVTAGTSSVVTIWK 3054
                  |..|.|||:.|  ..|...:|:.|...  :::||    .|  ...:::....:...:|:
  Rat  2470 KLLFSGGHWDGSLRVTL--LSRGRLLSQLSRHL--DVVTCLALDTC--GIYLISGSRDTTCMVWR 2528

  Fly  3055 F---DANRKSLAVK--HSLHGHTDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQLR--- 3111
            .   :.....||.|  ..|:||..||:|:|.|...::.||||.|||.|:..:.|..||..||
  Rat  2529 LLQQNGLSAGLAPKPVQVLYGHEAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPPG 2593

  Fly  3112 ------------GHAG-VVAAVSINELTGDIATCSATWLHVWSINGDALAMVNTCVGSADRMQQI 3163
                        |..| :|...|..|..|...|.|   ||::|:||...|.:     :.......
  Rat  2594 ATLPGPISHLALGSEGQIVVQSSACERPGAQVTYS---LHLYSVNGRLRASL-----TLTEQPTA 2650

  Fly  3164 LCVAFSQIREWDQQNVIITGSTD---GVVRMWSLEHTQVPIDRKLK-RGTEVSSQDKPDTVSLEG 3224
            |.||         ::.::.|:..   .::.:..|.....|:..|:. ....|:.:.....|.||
  Rat  2651 LTVA---------EDFVLLGTAQCSLHILHLNKLRPAVPPLPMKVPVHSVSVTKERSHVLVGLE- 2705

  Fly  3225 KDNKDDKMSLMKQIKSLSQSEEEMEIVKSASESSISEASQHSHGSSKSAEAGPKAEVQGERRKSS 3289
                |.|:                 ||..|.:.|...:||.:....:|:           ||.|.
  Rat  2706 ----DGKL-----------------IVVGAGQPSEVRSSQFARKLWRSS-----------RRISQ 2738

  Fly  3290 ISGAKS 3295
            :|..::
  Rat  2739 VSSGET 2744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	39/155 (25%)
		Beach	2638..2918	CDD:280327	153/280 (55%)
		WD40	<2991..3252	CDD:225201	68/314 (22%)
		WD40	2995..>3194	CDD:295369	57/251 (23%)
		WD40 repeat	3031..3070	CDD:293791	8/47 (17%)
		WD40 repeat	3075..3111	CDD:293791	15/35 (43%)
		FYVE_WDFY3	3418..3482	CDD:277259
Nbeal2	XP_003750638.1	DUF4704	878..1127	CDD:292415	61/304 (20%)
		DUF4800	1593..1859	CDD:292675	61/298 (20%)
		PH_BEACH	1916..2041	CDD:275391	40/163 (25%)
		Beach	2064..2343	CDD:280327	153/280 (55%)
		WD40	<2461..2711	CDD:225201	64/294 (22%)
		WD40 repeat	2461..2498	CDD:293791	8/38 (21%)
		WD40	2462..2711	CDD:295369	64/293 (22%)
		WD40 repeat	2504..2549	CDD:293791	8/46 (17%)
		WD40 repeat	2554..2590	CDD:293791	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920