DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bchs and Nbeal2

DIOPT Version :9

Sequence 1:	NP_608968.2	Gene:	bchs / 33819	FlyBaseID:	FBgn0043362	Length:	3489	Species:	Drosophila melanogaster
Sequence 2:	NP_899099.2	Gene:	Nbeal2 / 235627	MGIID:	2448554	Length:	2750	Species:	Mus musculus

Alignment Length:	3256	Identity:	730/3256 - (22%)
Similarity:	1146/3256 - (35%)	Gaps:	1013/3256 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 KELISLSLLLKHNQSTSCSILCLKTL--LNILRHNAVFKDVYREVGILEIFVGCLTRYAAHVQKI 567
            ::.||||.|.......:.:.:.|..|  |:.|.......|:.:.:.:|::|: .|.|   :::.:
Mouse    35 EKTISLSSLEPRRPEEAGAEVPLLPLDALHALAEQLDQDDLDQALLLLKLFI-ILCR---NLENV 95

  Fly   568 TKGDESVVV------------ELENESEEELFDTLGKHVLEALTMLLGGGASNNAQLFREYGGAK 620
            ..|...|:|            ||:..|:|.....|....|.||  ||..|..:..|.:|.....:
Mouse    96 EAGWGQVLVPRVLALLTVLMAELKGSSQESHGTQLENVALHAL--LLCEGLFDPYQTWRRQLTGE 158

  Fly   621 CVHELVKFKHCRPQAL------GIVRELILSAGGDDDMLHILSLMHSVSPL--------QVEFKI 671
            .:....|.|:..|.|.      ...:|.:..|......| :|.|:|....:        |:....
Mouse   159 VISSKEKSKYKFPPAALPCEFGAFFQENLQDAERLPPTL-LLRLIHLFGAILAGGKANGQMAVSA 222

  Fly   672 QILNMLLGCLK--------DSHRTRTVFRKVGGFVYVTSVFVSLDGSMALPQPDIPQQDLILLLQ 728
            ..:..|||.::        |..:.....|.:.|.|:|      |..|.|.|:    ..:|..||:
Mouse   223 GSVQGLLGVVRGWGRGPAQDPQQVPLALRALVGAVHV------LHASRAPPR----GPELRTLLE 277

  Fly   729 IVFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLGCFGGSSALQDYTGTYEPQQSLLKYYHEI 793
            ..|..|.......|:::                                    |:::|:
Mouse   278 GYFHILNADWPTSPSSS------------------------------------PEEALV------ 300

  Fly   794 FSGDILSVSFSEDVPYPLSYVCIVFRLLYSIALDN--FEAPNLSGIITLFSDPPTTLRSPSKELA 856
                .|.||..:.:|..|:  |....:|.:..|.|  ||     .:|.|..:....|::    .|
Mouse   301 ----TLRVSMLDAIPMMLA--CEDRPVLQATFLSNNCFE-----HLIRLIQNSKLYLQA----RA 350

  Fly   857 PPVHPSQLN---LTQPSPEPRI--------VH-PGVVLCMLQLLPAVEYDMAPLQAVQLQVYLSE 909
            ||...|.|.   ||:|..:..:        || ..|:.|::...|:.:                |
Mouse   351 PPEGDSDLATWLLTEPDVQKVLDQDTDAIAVHVVRVLTCIMSGSPSAK----------------E 399

  Fly   910 IIKSLVRSERNQQIMCDHG-----LAEKLLKLTRRALAEESHPLHVP------------MQYILE 957
            :.|..:..:..|:::..||     |.::||.:.    .|..|.:|.|            ||::
Mouse   400 VFKERIGYQHLQEVLQSHGPPTHRLLQELLNMA----VEGDHSMHPPPPIRNEQPVLVLMQWL-- 458

  Fly   958 RLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPLTR------------IKTLVSMTT- 1009
                .||...|||.||            .|:.:.|....|.:|            ::||.:.|.
Mouse   459 ----PALPTAELRLFL------------AQRLWWLCDSCPASRTTCVQAGLVGYLLETLNTGTAL 507

  Fly  1010 ---------------------PRDFRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGT 1053
                                 |.:.|    ..|.|...||..:.|        ...|....||..
Mouse   508 GARCQEQLLALLQALGRVSLRPLELR----RLLRPPPGLDSESSG--------NESQKARHAGAV 560

