DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bchs and NBEAL2

DIOPT Version :9

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:XP_016861499.1 Gene:NBEAL2 / 23218 HGNCID:31928 Length:2782 Species:Homo sapiens


Alignment Length:2933 Identity:637/2933 - (21%)
Similarity:1030/2933 - (35%) Gaps:904/2933 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   644 LSAGGDDDMLHILSLMHSVSPLQVEFKIQILNMLLGC-----LKDSHRTRTVFRKVGGFVYVTSV 703
            ||:|.::.::.:...|....|           |:|.|     |:.:..:...|..:...:..:.:
Human   292 LSSGPEEALVTLRVSMLDAIP-----------MMLACEDRPVLQATFLSNNCFEHLTRLIQNSKL 345

  Fly   704 FVSLDGSMALPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLGCFG 768
            ::.   |.|.|:.|              ..|||.:..||...|...|:..:.:: ..:|:|.|. 
Human   346 YLQ---SRAPPEGD--------------SDLATRLLTEPDVQKVLDQDTDAIAV-HVVRVLTCI- 391

  Fly   769 GSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPYPLSYVCIVFRLLYSIALDNFEAPN 833
                :.|.....|                    .|.|.:.||                       
Human   392 ----MSDSPSAKE--------------------VFKERIGYP----------------------- 409

  Fly   834 LSGIITLFSDPPTTLRSPSKELAPPVH---PSQLNLT-----QPSPEPRIVHPGVVLCMLQLLPA 890
                         .|:...:...||.|   ...||:.     ...|.|.|.:...||.:.|.||:
Human   410 -------------HLQEVLQSHGPPTHRLLQELLNMAVEGDHSMCPPPPIRNEQPVLVLAQWLPS 461

  Fly   891 VEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMC-DHGLAEKLLKLTRRALAEESHPLHVPMQY 954
                   |...:|:::|::.::.|..|....:..| ..||...||:.....||.|:. ....:..
Human   462 -------LPTAELRLFLAQRLRWLCDSCPASRATCVQAGLVGCLLETLSTGLALEAR-CQEQLLA 518

  Fly   955 ILERLAAQALQPTELRQFLRLGEPLSCADIDLQQP-------YKLGGPVPLTRIKTLVSMTTPRD 1012
            :|:.|...:::|.|||..||   |....|   .:|       .:..|.|    |:||..|.    
Human   519 LLQALGRVSIRPMELRHLLR---PRPGLD---SEPGGAEAGKARHAGAV----IRTLSGMA---- 569

  Fly  1013 FRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFP----PQT 1073
             |..|.:....:.:|           .||:                     ||..:.|    |..
Human   570 -RHQGPARALRYFDL-----------TPSM---------------------AGIMVPPVQRWPGP 601

  Fly  1074 GLTYSTWFCVEKFSDPKTDPHCVRLLTLVRTIHNPREENLACLSILLSARDKAIVVSTQE---TL 1135
            |.|:..|.|:... |....|...|.|...:.............:...:|....:.|.|::   |:
Human   602 GFTFHAWLCLHPM-DTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTM 665

  Fly  1136 VTPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWH--NLVVVLNRAVLKNSSLFLYLDG-----VP 1193
            ..|..|..|                     ..||  .:|.|..|.....:.:.:|.||     .|
Human   666 SLPEVSFAD---------------------SAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAP 709

  Fly  1194 MHTQKLHYIAQHPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCHLIEDVLTQ-QTVQTI 1257
            :....|.........|:|...:.|...| :.|||:          ..........||: |:|...
Human   710 LRCPSLSEPFSSCCIGSAGYRTTTTTTG-LPTPPV----------PATLAYTHPALTRSQSVPAS 763

