Protein Alignment bchs and Nbea

DIOPT Version :10

• Sequence 1: NP_608968.2
• Gene: bchs / 33819
• FlyBaseID: FBgn0043362
• Length: 3489
• Species: Drosophila melanogaster
• Sequence 2: XP_036019004.1
• Gene: Nbea / 26422
• MGIID: 1347075
• Length: 2968
• Species: Mus musculus
• Alignment Length: 3509
• Identity: 710/3509 - (20%)
• Similarity: 1176/3509 - (33%)
• Gaps: 1246/3509 - (35%)

  Fly    77 EPLSEQERD-DKLYEMLPLFC---------------------------KVFSSCPSNDMSEKFWD 113
            :||:....| ||.|    |:|                           |.|..|...|...:.|.
Mouse   256 DPLNNINVDKDKPY----LYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWY 316

  Fly   114 VVAFCQQVSRLMVSEIRKRASNQSTEAASIAIVKFLEVETTEETSS---GWMLLATLNLLANGDV 175
            :::.....:|...||||...:.|......:|    ..|.|.:....   |....|..|.:..|.:
Mouse   317 MISIVHIYNRWRNSEIRCYVNGQLVSYGDMA----WHVNTNDSYDKCFLGSSETADANRVFCGQL 377

  Fly   176 SLIQVMTAAAVPSTL---------VKCLYLF---FDLPIVEDDEPSA-DGGAVSE--FNAHERRT 225
            ..:.|.:.|..|:.:         .|..:.|   .|:.:.|..:... ||...|.  |:.:.:.|
Mouse   378 GAVYVFSEALNPAQIFAVHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFSYNAKAT 442

  Fly   226 LLQKVFVQLLVKLCSYPYPAEELARMDDLTLLFSAITSPCPIHNIVWRKNAAEILTTISRNGLTD 290
            ..|         ||....|.|..:       :|  :.||   |.::.:...|.:         |.
Mouse   443 DAQ---------LCLESSPKENAS-------IF--VHSP---HALMLQDVKAIV---------TH 477

  Fly   291 AVVSYIHSKGCMALC------VDNMQRLTFGNPLEI-VEMFVTVFCFLKDSSQVSQILMDDFRAS 348
            ::.|.|||.|.:.:.      :||.|.    |..:: ..:..|:..||.:..:.|..:.:.....
Mouse   478 SIHSAIHSIGGIQVLFPLFAQLDNRQL----NDSQVETTVCATLLAFLVELLKSSVAMQEQMLGG 538

  Fly   349 QGYVFLSDFLLKFDNNRSQSLEIQAAIRNLVL--------------MISSLCMCGFYELRPPASQ 399
            :|::.:. :||:    :|..:.|..|:....|              ::..||   .:.|..||..
Mouse   539 KGFLVIG-YLLE----KSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLC---DHILFNPAIW 595

  Fly   400 FNTAFKLQNFQLPQATSRETCVRNVYAFQVLQNVFLKSTTPALCCTILDAISRVYHSENANYFIL 464
            .:|..|:|              .::|.:  |...|:.:.|.......:..:.::.|:....|:::
Mouse   596 IHTPAKVQ--------------LSLYTY--LSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVI 644

  Fly   465 ESEQTLSSFAERIHMKSPQIQEKFYDLLEFIVFQLNFVPCKELISLSLLLKHNQSTSCSILCLKT 529
            ....: |..|.: .:..|:..:|  :::....|.|.|:  |:||.....:|.::        |::
Mouse   645 NPADS-SGIAPK-GLDGPRPSQK--EIISLRAFMLLFL--KQLILKDRGVKEDE--------LQS 695

  Fly   530 LLNILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKITKGDESVVVELENESEEELFDTLGKHV 594
            :||.|                                           |....:|.:.|     |
Mouse   696 ILNYL-------------------------------------------LTMHEDENIHD-----V 712

