Protein Alignment bchs and NBEAL2

DIOPT Version :10

• Sequence 1: NP_608968.2
• Gene: bchs / 33819
• FlyBaseID: FBgn0043362
• Length: 3489
• Species: Drosophila melanogaster
• Sequence 2: NP_055990.1
• Gene: NBEAL2 / 23218
• HGNCID: 31928
• Length: 2754
• Species: Homo sapiens
• Alignment Length: 2964
• Identity: 646/2964 - (21%)
• Similarity: 1040/2964 - (35%)
• Gaps: 908/2964 - (30%)

  Fly   644 LSAGGDDDMLHILSLMHSVSPLQVEFKIQILNMLLGC-----LKDSHRTRTVFRKVGGFVYVTSV 703
            ||:|.::.::.:...|....|           |:|.|     |:.:..:...|..:...:..:.:
Human   292 LSSGPEEALVTLRVSMLDAIP-----------MMLACEDRPVLQATFLSNNCFEHLTRLIQNSKL 345

  Fly   704 FVSLDGSMALPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLGCFG 768
            ::.   |.|.|:.|              ..|||.:..||...|...|:..:.:: ..:|:|.|.
Human   346 YLQ---SRAPPEGD--------------SDLATRLLTEPDVQKVLDQDTDAIAV-HVVRVLTCI- 391

  Fly   769 GSSALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPYPLSYVCIVFRLLYSIALDNFEAPN 833
                :.|.....|                    .|.|.:.||
Human   392 ----MSDSPSAKE--------------------VFKERIGYP----------------------- 409

  Fly   834 LSGIITLFSDPPTTLRSPSKELAPPVH---PSQLNLT-----QPSPEPRIVHPGVVLCMLQLLPA 890
                         .|:...:...||.|   ...||:.     ...|.|.|.:...||.:.|.||:
Human   410 -------------HLQEVLQSHGPPTHRLLQELLNMAVEGDHSMCPPPPIRNEQPVLVLAQWLPS 461

  Fly   891 VEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMC-DHGLAEKLLKLTRRALAEESHPLHVPMQY 954
                   |...:|:::|::.::.|..|....:..| ..||...||:.....||.|:. ....:..
Human   462 -------LPTAELRLFLAQRLRWLCDSCPASRATCVQAGLVGCLLETLSTGLALEAR-CQEQLLA 518

  Fly   955 ILERLAAQALQPTELRQFLRLGEPLSCADIDLQQP-------YKLGGPVPLTRIKTLVSMTTPRD 1012
            :|:.|...:::|.|||..||   |....|   .:|       .:..|.|    |:||..|.
Human   519 LLQALGRVSIRPMELRHLLR---PRPGLD---SEPGGAEAGKARHAGAV----IRTLSGMA---- 569

  Fly  1013 FRAHGSSTLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFP----PQT 1073
             |..|.:....:.:|           .||:                     ||..:.|    |..
Human   570 -RHQGPARALRYFDL-----------TPSM---------------------AGIMVPPVQRWPGP 601

  Fly  1074 GLTYSTWFCVEKFSDPKTDPHCVRLLTLVRTIHNPREENLACLSILLSARDKAIVVSTQE---TL 1135
            |.|:..|.|:... |....|...|.|...:.............:...:|....:.|.|::   |:
Human   602 GFTFHAWLCLHPM-DTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTM 665

  Fly  1136 VTPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWH--NLVVVLNRAVLKNSSLFLYLDG-----VP 1193
            ..|..|..|                     ..||  .:|.|..|.....:.:.:|.||     .|
Human   666 SLPEVSFAD---------------------SAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAP 709

  Fly  1194 MHTQKLHYIAQHPAAGNASLTSPTQIFGYIGTPPIWRRYSRLCWKQGVCHLIEDVLTQ-QTVQTI 1257
            :....|.........|:|...:.|...| :.|||:          ..........||: |:|...
Human   710 LRCPSLSEPFSSCCIGSAGYRTTTTTTG-LPTPPV----------PATLAYTHPALTRSQSVPAS 763

  Fly  1258 YQLG-------PHYMGSLQAPQLGKQSESL-APLVPEDRVLLGLNAKAVSKLTLVKIRKVYSRAD 1314
            ..||       |...||:.:...|.|.... :|...|..  ||..|.....|....:|.:.:...
Human   764 TGLGWGSGLVAPLQEGSIDSTLAGTQDTRWGSPTSLEGE--LGAVAIFHEALQATALRTLCTLGP 826