  Fly  1054 IDANSIGGIG------------------AGDRIFP----PQTGLTYSTWFCVEK-----FSDPKT 1091
            |.|  :.|:.                  ||..:.|    |..|.|:..|.|::.     .|.|..
Mouse   561 IRA--LSGMARHRGPARALRYFDLTPSMAGIMVPPVQRWPGAGFTFHAWLCLQSSEAVPTSAPSR 623

  Fly  1092 DPHCVRLLTLVRTIHNPREENLACLSILLSARDKAIVVSTQETLVT---PRKSIGDWEPEGSDDG 1153
            .....:|.:...:..:..|      :...:|....:.|.|::..||   |..|..|
Mouse   624 PLQRKQLYSFFTSSGSGFE------AFFTAAGTLVVAVCTRKEYVTVNLPEVSFAD--------- 673

  Fly  1154 IARIWCPDLLHEGQWH--NLVVVLNRAVLKNSSLFLYLDG-----VPMHTQKLHYIAQHP----- 1206
                        ..||  .:|.|..|.....:.:.::.||     ||.....|    ..|
Mouse   674 ------------SAWHCVAIVHVPGRRPFSQNLVNVFKDGHLVKTVPFRFPSL----SEPFSSCC 722

  Fly  1207 --AAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCHLIEDVLTQQTVQTIYQLG-------P 1262
              :||:.:.|:.|      |.|.     |.:  ...:.|....:...|:|.....||       |
Mouse   723 IGSAGHRTTTTTT------GLPA-----SSV--STALAHTHPSLTRSQSVPASTGLGWGPGLGTP 774

  Fly  1263 HYMGSLQAPQLGKQSESL-APLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNS 1326
            ...||:.:...|.|.... :|...|..  ||..|.....|....:|.:.|...|:....:.....
Mouse   775 LQEGSVSSTLAGTQDTRWGSPTSLEGE--LGAVAIFHEALQPSALRVLCSLGPNEPAPFKPEGEL 837

  Fly  1327 HENATPIKILH-------NSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMIDTVGGCNVLLGI 1384
            ||..|.: :||       |:.......|..|.|.:.|:   || ....|..:::.|||..|||.:
Mouse   838 HEFGTKL-LLHYSPQACKNNICLDLSPGHGLDGRLTGH---RV-ETWDVKDVVNCVGGMGVLLPL 897

  Fly  1385 I----AMAQDVES------------LYAGVKALTCVVRSNRAAQAEMDRKRCYQTLGMFFKKKKH 1433
            :    ...|:.|:            |.:|......::...::::..|:|    ..:..|....::
Mouse   898 LERVAVQPQEAEAGPCETHDLVGPELTSGRNTQGLLLPLGKSSEDRMER----NAVAAFLLMLRN 958

  Fly  1434 LLNSHILHLTF-------GLVGTV-----NSGQDMSAIPNVTAFQDLLCDLEIWHNAPNG---LL 1483
            .|.:|.::...       .::|.:     :|..||    ||.....||.:    ..|.:|   ||
Mouse   959 FLQNHTVNQESLVQCQGPAIIGALLRKVPSSAMDM----NVLMSAQLLME----QAAADGGGPLL 1015

  Fly  1484 RSLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHIITQIQDHSTREILFSLLETLLGGQPRHTD 1548
            ..|.:|||          .|..:.......|:|.||  |......||               |..
Mouse  1016 YLLYQHLL----------FNFHLWTLSDFAVRLGHI--QYMSSMVRE---------------HRQ 1053

  Fly  1549 LL--LFG-QYVAAKLPHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLL--FT 1608
            .|  .:| |::...|...:|         |..:.|....|        ||....||| ||:  |.
Mouse  1054 KLRKKYGVQFLLDALRTHYS---------PQRERPLAADD--------LRTVQTSLL-GLVREFL 1100

  Fly  1609 PRN--------TVNYVIC-DDISKTLG-MDWLLLFMQ------PHVHFTTVIIAVRILVVICANE 1657
            .||        .:|::.. .|..:.:| ::.||..:|      |...|...:..:.:|:.:
Mouse  1101 VRNFSVEDMQVVLNFLAATGDDGQVVGTLELLLTLLQGSPVQDPLAAFLLELGNLEVLLAL---- 1161

