DRSC/TRiP Functional Genomics Resources

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Protein Alignment bchs and lvs1

DIOPT Version :9

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:NP_595759.2 Gene:lvs1 / 2540571 PomBaseID:SPBC28E12.06c Length:2609 Species:Schizosaccharomyces pombe


Alignment Length:3112 Identity:719/3112 - (23%)
Similarity:1176/3112 - (37%) Gaps:820/3112 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   671 IQILNMLLGCLKDSHRTRTVFRKVGGFV-------YVTSVFVSLDGSMALPQ--PDIPQQDLILL 726
            :::|:.|.||..:......: ||:.||:       :...:|::.:|..|:.:  ..:..|.|:.|
pombe    12 VELLSRLEGCPSEKVLLEEL-RKLRGFIRNDIPSNFFPQLFITDNGFAAIKKAVTKLNFQSLLSL 75

  Fly   727 ------LQIV-FQTLATAMR------------FEPANAKFFHQEISSSSLC----DTLRLLGCFG 768
                  |||: ..|..|.:|            .|.|..:.|:      |.|    |:...:...|
pombe    76 DIFECCLQILGIATSYTILRSWLLSRKHIEAWIELAIRRMFY------SFCAIQDDSNISIYAIG 134

  Fly   769 GSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPY-------PLSYVCIVFRLLYSIAL 826
            .||..........|.:.|.....:.......:||.|.||.|       ..:.:|..:.|...:.|
pombe   135 TSSKTDSSIQAASPNEDLKSEGAQEIDSQSETVSISSDVDYDEDRKDLKKAKICSAYYLKTRLLL 199

  Fly   827 DNFEAPNLSGIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPRIVHPGVVLCMLQLLPAV 891
            ............:|....|:...:.:..|.......:..:.:.|.:| :..|.|:..:|.|.|::
pombe   200 AVLSFAQNDSTFSLLKLVPSLQDNTNASLVELSRVVEAAIQKLSIKP-LAFPNVLPQVLLLCPSI 263

  Fly   892 E-YDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKLTRRALAEESHPLHVPMQYI 955
            . :::..|.           :::|:||.....|...:                 |..:|..:.|:
pombe   264 SIFNLILLH-----------LRALIRSSPENAIKIGY-----------------SKTMHFLLTYL 300

  Fly   956 LERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKL-----------GGPVPLTRIKTLVSMTT 1009
            .|       .||..        |||....||.....|           ...|..|.:||......
pombe   301 FE-------PPTSF--------PLSDVSKDLLNEITLHCATFGVSNASTAKVLRTYLKTKSEFLR 350

  Fly  1010 PRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFPPQTG 1074
            ....:|......|.|. .:.|.:|:..:.....:|                        ..|..|
pombe   351 TWLLKALSHLVAPSFY-FNPSTKGYSSIDFTLSSP------------------------VMPING 390

  Fly  1075 LTYSTWFCVEKF--SDPKTDPHCVRLL------TLVRTIHNPREENLACLSILLSARDKAIVV-- 1129
            .:.|.|..:|..  .|....|..:.|:      ||.|              :||.|..|.:||  
pombe   391 YSVSLWLNIESLMNDDGNYAPTTLFLISDFLKSTLFR--------------LLLDASKKTVVVHI 441

  Fly  1130 -STQETLV----TPRKSIGDWEPEGSDDGIARIWCPD-LLHEGQWHNLVVVLNRAVLKNSSLFLY 1188
             |:::|.|    ||..:.           .::|:..: .|:...||.:.:|.........:|.||
pombe   442 GSSKDTCVVNFSTPITNF-----------FSKIYKDNPSLNPPSWHLITLVHRNEKSSLPNLELY 495

  Fly  1189 LDG---------VPMHTQKLH--YIAQHPAAGNASLTSPTQIFGYIG------------------ 1224
            :||         .|..:..|.  |::..|:.|:.:.::|:.:...:.                  
pombe   496 IDGSAVERAACPYPFLSSTLQPLYVSLGPSIGSRNQSTPSTLAPNVAETDALVSENTGAASQKTS 560