  Fly  1315 NKSIAKQLNMNSHENATPIKILH-------NSAGHLAGAGRSLGGVVVGYLGVRVFSPHPVSAMI 1372
            |::...:.....||.:|.: :||       |:..........|.|.:.|:   || ....|..::
Human   827 NETAPFKPEGELHELSTRL-LLHYSPQACKNNICLDLSPSHGLDGRLTGH---RV-ETWDVKDVV 886

  Fly  1373 DTVGGCNVLLGII----AMAQDVES------------LYAGVKALTCVVRSNRAAQAEMDRKRCY 1421
            :.|||...||.::    |..::.|:            |.:|......|:...::::..|:|
Human   887 NCVGGMGALLPLLERVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEERMER---- 947

  Fly  1422 QTLGMFFKKKKHLLNSHILH-----------LTFGLVGTVNS-GQDMSAI-------PNVTA--- 1464
            ..:..|....::.|..|:::           :...|:..|.| ..||:.:       ..|.|
Human   948 NAVAAFLLMLRNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGS 1012

  Fly  1465 -------FQDLLCDLEIWHNAPNGLLRSLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHIITQ 1522
                   :|.||.:..:|..:...:....::::..:|.|   .:|.::....:|.::..|.  |.
Human  1013 GPLLYLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSIVRE---HRQKLRKKYGVQFILDALR--TH 1072

  Fly  1523 IQDHSTREILFSLLETLLGGQPRHTDLLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAED---- 1583
            ......|.:....|.|:      .|.||                ||.|..|:.|:.  |:|
Human  1073 YSPQRERPLAADDLRTV------QTSLL----------------GLAREFLVRSLS--ADDVQVT 1113

  Fly  1584 --------QDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTLGMDWLLLFMQPHVHF 1640
                    ..|...|.:...:..|:||||.|              :.::|.    :..::|.
Human  1114 QTMLSFLAATGDDGQAVGALDLLLALLHGSL--------------VQESLA----VFLLEPG--- 1157

  Fly  1641 TTVIIAVRILVVICANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQQLNQRPTNGTGTVIV 1705
                 .:.:|:.:......|....|..     .:....:.|.:.|...::|..:....|...::.
Human  1158 -----NLEVLLALLVRPGSLPLLPDRV-----CKILRRLQQNERLPERSRQRLRLRECGLQGLVA 1212

  Fly  1706 ATPQNTIQHLPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQPVKVLATEHT 1770
            ..|:.|:.                                 |:|...:..|.:|.....|:
Human  1213 CLPEGTVS---------------------------------PQLCQGLYKLFLGADCLNLS---- 1240

  Fly  1771 KFDLDRVWSFLWGAPVSANTQLPKLNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFS 1835
              ||..|......|.:|.     :|:||           |.:.|      .::..|: :::||
Human  1241 --DLLAVVQLSLQADLSV-----RLDIC-----------RQLFH------LIYGQPD-VVRLL-- 1278

  Fly  1836 LYQNLTDFAPVMMTG--DVVTSLVAVLFPLASRPADSEPNSGAS-------TPTDDTG------- 1884
                      ....|  ||:|.|..:....|..|..|.|.|..|       .||:...
Human  1279 ----------ARQAGWQDVLTRLYVLEAATAGSPPPSSPESPTSPKPAPPKPPTESPAEPSDVFL 1333

  Fly  1885 -SSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIVVDSLGL---------------------- 1926
             |....|.|:..:.|..|..|..                .|||
Human  1334 PSEAPCPDPDGFYHALSPFCTPF----------------DLGLERSSVGSGNTAGGGGSSGTLTP 1382

  Fly  1927 -NMQGKPTPVIDLVLD------AAPESAELPLQVQYQTQIIIALMDHLLAADVLVGEQAALPLVP 1984
             :..|.|:|     ||      |||.        ::.:.:...|.|..|....:.|:..:....|
Human  1383 ASQPGTPSP-----LDGPRPFPAAPG--------RHSSSLSNVLEDGSLPEPTISGDDTSNTSNP 1434

  Fly  1985 LLQSQMQY--IAPNVFYLTARIVDKLWQG------CLARNPHDIFDFVIKLIVQAKRRSSSLSLE 2041
            ...|:.:.  :..||.:...      |:|      ...|....:|..:.:|       .:|.:|.
Human  1435 QQTSEEELCNLLTNVLFSVT------WRGVEGSDEAAWRERGQVFSVLTQL-------GASATLV 1486

