DRSC/TRiP Functional Genomics Resources

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Protein Alignment bchs and sel-2

DIOPT Version :9

Sequence 1:NP_608968.2 Gene:bchs / 33819 FlyBaseID:FBgn0043362 Length:3489 Species:Drosophila melanogaster
Sequence 2:NP_001379017.1 Gene:sel-2 / 175606 WormBaseID:WBGene00004760 Length:2563 Species:Caenorhabditis elegans


Alignment Length:2902 Identity:604/2902 - (20%)
Similarity:1004/2902 - (34%) Gaps:980/2902 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   768 GGSSALQDY--TGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPYPLSYVCIVFRLLYSIALDNFE 830
            |..|....|  ||....:.||.. :.:.|:   :|:.||:||...|..:.....|::|    |.|
 Worm   139 GTQSRRDSYSATGNISRRGSLAS-FSKSFN---ISIPFSDDVTSSLPRLLSKTTLIHS----NEE 195

  Fly   831 APN--LSGIIT-LFSDPPTTLRSPSKE----LAPPVHPSQLNLTQPSPEPRIVHPGVVLCMLQLL 888
            ..:  :..::| |.|:.|.|.|:...:    |....|..|.:.........:.|      ||.||
 Worm   196 GADETIQRLVTVLHSNSPNTDRTQVVDNLFNLLVGGHFDQESKFVIEDAANVDH------MLTLL 254

  Fly   889 PAVEYDMAPLQAVQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKLTRRALAEESHPLHVP-M 952
            ...:||:      |.::: |..:..:.:|.||.:.....||..|:|.     :..|:.||... :
 Worm   255 SHCDYDL------QNEIW-SLFLAVMKKSNRNLEACTRVGLISKVLD-----ILPEAPPLLADLL 307

  Fly   953 QYILERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPLTRIKTLVSMTTPRDFRAHG 1017
            ..|:..|.|.::...:.:..||.          |:...:...|..|..:..|..|  |:    |.
 Worm   308 VQIIAALVAYSINVKQTKHLLRA----------LKSTKEQWPPNSLKLLHVLKEM--PQ----HD 356

  Fly  1018 SS-TLPPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFPPQTGLTYSTWF 1081
            |: ....|...|.|.     :.||.:                        :..|.|.|.|::||.
 Worm   357 SADVFFSFPGKDQSG-----IILPPI------------------------KTMPYQQGWTFATWL 392

  Fly  1082 CVEKFSD---PKTDP---------------HCVRLLTLVRTIHNPREENLACLSILLSARDKAIV 1128
            .:|..:.   .|..|               |......:|.......:|...|:...|.||     
 Worm   393 RMEPLNSVTFEKEQPVLYSFRTSKGVGYSCHFTGNCLVVNVEKTKGKEQSRCVRAELGAR----- 452

  Fly  1129 VSTQETLVTPRKSIGDWEPEGSDDGIARIWCPDLLHEGQWHNLVVVLNRAVLKNSSLFLYLDGVP 1193
                                                  :||::.:....:....|.:..::||..
 Worm   453 --------------------------------------KWHHIAIAHCYSRWGRSDIKCFIDGQL 479

  Fly  1194 MHTQKLHYIAQHPAAGNASLTSPTQIFGYIGTPPIWRR-----------YSRLCWKQGVCHLIED 1247
            ..|.:|.::          :||.|.          |.|           .|..|.:.|..:|..:
 Worm   480 AETIELSWV----------VTSATN----------WDRCSIGVSADGTANSAFCGQMGAMYLFAE 524

  Fly  1248 VLTQQTVQTIYQLGPHYMGSLQAPQLGKQSESLAPLVPEDRVLLGLNAKAVSKLTLVKIRKVYSR 1312
            .||.|...:::.|||.|..:.:     ..||:   .:||.......:....|.|......|    
 Worm   525 ALTLQQANSLFCLGPVYQSTFK-----HDSET---SLPEGYKKHLFDGHLHSSLVFAYCPK---- 577

  Fly  1313 ADNKSIAKQLNMNSHENA---TP---------IKILHNSAGHLAGAGRSLGGVVVGYLGVRVFSP 1365
                        |.|...   ||         ::|.|                .|...||.|.:.
 Worm   578 ------------NCHGQLCLYTPPKTAASTYFVQIPH----------------AVMKEGVEVITT 614

  Fly  1366 HPVSAMIDTVGGCNVLLGIIAMAQ---------DVESLYAGVKALTCVVRSNRAAQAEMDRKRCY 1421
            |.:...:.:|||..:||.:.|...         |.|.....:..:..::.|::::|.::...:.:
 Worm   615 HSIHKSLQSVGGIQILLPLFAQIDLPSSNDNSIDGEVCQTLLSLIALLLSSSQSSQQQLFHSKGF 679