  Fly   595 LEALTMLLGGGASNNAQLFREYGGAKCVHELV--KFKHCRPQALGIVRELILSAGGDD--DMLHI 655
            |:.|..|:....::....|.:..|.:.:::|:  |.:....|||.::...:...|...  :::|
Mouse   713 LQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMH- 776

  Fly   656 LSLMHSVSPLQVE--------FKIQILNMLLGCLKDSHRTRTVFRKVGGFVYVTSVFVSLDGSMA 712
               .||:..|..|        ..:...|.|...|.:...|:.|.:
Mouse   777 ---THSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHK-------------------- 818

  Fly   713 LPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLG-------CFGGS 770
             |.|: |...:.:...::.:.:||.::....:|:.  .|:....|.|.::|..       |....
Mouse   819 -PHPE-PDSTVKIQNPMILKVVATLLKNSTPSAEL--MEVRRLFLSDMIKLFSNSRENRRCLLQC 879

  Fly   771 SALQDY---TGTYEPQQS-------------LLKYYHEI---FSG-----DILSVSFSEDVPYPL 811
            |..||:   .|...|:.|             .:..||.|   :.|     |.||::.|: |.|..
Mouse   880 SVWQDWMFSLGYINPKSSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSK-VTYEA 943

  Fly   812 --SYVCIVFRLLYSIALDNF---EAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSP 871
              .|:..::........:|.   :..|:|.|..|.|.  |.......|:......||    ..||
Mouse   944 HKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQ--TAGAKGGMEIREIEDLSQ----SQSP 1002

  Fly   872 EPRIVHPGVVLCMLQLLPAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKL 936
            |....:|                            :|...:.|:.|                .|:
Mouse  1003 ESETDYP----------------------------VSTDTRDLLMS----------------TKV 1023

  Fly   937 TRRALAEESHP---LHVPMQYILERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPL 998
            :...|.....|   :||.:..:|..:.|:.::.||::          ..|:||.....:||
Mouse  1024 SDDILGSSDRPGSGVHVEVHDLLVDIKAEKVEATEVK----------LDDMDLSPETLVGG---- 1074

  Fly   999 TRIKTLVSMTTPRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIG 1063
                                             |....:.:.||.....:.|...:..|..|.:|
Mouse  1075 ---------------------------------ENGALVEVESLLDNVYSAAVEKLQNNVHGSVG 1106

  Fly  1064 AGDRIFPPQTGLTYSTWFCVEKFSDPKTDPHCVRLLTLV---RTIHN----------PREENLAC 1115
                              .::|..:....|    |:||.   ..:.|          ||:|.
Mouse  1107 ------------------IIKKNEEKDNGP----LITLADEKEELPNSSTPFLFDKIPRQEE--- 1146

  Fly  1116 LSILLSARDKAIVVSTQETLVTPRKSIGDWEPEGSDD-GIARIWCPDLLHEGQWHNLVVVLNRAV 1179
             .:|.......|:.:.|:|.|    .:|     .||| |:       |.|......|....:...
Mouse  1147 -KLLPELSSNHIIPNIQDTQV----HLG-----VSDDLGL-------LAHMTASVELTCTSSIME 1194

  Fly  1180 LKNSSLFLYLDGVPMHTQKLHYIAQHPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCHL 1244
            .|:..:....|||...:::             .|.|.|:...|
Mouse  1195 EKDFRIHTTSDGVSSVSER-------------ELASSTKGLDY---------------------- 1224

  Fly  1245 IEDVLTQQTVQTIYQLGPHYMGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKV 1309
                 .:.|..|:                  ::||             .|:|||..:....|...
Mouse  1225 -----AEMTATTL------------------ETES-------------SNSKAVPNVDAGSIISD 1253

  Fly  1310 YSRADNKSIAKQLNMNSHENATPIKILHNSAGHLAGAGRSLG------GVVVGYLGV-------R 1361
            ..|:|          :..|:...|:.:..:|...|..|||..      .|.:|:.|:       |
Mouse  1254 TERSD----------DGKESGKEIRKIQTTATTQAVQGRSSTQQDRDLRVDLGFRGMPMTEEQRR 1308

