DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bchs and Wdr81

DIOPT Version :9

Sequence 1:	NP_608968.2	Gene:	bchs / 33819	FlyBaseID:	FBgn0043362	Length:	3489	Species:	Drosophila melanogaster
Sequence 2:	XP_006532609.1	Gene:	Wdr81 / 192652	MGIID:	2681828	Length:	1945	Species:	Mus musculus

Alignment Length:	1538	Identity:	300/1538 - (19%)
Similarity:	468/1538 - (30%)	Gaps:	578/1538 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2225 SKIQKV--TGGLSRLTSRTKTKKEELVRT----RSTLTREAAYESTGIHVQLI---KDLLDLRAK 2280
            |:.:||  |.|....:..:....|||:|:    .:...|:.|....|.||..:   :.|..||.:
Mouse     5 SRRRKVVLTAGSEGWSPSSGPDMEELLRSVERDLNIDARQLALAPGGTHVVALVSTRWLASLRER 69

  Fly  2281 --------------QYQQMLQHTQRYVYQDWVQSEMELTRERGLWGP--------TGSCSLDKWI 2323
                          :.:.:||.:.:.:...|.:.|:...|:|.|..|        .||||
Mouse    70 RLGPCPRAEGLGEAEVRTLLQRSVQRLPPGWTRVEVHGLRKRRLSYPLGGGVPFEEGSCS----- 129

  Fly  2324 LDTTEGPHRMRKKTMRNDVFYLHYPYRPELELADNRQLKYKVASSLDSKTYALHGPQQPRILAEA 2388
                  |..:.:             :..|:...:.|.|          ..:|.|...||...:.|
Mouse   130 ------PETLTR-------------FMQEVAAQNYRNL----------WRHAYHTYGQPYSHSTA 165

  Fly  2389 GEHHAMQQQSSLEAVQSHR---LETSSSTSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEE- 2449
                    .|:|.|:.|.|   ......|..|....:|.|......|||...... .|.....|
Mouse   166 --------PSALPALDSIRQALQRVYGCTFLPVGESIPCLSNVRDGPCPSRGSPA-CPSLLRAEA 221

  Fly  2450 --EDTSM-----------TSDNETF--LRLLEEQEKISF-MFRCARVQGLDTFEGLLLFGKEHCY 2498
              |...|           ..|..||  .:|...|.|:.| :||..|.......:||.      |
Mouse   222 LLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFLLFRVLRAMDACHRQGLA------C- 279

  Fly  2499 IVDGFTLLKNREIRDIDTLPPGAYEPIIPNSGGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRY 2563
                                            |..|....||..||  ||     |:|
Mouse   280 --------------------------------GALSLHHIAVDEKL--CS-----ELR------- 298

  Fly  2564 LLQPIALEVFSEDGRNYLLSFPRKVRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFS 2628
             |...|.|:.|||               .||............:::...|:....:.::.   ..
Mouse   299 -LDLSAYEMPSED---------------ENQEGSEEKNGTGIKSEKEGEGRTECPTCQKE---LR 344

  Fly  2629 GLIGETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNP-KTFR 2692
            ||:.:      ||.|.||||.|||.||.||||...|...:||.||:        :|.|.| ..||
Mouse   345 GLVLD------WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWV--------VDFTTPYGRFR 395

  Fly  2693 DFSRPM------GAQAEERLEQFQKRFKEWDDPHGETP--PYHYG------THY------SSAMI 2737
            |..:..      ..|.:...|..::.|.......||.|  |:|..      |:|      :...:
Mouse   396 DLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPPHVPHHISDVLSDITYYVYKARRTPRSV 460

  Fly  2738 VCSYL-VRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELIPEFFYLPEFLSN 2801
            :|.:: .:.||...|         ...:||     :.|..         .|.||||:..|....:
Mouse   461 LCGHVRAQWEPHEYP---------ATMERM-----QTWTP---------DECIPEFYTDPSIFCS 502

  Fly  2802 FNNFDLGTKQNGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAA 2866
            .:          ..:..:.:|.|...: :||:..||:.||...|||.||.||||.||.|.||..|
Mouse   503 IH----------PDMPDLDVPAWCSSN-QEFVAAHRALLESWEVSQDLHHWIDLTFGYKLQGKEA 556

  Fly  2867 VDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAKKMGGSRHSALIDP 2931
            |...||..||     ||.:.            .:.::|.:  |||.:.|| :::.||  .||...
Mouse   557 VKEKNVCLHL-----VDAHT------------HLTSYGVV--QLFDQPHP-QRLAGS--PALAPE 599

  Fly  2932 TSLIQGNSTVLQTDRLFFHNLDNLKPSLQPIKELKGP---VGQILQPDKTVFAVEQNKVMMPPSY 2993
            ..||         .||.          :|||:|..|.   .||::.      ...:..|...|..
Mouse   600 PPLI---------PRLL----------VQPIREATGQEDISGQLIN------GAGRLVVEATPCE 639

