Protein Alignment bchs and nbeal1

DIOPT Version :9

• Sequence 1: NP_608968.2
• Gene: bchs / 33819
• FlyBaseID: FBgn0043362
• Length: 3489
• Species: Drosophila melanogaster
• Sequence 2: XP_002937765.2
• Gene: nbeal1 / 100494980
• XenbaseID: XB-GENE-990549
• Length: 2716
• Species: Xenopus tropicalis
• Alignment Length: 3197
• Identity: 694/3197 - (21%)
• Similarity: 1125/3197 - (35%)
• Gaps: 1080/3197 - (33%)

  Fly   492 LEFIVFQLNFVPC-------KELISLSLL---------LKHNQSTSCSILCLKTLLNILRHNAVF 540
            :|||.|   |..|       ||.:...||         .:.|...:.|...::.|:.||.....:
 Frog   192 VEFIPF---FYQCFQESEHLKESLKCCLLHLFGSILSGSQRNALQAISPATIEVLMRILADCDTW 253

  Fly   541 KD-----VYREVGILEIFVGCLTRYAAHVQKITKGDE-----SVVVE----LENESE-------- 583
            .|     |.|:.   |:.:.|||. ..|:..::..|:     |.::|    |.|...
 Frog   254 NDGDTGEVSRKA---ELTLKCLTE-VIHILLVSSSDQRQVEISTILENYFKLLNSDHSALSSQRR 314

  Fly   584 ----EELFDTLGKHVLEALTMLLGGGASNNAQLFREYGGAKCVHELVK-FKHCRPQALGIVRELI 643
                |..|.||...:|..:|.:|  ...:...|...:..:.|...|:: .::||         |:
 Frog   315 SRHWENRFITLQIKMLTCMTDML--NCKDRPVLQAIFLNSNCFEHLIRLLQNCR---------LL 368

  Fly   644 LSA---GGDDDMLHILSLMHSVSPLQVEFKIQILNMLLGCLKDSHRTRTVFRKVGGFVYVTSVFV 705
            |:|   |.:                  :.:.:::|.||..:.::                 .||
 Frog   369 LNANYRGAE------------------KSEKELVNKLLTEMNEN-----------------QVF- 397

  Fly   706 SLDGSMALPQPDIPQQDLILLLQIVFQTLATAMRFEPANAKFFHQEISSSSLCDTLRLLGCFGGS 770
                          |:.|..|.....|.|.......|:..:.|.:.|..:...|.|:.||
 Frog   398 --------------QERLDRLSVTTIQALTAVKHKSPSAKEVFKERIGYAHFLDVLKSLG----- 443

  Fly   771 SALQDYTGTYEPQQSLLKYYHEIFSGDILSVSFSEDVPYPLSYVCIVFRLLYSIALDNFEAPNLS 835
                      :|.:.||:        ::|:::...|                         .|:.
 Frog   444 ----------QPTRLLLE--------ELLNMAVEGD-------------------------HNIV 465

  Fly   836 GIITLFSDPPTTLRSPSKELAPPVHPSQLNLTQPSPEPRIVHPGVVLCMLQLLPAVEYDMAPLQA 900
            ||:.:.:..|                                   :|.::|.||.:       |:
 Frog   466 GILGISNVQP-----------------------------------LLLLIQWLPEI-------QS 488

  Fly   901 VQLQVYLSEIIKSLVRSERNQQIMCDHGLAEKLLKL---------TRRALAEESHPLHVPMQYIL 956
            ..||:::||.:|.:....:..:.||.:  |..::::         ..||.||.       :..:|
 Frog   489 HDLQIFISEWLKRICCINKQSRTMCVN--ANMVIRIIETLNSHYSLHRACAEN-------LIGLL 544

  Fly   957 ERLAAQALQPTELRQFLRLGEPLSCADIDLQQPYKLGGPVPLTRIKTLVSMTTPRDFRAHGSSTL 1021
            ..|.:|::...||...|.|   |...:.....||    .:|:||  .|:::|     |..|..:.
 Frog   545 GSLGSQSMSSEELFHLLSL---LRTKEHKQSHPY----VIPVTR--ALLAIT-----RKQGLCSA 595

  Fly  1022 PPFVELDMSAEGFGCLYLPSLAPQATATAGGTIDANSIGGIGAGDRIFPPQTGLTYSTWFCVEK- 1085
            ..:..|..|..|   :.:|::...                         |.:..::..|.|:::
 Frog   596 LQYFNLSHSLAG---IAVPTVQKW-------------------------PGSAFSFFAWLCLDQD 632