  Fly  1258 YQLG-------PHYMGSLQAPQLGKQSESL-APLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRAD 1314
            ..||       |...||:.:...|.|.... :|...|..  ||..|.....|....:|.:.:...
Human   764 TGLGWGSGLVAPLQEGSIDSTLAGTQDTRWGSPTSLEGE--LGAVAIFHEALQATALRTLCTLGP 826

  Fly  1315 NKSIAKQLNMNSHENATPIKILH-------NSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMI 1372
            |::...:.....||.:|.: :||       |:..........|.|.:.|:   || ....|..::
Human   827 NETAPFKPEGELHELSTRL-LLHYSPQACKNNICLDLSPSHGLDGRLTGH---RV-ETWDVKDVV 886

  Fly  1373 DTVGGCNVLLGII----AMAQDVES------------LYAGVKALTCVVRSNRAAQAEMDRKRCY 1421
            :.|||...||.::    |..::.|:            |.:|......|:...::::..|:|    
Human   887 NCVGGMGALLPLLERVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEERMER---- 947

  Fly  1422 QTLGMFFKKKKHLLNSHILH-----------LTFGLVGTVNS-GQDMSAI-------PNVTA--- 1464
            ..:..|....::.|..|:::           :...|:..|.| ..||:.:       ..|.|   
Human   948 NAVAAFLLMLRNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGS 1012

  Fly  1465 -------FQDLLCDLEIWHNAPNGLLRSLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHIITQ 1522
                   :|.||.:..:|..:...:....::::..:|.|   .:|.::....:|.::..|.  |.
Human  1013 GPLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSIVRE---HRQKLRKKYGVQFILDALR--TH 1072

  Fly  1523 IQDHSTREILFSLLETLLGGQPRHTDLLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAED---- 1583
            ......|.:....|.|:      .|.||                ||.|..|:.|:.  |:|    
Human  1073 YSPQRERPLAADDLRTV------QTSLL----------------GLAREFLVRSLS--ADDVQVT 1113

  Fly  1584 --------QDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTLGMDWLLLFMQPHVHF 1640
                    ..|...|.:...:..|:||||.|              :.::|.    :..::|.   
Human  1114 QTMLSFLAATGDDGQAVGALDLLLALLHGSL--------------VQESLA----VFLLEPG--- 1157

  Fly  1641 TTVIIAVRILVVICANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQQLNQRPTNGTGTVIV 1705
                 .:.:|:.:......|....|..     .:....:.|.:.|...::|..:....|...::.
Human  1158 -----NLEVLLALLVRPGSLPLLPDRV-----CKILRRLQQNERLPERSRQRLRLRECGLQGLVA 1212

  Fly  1706 ATPQNTIQHLPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHT 1770
            ..|:.|:.                                 |:|...:..|.:|.....|:    
Human  1213 CLPEGTVS---------------------------------PQLCQGLYKLFLGADCLNLS---- 1240

  Fly  1771 KFDLDRVWSFLWGAPVSANTQLPKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFS 1835
              ||..|......|.:|.     :|:||           |.:.|      .::..|: :::||  
Human  1241 --DLLAVVQLSLQADLSV-----RLDIC-----------RQLFH------LIYGQPD-VVRLL-- 1278

  Fly  1836 LYQNLTDFAPVMMTG--DVVTSLVAVLFPLASRPADSEPNSGAS-------TPTDDTG------- 1884
                      ....|  ||:|.|..:....|..|..|.|.|..|       .||:...       
Human  1279 ----------ARQAGWQDVLTRLYVLEAATAGSPPPSSPESPTSPKPAPPKPPTESPAEPSDVFL 1333

  Fly  1885 -SSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVDSLGL---------------------- 1926
             |....|.|:..:.|..|..|..                .|||                      
Human  1334 PSEAPCPDPDGFYHALSPFCTPF----------------DLGLERSSVGSGNTAGGGGSSGTLTP 1382