  Fly  1225 ----------TPPIWRRYSRLCWKQGVCHLIEDVLTQQTVQTIYQLGPHYMGSLQAP----QLGK 1275
                      .||:      :....|........|....:..|..|||.|.|..|.|    ...|
pombe   561 KSYKTNDSLKVPPL------VPLLIGTTRFFPVPLVSSQIAIISSLGPSYSGCFQGPINDYMTYK 619

  Fly  1276 QSESLAPLVPEDR-----VLLGLNAKAVSKLTLVKIRKVY--------SRADNKSIAKQLNM--N 1325
            .|.:|...:.:.:     :|..:.|.:.|.:..:...:.|        |...:.|:.:.|..  |
pombe   620 ASTALTLEIQDSKSNTEDLLHSIQAFSRSPIAFMSCARDYVDIMDLQLSDFCSFSVLETLKKLEN 684

  Fly  1326 SHENATPIKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDTVGGCNVLLGIIAMAQD 1390
            .:.:...|....:|......|.:...||..|  .|.......:|..|..:||.::||.::..|:.
pombe   685 QYYSHVYINRAVSSYDKAFSAEQPSFGVSSG--SVTPIIMQSISDAIYNIGGSSILLELVGTAET 747

  Fly  1391 VESLYAGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKKKKHLL-NSHILHLTFGLVGTVNSGQ 1454
            ...|..|::.....:..|......:::...::.|......|.||| :...|.:...:.|..::..
pombe   748 EAELNFGLQVFFSSIEDNWRFSENVEQTHSFEILAQILHSKSHLLVSEETLKIIALMSGVHHTRF 812

  Fly  1455 DMSAIPNVTAFQDLLCDLEIWHNAPN-GLLRSLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLH 1518
            ....:.|...|:.|:.|.::|..||| .|....|.:::.|:..:.....|||.:..:|:|.||| 
pombe   813 KHPLVMNPLLFRYLILDFDLWSKAPNSNLFVQQLGYIVSLIENNDYAGFNVKRLMKMQILKKLL- 876

  Fly  1519 IITQIQDHSTREILFSLLETLLGGQPRHTDL-----LLFGQYVAAKLPHAHSGGLERAVLLPSMK 1578
                   .:.|..||            |.||     |||...:.:.....:...:...::..|  
pombe   877 -------TAMRNCLF------------HKDLLPILRLLFKVLMTSAFVSENIRSVATYIIYAS-- 920

  Fly  1579 NPAEDQDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYV--------ICDD--------------- 1620
                 |..|.::.|  |...:|:.     ..|:..||:        ||::               
pombe   921 -----QATGKSKPI--RRSSVSIA-----VDRSDSNYISIKESGYAICEEFIDLLIKSNGEPSFL 973

  Fly  1621 --ISKTLGMDWLL-LFMQPHVHFTTVIIAVRIL-VVICA-NESFLVRFRDATHNGGYLRFTEMVS 1680
              .|..:...||| |..|..:|:  .|..:|:| ..||: ..|||.:|....|  |:|...:.:.
pombe   974 RRFSSMITPAWLLFLLRQQDIHY--FICGIRLLNQSICSLGSSFLSKFSQKFH--GFLILHDNLK 1034

  Fly  1681 QR------------KMLGLGAQQLNQRPTNGTGTVIVATPQNTIQHLPTQIAGEVRAAALNIPGF 1733
            ..            ..||||.:.:..|                     |.:..:           
pombe  1035 DHIHLEELWLNLLFLSLGLGIRSVQFR---------------------TDLTYK----------- 1067

  Fly  1734 QLLEWLMNHHLD--------VPELYFLITALIMGQPVKVLATEHTKFDLDRV---------WSFL 1781
            |.|::::.:.||        .|.|:..|.|.:     :.::..:.|.:.:.|         .|||
pombe  1068 QKLDFVLKNELDNILPLSEVFPSLFHAIQATL-----EKVSNVNGKLNSENVAALRYADDTMSFL 1127

  Fly  1782 WGAPVSANTQLPKLN-----ICPEGVCVLLAMVRGIVHGGECAPWLHS----HPETIIQLLF--S 1835
            .....:.:.:| .||     :..:.|...|:.|..|....|....||:    .|.:.....|  .
pombe  1128 VTLQTTYSFEL-TLNYDFSELLTKVVFPFLSPVDTITAEQEMRDLLHNIRQPLPRSSSSKTFGEG 1191