  Fly  1658 SFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQQLNQRPTNGTGTVIVATPQNTIQHLPTQIAGE 1722
              |||.:.          |.:::.|....|...|.|:|                   ||.:....
Mouse  1162 --LVRPKS----------TPLLTDRVCKILRRLQQNER-------------------LPERNRQR 1195

  Fly  1723 VRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHTKF-DLDRVWSFLWGAPV 1786
            :|   |:..|.|.|...::.....|:|...:..|.:|...:|::.:.... ||..|......|.:
Mouse  1196 IR---LHDCGLQGLVASLSEESISPQLCQGLYKLFVGTVPQVVSPDCLNLSDLLAVVQLSLQADL 1257

  Fly  1787 SANTQLPKLNICPE---------GVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQNLTD 1842
            |.     :|:||.:         .|..|||...|         |     :.::..|:.| :..||
Mouse  1258 SV-----RLDICRQLFYLIYGQPDVVRLLARQAG---------W-----QDVLTRLYVL-EAATD 1302

  Fly  1843 FAPVMMTGDV-VTSLVAVLFPLASRPADSE----------PNSGA--------STPTD------- 1881
            .:|.....:: ::|.:|:..|....||||.          |:..|        |||.|
Mouse  1303 SSPPRFLPELPISSELALSPPPTELPADSSDVFLPSESPCPDQDAFYQALSPFSTPFDLGLERAS 1367

  Fly  1882 -------DTGSSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVDSLGLNMQG-KPTPVIDL 1938
                   ..|||.....|.:..|.|.|                          :.| :|.|.
Mouse  1368 IGSGNTAGGGSSNGTVTPASQPGTPSP--------------------------LDGPRPFPT--- 1403

  Fly  1939 VLDAAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVP--LLQSQMQYIAPNVFYLT 2001
                        .|.::.:.:...|.|..|....:.|:..:....|  ..:.::..:..||.:..
Mouse  1404 ------------AQGRHSSSLSNVLEDGSLLEPNISGDDTSNTSNPQQTPEEELCNLLTNVLFSV 1456

  Fly  2002 ARIVDKLWQG------CLARNPHDIFDFVIKLIVQAKRRSSSLSLEHLHHSLNRSIL--FLLSRP 2058
            .      |:|      ...|....:|..:.:|       .:|.:|......:.||:|  .|.|..
Mouse  1457 T------WRGVEGSAEAAWRERGQVFSVLTQL-------GASATLVRPPDCIKRSLLEMMLESAL 1508

  Fly  2059 TDDSRADQMSVLEA------LHKIIQHRLLIFGAGNHE-------------LEFIGCLTYCLLQL 2104
            ||...|....:...      |.:::|..|...|.||.|             |:.:|...: |...
Mouse  1509 TDIKEAPPGGLANLSQQALWLLRLLQDFLCAEGHGNQELWSEKLFEGVCNLLDRLGAWPH-LANS 1572

  Fly  2105 TADMK-------------IILE-PATSRNTTWHVNPQTETAEPKDED-----LNQLQG------- 2143
            |||::             |:|| |.........::...:||.|...:     |::|:.
Mouse  1573 TADLREMAQIGLRLVLGYILLEDPQLHAQAYVKLHTLLQTAVPTRREEACYVLSKLEAALSRALT 1637

  Fly  2144 --------RNLIVGAAFRV-WEELYVCKKPAIEEVF-----KVSLTSPPPNSKAP----DLQTTR 2190
                    .:..|.|:.|. |  |....:..::..:     :..|.|.||.:.:|    |.|..
Mouse  1638 TSSSETEHASTAVAASERCSW--LVPLVRTLLDRAYGPLGLQWGLPSLPPTNGSPTFFEDFQAF- 1699

  Fly  2191 EQVMELASKLWFNYVEAERKATYRAPWELHTQIQSKIQKVTGGL-----SRLTSRTKTKKEELVR 2250
                 .|:..|.::::.:.:.| .:.:|:.|  .:|...:..|.     ..|.|..:..:.:.::
Mouse  1700 -----CATAEWRHFIDKQVQPT-MSKFEMDT--YAKSHDLMSGFWNACYDTLMSSGQRHQRDRIQ 1756