  Fly  1362 VFSPHPVSAMI----------------DTVGGCNVLLGIIAMAQDVESLYAGVKALTCVVRSNRA 1410
            .|||.|.:.|.                |.         :.|:..||.           |.||: :
Mouse  1309 QFSPGPRTTMFRIPEFKWSPMHQRLLTDL---------LFALETDVH-----------VWRSH-S 1352

  Fly  1411 AQAEMDRKRCYQTLGMFFKKKKHLLNSHILHLTFGLVGTVNSGQDMSAIPNVTAFQDLLCDLEIW 1475
            .::.||.....:.: :|.....||::..:.::.....|.:..   :||..:.|..:..|.::|:.
Mouse  1353 TKSVMDFVNSNENI-IFVHNTIHLISQMVDNIIIACGGILPL---LSAATSPTGSKTELENIEVT 1413

  Fly  1476 HNAPNGLLRSLLEHLLELV-------------VESSDKKQNVKIMRDLQLLVKLLHIITQIQDHS 1527
            .........:.|..|:.:|             :|:.....:..:||....||..:.:...::...
Mouse  1414 QGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQ 1478

  Fly  1528 TREILFSLLETLLGGQPRHTDLLLFGQYVAAKLPH------AHSGGLERAVLLPSMKNPAEDQDG 1586
            .:..        .|.:..|      |.....:.||      |....||.   :|...:|.:|.|
Mouse  1479 RQRD--------RGSKSSH------GSSKPQEAPHSVTAASASKTPLEN---VPGNLSPIKDPD- 1525

  Fly  1587 GVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTLGMDWLLLFMQPHVHFTTVIIAVRILV 1651
            .:.|::.:                |.:..|:..|:..:....:|.|.:   |:|.:|::
Mouse  1526 RLLQDVDI----------------NRLRAVVFRDVDDSKQAQFLALAV---VYFISVLM------ 1565

  Fly  1652 VICANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQ---QLNQRPTNGTGTVIV--ATPQNT 1711
                    :.::||.           :..||:....|:|   .:.|...:.|.||:|  :.|..:
Mouse  1566 --------VSKYRDI-----------LEPQRETARTGSQPGRNIRQEINSPTSTVVVIPSIPHPS 1611

  Fly  1712 IQHLPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHTKFDLDR 1776
            :.|                   .||..||      ||..|
Mouse  1612 LNH-------------------GLLAKLM------PEQSF------------------------- 1626

  Fly  1777 VWSFLWGAPVSANTQLPKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETI-----------I 1830
            ..||....|.                                     :.|:|:           |
Mouse  1627 AHSFYKETPA-------------------------------------TFPDTVKEKETPTPGEDI 1654

  Fly  1831 QLLFSLYQNLTDFAPVMMTGDVVTSLV--AVLFPLASRPADSEPNSGASTPTDDTGSSFALPPPE 1893
            ||..|:..  ||..   |..:.|.|::  |.|.|.|...|.||..|..|:....:..|....|.|
Mouse  1655 QLESSVPH--TDSG---MGEEQVASILDGAELEPAAGPDAMSELLSTLSSEVKKSQESLTEHPSE 1714

  Fly  1894 TLHGAPQPKLTAHPVCNCIIDFLRVIVVDSLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQ 1958
            .|  .|.|.:::              :..:.|:|::
Mouse  1715 ML--KPAPSISS--------------ISQTKGINVK----------------------------- 1734

  Fly  1959 IIIALMDHLLAADVLVGEQAALPLV---PLLQSQMQYIAPNVFYLTARIVDKLWQGCLARNPHDI 2020
               .::..|:||.|.:.|....|:.   |.|:.:...|.|..|
Mouse  1735 ---EILKSLVAAPVEIAECGPEPIPYPDPALKREAHAILPMQF---------------------- 1774