  Fly  1086 --FSDPKTDPHCVRLLTLVRTIHNPREENLACLSILLSARDKAIVVSTQETLVTPRKSIGDWEPE 1148
              ||...:.....:.|....|......|     :.:.|:....:.|.|::...|
 Frog   633 QSFSAVSSSGTKRKQLYSFFTSSGTGFE-----AFITSSGVLVVAVCTKKEYAT----------- 681

  Fly  1149 GSDDGIARIWCPDLLH---EGQWHNLVV--VLNRAVLKNSSLFLYLDGVPMHTQKLHYIAQHPA- 1207
                    :..||  |   :..|||:.:  |..:.....|.:::|::|....:..|.:.:.:.|
 Frog   682 --------VMLPD--HCFCDSLWHNVTIVHVPGKRPFGQSFVYIYVNGQQKASAPLKFPSMNEAF 736

  Fly  1208 -------AGNASLTSP-----------------TQIFGYIGTP---------------------- 1226
                   ||..:.|.|                 |.:.|.:.:|
 Frog   737 TSCCIGSAGQRTNTPPPSQIPDPPISPPSAGTRTSLGGILSSPSWSGTHGKTDGVTKLISAGTQD 801

  Fly  1227 PIWRRYSRLCWKQGVCHLIEDVLTQQTVQTIYQLGPHYMGSLQAPQLGKQSESLAPLVPEDRVLL 1291
            ..|...:.|....|...:..|||....|:|:|..||:.:      .|.|..||....:|
 Frog   802 SEWGSPTSLEGHLGSVLIFHDVLQAAQVKTLYLAGPNSL------SLWKSQESELTDLP------ 854

  Fly  1292 GLNAKAVSKLTLVKIRKVYSRADNKSIAKQLNMNSHENATPIKILHNSAGHLAGAGRSLGGVVVG 1356
                   :||.|....|    |....|...|:.|         :||         ||..|..||.
 Frog   855 -------TKLLLYYTPK----ACKNPICLDLSSN---------VLH---------GRLTGNKVVN 890

  Fly  1357 YLGVRVFSPHPVSAMIDTVGGCNVLLGIIAM--------AQDVESLYAGVKALT------CVVRS 1407
            :         .:..||:.:||.|.|..::..        .:..:|.....:.||      .|:.|
 Frog   891 W---------DIKDMINCIGGLNSLFPLLEQISYLNELPCEKTDSCVTATEHLTPIEGDFVVLSS 946

  Fly  1408 NRAAQAEMDRKRCYQTLGMFFKKKKHLLNSHILH----------LTFGLVGTVNSGQDMSA---- 1458
            .:|::|.:::    ..:..|....|||:..|.::          .|.|::....||..|..
 Frog   947 TKASEARLEK----NIVATFILLIKHLIQRHPINQEVLTYSHGVATLGVLLQKVSGNLMDVNVLM 1007

  Fly  1459 -----IPNVTA----------FQDLLCDLEIWHNAPNGLLRSLLEHLLELVVESSD---KKQNVK 1505
                 |..|:.          :|.||.|..||:..........::::..::.:|..   ||..::
 Frog  1008 AVQLLIEQVSVEKNTLLLQQMYQYLLFDFRIWNRGDFPFRIGHIQYVSTIIKDSRKLFRKKYGIQ 1072

  Fly  1506 IMRDLQLLVKLLHIITQIQDHST-REILFSLLETLL--GGQPRHTDLLLFGQYVAAKLPHAHSGG 1567
            .:.|...:...........|.:| |..||.|::..|  ||.|.....::  .|:||...
 Frog  1073 FLLDTIRIYYSKENALAADDLTTIRTSLFGLIKYFLSKGGAPEEIQSII--GYIAAITD------ 1129

  Fly  1568 LERAVLLPSMKNPAEDQDGGVAQNIYLRNRCLSLLHGLLFTPRNTVNYVICDDISKTLGMDWLLL 1632
                          |:|..|:.:.|      |.||:|                 |..|...:|||
 Frog  1130 --------------EEQIYGILEII------LHLLNG-----------------SPVLDQLFLLL 1157