  Fly  2251 TR---STLTREAAYESTGIHVQLIKDLLDLRAKQYQQMLQHTQRYVYQDWVQSEMELTRERGLWG 2312
            :|   ..|..|.|.....:.......:|..:|.|:...|.|        |.....:|:...|.|.
Mouse  1757 SRRAFKELVLEPAQRRARVEGLRYASVLKQQAAQHSTALLH--------WGALWRQLSSPCGAWA 1813

  Fly  2313 ---PTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLHYPYRPELE---LADNRQLKYKVASSLDS 2371
               |..    ..|.|.:.|...|||.|.:.|     |: :.|.||   |.||
Mouse  1814 LRIPPA----PHWKLSSAETYSRMRLKLVPN-----HH-FDPHLEASALRDN------------- 1855

  Fly  2372 KTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSSTSTPPPMVLPKLVGHGSTPCPQE 2436
                         |.||                    ..:.:..|..|:.:.|   ......|.|
Mouse  1856 -------------LGEA--------------------PMTPTEETSLPLAVTK---EAKISAPPE 1884

  Fly  2437 SVDGNAPEDDEEEED-TSMTSDNETFLRLLEEQEKISFMFRCARVQGLDTFEGLLLFGKEHCYIV 2500
            .:    ||:...||| .::.|..|....|.|::||:.....|..|..:....|||....:|.|..
Mouse  1885 EL----PEEQLGEEDLAALESLMEEAAELDEKREKLVLSAECQLVTVVAVVPGLLEITTQHVYFY 1945

  Fly  2501 DGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLL 2565
            ||.|                  |.:         .|...:.|..|:    ...::||||.||:.|
Mouse  1946 DGST------------------ERV---------ETEEGIGHDFRR----PLAQLREVHLRRFNL 1979

  Fly  2566 QPIALEVFSEDGRNYLLSFPRKV-------------------------RNKVNQRFLALATALND 2605
            :..|||:|..|..||.|:||.||                         ||:|....|.|.
Mouse  1980 RRSALELFFIDQSNYFLNFPHKVAASSASSPCQAPRPQLYPIPSHTQLRNQVYSLLLRLR----- 2039

  Fly  2606 NAQQSVAGQKRTASVEQTAGIFSG-----LIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDL 2665
                           ..|.|..|.     ::..:.:||:||:.|||||:|||.|||:|||:||||
Mouse  2040 ---------------PPTQGYLSSRSPLEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDL 2089

  Fly  2666 MQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETPPYHYGT 2730
            .|||||||:|.||.|..|||:||..|||.|:|:|....:..:..:::::.::||.|....:||||
Mouse  2090 SQYPVFPWVLQDYVSPVLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGT 2154

  Fly  2731 HYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYL 2795
            |||:|..|..||:|:|||:...::||.|.||.:||.|||:..|| .|...:.||||||||||||.
Mouse  2155 HYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAW-QARLESPADVKELIPEFFYF 2218

  Fly  2796 PEFLSNFNNFDLGTKQ-NGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGC 2859
            |:||.|.|.||||..| ..|.:..|:||||| ..|.:||:.||.|||.:|||.|||.|||||||.
Mouse  2219 PDFLENQNGFDLGCLQLTNEKVGDVVLPPWA-GSPEDFIQKHRQALESEYVSTHLHEWIDLIFGY 2282

  Fly  2860 KQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKMGGSR 2924
            ||:||||.:|:|||::..|||.||:.::.|..::.|..|.|:||||.|.||.|:.||.:......
Mouse  2283 KQRGPAAEEALNVFYYCTYEGAVDLDHVADERERKALEGIISNFGQTPCQLLKEPHPPRLSAEEA 2347

  Fly  2925 HSALIDPTSLIQGNSTVLQTDRLFFHNLDNLKPSLQPIKELKGPVGQILQP-------------- 2975
            .:.|    :.:..||..:      |.||:.||.....:.....|:...|.|
Mouse  2348 ANRL----ARLDTNSPSI------FQNLNQLKAFFAEVVSEAVPLVLALVPHRQSHSFITQSSSD 2402