  Fly  1836 LYQNLTDFAPVMMTGDVVTSLVAVLFPLASR---------PADSEPNSG--ASTPTDDTG----S 1885
            :.:::..|:   |:|    |...|:.||.::         ..|.|..|.  ||.|..|..    .
pombe  1192 IKKSVRKFS---MSG----SFKRVVTPLGTQLRKDILNDSITDMENTSSFTASFPQSDQALQYFD 1249

  Fly  1886 SFALPPPE---TLHGAPQPKLTAHPVCNCIIDFLRVIVVDSLGLNMQGKPTPVIDLVLDAAPESA 1947
            :|.:...|   .:.|      ....:..||.:.:           ..|:......|::...|  :
pombe  1250 NFTVQYAEAKDVIKG------LLFSILTCIYNRI-----------TSGQGFSYSRLLVYLPP--S 1295

  Fly  1948 ELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVPLLQSQMQYIAPNVF------YLTA---R 2003
            ::..:..:.:.|:.:.|..|:.|   |.....|...|.:.:.:.||.....      ||..   .
pombe  1296 QIEKKSTFFSGILRSTMSKLIEA---VKNDKLLLAEPSILANISYIFTKFIRMHLLGYLKGSWLE 1357

  Fly  2004 IVDKLWQGCLARNPHDIFDFVIKLIVQAKRRSSSLSLEHLHHSLNRSILFLLS----RPTD-DSR 2063
            |||.|  |.|........||:.||....:..:.::....|.       ||||.    :.|: :::
pombe  1358 IVDDL--GSLLEEIISRPDFLAKLPKNGRNAAMNMYSCFLD-------LFLLEVSDLKQTECNAQ 1413

  Fly  2064 ADQMSVLEALHKIIQHRLLIFGAGNHELEFIGCLTYCLLQLTADMKIILEPATSRNTTWHVNPQT 2128
            :|::     :..|...:.|:|.:..::.:....|.|.:.       |::|..|.           
pombe  1414 SDKI-----IKSITYWQSLLFNSKTYQKDLFSLLWYAVY-------IMVETTTG----------- 1455

  Fly  2129 ETAEPKDEDLNQLQGRNLIVGAAFRVWEELYVCKKPAIEEVFKVSLTSPPPNSKAPDLQTTREQV 2193
                     :.:||        |...|..|::.....:.::.|.....|             ...
pombe  1456 ---------VVRLQ--------AVDAWRLLFLHSPGYLSDIAKTCNNDP-------------RFA 1490

  Fly  2194 MELASKL---------WFNYVEAE----RKATYRAPWELHTQIQSKIQKVTGGLSRLTSRTKTKK 2245
            .|:...|         |.:...||    ..:.:...||...:.|.|:......|.:. ||.:..:
pombe  1491 YEICKTLDNDSDKFVRWLDDNAAEVNQFMLSCFFCRWEDFLKQQHKLADEEASLLQF-SRLEHLR 1554

  Fly  2246 EELVRTRSTLTREAAYESTGIHVQLIKDLLDLRAKQYQQMLQ---HTQRYVYQDWVQSEMELTRE 2307
            ::|  .::|.......||:..:...|..|..|...::::|.|   ..:.:|....:..:.||:.|
pombe  1555 KQL--AQNTFNENILNESSASYHVWISSLFALECNRFKKMSQDQSDQENFVAAALLSQKNELSHE 1617

  Fly  2308 RGLWGPTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLHYPYRPELELADNRQLKYKVASSLDSK 2372
            ..:.|    .....|.||:|||..||||:.|            |.|          ..:|.||||
pombe  1618 NSILG----SKTTSWELDSTEGSERMRKRLM------------PCL----------LQSSELDSK 1656

  Fly  2373 TYALHGPQQPRILAEAGEHHAMQQQSSLEAVQS-HRLETSSSTSTPPPMVLPKLVGHGST---PC 2433
                                       |||..| .|...|..||...|:.|.......:|   |.
pombe  1657 ---------------------------LEARSSGARRNRSFDTSVEAPVSLTNEEKQAATLILPS 1694