  Fly  1422 QTLGMFFKKK------------------------------KHLLNSHIL---------------- 1440
            ..:....:|.                              |||.: :||                
 Worm   680 LIISSCLQKASPSHLSMKVLEQLIHIAKFLLRCPAGGPLLKHLFD-YILFNPKLWIRARPEVQVH 743

  Fly  1441 ---HLTFGLVGTVNSGQDMSAIPNV------------TAFQDLLCDLEIWHNAPN-------GLL 1483
               :|....:...|..|.:..:|.|            .|....:.|..|.....|       .:.
 Worm   744 LYQYLATDFLANNNFSQMLRRVPTVIEMCHTLKHFYWLALPQTVSDYTIEERPENFATADIVAIR 808

  Fly  1484 RSLLEHLLELVVESSDKKQNVKIMRDLQLLVKLLHIITQIQDHSTREILFSLLETLLGGQPRHTD 1548
            .|:|..:..:::.|:..::..:: || |.:..||:::..:::......:.:|:..||...|    
 Worm   809 SSILTFINRIIIASAGPEEEERV-RD-QEVHTLLNLLATVREDDNLYDVLALVTRLLAEHP---- 867

  Fly  1549 LLLFGQYVAAKLPHAHSGGLERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLLFTPRNTV 1613
                                  |:::|::.                :|:.|.::..||..|...:
 Worm   868 ----------------------AIMIPAID----------------KNKALGIIFNLLAAPNELI 894

  Fly  1614 NYVICDDISKTLGMDWLLLFMQPHVHFTTVIIAVRILVVICANESFLVRFRDATHNGGYLRF--T 1676
            .                             |.|::||... .:.|.|.|..::..|......  .
 Worm   895 R-----------------------------IPALKILGFF-LSRSTLKRKTESMGNQNLFSLIGE 929

  Fly  1677 EMVSQRKMLGLGAQQLNQRPTNGTGTVIVA---TPQNTIQ-HLPTQIAGEVRAAALNIPGFQLLE 1737
            .::|.:|:|.|        ||......|:.   ||..|.. |.|.|            |     |
 Worm   930 RLLSHKKVLSL--------PTYNVLLEILVEQMTPTFTYACHQPAQ------------P-----E 969

  Fly  1738 W-LMNHHLDVPELYFLITALIMGQPVKVLATEHTKFDLDRVWSFLWGAPVSAN-TQLPK------ 1794
            | ..|.||                 :||:|  |.....:.          |.| .|:.|      
 Worm   970 WKFENPHL-----------------LKVIA--HVISQCEE----------SENIVQIKKCFLIDI 1005

  Fly  1795 LNICPEGVCVLLAMVRGIVHGGECAPWLHSHPETIIQLLFSLYQN-LTDFAPVMMTGD---VVTS 1855
            :|:|.|.                     ..:..||:|:  |::|: |...|.|..|.:   .|:.
 Worm  1006 INLCRES---------------------KENRRTILQM--SVWQDWLIGLAYVFHTTESQNEVSE 1047

  Fly  1856 LVAVLFPLASRPADSEPNSGASTPTDDTGSSFALPPPETLHGAPQPKLTAHPVCNCIIDFLRVIV 1920
            ||...|.:....|......|.....|    :.|:...:......:.||....:        :...
 Worm  1048 LVWEAFSILLHHALRNEYGGWRVWVD----TLAIAHSKVSFEKFKRKLAEAKI--------KAER 1100

  Fly  1921 VDSLGLNMQGKPTPVIDLVLDAAPESAELPLQVQYQTQIIIAL---MDHLLAADVLVGEQAALPL 1982
            .:|.|...:.:|||:.     .|||.|...:.|:....::..:   :|....|:..:.:|..   
 Worm  1101 SESGGEEAKMEPTPIY-----RAPEFAWSDVHVRLLADLLSGIERVVDEWKVAECGISDQCN--- 1157

  Fly  1983 VPLLQSQMQYIAPNVFYLTARIVDKLWQGC------LA-----RNPHDIFD-------------- 2022
                .|:.|....||.::.:::.|.|...|      ||     .|..:|.|              
 Worm  1158 ----ASENQVFVGNVVHVVSQLSDSLIMACGGLLPLLASATAPNNDMEIVDPCQQQLPISVSAGF 1218

  Fly  2023 ----------FVIK------------------LIVQAKRRSSSLSLEHLHHSLNRSILFLLSR-- 2057
                      ||:.                  ::.|:.|.|:::::.|:          |.||  
 Worm  1219 LMRFARLVDTFVLASGVSFSELEQEKNMPAGGVLRQSLRISATVTVRHI----------LASRIQ 1273

