Protein Alignment bchs and NBEA

DIOPT Version :10

• Sequence 1: NP_608968.2
• Gene: bchs / 33819
• FlyBaseID: FBgn0043362
• Length: 3489
• Species: Drosophila melanogaster
• Sequence 2: NP_001371941.1
• Gene: NBEA / 26960
• HGNCID: 7648
• Length: 2967
• Species: Homo sapiens
• Alignment Length: 3503
• Identity: 705/3503 - (20%)
• Similarity: 1182/3503 - (33%)
• Gaps: 1245/3503 - (35%)

  Fly    77 EPLSEQERD-DKLYEMLPLFC---------------------------KVFSSCPSNDMSEKFWD 113
            :||:....| ||.|    |:|                           |.|..|...|...:.|.
Human   266 DPLNNINVDKDKPY----LYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWY 326

  Fly   114 VVAFCQQVSRLMVSEIRKRASNQSTEAASIAIVKFLEVETTEETSS---GWMLLATLNLLANGDV 175
            :::.....:|...||||...:.|......:|    ..|.|.:....   |....|..|.:..|.:
Human   327 MISIVHIYNRWRNSEIRCYVNGQLVSYGDMA----WHVNTNDSYDKCFLGSSETADANRVFCGQL 387

  Fly   176 SLIQVMTAAAVPSTL---------VKCLYLF---FDLPIVEDDEPSA-DGGAVSE--FNAHERRT 225
            ..:.|.:.|..|:.:         .|..:.|   .|:.:.|..:... ||...|.  |..:.:.|
Human   388 GAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKAT 452

  Fly   226 LLQKVFVQLLVKLCSYPYPAEELARMDDLTLLFSAITSPCPIHNIVWRKNAAEILTTISRNGLTD 290
            ..|         ||....|.|..:       :|  :.||   |.::.:...|.:         |.
Human   453 DAQ---------LCLESSPKENAS-------IF--VHSP---HALMLQDVKAIV---------TH 487

  Fly   291 AVVSYIHSKGCMALC------VDNMQRLTFGNPLEI-VEMFVTVFCFLKDSSQVSQILMDDFRAS 348
            ::.|.|||.|.:.:.      :||.|.    |..:: ..:..|:..||.:..:.|..:.:.....
Human   488 SIHSAIHSIGGIQVLFPLFAQLDNRQL----NDSQVETTVCATLLAFLVELLKSSVAMQEQMLGG 548

  Fly   349 QGYVFLSDFLLKFDNNRSQSLEIQAAIRNLVL--------------MISSLCMCGFYELRPPASQ 399
            :|::.:. :||:    :|..:.|..|:....|              ::..||   .:.|..||..
Human   549 KGFLVIG-YLLE----KSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLC---DHILFNPAIW 605

  Fly   400 FNTAFKLQNFQLPQATSRETCVRNVYAFQVLQNVFLKSTTPALCCTILDAISRVYHSENANYFIL 464
            .:|..|:|              .::|.:  |...|:.:.|.......:..:.::.|:....|:::
Human   606 IHTPAKVQ--------------LSLYTY--LSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVI 654

  Fly   465 ESEQTLSSFAERIHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKHNQSTSCSILCLKT 529
            ....  ||......:..|:..:|  :::....|.|.|:  |:||.....:|.::        |::
Human   655 NPAD--SSGITPKGLDGPRPSQK--EIISLRAFMLLFL--KQLILKDRGVKEDE--------LQS 705

  Fly   530 LLNILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKITKGDESVVVELENESEEELFDTLGKHV 594
            :||.|                                           |....:|.:.|     |
Human   706 ILNYL-------------------------------------------LTMHEDENIHD-----V 722

  Fly   595 LEALTMLLGGGASNNAQLFREYGGAKCVHELV--KFKHCRPQALGIVRELILSAGGDD--DMLHI 655
            |:.|..|:....::....|.:..|.:.:::|:  |.:....|||.::...:...|...  :::|
Human   723 LQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMH- 786

  Fly   656 LSLMHSVSPLQVE--------FKIQILNMLLGCLKDSHRTRTVFRKVGGFVYVTSVFVSLDGSMA 712
               .||:..|..|        ..:...|.|...|.:...|:.|.:
Human   787 ---THSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHK-------------------- 828

  Fly   713 LPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLG-------CFGGS 770
             |.|: |...:.:...::.:.:||.::....:|:.  .|:....|.|.::|..       |....
Human   829 -PHPE-PDSTVKIQNPMILKVVATLLKNSTPSAEL--MEVRRLFLSDMIKLFSNSRENRRCLLQC 889

  Fly   771 SALQDY---TGTYEPQQS-------------LLKYYHEI---FSG-----DILSVSFSEDVPYPL 811
            |..||:   .|...|:.|             .:..||.|   :.|     |.||::.|: |.|..
Human   890 SVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSK-VTYEA 953