  Fly  2434 PQESV-------DGNAPEDDEEEEDTSMTSD-NETFLRLLEEQEKISFMFRCARVQGLDTFEGLL 2490
            .:|::       ..|:.||:|::.|.....| |.|.:|.:|..:.|..::..:|:.||:..||:|
pombe  1695 QEETLHDAARSDSNNSMEDEEDDVDEEDKEDKNRTVMRSIESGDSIQDVYNVSRIFGLEATEGIL 1759

  Fly  2491 LFGKEHCYIVDGFTLLKNREIRD------IDTLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSK 2549
            |.||::.|::|.|.|..:.||.|      ||...|  |..::.....:||...|      |..||
pombe  1760 LLGKQYLYLMDNFFLRSDNEIVDVNDNSIIDERDP--YLQLLHLQSLSSSGKVR------RHISK 1816

  Fly  2550 -----FAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFPR-KVRNKVNQRFLA-------LAT 2601
                 :.:.::..|.||.|||:.:.||:|.:|||::|..... |.|:.:.|:.:|       |:|
pombe  1817 ENNWHWDFIDLSLVLKRFYLLRDVGLELFFKDGRSFLTILSNTKNRDSLYQKLVARAPGADVLST 1881

  Fly  2602 ALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETS--VTQRWVRGEISNFQYLMHLNTLAGRSYND 2664
            :....:.....|:....|...::.:.:.|...|:  .|:||.|.|||||.||..:||||||:|||
pombe  1882 SHFATSMSRDLGKANGKSNFLSSKLANALSFSTTHPATKRWERREISNFNYLQIVNTLAGRTYND 1946

  Fly  2665 LMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFK---EWDDPHGETPPY 2726
            |.|||||||::|||.|:||||.||||:|:|.:|||||..||..||.:|:.   ..:|  .:..|:
pombe  1947 LTQYPVFPWVIADYTSKELDLNNPKTYRNFCKPMGAQHPERESQFNERYDLLLGLND--SQQQPF 2009

  Fly  2727 HYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPE 2791
            ||||||||||||||||:||.||...:|.||||.||.|||:|:||::||.|:||.|||||:|||||
pombe  2010 HYGTHYSSAMIVCSYLIRLRPFVDSYLALQGGQFDHADRLFYSIEQAWRSSSKENMADVRELIPE 2074

  Fly  2792 FFYLPEFLSNFNNFDLGTKQNGET-LNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDL 2855
            ||||.|...|.|.||.|::|...| :|.||||||||.||..|::.:|.|||..|||.|||.||||
pombe  2075 FFYLSEMFINGNGFDFGSRQKESTPINDVILPPWAKGDPAIFVQKNREALESKYVSAHLHEWIDL 2139

  Fly  2856 IFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKM 2920
            :|||||:|..||.|.||||||.|:|.:|:.||::..:..|.:|.|:||||.|||:|||.||.:  
pombe  2140 VFGCKQRGDEAVAATNVFHHLSYQGAIDLENIENEFELAAAVGIIHNFGQTPKQVFKKPHPQR-- 2202

  Fly  2921 GGSRHSALIDPTSLIQGNSTVLQTDRLFFHNLDNLKPSLQPIKELKGPVGQI-LQPDKT---VFA 2981
            |.......:.|  .:.|.         |..::..|..|..||..:...|..| ..|.|.   .||
pombe  2203 GPDFTDTPLGP--YLFGR---------FEDSIHLLFQSCSPIIRICKKVAHIQYDPSKDEVGAFA 2256

  Fly  2982 VEQNKVMMPPSYTKYIAWGFADHSLRIGLYDTDRASFV-SEASAQNSGEILTCACPNAKMIVTAG 3045
            .:..    |.....::|||..|:::::.....|:...: .|..::....::.|   :.:..:||.
pombe  2257 ADYT----PLGPNTFLAWGRVDNTVQLISDQLDKQPVMFEELHSEKITHVVAC---DERTFLTAS 2314