  Fly  1633 FMQPHVHFTTVIIAVRILVVICANESFLVRFRDATHNGGYLRFTEMVSQRKMLGLGAQQLNQRPT 1697
            | :|.        :..:|..:..|:    |:.|......:..|.:|:...|:.....|::..|..
 Frog  1158 F-EPG--------SADMLYALLLNQ----RYSDKLKETVFKIFEQMLKCNKVYEKSKQRIRLREV 1209

  Fly  1698 --NGTGTVIVATPQNTIQHLPTQIAGEVRAAALNIPGFQLLEWLMNHHLDVPELYFLITALIMGQ 1760
              :|.|.::..:..:|:                      |::.|:|..|....:.:
 Frog  1210 GYSGLGLLLNDSSISTV----------------------LIKGLLNQILTADTINY--------- 1243

  Fly  1761 PVKVLATEH--TKFDLD-RVWSFLWGAPVSANTQLPKLNICPEGVCVLLAMVRGIVHGG-----E 1817
             ..:||..|  |:.||. ||                       .||..:..:....|..     :
 Frog  1244 -KDLLAVVHLSTRADLTVRV-----------------------AVCRKILQLLQFQHDAAFQVCQ 1284

  Fly  1818 CAPWLHSHPETIIQLLFSLYQNL----------TDFAP-------------------VMMTGDVV 1853
            ...|    .||:::  |.|.:||          ||...                   ||...|..
 Frog  1285 QVGW----QETLVR--FFLKENLECKSNFRASCTDSIKEDEQNAVSEETQKQSSEEVVMDQADGC 1343

  Fly  1854 T---SLVAVLFPLASRPADSEPNS----------------------GASTPTDDTGSSFALPP-- 1891
            |   :.....||..|:..||...|                      |...|:|.:..:..|.|
 Frog  1344 TLNNNQYNSYFPEESKSLDSSNQSSCALLDDEESIFSEAQYKVEDQGNDWPSDHSHLTLDLTPFD 1408

  Fly  1892 --------PETLHGAPQPKLTAHPVCNCIIDFLRVIVVD------------------SLGLNMQG 1930
                    |.:|...|.|           ::..:..|::                  ||.:||:.
 Frog  1409 AGFRENQIPGSLPSTPSP-----------VENSKQFVMNQSDKDSNSLKNVFFRDDLSLSVNMES 1462

  Fly  1931 KPTPVIDLVLDAAPESAELPLQVQYQTQIIIALM----DHLLAADVLVGEQAALPLVPLLQSQMQ 1991
            :             |..|..| ||..|.|::.||    |...:|..:...|....|..|..|.|.
 Frog  1463 R-------------EDCEEEL-VQLVTDILLCLMWKGLDKSDSATWIERGQIFSALTCLESSSML 1513

  Fly  1992 YIAPNVFYLTARIVDKLWQGCLARNPHDIFDFVIKLIVQAKRRSSSLSLEHLHHSLNRSILFLLS 2056
            ..:.:...|  .:::|:.:..:..|              .:.:|..:..|:....|:....||.:
 Frog  1514 LRSSDEIKL--NLLEKMPEWAVTEN--------------RESKSQPIYCENAKRLLHIVQDFLQT 1562

  Fly  2057 RPTDDSRADQMSVLEALHKIIQHRLLIFGAGNH-----ELEF---IGCLTYCLLQLTADMKIILE 2113
            ....:.......:||.:..::....:.:.:|..     :|||   :|.:....||:.|      .
 Frog  1563 EGLKNPVLWTEKLLEEIVTLMDGISVWYSSGPESESLSQLEFRLLLGFIAQDNLQVCA------M 1621

  Fly  2114 PATSRNTTWHVNPQTETAEPKDED---LNQLQGRNLIVGAAFRVWEELYVCKKPAIEEV------ 2169
            .|...||..    ||:..|.::|.   |.:|:|   |:|.:.:...|.|....|.:..:
 Frog  1622 AAAKLNTLL----QTKVIENQEEACYLLGKLEG---ILGKSIKEKTETYSFLIPIVRTLVSKIYQ 1679

  Fly  2170 ---FKVSLTSPPPNSKAPDLQTTREQVMELA-SKLWFNYVEA------------------ERKAT 2212
               ..:.|.|.|..:..|.|   .|...|.. |..|..:::.                  |:.||
 Frog  1680 LLFMHLHLPSLPITNGNPSL---FEDFQEYCNSDEWRIFIDKYIILYMKQYEVDTFGKCHEQMAT 1741