  Fly  2042 HLHHSLNRSIL-FLLSRPTDDSRADQMSVLEALH-------KIIQHRLLIFGAGNHE-------- 2090
            .....:.||:| .:|.....|.:...:.||.:|.       :::|..|...|.||.|
Human  1487 RPPDCIKRSLLEMMLESALTDIKEAPVGVLASLTQQALWLLRLLQDFLCAEGHGNQELWSEKLFE 1551

  Fly  2091 -----LEFIGCLTYCLLQLTADMK-------------IILE-PATSRNTTWHVNPQTETAEPKDE 2136
                 |:.:|...: |...|||::             |:|| |.........::...:||.|...
Human  1552 GVCSLLDRLGAWPH-LANGTADLREMAQIGLRLVLGYILLEDPQLHAQAYVRLHMLLQTAVPARR 1615

  Fly  2137 D-----LNQLQ-------------------GRNLIVGAAFRVWEE---LYVCKKPAIEEVFKV-- 2172
            :     |::|:                   |..|...||....|.   |....:..::..::.
Human  1616 EEACYVLSKLEAALGRVLNTSSLESATDEAGSPLAAAAAAAAAERCSWLVPLVRTLLDRAYEPLG 1680

  Fly  2173 ---SLTSPPPNSKAP----DLQTTREQVMELASKLWFNYVEAERKATYRAPWELHTQIQSK---- 2226
               .|.|.||.:.:|    |.|..      .|:..|.::::.:.:.| .:.:|:.|..:|.
Human  1681 LQWGLPSLPPTNGSPTFFEDFQAF------CATPEWRHFIDKQVQPT-MSQFEMDTYAKSHDLMS 1738

  Fly  2227 -------IQKVTGGLSRLTSRTKTKK--EELVRTRSTLTREAAYESTGIHVQLIKDLLDLRAKQY 2282
                   ...::.|..|...|.::::  :|||  .....|.|..|.           |...|...
Human  1739 GFWNACYDMLMSSGQRRQWERAQSRRAFQELV--LEPAQRRARLEG-----------LRYTAVLK 1790

  Fly  2283 QQMLQHTQRYVYQDWVQSEMELTRERGLWGPTGSCSLDKWILDTTEGPHRMRKKTMRNDVFYLHY 2347
            ||..||:...::  |.....:|....|.|. .....:.:|.|.:.|...|||.|.:.|     |:
Human  1791 QQATQHSMALLH--WGALWRQLASPCGAWA-LRDTPIPRWKLSSAETYSRMRLKLVPN-----HH 1847

  Fly  2348 PYRPELELADNRQLKYKVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSS 2412
             :.|.||           ||:|......:  |..|            .:::||...    :...:
Human  1848 -FDPHLE-----------ASALRDNLGEV--PLTP------------TEEASLPLA----VTKEA 1882

  Fly  2413 STSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMFRC 2477
            ..||||.::....:|                ||:..|.:|.|.:     ..|.|::||:.....|
Human  1883 KVSTPPELLQEDQLG----------------EDELAELETPMEA-----AELDEQREKLVLSAEC 1926

  Fly  2478 ARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSH 2542
            ..|..:....|||....::.|..||.|                  |.:         .|...:.:
Human  1927 QLVTVVAVVPGLLEVTTQNVYFYDGST------------------ERV---------ETEEGIGY 1964

  Fly  2543 KLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFPRK-------------------- 2587
            ..|:    ...::||||.||:.|:..|||:|..|..||.|:||.|
Human  1965 DFRR----PLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPI 2025

  Fly  2588 -----VRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISN 2647
                 |||:|....|.|        :....|...:.|.::       ::..:.:||:||:.||||
Human  2026 PPHTQVRNQVYSWLLRL--------RPPSQGYLSSRSPQE-------MLRASGLTQKWVQREISN 2075

  Fly  2648 FQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKR 2712
            |:|||.|||:|||:||||.|||||||:|.||.|..|||:||..|||.|:|:|....:..:..:::
Human  2076 FEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREK 2140

  Fly  2713 FKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSA 2777
            ::.::||.|....:|||||||:|..|..||:|:|||:...::||.|.||.:||.|||:..|| .|
Human  2141 YESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAW-QA 2204