  Fly   812 --SYVCIVFRLLYSIALDNF---EAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSP 871
              .|:..::........:|.   :..|:|.|..|.|.  ||......|:......||    ..||
Human   954 HKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQ--TTGAKGGMEIREIEDLSQ----SQSP 1012

  Fly   872 EPRIVHPGVVLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKL 936
            |....:|                            :|...:.|:.|                .|:
Human  1013 ESETDYP----------------------------VSTDTRDLLMS----------------TKV 1033

  Fly   937 TRRALAEESHP---LHVPMQYILERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPL 998
            :...|.....|   :||.:..:|..:.|:.::.||::          ..|:||.....:||
Human  1034 SDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVK----------LDDMDLSPETLVGG---- 1084

  Fly   999 TRIKTLVSMTTPRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIG 1063
                                             |....:.:.||.....:.|...:..|..|.:|
Human  1085 ---------------------------------ENGALVEVESLLDNVYSAAVEKLQNNVHGSVG 1116

  Fly  1064 AGDRIFPPQTGLTYSTWFCVEKFSDPKTDPHCVRLLTLVRTIHNPREENL--ACLSILLSARDKA 1126
                              .::|..:....|    |:||.     ..:|:|  :..|.|.   ||
Human  1117 ------------------IIKKNEEKDNGP----LITLA-----DEKEDLPNSSTSFLF---DK- 1150

  Fly  1127 IVVSTQETLVTPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWHNLVVVLNRAVLKNSSLFLYLDG 1191
              :..||..:.|..|.....|...|..:         |.|...:|                   |
Human  1151 --IPKQEEKLLPELSSNHIIPNIQDTQV---------HLGVSDDL-------------------G 1185

  Fly  1192 VPMHTQKLHYIAQHPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCHLIEDVLTQQTVQT 1256
            :..|           ..|:..||..:.|...       :.:.......|:..:.|..|...|...
Human  1186 LLAH-----------MTGSVDLTCTSSIIEE-------KEFKIHTTSDGMSSISERDLASSTKGL 1232

  Fly  1257 IYQLGPHYMGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQ 1321
            .|       ..:.|..|..:|.| :.:||      .::|.::...|        .|:|
Human  1233 EY-------AEMTATTLETESSS-SKIVP------NIDAGSIISDT--------ERSD------- 1268

  Fly  1322 LNMNSHENATPIKILHNSAGHLAGAGRSLG------GVVVGYLGV-------RVFSPHPVSAMI- 1372
               :..|:...|:.:..:....|..|||:.      .|.:|:.|:       |.|||.|.:.|.
Human  1269 ---DGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFR 1330

  Fly  1373 ---------------DTVGGCNVLLGIIAMAQDVESLYAGVKALTCVVRSNRAAQAEMDRKRCYQ 1422
                           |.         :.|:..||.           |.||: :.::.||.....:
Human  1331 IPEFKWSPMHQRLLTDL---------LFALETDVH-----------VWRSH-STKSVMDFVNSNE 1374

  Fly  1423 TLGMFFKKKKHLLNSHILHLTFGLVGTVNSGQDMSAIPNVTAFQDLLCDLEIWHNAPNGLLRSLL 1487
            .: :|.....||::..:.::.....|.:..   :||..:.|..:..|.::|:..........:.|
Human  1375 NI-IFVHNTIHLISQMVDNIIIACGGILPL---LSAATSPTGSKTELENIEVTQGMSAETAVTFL 1435

  Fly  1488 EHLLELV-------------VESSDKKQNVKIMRDLQLLVKLLHIITQIQ------------DHS 1527
            ..|:.:|             :|:.....:..:||....||..:.:...::            .|.
Human  1436 SRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHG 1500

  Fly  1528 T---REILFSLLETLLGGQPRHTDLLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAEDQDGGVA 1589
            :   :|:..|:..|                 .|:|.|      ||.   :|...:|.:|.| .:.
Human  1501 SSKPQEVPQSVTAT-----------------AASKTP------LEN---VPGNLSPIKDPD-RLL 1538

  Fly  1590 QNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTLGMDWLLLFMQPHVHFTTVIIAVRILVVIC 1654
            |::.:                |.:..|:..|:..:....:|.|.:   |:|.:|::
Human  1539 QDVDI----------------NRLRAVVFRDVDDSKQAQFLALAV---VYFISVLM--------- 1575

  Fly  1655 ANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQ---QLNQRPTNGTGTVIV--ATPQNTIQH 1714
                 :.::||.           :..||:....|:|   .:.|...:.|.||:|  :.|..::.|
Human  1576 -----VSKYRDI-----------LEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNH 1624