  Fly  2213 YRAPWELHTQIQSKIQKVTGGLSRLTSRTKTKKEELVRTR----STLTREAAYESTGIHVQLIKD 2273
            |   |:...:.|         :..:..|.:.:.|..::.:    ....|:...|::
 Frog  1742 Y---WKECYEAQ---------MVNMHKRERERGESKLKFKEFFLEPFNRKTRQENS--------- 1785

  Fly  2274 LLDLRAKQYQQML-QHTQRY--VYQDWVQSEMELTRERGLWGPTGSCSLDKWILDTTEGPHRMRK 2335
                   :|..|| |...:|  ..:.|..::..|..|||.|..... :...|.|.|.|...|||.
 Frog  1786 -------RYNNMLKQVNSQYTATLRQWKAAQRYLFCERGPWADRKE-NWQYWKLSTVENYSRMRL 1842

  Fly  2336 KTMRNDVFYLHYPYRPELELADNRQLKYKVASSL-DSKTYALHGPQQPRILAEAGEHHAMQQQSS 2399
            |.::|..|..|      ||           ||:| |:.......|....:|.||.      :|..
 Frog  1843 KLVQNLNFDAH------LE-----------ASALRDNLGVQQTEPSSESLLLEAA------KQVK 1884

  Fly  2400 LEAVQSHRLETSSSTSTPPPMVLPKLVGHGSTPCPQESVDGNAPEDDEEEEDTSMTSDNETFLRL 2464
            :..::..:||            ||                        |||:....:|.|..:
 Frog  1885 VSDLEEDQLE------------LP------------------------EEENVVNMNDKEEQI-- 1911

  Fly  2465 LEEQEKISFMFRCARVQGLDTFEGLLLFGKEHCYIVDGFTLLKNREIRDIDTLPPGAYEPIIPNS 2529
              ::||:.....|..:..:|...|.|....:|.|..||.|  :..|....|
 Frog  1912 --QKEKLVLSEECDLITVMDAISGHLEVTTQHIYFYDGST--EKEEGVGFD-------------- 1958

  Fly  2530 GGTSSTTSRAVSHKLRQCSKFAYEEIREVHKRRYLLQPIALEVFSEDGRNYLLSFPRKVRNKVNQ 2594
                              .|:...:|||:|.|||.|:..|||:|..|..||.|:|.::|||||..
 Frog  1959 ------------------FKWPLSQIREIHLRRYNLRRSALEIFLIDQTNYFLNFKKEVRNKVYS 2005

  Fly  2595 RFLALATALNDNAQQSVAGQKRTASVEQTAGIFSGLIGETSVTQRWVRGEISNFQYLMHLNTLAG 2659
            |.|:|..       .::.|.:....:.:.:|:          ||:||..|||||.||:.|||:||
 Frog  2006 RILSLRL-------PNIYGTRSPQELLKASGL----------TQKWVNREISNFDYLIQLNTIAG 2053

  Fly  2660 RSYNDLMQYPVFPWILADYDSEELDLTNPKTFRDFSRPMGAQAEERLEQFQKRFKEWDDPHGETP 2724
            |:||||.|||||||:|.||.||||||.||..|||.|:|:|...|:.....:.:::.::||.|...
 Frog  2054 RTYNDLAQYPVFPWVLQDYTSEELDLNNPAVFRDLSKPIGVVNEKNAAIVKDKYESFEDPLGTID 2118

  Fly  2725 PYHYGTHYSSAMIVCSYLVRLEPFSQPFLKLQGGHFDLADRMFHSIKEAWLSASKLNMADVKELI 2789
            .:|||||||:|..|..||:|:||::...::||.|.||.|||.||||...| .|...|..||||||
 Frog  2119 KFHYGTHYSNAAGVMHYLIRVEPYTTLHIQLQSGRFDCADRQFHSIPATW-QALMDNPNDVKELI 2182

  Fly  2790 PEFFYLPEFLSNFNNFDLGTKQ-NGETLNHVILPPWAKHDPREFIRLHRSALECDYVSQHLHLWI 2853
            |||||.||||.|.|.||||..| ..|.:|.||||.||| .|.:||..||.|||.::||.|||.||
 Frog  2183 PEFFYFPEFLENKNGFDLGHLQITKEQVNDVILPKWAK-SPEDFILKHRKALESEFVSAHLHEWI 2246