  Fly  2058 -------PTDDSRADQMSV--------------LEALHKIIQ-----------HRLLIFGAGNHE 2090
                   .|:.::.:|..:              ||.:.:::|           :|.::  ..|.:
 Worm  1274 QPDTPRYETNSTKKNQCIMEFVREALEKRSPDGLENVERLVQDSDITRIKGVVYRDMV--EENRQ 1336

  Fly  2091 LEFIGCLTYCLLQ--LTADMKIILEPATS-----------RNTTWHVNPQT-------------- 2128
            .:|:......|:.  :.:..:.||||.:|           :..:.:||.:|              
 Worm  1337 AQFLALSVIYLVSVLMVSRYRDILEPPSSPSPFFDSTTQKQENSENVNSETSPENGSNGKLANGG 1401

  Fly  2129 ----------ETAEPKDEDLNQLQGRNLIVG--AAFRV------------WEELYVCKKPAIEEV 2169
                      ......:|:.|..:|:....|  ||.:|            ::|         ||:
 Worm  1402 DNLSIKNGIESNGNDGEEEENGEEGQGDDGGRIAAIKVANADMKRGDGNEYDE---------EEL 1457

  Fly  2170 FKVSLTSPPPNSKAPDLQTTREQVMELASKLWFNYVEAERKATYRAPW--ELHTQIQSKIQKVTG 2232
            .|:..::....|....:|.|.|:...|.:||       :......||.  |:.:..:..:||...
 Worm  1458 SKMHQSNGRRPSTMMPVQQTAERRAYLTTKL-------QTALETCAPLLREMMSDFRGYLQKTLL 1515

  Fly  2233 GLSRLTSRTKTKKEELVRTRSTLTREAAYESTGIHVQLIKDLLDLRAKQYQQMLQHTQRYVYQDW 2297
            |.........||..|.:|.|              :..:|:.::.|.::::|..||......:   
 Worm  1516 GTHGQEIMNDTKVLETLRNR--------------NASVIELVMLLCSQEWQTSLQKHAGLAF--- 1563

  Fly  2298 VQSEMELTRERGLWGPTGSCSLDKWILDTTEGP---HRMRKKTM----------RNDVFYLHYPY 2349
                :||..|..|   ....:.|..:....|..   :|:|.:.:          |..:...|..|
 Worm  1564 ----IELVNEGRL---MAHATRDHVLRVANEADFILNRLRAEDVSKHAQFEAESREQLAARHEEY 1621

  Fly  2350 -RPELELADNRQLKYKVASSLDSKTYALHGPQQPRILAEAGEHHAMQQQSSLEAVQSHRLETSSS 2413
             |.:|.:|..|......|:.|..|..|        ||::        |..|....|..:|:....
 Worm  1622 GRCDLLIASGRLRDSINATRLLEKMSA--------ILSD--------QDDSKSGTQFWKLDVWED 1670

  Fly  2414 TSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRLLEEQEKISFMFRCA 2478
            .|......:|...|       ....:.|.||.::.||..            :.|||||..:.:. 
 Worm  1671 DSRRRKRFVPNAYG-------SRHEEANLPEGEKNEEPE------------ISEQEKIRKVLKG- 1715

  Fly  2479 RVQGLDTFEGLLLFGK------EHCYIVDGFTLLKNREIRDIDTLP---------------PGAY 2522
                        ||.|      .| .:||...:  ::..:::|..|               ||..
 Worm  1716 ------------LFSKRQNSSGSH-ELVDESDI--DKWAQEVDPTPSSQSACFSTTAKLIAPGVV 1765

  Fly  2523 EPIIPNSGGTSSTTS---------------RAVSHKLRQC----SKFAYEEIREVHKRRYLLQPI 2568
            .|      ||.|.|:               :..:..||.|    :::..:|||.:..||||||..
 Worm  1766 VP------GTLSVTANDLFFDANESDPNYKKQCAQVLRYCEALHARWNLQEIRAIFLRRYLLQNT 1824

  Fly  2569 ALEVFSEDGRNYLLSFPRK-VRNKVNQRFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIG 2632
            |||:|.......:.:|..: ...||..:...:...:.....||     |..|:.....:|.    
 Worm  1825 ALELFLASRTAIMFAFDSEDAVKKVVYQLPRVGVGVKYGLPQS-----RKTSLMTPRQLFK---- 1880

  Fly  2633 ETSVTQRWVRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRP 2697
            .:.:..:|.:.|||||.|||.|||:|||::|||.|||||||||.:|.|:.|||:....|||.|:|
 Worm  1881 HSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVASNFRDLSKP 1945

  Fly  2698 MGAQAEERLEQFQKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDL 2762
            :||.:|.|.:.|..|:..|||  .:.|.:|||||||:.....::|:|:|||:..|:.|..|.||.
 Worm  1946 IGALSEARRKFFNDRYTSWDD--DQVPAFHYGTHYSTPAFTLNWLLRVEPFASMFINLHDGKFDH 2008