  Fly  1715 ------LPTQIAG-----EVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLAT- 1767
                  :|.|..|     |..||   .|     :.:.......|           |:.::|.::
Human  1625 GFLAKLIPEQSFGHSFYKETPAA---FP-----DTIKEKETPTP-----------GEDIQVESSI 1670

  Fly  1768 EHTKFDL--DRVWSFLWGAPVSANTQLPKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETII 1830
            .||...:  ::|.|.|.||.:..:|                                  .|:.:.
Human  1671 PHTDSGIGEEQVASILNGAELETST----------------------------------GPDAMS 1701

  Fly  1831 QLLFSLYQNLTDFAPVMMTGDVVTSLVAVLFPLASRPADSEPNSGASTPTDDTGSSFALPPPETL 1895
            :||.:|                                .||......:.|::        |.|||
Human  1702 ELLSTL--------------------------------SSEVKKSQESLTEN--------PSETL 1726

  Fly  1896 HGAPQPKLTAHPVCNCIIDFLRVIVVDSLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQII 1960
              .|...:::              :..:.|:|::
Human  1727 --KPATSISS--------------ISQTKGINVK------------------------------- 1744

  Fly  1961 IALMDHLLAADVLVGEQAALPLV---PLLQSQMQYIAPNVFYLTARIVDKLWQGCLARNPHDIFD 2022
             .::..|:||.|.:.|....|:.   |.|:.:.|.|.|..|
Human  1745 -EILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQF------------------------ 1784

  Fly  2023 FVIKLIVQAKRRSSSLSLEHLHHSLNRSILFLLSRPTDDSRADQMSVLEALHKIIQHRLLIFGAG 2087
                                  ||.:||::..:.:|...|.|     :..:........|..|:.
Human  1785 ----------------------HSFDRSVVVPVKKPPPGSLA-----VTTVGATTAGSGLPTGST 1822

  Fly  2088 NHELEFIGCLTYCLLQLT----------ADMKIILEPATSRNTTWHVNPQTETAEPKDEDLNQLQ 2142
            ::.....|.....::..|          :.....:..|||:|.     |..:|..|..||    .
Human  1823 SNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNL-----PAVQTVAPMPED----S 1878

  Fly  2143 GRNLIVGAAF-RVWEELYVCKKPAIEEVFKVSLTSPPPNSKAPDLQTTR---------------- 2190
            ..|:.:.|.. |..|::    .|.:.|:|.         ..||.|..|.
Human  1879 AENMSITAKLERALEKV----APLLREIFV---------DFAPFLSRTLLGSHGQELLIEGLVCM 1930

  Fly  2191 -------EQVMELASKLWFNYVEAERKATYRAPWELHTQIQSKIQKVTGGLSRLTSRTKTKKEEL 2248
                   |.||.|.|:.|.|.::......:             |:.:..|  ||...  ..|:.:
Human  1931 KSSTSVVELVMLLCSQEWQNSIQKNAGLAF-------------IELINEG--RLLCH--AMKDHI 1978

  Fly  2249 VRTRS----TLTREAAYESTGIHVQLIKDLLDLRA--KQYQQMLQH-TQRYVYQDWVQSEM---- 2302
            ||..:    .|.|:.| |....|.:.........|  ::.::|..| .....::|.|.:..
Human  1979 VRVANEAEFILNRQRA-EDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQK 2042

  Fly  2303 ---ELTRERGLWGPTGSCSL-DKWILDTTEGPHRMRKKTMRNDVFYLHYPYRPELELADNRQLKY 2363
               .||.:.|.||......| |.|.||..|...|.|::.:||.....|
Human  2043 ILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTH----------------- 2090

  Fly  2364 KVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLVGH 2428
                                  |||....|::..:..:.|:|.:...|
Human  2091 ----------------------AEALLKAAIEYGTEEDVVKSKKTFRS----------------- 2116

  Fly  2429 GSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMFRCARVQGLDTFEGLLLFG 2493
                  |..|:.||      |.:..:..|::. :.||:|:|             :|...|.::.
Human  2117 ------QAIVNQNA------ETELMLEGDDDA-VSLLQEKE-------------IDNLAGPVVL- 2154

  Fly  2494 KEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTT------------------SRAV 2540
                                  :.|.....|::...|..|.||                  ::.:
Human  2155 ----------------------STPAQLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVL 2197

  Fly  2541 SHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFP-----RKVRNKVNQRFLALA 2600
            ::......|:.:.|||.|..||||||..|||||..:..:.:.:||     :||...:.:..:..:
Human  2198 AYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTS 2262

  Fly  2601 TALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDL 2665
            ..|....:.|:|..::             |...:::||||.|.|||||:|||.|||:|||:||||
Human  2263 YGLPQARRISLATPRQ-------------LYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDL 2314

  Fly  2666 MQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGT 2730
            .|||||||:|.:|:|||||||.|..|||.|:|:||...:|...:.:|::.|:|  .::|||||.|
Human  2315 NQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWED--DQSPPYHYNT 2377