  Fly  3046 TSSVVTIWKFDANRK-SLAVKHSLHGHTDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQ 3109
            ....:.:|....|:. ..::|..|:||...:||:....|:::||||...|..|:||:.|..||..
pombe  2315 LDLTLRLWTLSTNKPIKASLKRVLYGHRYRITCVTVCKAFSIIVSGDAGGNLIIWDLNRAEFVSS 2379

  Fly  3110 LRGHAGVVAAVSINELTGDIATCSATWLHVWSING-----DALAMVNTCVGSADRMQQILCVAF- 3168
            |..:...:..:::|....:||..:..:..|.::||     |.|:.:.    :.:..:.|||..| 
pombe  2380 LSVYKLPIQTIAVNARNAEIAFSTGFYCCVVNVNGKILVKDKLSRIY----NENSDENILCSCFY 2440

  Fly  3169 -SQIREWDQQNVIITGSTDGVVRMWSLEHTQVPIDRKLKRGTEVSSQDKPDTVSLEGKDNKDDKM 3232
             ....||..:|:.|||..||::|:|.                                       
pombe  2441 TGANSEWLHKNLFITGHPDGIIRIWE--------------------------------------- 2466

  Fly  3233 SLMKQIKSLSQSEEEMEIVKSASESSISEASQHSHGSSKSAEAGPKAEVQGERRKSSISGAKSLH 3297
               |:::|.::.|.|                                                  
pombe  2467 ---KRLQSNAKLEAE-------------------------------------------------- 2478

  Fly  3298 EMKSATVEGQGSSYDPKSNEDEHAIRPSKSDTSLTDGFVVIDNDRHKGDQILRKGFRWQRQLMFR 3362
                            |:|.|    ||                             :|:..|:  
pombe  2479 ----------------KNNAD----RP-----------------------------KWRFHLL-- 2492

  Fly  3363 SKLTMHT-AYDRKDNAEPASITALTVSKDHKILYVGDARGRIFSWSVTEQPGRGVADHWLKDEGA 3426
             :...|| ...|...|...:|..:|.:...:.::.||.:|::|||.:   |......|..||..:
pombe  2493 -RQLQHTKGLGRNRVATRQNIITITPNGQARGIFAGDDKGQVFSWML---PDTTSNVHLEKDNTS 2553

  Fly  3427 DQCVKCHVKFTLYERKHHCRNCGQV-FCNKCSRFESEISRLRILKPVRVCQACYSQL 3482
            :.|..|..:|:|.|.:..||.||.. .|:.|      :|.|:... ::.|..||.|:
pombe  2554 ELCSLCDSRFSLMEWRSQCRACGNSNVCSDC------VSMLKDTN-IKTCYECYRQM 2603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 44/149 (30%)
Beach 2638..2918 CDD:280327 174/283 (61%)
WD40 <2991..3252 CDD:225201 56/269 (21%)
WD40 2995..>3194 CDD:295369 52/207 (25%)
WD40 repeat 3031..3070 CDD:293791 7/39 (18%)
WD40 repeat 3075..3111 CDD:293791 14/35 (40%)
FYVE_WDFY3 3418..3482 CDD:277259 19/64 (30%)
lvs1NP_595759.2 LamG 380..534 CDD:304605 38/202 (19%)
DUF4704 715..>837 CDD:292415 24/123 (20%)
PH_BEACH 1738..1871 CDD:275391 43/140 (31%)
Beach 1919..2202 CDD:214982 175/284 (62%)
WD40 <2255..2485 CDD:225201 62/352 (18%)
WD40 2255..>2466 CDD:295369 54/221 (24%)
WD40 repeat 2255..2294 CDD:293791 8/42 (19%)
WD40 repeat 2300..2340 CDD:293791 7/42 (17%)
WD40 repeat 2345..2398 CDD:293791 16/52 (31%)
WD40 repeat 2406..2435 CDD:293791 5/32 (16%)
FYVE_like_SF 2556..2600 CDD:277249 14/50 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 361 1.000 Domainoid score I154
eggNOG 1 0.900 - - E1_KOG1786
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 611 1.000 Inparanoid score I156
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001924
OrthoInspector 1 1.000 - - oto101602
orthoMCL 1 0.900 - - OOG6_102608
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R143
SonicParanoid 1 1.000 - - X1446
TreeFam 00.000 Not matched by this tool.
109.790

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