  Fly  2854 DLIFGCKQQGPAAVDAVNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPAK 2918
            |||||.||:||||::|:|||::..|||.||:..|.:..::.|..|.||||||.|.||.|:.||.:
 Frog  2247 DLIFGYKQRGPAAIEALNVFYYCTYEGAVDLDAIANEKERKALEGMINNFGQTPCQLLKEPHPTR 2311

  Fly  2919 KMGGSRHSALIDPTSLIQGNSTVLQTDRL------FFHNLDNLK-----------PSLQPI---- 2962
                            :......|:..:|      .|.||.:||           |.::.|
 Frog  2312 ----------------LSAEEVYLKQSKLDNVTLNLFQNLPDLKSFFIEGISDDVPVVKAIVPKN 2360

  Fly  2963 ----------KELKGPVGQI--------LQPDKTV---FAVEQNKVMMPPSYTKYIAWGFADHSL 3006
                      .||...|.|.        |..|:|:   |...:::.:..|...:.::..||.
 Frog  2361 QLRSFLSPGSPELLVTVSQTLIIGTHGWLPYDRTISNYFTFSKDQTVTNPKTQRLVSGPFAP--- 2422

  Fly  3007 RIGLYDTDRASFVS-EASAQNSG-------------------------EILTCACPN--AKMIVT 3043
              ||..|.:...|| :.....||                         :|:||...:  ...:::
 Frog  2423 --GLEITSKLFVVSHDGKVLFSGGHWDNSIRVTSLTKGKVTSQHIRHMDIVTCLSTDFCGIHLIS 2485

  Fly  3044 AGTSSVVTIWKF-----DANRKSLAVKHSLHGHTDAVTCLAASAAYNVIVSGSRDGTAIVWDMTR 3103
            ....:...||:.     |.:.|.|.:   |:||||.:|.:..|...:..|||::||..|:..:.|
 Frog  2486 GSRDTTCMIWQIGQQGGDLSSKPLQI---LYGHTDEITSVCISTELDTAVSGAKDGAVIIHTIRR 2547

  Fly  3104 FTFVRQLRGHAGVVAAVSINELT----GDIATCSA---------TWLHVWSINGDALAMVNTCVG 3155
            ..:||.|:..:.....:||..|.    |.|...|:         ..||::||||..|.
 Frog  2548 GQYVRTLKPPSESSLLMSIPNLAMSLDGHIVIHSSIEGKSIKNKNALHLYSINGKYLV------- 2605

  Fly  3156 SADRMQQI--LCVAFSQIREWDQQNVIITGSTDGVVR---MWSLEHTQVPIDRKLK-RGTEVSSQ 3214
            |....:|:  :|:.        .:|::: ||..|.:.   ::||..:..|:..::. ....|:.:
 Frog  2606 SELLKEQVTDMCII--------SENIVL-GSRQGFLSIRDLYSLNLSLTPLVMRVPIHCVSVTKE 2661

  Fly  3215 DKPDTVSLEGKDNKDDKMSLMKQIKSLSQSEEEMEIVKSASESSISEASQHSHGSSKSAEAGPKA 3279
            :....|.||     |.|:.::.              :...:|:...:.|:...|||
 Frog  2662 NSHILVGLE-----DGKLIIVG--------------IGKPAEARSGQISRKLWGSS--------- 2698

  Fly  3280 EVQGERRKSSIS 3291
                 ||.|.||
 Frog  2699 -----RRLSQIS 2705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bchs	NP_608968.2	PH_BEACH	2469..2600	CDD:275391	38/130 (29%)
		Beach	2638..2918	CDD:280327	158/280 (56%)
		WD40	<2991..3252	CDD:225201	64/312 (21%)
		WD40	2995..>3194	CDD:295369	54/249 (22%)
		WD40 repeat	3031..3070	CDD:293791	8/45 (18%)
		WD40 repeat	3075..3111	CDD:293791	11/35 (31%)
		FYVE_WDFY3	3418..3482	CDD:277259
nbeal1	XP_002937765.2	DUF4704	888..1144	CDD:374111	55/296 (19%)
		DUF4800	1610..1863	CDD:374334	65/314 (21%)
		PH_BEACH	1914..2011	CDD:275391	38/130 (29%)
		Beach	2032..2311	CDD:366934	158/280 (56%)
		WD40	2436..2705	CDD:392136	64/320 (20%)
		WD40 repeat	2472..2514	CDD:293791	8/44 (18%)
		WD40 repeat	2519..2556	CDD:293791	12/36 (33%)
		WD40 repeat	2564..2592	CDD:293791	6/27 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920