  Fly  2778 SKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQ-NGETLNHVILPPWAKHDPREFIRLHRSALE 2841
            ...:.||||||||||||.|:||.|.|.||||..| ..|.:..|:|||||. .|.:||:.||.|||
Human  2205 RLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWAS-SPEDFIQQHRQALE 2268

  Fly  2842 CDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQI 2906
            .:|||.|||.|||||||.||:||||.:|:|||::..|||.||:.::.|..::.|..|.|:||||.
Human  2269 SEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQT 2333

  Fly  2907 PKQLFKKAHPAKKMG--GSRHSALIDPTSLIQGNSTVLQTDRLFFHNLDNLK-----------PS 2958
            |.||.|:.||.:...  .:...|.:|..|            ...|.:||.||           |.
Human  2334 PCQLLKEPHPTRLSAEEAAHRLARLDTNS------------PSIFQHLDELKAFFAEVVSDGVPL 2386

  Fly  2959 LQPIKELKGPVGQILQ--PDKTV-----------------------FAVEQNKVM---------- 2988
            :..:...:.|...|.|  ||..|                       |:..::..|
Human  2387 VLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLS 2451

  Fly  2989 ---------------MPPSYTKYIAWGFADHSLRIGLYDTDRASFVSEASAQNSGEILTC----A 3034
                           :.|......:.|..|.|||:..  ..|...:|:.|...  :::||    .
Human  2452 GPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVTA--LPRGKLLSQLSCHL--DVVTCLALDT 2512

  Fly  3035 CPNAKMIVTAGTSSVVTIWKFDANRKSLAV------KHSLHGHTDAVTCLAASAAYNVIVSGSRD 3093
            |  ...:::....:...:|:. .::..|:|      ...|:||..||:|:|.|...::.||||.|
Human  2513 C--GIYLISGSRDTTCMVWRL-LHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSED 2574

  Fly  3094 GTAIVWDMTRFTFVRQLR----GHAGVVAAVSINELTGDIATCSATW----------LHVWSING 3144
            ||.|:..:.|..||..||    ...|.:..:::.. .|.|...|:.|          ||::|:||
Human  2575 GTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGS-EGQIVVQSSAWERPGAQVTYSLHLYSVNG 2638

  Fly  3145 DALA------------------------------MVNTCVGSADRMQQILCVAFSQIREWDQQNV 3179
            ...|                              .:||.:.:|..:.  :.||...:....:::.
Human  2639 KLRASLPLAEQPTALTVTEDFVLLGTAQCALHILQLNTLLPAAPPLP--MKVAIRSVAVTKERSH 2701

  Fly  3180 IITGSTDG----VVRMWSLEHTQVPIDRKLKRGTEVSSQ 3214
            ::.|..||    ||.....|.......|||.|.:...||
Human  2702 VLVGLEDGKLIVVVAGQPSEVRSSQFARKLWRSSRRISQ 2740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	37/155 (24%)
		Beach	2638..2918	CDD:460459	153/280 (55%)
		WD40	2995..>3194	CDD:475233	56/256 (22%)
		WD40 repeat	3031..3070	CDD:293791	7/48 (15%)
		WD40 repeat	3075..3111	CDD:293791	15/35 (43%)
		FYVE_WDFY3	3418..3482	CDD:277259
NBEAL2	NP_055990.1	Neurobeachin	<298..499	CDD:466574	49/297 (16%)
		DUF4704	877..>1128	CDD:464870	48/284 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1298..1338		9/39 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1364..1438		13/86 (15%)
		DUF4800	1587..1861	CDD:464996	62/313 (20%)
		PH_BEACH	1918..2043	CDD:275391	38/163 (23%)
		Beach	2065..2345	CDD:214982	154/281 (55%)
		WD 1	2386..2424		6/37 (16%)
		NBCH_WD40	2408..2713	CDD:466575	58/314 (18%)
		WD 2	2448..2491		6/44 (14%)
		WD40 repeat	2463..2500	CDD:293791	8/38 (21%)
		WD 3	2494..2531		6/40 (15%)
		WD40 repeat	2506..2551	CDD:293791	7/47 (15%)
		WD 4	2544..2582		16/37 (43%)
		WD40 repeat	2556..2595	CDD:293791	17/38 (45%)
		WD 5	2589..2631		7/42 (17%)
		WD 6	2639..2674		1/34 (3%)
		WD 7	2682..2717		7/36 (19%)