  Fly  2021 FDFVIKLIVQAKRRSSSLSLEHLHHSLNRSILFLLSRPTDDSRADQMSVLEALHKIIQHRLLIFG 2085
                                    ||.:||::..:.:|...|.|     :..:........|..|
Mouse  1775 ------------------------HSFDRSVVVPVKKPPPGSLA-----VTTVGATAAGSGLPTG 1810

  Fly  2086 AGNHELEFIGCLTYCLLQLT----------ADMKIILEPATSRNTTWHVNPQTETAEPKDEDLNQ 2140
            :.:......|.....::..|          :.....:..|||:|.     |..:|..|..||
Mouse  1811 STSSIFAAPGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNL-----PAVQTVAPMPED--- 1867

  Fly  2141 LQGRNLIVGAAF-RVWEELYVCKKPAIEEVFKVSLTSPPPNSKAPDLQTTR-------------- 2190
             ...|:.:.|.. |..|::    .|.:.|:|.         ..||.|..|.
Mouse  1868 -SAENMSITAKLERALEKV----APLLREIFV---------DFAPFLSRTLLGSHGQELLIEGLV 1918

  Fly  2191 ---------EQVMELASKLWFNYVEAERKATYRAPWELHTQIQSKIQKVTGGLSRLTSRTKTKKE 2246
                     |.||.|.|:.|.|.::......:             |:.:..|  ||...  ..|:
Mouse  1919 CMKSSTSVVELVMLLCSQEWQNSIQKNAGLAF-------------IELINEG--RLLCH--AMKD 1966

  Fly  2247 ELVRTRS----TLTREAAYESTGIHVQLIKDLLDLRA--KQYQQMLQH-TQRYVYQDWVQSEM-- 2302
            .:||..:    .|.|:.| |....|.:.........|  ::.::|..| .....::|.|.:..
Mouse  1967 HIVRVANEAEFILNRQRA-EDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLK 2030

  Fly  2303 -----ELTRERGLWGPTGSCSL-DKWILDTTEGPHRMRKKTMRNDVFYLHYPYRPELELADNRQL 2361
                 .||.:.|.||......| |.|.||..|...|.|::.:||.....|
Mouse  2031 QKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTH--------------- 2080

  Fly  2362 KYKVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLV 2426
                                    |||....|::..:..:.|:|.:...|
Mouse  2081 ------------------------AEALLKSAVEYGTEEDVVKSKKAFRS--------------- 2106

  Fly  2427 GHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQE----KISFMFRCARVQGLDTFE 2487
                    |..|:.|:      |.:..:..|::. :.||:|:|    .:||:
Mouse  2107 --------QAIVNQNS------ETELMLEGDDDA-VSLLQEKEIDNLAVSFL------------- 2143

  Fly  2488 GLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTT---------------- 2536
                   ...:|..|..:|         :.|.....|::...|..|.||
Mouse  2144 -------PKLFISRGPVVL---------STPAQLIAPVVVAKGTLSITTTEIYFEVDEDDAAFKK 2192

  Fly  2537 --SRAVSHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFP-----RKVRNKVNQ 2594
              ::.:::......|:.:.|||.|..||||||..|||||..:..:.:.:||     :||...:.:
Mouse  2193 IDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPR 2257

  Fly  2595 RFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAG 2659
            ..:..:..|....:.|:|..::             |...:::||||.|.|||||:|||.|||:||
Mouse  2258 VGVGTSYGLPQARRISLATPRQ-------------LYKSSNMTQRWQRREISNFEYLMFLNTIAG 2309

  Fly  2660 RSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETP 2724
            |:||||.|||||||:|.:|:|||||||.|..|||.|:|:||...:|...:.:|::.|::  .::|
Mouse  2310 RTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEE--DQSP 2372

  Fly  2725 PYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELI 2789
            |:||.||||:|....|:|||:|||:..||....|.||..||.|.||..:| ..|:.:.:||||||
Mouse  2373 PFHYNTHYSTATSALSWLVRIEPFTTFFLNANDGKFDHPDRTFSSIARSW-RTSQRDTSDVKELI 2436