  Fly  1927 -NMQGKPTPVIDLVLD------AAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVP 1984
             :..|.|:|     ||      |||.        ::.:.:...|.|..|....:.|:..:....|
Human  1383 ASQPGTPSP-----LDGPRPFPAAPG--------RHSSSLSNVLEDGSLPEPTISGDDTSNTSNP 1434

  Fly  1985 LLQSQMQY--IAPNVFYLTARIVDKLWQG------CLARNPHDIFDFVIKLIVQAKRRSSSLSLE 2041
            ...|:.:.  :..||.:...      |:|      ...|....:|..:.:|       .:|.:|.
Human  1435 QQTSEEELCNLLTNVLFSVT------WRGVEGSDEAAWRERGQVFSVLTQL-------GASATLV 1486

  Fly  2042 HLHHSLNRSIL-FLLSRPTDDSRADQMSVLEALH-------KIIQHRLLIFGAGNHE-------- 2090
            .....:.||:| .:|.....|.:...:.||.:|.       :::|..|...|.||.|        
Human  1487 RPPDCIKRSLLEMMLESALTDIKEAPVGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFE 1551

  Fly  2091 -----LEFIGCLTYCLLQLTADMK-------------IILE-PATSRNTTWHVNPQTETAEPKDE 2136
                 |:.:|...: |...|||::             |:|| |.........::...:||.|...
Human  1552 GVCSLLDRLGAWPH-LANGTADLREMAQIGLRLVLGYILLEDPQLHAQAYVRLHMLLQTAVPARR 1615

  Fly  2137 D-----LNQLQ-------------------GRNLIVGAAFRVWEE---LYVCKKPAIEEVFKV-- 2172
            :     |::|:                   |..|...||....|.   |....:..::..::.  
Human  1616 EEACYVLSKLEAALGRVLNTSSLESATDEAGSPLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLG 1680

  Fly  2173 ---SLTSPPPNSKAP----DLQTTREQVMELASKLWFNYVEAERKATYRAPWELHTQIQSK---- 2226
               .|.|.||.:.:|    |.|..      .|:..|.::::.:.:.| .:.:|:.|..:|.    
Human  1681 LQWGLPSLPPTNGSPTFFEDFQAF------CATPEWRHFIDKQVQPT-MSQFEMDTYAKSHDLMS 1738

  Fly  2227 -------IQKVTGGLSRLTSRTKTKK--EELVRTRSTLTREAAYESTGIHVQLIKDLLDLRAKQY 2282
                   ...::.|..|...|.::::  :|||  .....|.|..|.           |...|...
Human  1739 GFWNACYDMLMSSGQRRQWERAQSRRAFQELV--LEPAQRRARLEG-----------LRYTAVLK 1790

  Fly  2283 QQMLQHTQRYVYQDWVQSEMELTRERGLWGPTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLHY 2347
            ||..||:...::  |.....:|....|.|. .....:.:|.|.:.|...|||.|.:.|     |:
Human  1791 QQATQHSMALLH--WGALWRQLASPCGAWA-LRDTPIPRWKLSSAETYSRMRLKLVPN-----HH 1847

  Fly  2348 PYRPELELADNRQLKYKVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSS 2412
             :.|.||           ||:|......:  |..|            .:::||...    :...:
Human  1848 -FDPHLE-----------ASALRDNLGEV--PLTP------------TEEASLPLA----VTKEA 1882

  Fly  2413 STSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMFRC 2477
            ..||||.::....:|                ||:..|.:|.|.:     ..|.|::||:.....|
Human  1883 KVSTPPELLQEDQLG----------------EDELAELETPMEA-----AELDEQREKLVLSAEC 1926

  Fly  2478 ARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSH 2542
            ..|..:....|||....::.|..||.|                  |.:         .|...:.:
Human  1927 QLVTVVAVVPGLLEVTTQNVYFYDGST------------------ERV---------ETEEGIGY 1964

  Fly  2543 KLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFPRK-------------------- 2587
            ..|:    ...::||||.||:.|:..|||:|..|..||.|:||.|                    
Human  1965 DFRR----PLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPI 2025