  Fly  2763 ADRMFHSIKEAWLSASKLNMADVKELIPEFFYLPEFLSNFNNFDLGTKQNGETLNHVILPPWAKH 2827
            .||:.||||::| ...:.:..||||||||.|||||...|.:.|:||.:.:|..::.|:|||||: 
 Worm  2009 PDRITHSIKDSW-DRCQRDSHDVKELIPELFYLPEMFRNSSKFNLGRRADGTPVDDVVLPPWAE- 2071

  Fly  2828 DPREFIRLHRSALECDYVSQHLHLWIDLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLK 2892
            .|..|:.:||.|||.|.||..|:.|||||||.||:|..||.|.|||:||.|||.|.....:.|.:
 Worm  2072 SPEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNVFYHLTYEGTVTPKMAETPGQ 2136

  Fly  2893 KNATIGFINNFGQIPKQLFKKAHPAKKMGGSRHSAL-IDPTSLIQ------------GNSTVLQT 2944
            ..|....|.:|||.|.||..:|||      .|||.: :.||...:            .||.|:..
 Worm  2137 VAAIEQQILSFGQTPSQLLTEAHP------PRHSIMSMAPTMFRRHDEDLCMMMKYISNSPVVYL 2195

  Fly  2945 DRLFFHNLDNLKPSLQPIKELKGPVGQILQPDKTVFAVEQNKVM--------------------M 2989
            ....||.|                      |..||..|.||.|.                    |
 Worm  2196 AANTFHQL----------------------PQPTVVGVAQNLVFSLNKWDNSYSYGASQRSALSM 2238

  Fly  2990 PPSY-------------------------------------------------TKYI-AWGFADH 3004
            .||.                                                 :|:| |.|:.|:
 Worm  2239 DPSNAEGQVSLPLTADAQLASAASTTPVARRHLGDAFDQRLTVQCSNFVTTTDSKFIFACGYPDY 2303

  Fly  3005 SLRIGLYDTDRASFVSEASAQNSGEILTCACPNAK------MIVTAGTSSVVTIWKFDANRKSLA 3063
            |.||  .||| :..|.:| ....|:::||...:..      .:||......|.:|.::.....:|
 Worm  2304 SFRI--VDTD-SGRVRQA-VYGHGDVVTCIARSETSLFSDCYVVTGSMDCTVVLWHWNGTTGFIA 2364

  Fly  3064 VKHS-----------LHGHTDAVTCLAASAAYNVIVSGSRDGTAIVWDMTRFTFVRQLRGHAGVV 3117
            .:::           |.||..:::.|..||.:.::|||..||..:: ..|....:|::||| |:|
 Worm  2365 GEYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVILI-HTTSSDLLRRIRGH-GIV 2427

  Fly  3118 AAVSINELTGDIATCSATWLHVWSINGDALAMVNTCVGSADRMQQIL------CVAFSQIREWDQ 3176
            ..:|::.      .|....|.      |:..|| |...:|.::.::|      ||..::..|:  
 Worm  2428 TQLSMSR------ECILLSLF------DSKRMV-TYSATAKKLDEVLVDDKIECVTVTRDGEF-- 2477

  Fly  3177 QNVIITGSTDGVVRMWSL-----EHTQVPIDRKLKRGTEVSS 3213
               .:||:.:|.:.:|.:     .:|..|::..::....|:|
 Worm  2478 ---AVTGAVNGRINIWRMFPLTKLYTYQPLNSAVRSVAVVAS 2516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bchsNP_608968.2 PH_BEACH 2469..2600 CDD:275391 37/171 (22%)
Beach 2638..2918 CDD:280327 140/279 (50%)
WD40 <2991..3252 CDD:225201 61/301 (20%)
WD40 2995..>3194 CDD:295369 55/222 (25%)
WD40 repeat 3031..3070 CDD:293791 8/55 (15%)
WD40 repeat 3075..3111 CDD:293791 10/35 (29%)
FYVE_WDFY3 3418..3482 CDD:277259
sel-2NP_001379017.1 LamG 384..530 CDD:419873 32/208 (15%)
DUF4704 605..870 CDD:406270 42/293 (14%)
DUF1088 1569..1733 CDD:399463 42/215 (20%)
PH_BEACH 1757..1854 CDD:405526 26/102 (25%)
Beach 1887..2162 CDD:396627 140/284 (49%)
WD40 repeat 2283..2321 CDD:293791 13/41 (32%)
WD40 2291..2535 CDD:421866 59/250 (24%)
WD40 repeat 2327..2382 CDD:293791 8/54 (15%)
WD40 repeat 2387..2422 CDD:293791 10/35 (29%)
WD40 repeat 2430..2462 CDD:293791 8/44 (18%)
WD40 repeat 2466..2502 CDD:293791 8/40 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160162559
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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