  Fly  2731 HYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYL 2795
            |||:|....|:|||:|||:..||....|.||..||.|.|:..:| ..|:.:.:|||||||||:||
Human  2378 HYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSW-RTSQRDTSDVKELIPEFYYL 2441

  Fly  2796 PEFLSNFNNFDLGTKQNGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCK 2860
            ||...|.|.::||.:::...:|.|.|||||| .|.:|:|::|.|||.::||..||.|||||||.|
Human  2442 PEMFVNSNGYNLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLHQWIDLIFGYK 2505

  Fly  2861 QQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGF---------------------INNFG 2904
            |:||.||.|:||||:|.|||:|::.:|.||:.:.....:                     |.|||
Human  2506 QRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREIPEAYFIRDPHTFLLTKDFIKAMEAQIQNFG 2570

  Fly  2905 QIPKQLFKKAHPAKKMGGSRHSALIDPTSLIQGNSTVLQTDRLFFHNLDNLK-PSLQPIKELKGP 2968
            |.|.||..:.||.:  ..:.|...:..:.|:..:.  :|.|.:..     || ||..|:..
Human  2571 QTPSQLLIEPHPPR--SSAMHLCFLPQSPLMFKDQ--MQQDVIMV-----LKFPSNSPVTH---- 2622

  Fly  2969 VGQILQPDKTVFAVEQNKVMMPPSYTKYIA---WGFADHSLRIGL-----YDTDRA--------S 3017
            |.....|..|:.||      :..:.::..|   |    |: .:||     |..|:|        .
Human  2623 VAANTLPHLTIPAV------VTVTCSRLFAVNRW----HN-TVGLRGAPGYSLDQAHHLPIEMDP 2676

  Fly  3018 FVSEASAQNSGEI---------LTCACPNAKMIVTAGTSSVVTIWKFDANRKSLAVKHS------ 3067
            .::..|..|..:|         :...|    .:|||....::....:|   ||..|..:
Human  2677 LIANNSGVNKRQITDLVDQSIQINAHC----FVVTADNRYILICGFWD---KSFRVYSTETGKLT 2734

  Fly  3068 --LHGHTDAVTCLAASAAY----NVIVSGSRDGTAIVW-------------DMTRFTFVRQ-LRG 3112
              :.||.|.|||||.|.:|    ..|||||||.|.::|             :.:.:...|. |.|
Human  2735 QIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTG 2799

  Fly  3113 HAGVVAAVS------------------INELTGDI-------ATCSATWL-------HV------ 3139
            |...|..||                  ::.:|||:       ..|....|       |.
Human  2800 HDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYER 2864

  Fly  3140 -----WSINGDALAMVNTCVGSADRMQQILCVAFSQIREWDQQNVIITGSTDGVVRMW 3192
                 :||||..||.:..    .|..:.||..:       |.|| ::||..:|||.:|
Human  2865 GRFSNFSINGKLLAQMEI----NDSTRAILLSS-------DGQN-LVTGGDNGVVEVW 2910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	29/153 (19%)
		Beach	2638..2918	CDD:460459	150/300 (50%)
		WD40	2995..>3194	CDD:475233	69/292 (24%)
		WD40 repeat	3031..3070	CDD:293791	8/46 (17%)
		WD40 repeat	3075..3111	CDD:293791	17/53 (32%)
		FYVE_WDFY3	3418..3482	CDD:277259
NBEA	NP_001371941.1	Laminin_G_3	255..402	CDD:463865	29/143 (20%)
		DUF4704	467..947	CDD:464870	104/618 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..995		8/25 (32%)
		WD 1. /evidence=ECO:0000305	1326..1368		8/62 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1490..1531		10/66 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1651..1675		5/34 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1711..1731		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1841..1860		0/18 (0%)
		DUF1088	1966..2132	CDD:461925	44/238 (18%)
		PH_BEACH	2158..2255	CDD:434260	25/96 (26%)
		Beach	2287..2584	CDD:460459	150/300 (50%)
		NBCH_WD40	2684..2956	CDD:466575	60/246 (24%)
		WD 2. /evidence=ECO:0000305	2739..2782		19/42 (45%)
		WD40 repeat	2745..2799	CDD:293791	17/53 (32%)
		WD 3. /evidence=ECO:0000305	2799..2839		8/39 (21%)
		WD40 repeat	2804..2839	CDD:293791	6/34 (18%)
		WD40 repeat	2844..2873	CDD:293791	4/28 (14%)
		WD 4. /evidence=ECO:0000305	2881..2920		12/42 (29%)
		WD40 repeat	2882..2920	CDD:293791	12/41 (29%)
		WD 5. /evidence=ECO:0000305	2923..2962
		WD40 repeat	2928..2954	CDD:293791