  Fly  2790 PEFFYLPEFLSNFNNFDLGTKQNGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWID 2854
            |||:||||...|.|.:.||.:::...:|.|.|||||| .|.:|:|::|.|||.::||..||.|||
Mouse  2437 PEFYYLPEMFVNSNGYHLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLHQWID 2500

  Fly  2855 LIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGF-------------------- 2899
            ||||.||:||.||.|:||||:|.|||:|::.:|.||:.:.....:
Mouse  2501 LIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREIPEAYFIRDPHTFLLTKDFIKAMEA 2565

  Fly  2900 -INNFGQIPKQLFKKAHPAKKMGGSRHSALIDPTSLIQGNSTVLQTDRLFFHNLDNLK-PSLQPI 2962
             |.||||.|.||..:.||.:  ..:.|...:..:.|:..:.  :|.|.:..     || ||..|:
Mouse  2566 QIQNFGQTPSQLLIEPHPPR--SSAMHLCFLPQSPLMFKDQ--MQQDVIMV-----LKFPSNSPV 2621

  Fly  2963 KELKGPVGQILQPDKTVFAVEQNKVMMPPSYTKYIA---WGFADHSLRIGL-----YDTDRA--- 3016
            ..    |.....|..|:.||      :..:.::..|   |    |: .:||     |..|:|
Mouse  2622 TH----VAANTLPHLTIPAV------VTVTCSRLFAVNRW----HN-TVGLRGAPGYSLDQAHHL 2671

  Fly  3017 -----SFVSEASAQNSGEI---------LTCACPNAKMIVTAGTSSVVTIWKFDANRKSLAVKHS 3067
                 ..::..|..|..:|         :...|    .:|||....::....:|   ||..|..:
Mouse  2672 PIEMDPLIANNSGVNKRQITDLVDQSIQINAHC----FVVTADNRYILICGFWD---KSFRVYST 2729

  Fly  3068 --------LHGHTDAVTCLAASAAY----NVIVSGSRDGTAIVW-------------DMTRFTFV 3107
                    :.||.|.|||||.|.:|    ..|||||||.|.::|             :.:.:...
Mouse  2730 ETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAP 2794

  Fly  3108 RQ-LRGHAGVVAAVS------------------INELTGDI-------ATCSATWL-------HV 3139
            |. |.||...|..||                  ::.:|||:       ..|....|       |.
Mouse  2795 RAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHC 2859

  Fly  3140 -----------WSINGDALAMVNTCVGSADRMQQILCVAFSQIREWDQQNVIITGSTDGVVRMW 3192
                       :||||..||.:..    .|..:.||..:       |.|| ::||..:|||.:|
Mouse  2860 IIYYERGRFSNFSINGKLLAQMEI----NDSTRAILLSS-------DGQN-LVTGGDNGVVEVW 2911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	32/157 (20%)
		Beach	2638..2918	CDD:460459	149/300 (50%)
		WD40	2995..>3194	CDD:475233	69/292 (24%)
		WD40 repeat	3031..3070	CDD:293791	8/46 (17%)
		WD40 repeat	3075..3111	CDD:293791	17/53 (32%)
		FYVE_WDFY3	3418..3482	CDD:277259
Nbea	XP_036019004.1	Laminin_G_3	245..392	CDD:463865	29/143 (20%)
		DUF4704	457..937	CDD:464870	104/618 (17%)
		DUF1088	1956..2122	CDD:461925	43/238 (18%)
		PH_BEACH	2159..2256	CDD:434260	25/96 (26%)
		Beach	2288..2585	CDD:460459	149/300 (50%)
		NBCH_WD40	2685..2957	CDD:466575	60/246 (24%)
		WD40 repeat	2746..2800	CDD:293791	17/53 (32%)
		WD40 repeat	2805..2840	CDD:293791	6/34 (18%)
		WD40 repeat	2845..2874	CDD:293791	4/28 (14%)
		WD40 repeat	2883..2921	CDD:293791	12/41 (29%)
		WD40 repeat	2929..2955	CDD:293791