  Fly  2976 -------------------DKTV---FAVEQNKVMMPPSYTKYIA--W----------------- 2999
                               |:.:   |...::..|..|...|.::  |
Mouse  2403 MLVTVSASGLLGTHTWLPYDRNINNYFTFSKDPTMGSPKVQKLLSGPWVSDSGVSAQALAVAPDG 2467

  Fly  3000 ------GFADHSLRIGLYDTDRASFVSEASAQNSGEILTC----ACPNAKMIVTAGTSSVVTIWK 3054
                  |..|.|||:  ....|...:::.|...  :|:||    .|  ...:::....:...:|:
Mouse  2468 KLLFSGGHWDGSLRV--TSLPRGRLLNQLSRHL--DIVTCLALDTC--GIYLISGSRDTTCMVWR 2526

  Fly  3055 F---DANRKSLAVK--HSLHGHTDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQLR--- 3111
            .   ......||.|  ..|:||..||:|:|.|...::.||||.|||.|:..:.|..||..||
Mouse  2527 LLQQSGLSAGLAPKPVQVLYGHVAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQFVAALRPPG 2591

  Fly  3112 ------------GHAG-VVAAVSINELTGDIATCSATWLHVWSINGDALAMVNTCVGSADRMQQI 3163
                        |..| :|...|..|..|...|.|   ||::|:||...|.|     :.......
Mouse  2592 ATLPGPISHLALGAEGQIVVQSSACERPGAQVTYS---LHLYSVNGRLRASV-----TLTEQPTA 2648

  Fly  3164 LCVAFSQIREWDQQNVIITGSTD---GVVRMWSLEHTQVPIDRKLK-RGTEVSSQDKPDTVSLEG 3224
            |.||         ::.::.|:..   .::.:..|.....|:..|:. ....|:.:.....|.||
Mouse  2649 LTVA---------EDFVLLGTAQCSLHILHLNKLRPAVPPLPMKVPVHSVSVTKERSHVLVGLE- 2703

  Fly  3225 KDNKDDKMSLMKQIKSLSQSEEEMEIVKSASESSISEASQHSHGSSKSAEAGPKAEVQGERRKSS 3289
                |.|:                 ||..|.:.|...:||.:....:|:           ||.|.
Mouse  2704 ----DGKL-----------------IVVGAGQPSEVRSSQFARRLWRSS-----------RRISQ 2736

  Fly  3290 ISGAKS 3295
            :|..::
Mouse  2737 VSSGET 2742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	39/155 (25%)
		Beach	2638..2918	CDD:280327	153/280 (55%)
		WD40	<2991..3252	CDD:225201	68/314 (22%)
		WD40	2995..>3194	CDD:295369	57/251 (23%)
		WD40 repeat	3031..3070	CDD:293791	8/47 (17%)
		WD40 repeat	3075..3111	CDD:293791	15/35 (43%)
		FYVE_WDFY3	3418..3482	CDD:277259
Nbeal2	NP_899099.2	DUF4704	876..1125	CDD:292415	62/306 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1319..1340		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1363..1441		16/118 (14%)
		DUF4800	1590..1856	CDD:292675	59/320 (18%)
		PH_BEACH	1914..2039	CDD:275391	39/155 (25%)
		Beach	2062..2341	CDD:280327	153/280 (55%)
		WD 1	2382..2420		2/37 (5%)
		WD 2	2444..2487		7/44 (16%)
		WD40	<2459..2709	CDD:225201	64/294 (22%)
		WD40 repeat	2459..2496	CDD:293791	6/38 (16%)
		WD40	2460..>2614	CDD:295369	39/159 (25%)
		WD 3	2490..2527		6/40 (15%)
		WD40 repeat	2502..2547	CDD:293791	8/46 (17%)
		WD 4	2540..2578		17/37 (46%)
		WD40 repeat	2552..2588	CDD:293791	15/35 (43%)
		WD 5	2585..2627		10/44 (23%)
		WD40 repeat	2627..2666	CDD:293791	11/52 (21%)
		WD 6	2635..2670		6/48 (13%)
		WD 7	2678..2713		10/56 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920