  Fly  2588 -----VRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISN 2647
                 |||:|....|.|        :....|...:.|.::       ::..:.:||:||:.||||
Human  2026 PPHTQVRNQVYSWLLRL--------RPPSQGYLSSRSPQE-------MLRASGLTQKWVQREISN 2075

  Fly  2648 FQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKR 2712
            |:|||.|||:|||:||||.|||||||:|.||.|..|||:||..|||.|:|:|....:..:..:::
Human  2076 FEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREK 2140

  Fly  2713 FKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSA 2777
            ::.::||.|....:|||||||:|..|..||:|:|||:...::||.|.||.:||.|||:..|| .|
Human  2141 YESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAW-QA 2204

  Fly  2778 SKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQ-NGETLNHVILPPWAKHDPREFIRLHRSALE 2841
            ...:.||||||||||||.|:||.|.|.||||..| ..|.:..|:|||||. .|.:||:.||.|||
Human  2205 RLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWAS-SPEDFIQQHRQALE 2268

  Fly  2842 CDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQI 2906
            .:|||.|||.|||||||.||:||||.:|:|||::..|||.||:.::.|..::.|..|.|:||||.
Human  2269 SEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQT 2333

  Fly  2907 PKQLFKKAHPAKKMG--GSRHSALIDPTSLIQGNSTVLQTDRLFFHNLDNLK-----------PS 2958
            |.||.|:.||.:...  .:...|.:|..|            ...|.:||.||           |.
Human  2334 PCQLLKEPHPTRLSAEEAAHRLARLDTNS------------PSIFQHLDELKAFFAEVVSDGVPL 2386

  Fly  2959 LQPIKELKGPVGQILQ--PDKTV-----------------------FAVEQNKVM---------- 2988
            :..:...:.|...|.|  ||..|                       |:..::..|          
Human  2387 VLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLS 2451

  Fly  2989 ---------------MPPSYTKYIAWGFADHSLRIGLYDTDRASFVSEASAQNSGEILTC----A 3034
                           :.|......:.|..|.|||:..  ..|...:|:.|...  :::||    .
Human  2452 GPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVTA--LPRGKLLSQLSCHL--DVVTCLALDT 2512

  Fly  3035 CPNAKMIVTAGTSSVVTIWKFDANRKSLAV------KHSLHGHTDAVTCLAASAAYNVIVSGSRD 3093
            |  ...:::....:...:|:. .::..|:|      ...|:||..||:|:|.|...::.||||.|
Human  2513 C--GIYLISGSRDTTCMVWRL-LHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSED 2574

  Fly  3094 GTAIVWDMTRFTFVRQLR----GHAGVVAAVSINELTGDIATCSATW----------LHVWSING 3144
            ||.|:..:.|..||..||    ...|.:..:::.. .|.|...|:.|          ||::|:||
Human  2575 GTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGS-EGQIVVQSSAWERPGAQVTYSLHLYSVNG 2638

  Fly  3145 DALA------------------------------MVNTCVGSADRMQQILCVAFSQIREWDQQNV 3179
            ...|                              .:||.:.:|..:.  :.||...:....:::.
Human  2639 KLRASLPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLP--MKVAIRSVAVTKERSH 2701

  Fly  3180 IITGSTDG 3187
            ::.|..||
Human  2702 VLVGLEDG 2709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 37/155 (24%)
Beach 2638..2918 CDD:280327 153/280 (55%)
WD40 <2991..3252 CDD:225201 55/251 (22%)
WD40 2995..>3194 CDD:295369 54/247 (22%)
WD40 repeat 3031..3070 CDD:293791 7/48 (15%)
WD40 repeat 3075..3111 CDD:293791 15/35 (43%)
FYVE_WDFY3 3418..3482 CDD:277259
NBEAL2XP_016861499.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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