  Fly  2994 TKYIAW-----GFADHSLRIGLYDTDRASFVSEA-------SAQNSGEILTCACPN--------- 3037
            |   .|     |..:..|.......|..|...:|       |:|.|..:|:.:.|:
Mouse   640 T---GWTRDRPGTGEDDLEQATEALDSISLPGKAGDQPGSSSSQASPGLLSFSAPSGSRPGRRSK 701

  Fly  3038 -----------AKMIVTAGTSSVVTIWKFDANRKSLA--------------------VKHSLHGH 3071
                       .|:::..|.|.:..:.:.:.....||                    ::...|..
Mouse   702 AAGLDPGEGEEGKIVLPEGFSPIQALEELEKVGNFLAKGLGSQLEEPEKPHAQPPVHLQSLFHRD 766

  Fly  3072 TDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQLRGHAGVVAAVSINELTGDIATCSATW 3136
            ...:..|.|...:...|. .....|.:|  .||..||.|.........||:..:...:.
Mouse   767 MQVLGVLLAEMVFATRVR-ILQPDAPLW--VRFEAVRGLCIRHSKDIPVSLQPVLDTLL------ 822

  Fly  3137 LHVWSINGDALAMVNTCVGSADRMQQI--------------LCVAFSQI---------------- 3171
                .::|....||:. .|..|.:.:.              |...||.:
Mouse   823 ----QLSGPKSPMVSK-KGKLDPLFEYRPVSQGLPPPSPAQLLSPFSSVVPFPPYFPALHKFILL 882

  Fly  3172 ------------RE-----WDQQNVIITGST-DG-------VVRMWSLEHTQV--------PIDR 3203
                        ||     |.|...::...| :|       |:.:.|.|||.|        |:.:
Mouse   883 YQARRVEDEVQGRELAFALWQQLGAVLNDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAK 947

  Fly  3204 KL----------------------------------------------------------KRGTE 3210
            .|                                                          ..|.|
Mouse   948 ALGPKNANKYLLKPLIGAYESPCRLHGRFYLYTDCFVAQLVVRLGLQAFLTHLLPHVLQVLAGVE 1012

  Fly  3211 VSSQDKP------------------------DTVSLEGK-------------------------D 3226
            .|.::..                        :.:.::|:                         |
Mouse  1013 ASQEEGKGLVGTTEDEESELPVSGPGSCAFGEEIQMDGQPAASSGLGLPDYRSGVSFHDQADLPD 1077

  Fly  3227 NKDDKMSLMKQIKSLSQSEEEMEIVKSASESSISEASQHSHGSSKSA-EAGPKAEVQGERRKSSI 3290
            .:|.:..|........|..|.:.:.:.:.:||.|||||   |..:.. :.|..|:      |:|:
Mouse  1078 TEDFQAGLYVAESPQPQEAEAVSLGQLSDKSSTSEASQ---GEERGGDDGGAPAD------KNSV 1133

  Fly  3291 SGAKSLHEMKSATVEGQGSSYDPKSNEDEHAIRPSKSDTSLTDGFVVIDNDRHKGDQILRKGFRW 3355
            ....|..::|.:  ||        |.|:|.           .:|.||::.|:.  |::...
Mouse  1134 KSGDSSQDLKQS--EG--------SEEEEE-----------EEGCVVLEEDQE--DEVTGT---- 1171

  Fly  3356 QRQLMFRSKLTMHTAY------DRKDNAEPASITALTVSKDHKILYVGDARGRIFSWSVTEQPGR 3414
            ....:..:.|:|.|..      ||::..||  :|..|..|:.|||.  |...::..| ::.:.|.
Mouse  1172 SELTLSDTMLSMETVVAPGDGRDREEEEEP--LTEQTEGKEQKILL--DTACKMVRW-LSAKLGP 1231

  Fly  3415 GVADHWLKDEGADQCVKCHV-----KFTLYERKHHCRNCGQVF 3452
            .||...:..........|:|     :||:........|.|.::
Mouse  1232 TVASRHVARNLLRLLTSCYVGPTRQQFTVSSDDTPPLNAGNIY 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	26/131 (20%)
		Beach	2638..2918	CDD:280327	86/301 (29%)
		WD40	<2991..3252	CDD:225201	62/482 (13%)
		WD40	2995..>3194	CDD:295369	44/305 (14%)
		WD40 repeat	3031..3070	CDD:293791	7/78 (9%)
		WD40 repeat	3075..3111	CDD:293791	9/35 (26%)
		FYVE_WDFY3	3418..3482	CDD:277259	6/40 (15%)
Wdr81	XP_006532609.1	Beach	349..589	CDD:100117	86/307 (28%)
		WD40	1645..1943	CDD:392136
		WD40 repeat	1656..1699	CDD:293791
		WD40 repeat	1704..1738	CDD:293791
		WD40 repeat	1747..1783	CDD:293791
		WD40 repeat	1793..1826	CDD:293791
		WD40 repeat	1835..1868	CDD:293791
		WD40 repeat	1875..1897	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910